CN100475967C - Preparation for Chinese medicine multiple fungus mixed fermenting oral liquid and producing process thereof - Google Patents
Preparation for Chinese medicine multiple fungus mixed fermenting oral liquid and producing process thereof Download PDFInfo
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Abstract
A Chinese medicine in the form of oral liquid is prepared from the Chinese-medicinal materials and more useful bacteria through mixing and fermenting to generate a lot of organic acid, alcohol and microbial enzyme for fully dissolving the minerals and active components of Chinese-medicinal materials and increasing its curative effect.
Description
The present invention relates to a kind of Chinese medicine multiple bacteria compound fermentation oral liquid and production technique thereof.
Along with the continuous development of science and technology, human understanding and application to Chinese medicine is more and more, and " Chinese medicine voluminous dictionary " included 5767 kinds in Chinese medicine.According to the medical treatment and the needs of preparation, the concocting method of Chinese medicine is also constantly increased, its purpose nothing more than: 1. reduce or the toxic side effect of elimination medicine; 2. change or relax the performance of medicine; 3. medicament curative effect enhancement; 4. priming return through; 5. be convenient to adjust and preparation; 6. improve the medicine cleanliness; 7. correct drug smell; 8. be beneficial to drug storage.Its concocting method has steaming, boils, fries, bakes, processs, forges, big gun, refine, soak and fly and germination, fermentation, making drugs into frostlike powder or the like.But all be form based on the prepared slices of Chinese crude drugs.Traditional water boiling method, bother many, dosage is big, the patient will drink a lot of tasty liquid medicine, curative effect not only slowly but also poor.Along with the research of the mankind to the Chemistry for Chinese Traditional Medicine and the science of Chinese drug processing, it is few to find that gradually the Chinese medicine pharmaceutical compositions transforms, transforming slow reason, is because the pharmaceutical compositions of Chinese medicine not only has ore deposit element, VITAMIN, amino acid, also has plant bases, flavonoid, the rare class of terpene etc. a variety of.As the rare class composition of terpene of contained kind more than 2200 in the Chinese medicine, have several thousand kinds only water-soluble, have several thousand kinds only to be dissolved in organic acid, the solvent that only is dissolved in other that has.Every class pharmaceutical compositions all has this specific character.But these pharmaceutical compositions can both be decomposed by corresponding enzyme.Traditional poach Chinese medicine of using can only water-soluble pharmaceutical compositions be dissolved out, so curative effect is very poor.
Technologies such as the lixiviate of modern Chinese herbal medicine, ultrafiltration are refining, concentrate have been walked out the prepared slices of Chinese crude drugs ancient traditional process of preparing Chinese medicine pattern in several thousand, develop refining Chinese patent medicine and the Chinese-western medicine mixed preparation of concentrating.But this method only is to extract effective ingredient in single medicinal material, and then mixes and make Chinese patent medicine.Some pharmaceutical compositions is that the new composition that two flavors or a few flavor Chinese medicine could produce together the time then can not produce.This type of situation is the verified fact of long-term practice.
The domestic food industry adopts microbial technique fermented wine, vinegar, soy sauce, allow microorganisms enzymatic conversion, decompose sugar and protein.Production Chinese medicinal liquor, Chinese medicine vinegar are also arranged, but all be to soak Chinese medicine, be still traditional Chinese medicine preparation method, can only transform the pharmaceutical compositions that is dissolved in wine, is dissolved in acid out with wine or vinegar.And the bacterial classification of fermented wine, vinegar is single, and the enzyme class of generation is few, and the material of decomposition is also few.Fermented yogurt is used lactobacillus, streptococcus acidi lactici, bifidus bacillus combined ferment always.Sour milk only is healthcare products.
Show that according to data only there are Taiyuan, Shanxi institute of traditional Chinese medicine and Beijing institute of microbiology in China, " you relax stomach " of joint development is to form with the Hericium erinaceus (Bull. Ex Fr.) Pers. fermentation, also only is a kind of edible mushrooms, and its metabolites kinds is few, and the curative effect of controlling stomach trouble has much room for improvement.
