CN102056485A - 用于局部治疗免疫相关疾病的局部lfa-1拮抗剂 - Google Patents
用于局部治疗免疫相关疾病的局部lfa-1拮抗剂 Download PDFInfo
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- CN102056485A CN102056485A CN2009801216301A CN200980121630A CN102056485A CN 102056485 A CN102056485 A CN 102056485A CN 2009801216301 A CN2009801216301 A CN 2009801216301A CN 200980121630 A CN200980121630 A CN 200980121630A CN 102056485 A CN102056485 A CN 102056485A
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- lfa
- antagonist
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
- A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
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- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Immunology (AREA)
- Dermatology (AREA)
- Ophthalmology & Optometry (AREA)
- Pulmonology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Diabetes (AREA)
- Transplantation (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Endocrinology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610115732.4A CN105943534A (zh) | 2008-04-15 | 2009-04-15 | 用于局部治疗免疫相关疾病的局部lfa-1拮抗剂 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US4524008P | 2008-04-15 | 2008-04-15 | |
| US61/045,240 | 2008-04-15 | ||
| PCT/US2009/002389 WO2009128934A1 (en) | 2008-04-15 | 2009-04-15 | Topical lfa-1 antagonists for use in localized treatment of immune related disorders |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610115732.4A Division CN105943534A (zh) | 2008-04-15 | 2009-04-15 | 用于局部治疗免疫相关疾病的局部lfa-1拮抗剂 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN102056485A true CN102056485A (zh) | 2011-05-11 |
Family
ID=41164200
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2009801216301A Pending CN102056485A (zh) | 2008-04-15 | 2009-04-15 | 用于局部治疗免疫相关疾病的局部lfa-1拮抗剂 |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US20090258070A1 (https=) |
| EP (2) | EP2265125B1 (https=) |
| JP (2) | JP2011521896A (https=) |
| CN (1) | CN102056485A (https=) |
| ES (1) | ES2763703T3 (https=) |
| WO (1) | WO2009128934A1 (https=) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115707698A (zh) * | 2021-08-18 | 2023-02-21 | 辽宁何氏医学院 | 5,7-二氯-1,2,3,4-四氢异喹啉-6-甲酰胺类化合物及其制备方法和应用 |
| WO2025223511A1 (zh) * | 2024-04-25 | 2025-10-30 | 上海翊石医药科技有限公司 | 一类苯甲酰基甘氨酸衍生物及其制备方法和应用 |
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| AU2004287875B2 (en) | 2003-11-05 | 2011-06-02 | Bausch + Lomb Ireland Limited | Modulators of cellular adhesion |
| DK2444079T3 (en) | 2005-05-17 | 2017-01-30 | Sarcode Bioscience Inc | Compositions and Methods for the Treatment of Eye Diseases |
| DK1915620T3 (da) | 2005-08-02 | 2010-10-04 | Xbiotech Inc | Diagnose, behandling og prævention af vaskulære sygdomme ved hjælp af IL-1alpha-autoantistoffer |
| ES2630406T3 (es) | 2007-10-19 | 2017-08-21 | Sarcode Bioscience Inc. | Composición y procedimientos para el tratamiento de la retinopatía diabética |
| EP2276508A4 (en) * | 2008-04-15 | 2011-12-28 | Sarcode Bioscience Inc | ADMINISTRATION OF LFA-1 ANTAGONISTS TO THE GASTROINTESTINAL SYSTEM |
| EP2265124A4 (en) * | 2008-04-15 | 2011-12-28 | Sarcode Bioscience Inc | AEROSOLISED