Inquiring about on the Internet, Japan's three big microorganism brands: " enzymatic microorganism ", " EM ", " fermentation of ten thousand fields " can be widely used in plantation, breed, environment protection and body-care.At present, these technology are in the body-care field, are used for fermented fruits and vegetables juice.Be located at the power benevolence enzyme microb business department in Hong Kong as Japan, the product of the domestic Tai Boer of Tangshan City biotechnology company limited does not all relate to fermented tcm.
The expert of China and Japanese Chinese materia medica circle has a common recognition: the pharmaceutical compositions part of Chinese medicine is that organic acid and 2000 kinds of enzymes, multiple organic acid and ethanol of relying in the stomach more than 500 kind of microorganism to produce in secondary metabolism digest, transform pharmaceutical compositions.If when the human body stomach lacks a large amount of probioticss, just can not produce materials such as a large amount of useful enzymes and organic acid, the pharmaceutical compositions of Chinese medicine transforms just few, and curative effect is as the same relatively poor.
Adopt the ferment-fermented prescription Chinese medicine of Chinese medicine, have the specific function of following several respects to promote the conversion of pharmaceutical compositions.
1. beneficial microorganism produces lot of organic acids, ethanol and enzyme in the secondary metabolism process, can fully dissolve, transform Chinese medicinal ingredients.
All biochemical reactions of human body all be unable to do without enzyme, comprise digestion, the absorption of nutrition, neural conduction, cells whose development, gene synthetic etc.The imbalance of human body endoenzyme must cause the generation of disease.Lacked as zymoplasm, the people suffers from hemorrhage easily, and too much, then can cause thrombosis again.And streptokinase can melt thrombus, and streptokinase comprises streptokinase, urokinase and fibrinoclase.These useful enzymes all can be produced by microbial metabolism.With the prescription Chinese medicine of such microbial fermentation treatment cerebral thrombosis, effect is fine.
2. the human antibiosis of understanding have kind more than 3000, and wherein more than 1700 kind is provided for the mankind by actinomycetes.Actinomycetes in the starter can produce multiple natural antibiotics, promote anti-inflammation and sterilization.
3. owing to be fermentation prescription Chinese medicine, can produce new pharmaceutical compositions, the drug effect of mutually promoting.
4. the multiple nutrients of microorganisms as amino acid, VITAMIN, saccharide compound, lipoid substance, nucleic acid etc., also can improve immune function of human body, promotes patient's rehabilitation.
5. one pair of Chinese medicine can ferment 1000 milliliters to 5000 milliliters, can take 15 days or 50 days, and not only good effect has also significantly reduced middle survival dose, reduces patient's cost of curing the disease, and avoids the natural resources of Chinese medicinal materials waste.
6. to uremic patient, because renal failure, can't be oral advance medicine, can adopt the fermentation soup whole body bathing of dilution, treat by the skin absorption pharmaceutical compositions.
7. can also be according to different syndromes, different Chinese medicine, the bacterial classification kind of plus-minus starter.As treat enteritis, intestinal cancer, and add Bacillus licheniformis, produce SOD (superoxide-dismutase) and cure diarrhoea and cancer.Control thrombus and add the bacterial strain that produces fibrinoclase.
8. fermented tcm can also be used in the agriculture production prevention and elimination of disease and pests.The Organic farming of 21 century must be produced green food, forbids spraying on farm crop chemical pesticide, adopts plant-sourced to produce public nuisance-free agricultural chemicals, is the common recognition of International Technology circle.Can make traditional Chinese medicine bactericide, Pesticide with Chinese medicinal material, Chinese medicine virucide with the ferment-fermented Chinese medicine of Chinese medicine.
The present invention is a purpose to improve medical effect, is substrate by prescription with the prepared slices of Chinese crude drugs of pulverizing, add 7 times to the garden spgarden stuff of substrate, 3 times to the brown sugar of substrate, be blended under 100 ℃ of temperature and heated 10 minutes, the cooling back adds 0.5 times to 10 kinds of probioticss of substrate, stirs, cultivated 15 days under 25 ℃ of-30 ℃ of temperature, filter cleaner becomes clarification shape fermentation oral liquid.Chemical examination detects sugar-free, pH value 4.5 ± 0.5, every milliliter of bacteria containing amount of microscopy soup 〉=100,000,000.Contain the SOD superoxide dismutase simultaneously.
0.5 doubly 10 kinds of probioticss to substrate are:
Thermophilic bacillus Bacillus acidocldarius
Oval or short and thick shaft-like, gemma is arranged, the limit hair is arranged, can move, it is similar influenced by substratum.
Bacstearothermophilus Bacstearothermophilus
Oval or short and thick shaft-like, gemma is arranged, the limit hair is arranged, can move, it is similar influenced by substratum.
Thermophilic lactobacillus Lactobacillus Beijerinc
Oval or short and thick shaft-like, gemma is arranged, the limit hair is arranged, can move, it is similar influenced by substratum.
Bacillus licheniformis Bacilluslicheniformis
Oval, gemma is arranged, the limit hair is arranged, can move.
Bacillus macerans Bmacerans
Oval or short and thick shaft-like, gemma is arranged, the limit hair is arranged, can move, it is similar influenced by substratum.
Bacillus polymyxa Bpalymyxa
Oval or short and thick shaft-like, gemma is arranged, the limit hair is arranged, can move, it is similar influenced by substratum.
Thermoactinomyces Thermoactinomyces
Radial mycelia, diameter 0.2-0.8 micron can develop into fibrillae of spores, and bacterium colony becomes thread group, and faint yellow or light brown can not moved.
Thermomonospora Tnermomonospora
Mycelia is very thin, and diameter 0.3-0.6 micron does not have disconnected barrier film, does not rupture, and there is spore on the top, and bacterial strain is orange-yellow.
Thermophilic lacto-bacilli Lactobacillus thermophilus
Oval or short and thick shaft-like, gemma is arranged, the limit hair is arranged, can move, it is similar influenced by substratum.
High temperature yeast Thermoyeast
Sub-circular or ellipse, body is bigger, does not move, and is colourless.
Technology according to technology of having grasped and developed country is compared, and as Japanese nourishing drink " enzyme microb ", " EM ", the every gram bacteria containing amount of its bacterial classification is generally 600,000,000.The every gram of Chinese medicine starter carrier contains useful viable bacteria all more than 600,000,000.Simultaneously, the enzyme that produces in the metabolism, titre is very high.As amylase is 1500u/g.
Optimum implementation of the present invention and examples of implementation
(1) technological line
1, prepares nutrient agar and add corresponding inhibitor, carry out the single culture test tube slant and cultivate, guarantee bacterial classification purity.
2, carrying out triangle cup shaking table cultivates.
3, be mixed in proportion bacterial classification, carry out fermentor cultivation.
4, liquid spawn is admixed in the wheat bran or starch after the sterilization, dry, or the oven dry of 68 ℃ of weighing apparatus temperature, contained humidity 6% chemically examine qualified back and is packed.
5, the also available generation bacterial classification inoculation that mixes carries out fermentation culture in the carrier wheat bran.
(2) bacterial classification technical indicator
1, the bacterial classification mushroom has been the thermophilic probiotics of gas.Optimum growth temp is 25 ℃-30 ℃.30 ℃-70 ℃ of leavening temperatures.Fatal temperature is more than 70 ℃.
2, carrier bacteria containing amount: B 〉=4 * 10
8Individual/g Y 〉=2 * 10
8Individual/g M 〉=1 * 10
6Individual/g
3, the bacterial classification shelf time: 4 ℃ of temperature, humidity 26-46, test tube sealing or plastics bag sealing were deposited 5 years.0 ℃-35 ℃ of temperature, humidity 26-60, the plastics bag sealing was deposited 3 years.Bacteria containing amount is constant, and bacterial classification is not degenerated.Surpass the shelf-time, through chemical examination, spawn degeneration person will carry out rejuvenation.
4, will be according to result of laboratory test, the bacterial classification of in time purifying.
5, bacterial classification is made to cultivate and will be strictly on guard against bacteria infection.
(3) Chinese medicine zymotechnique
1, fermentation utensil: through the Porcelain Jar of strict sterilization, or the stainless steel fermentor tank, in sterilisable chamber, ferment.But fermentor tank continuous production.
2, raw material: about 2 pairs of 800-1000 grams of Chinese medicine is substrate, 7 liters of garden spgarden stuffs (7 times to substrate), 3 kilograms in brown sugar (3 times to substrate), 10 kind of 500 gram of probiotics (0.5 times to substrate).
3, fermenting procedure: Chinese medicine is pulverized, mixed, be heated to 100 ℃ in pot or in the steam tank, kept 10 minutes with garden spgarden stuff, brown sugar.Again soup is poured in the fermentation utensil, when cooling to 68 ℃, added 10 kinds of probioticses.Room temperature keeps 25 ℃-35 ℃.Every day, stirring was no less than twice, each 2 minutes.Fermentor tank continuously ferments, and add air in good time.The disposable fermentation success of can fermenting in general 15 days.At this moment, fermented liquid is the clarification shape.Otherwise, need filter.
4, technical indicator
Taste with mouth, no pol is chemically examined in the sweet acid of distinguishing the flavor of, and PH=4.5 can float 0.5 up and down.When sweet taste is heavy, the nutrition height, when acidity was big, the pharmaceutical compositions height when not having sweet tart flavour, should be considered as losing effect.The microscopy soup, every milliliter of total bacteria containing amount is greater than 100,000,000.Content and the pharmaceutical compositions content of chemically examining enzyme with good conditionsi.
5, packaging and storing: pack into Brown Glass Brown glass bottles and jars only or Plastic Bottle, leave the dry place of lucifuge in, 0 ℃-38 ℃, validity period 2 years.
6, instructions of taking: take 5 milliliters for the first time oral three times of every day, increase by 5 milliliters for the second time, and the like, increase by 5 milliliters at every turn, when adding to 40 milliliters, all take later on by this amount.To prevent centesimal crowd, to indivedual Chinese medicine allergy to fermented product allergy.
Patient's case
1, " secret that the delays senility " book that adopts Shanghai traditional Chinese medical science medical university to publish is introduced, the empirical formula of Qing Dynasty's treatment stomach trouble:
The white cool 6g bighead atractylodes rhizome 12g seed of jog's tears 30g dried orange peel 15g of Radix Codonopsis 30g
Hawthorn 12g Divine Comedy 10g Poria cocos 30g Chinese yam 30g Gorgon fruit 30g
French beans 15g rice sprout 15g builds lotus 15g cassia bark 5g rhizoma alismatis 9g
Radix Glycyrrhizae 9g wrinkled giant hyssop 9g river lotus 9g
5000 milliliters of two pairs of Chinese medicine fermentation soups are adorned 10 bottles, 500 milliliters every bottle.Name: taste health fermentation oral liquid.
Case:
Feng Junyi, woman, 60 years old, Minquan County, the Henan Province retired cadre of Materials Bureau.Suffer from gastritis, stomach spasm more than 20 year.Annual morbidity three, four times.Need to hang the garter transfusion at every turn.Take 3 bottles of taste health fermentation oral liquids, 1500ml cures, not recurrence in 3 years.
Huang Siyi, man, 29 years old, Henan Province's Shangqiu City cadre of economic and commercial committee.Suffered from gastritis four, five years.Took a variety of Chinese-western medicine, curative effect is all not obvious.In early spring calendar year 2001, only take 2000ml taste health fermentation oral liquid, i.e. recovery from illness, not recurrence in 2 years.
2, fermentation experience prescription among the people Chinese medicine, treatment hypertension, cerebral thrombosis, apoplexy sequela.
The two red spoon of the 45g 10g root bark of tree peony 10g dried rhizome of rehmannia 30g that collude of rhizoma Gastrodiae 20g
Ligusticum wallichii 20g Concha Haliotidis 30g is for the full worm 10g of Chu Shi 30g Os Draconis 30g
The windproof 10g of the stiff silkworm 15g bark of eucommia 9g of centipede 3g earthworm 30g
Calamus 10g polygala root 10g root tuber of aromatic turmeric 20g Arisaema with Bile 10g chrysanthemum 30g
Fructus Hordei Germinatus 30g hawthorn 30g
(, can add a few flavor awaking drugs again) if any language serious hindrance person
Two pairs of Chinese medicine fermentation 5000ml soups.Name the Xinkaokang fermentation oral liquid.
Case:
Hu Lianzhen, woman, 61 years old, the doctor of Minquan County, Henan Province factory of freezer factory.Suffered from hypertension in 1974, and took medicine for a long time, take the medicine of Zhengzhou institute in recent years, effect is not too obvious, and blowdown rate is slow, and fall is little.Only obey 2 bottles of Xinkaokang fermentation oral liquids (1000ml), last 10 days, high pressure drops to 120 from 150, and low pressure drops to 75 from 95.At present, obey once every day, and each 15ml is in the consolidation phase.
The political commissar Shen Ruixing of Zhengzhou City, Henan Province Shangjie District public security subbureau, its female 73 years old, suffered from cerebral infarction sequela 7 years, can not walk, it is not clear at all to speak, and what medicine of clothes is all invalid in 7 years.May calendar year 2001, take 7 bottles of Xinkaokang fermentation oral liquids (3500ml), last 35 days, the freedom of movement of walking, it is clear to talk.
3, Chinese medicine agricultural bactericidal agent prescription
Rhizoma Rhei and Rhizoma Coptidis golden cypress root of large-flowered skullcap Root-bark of Densefruit Pittany pomegranate rind blackberry lily kuh-seng
Sweet wormwood Armstrong radix scrophulariae ginkgo Motherwort Herb Herba Houttuyniae Cortex Meliae
Chinese medicine agricultural insecticidal agent prescription
Trypterygine Cortex Meliae ginkgo tuber of stemona goat's horn is turned round root of langdu tobacco leaf kuh-seng
The white stone-like omphalia aloe of Fructus Cnidii Semen Armeniacae Amarum Chinese prickly ash betel nut melanterite Rangooncreeper Fruit
Every flavor medicine 500 grams add 50 kilograms in water, 25 kilograms in brown sugar, 3 kilograms of Chinese medicine starters.Manufacture craft is identical with medicine.
Chinese medicine disinfectant use in agriculture 3 years on probation.Adapt to various farm crop and vegetables, fruit tree.Broad-spectrum sterilization, respond well.Also but the fiting chemical agricultural chemicals reduces half consumption of agricultural chemicals, and can reduce pesticide residue greatly.
Claims (1)
1, a kind of Chinese medicine multiple bacteria compound fermentation oral liquid, it is characterized in that to improve medical effect be purpose, with prescription 1 or 2 prepared slices of Chinese crude drugs is substrate, pulverizes the back and adds 7 times to the garden spgarden stuff of substrate, and 3 times to the brown sugar of substrate, be blended under 100 ℃ of temperature and heated 10 minutes, the cooling back adds 0.5 times to 10 kinds of probioticss of substrate, stirs, and cultivates 15 days under 25 ℃ of-30 ℃ of temperature, filter cleaner becomes clarification shape fermentation oral liquid, and prescription 1 wherein is:
The white cool 6g bighead atractylodes rhizome 12g seed of jog's tears 30g dried orange peel 15g of Radix Codonopsis 30g
Hawthorn 12g Divine Comedy 10g Poria cocos 30g Chinese yam 30g Gorgon fruit 30g
Flat 15g rice sprout 15g builds lotus 15g cassia bark 5g rhizoma alismatis 9g
Radix Glycyrrhizae 9g wrinkled giant hyssop 9g river lotus 9g
Prescription 2 is:
The two red spoon of the 45g 10g root bark of tree peony 10g dried rhizome of rehmannia 30g that collude of rhizoma Gastrodiae 20g
Ligusticum wallichii 20g Concha Haliotidis 30g is for the full worm 10g of Chu Shi 30g Os Draconis 30g
The windproof 10g of the stiff silkworm 15g bark of eucommia 9g of centipede 3g earthworm 30g
Calamus 10g polygala root 10g root tuber of aromatic turmeric 20g Arisaema with Bile 10g chrysanthemum 30g
Fructus Hordei Germinatus 30g hawthorn 30g
Probiotics wherein is:
Thermophilic bacillus (Bacillus acidocldarius)
Oval or short and thick shaft-like, gemma is arranged, the limit hair is arranged, can move, it is similar influenced by substratum;
Bacstearothermophilus (Bacstearothermophilus)
Oval or short and thick shaft-like, gemma is arranged, the limit hair is arranged, can move, it is similar influenced by substratum;
Thermophilic lactobacillus (Lactobacillus Beijerinc)
Oval or short and thick shaft-like, gemma is arranged, the limit hair is arranged, can move, it is similar influenced by substratum;
Bacillus licheniformis (Bacilluslicheniformis)
Oval, gemma is arranged, the limit hair is arranged, can move;
Bacillus macerans (Bmacerans)
Oval or short and thick shaft-like, gemma is arranged, the limit hair is arranged, can move, it is similar influenced by substratum;
Bacillus polymyxa (Bpalymyxa)
Oval or short and thick shaft-like, gemma is arranged, the limit hair is arranged, can move, it is similar influenced by substratum;
Thermoactinomyces (Thermoactinomyces)
Radial mycelia, diameter 0.2-0.8 micron can develop into fibrillae of spores, and bacterium colony becomes thread group, and faint yellow or light brown can not moved;
Thermomonospora (Tnermomonospora)
Mycelia is very thin, and diameter 0.3-0.6 micron does not have disconnected barrier film, does not rupture, and there is spore on the top, and bacterial strain is orange-yellow;
Thermophilic lacto-bacilli (Lactobacillus thermophilus)
Oval or short and thick shaft-like, gemma is arranged, the limit hair is arranged, can move, it is similar influenced by substratum;
High temperature yeast (Thermoyeast)
Sub-circular or ellipse, body is bigger, does not move, and is colourless.
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| CN100475967C true CN100475967C (en) | 2009-04-08 |
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Families Citing this family (16)
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| CN101697740B (en) * | 2009-04-04 | 2014-02-19 | 冯子龙 | Novel traditional Chinese medicine pesticide and production technology thereof |
| CN101803620B (en) * | 2010-03-15 | 2012-12-19 | 潍坊奥丰作物病毒防治技术服务有限公司 | Plant active glycoside peptide fungicide and preparation method thereof |
| CN101843267A (en) * | 2010-05-20 | 2010-09-29 | 北京绿神保科技有限公司 | High-efficiency nontoxic insecticide and preparation method thereof |
| CN102058759B (en) * | 2010-12-31 | 2012-02-29 | 广东太安堂药业股份有限公司 | Medicinal tea prepared from Chinese medicinal materials by microbial fermentation |
| CN102166250B (en) * | 2011-01-20 | 2012-06-20 | 胡全义 | Liquid biological medicament for treating esophagus cancer, cardiac cancer and diseases of digestive tract |
| CN103740657A (en) * | 2012-10-17 | 2014-04-23 | 沈阳尊龙生物技术有限公司 | Earthworm biological composite enzyme |
| CN103304309A (en) * | 2013-05-17 | 2013-09-18 | 安徽三星化工有限责任公司 | Special hindu datura flower organic compound fertilizer for corns |
| CN103432387B (en) * | 2013-08-20 | 2016-09-28 | 冯子龙 | The Chinese herbal medicament oral liquid for the treatment of diabetes and production technology thereof |
| CN103704837B (en) * | 2013-12-09 | 2015-03-11 | 安徽圣芝堂生物科技有限公司 | Beverage with function of invigorating stomach |
| CN103689626A (en) * | 2013-12-30 | 2014-04-02 | 徐州绿之野生物食品有限公司 | Nutritious food and processing method thereof |
| CN104824767A (en) * | 2014-02-12 | 2015-08-12 | 于汇 | Hericium erinaceus fermentation appetite-enhancing and digestion-promoting beverage |
| CN103908475A (en) * | 2014-03-26 | 2014-07-09 | 深圳市新华南方生物科技股份有限公司 | Traditional Chinese medicine preparation method |
| CN105285230A (en) * | 2014-06-05 | 2016-02-03 | 刘铁民 | Ginseng health preserving tea and preparation method thereof |
| CN106262824A (en) * | 2016-08-12 | 2017-01-04 | 青岛康大万叶生物科技有限公司 | A kind of production method of Chinese herbal medicine ferment stock solution |
| CN106667905A (en) * | 2017-03-20 | 2017-05-17 | 河南省长义农业科技有限公司 | Method for producing complete plant enzyme/traditional Chinese medicine oral liquid |
| CN113769000B (en) * | 2021-08-27 | 2022-05-06 | 四川百胜药业有限公司 | Preparation method of Arisaema cum bile and Arisaema cum bile |
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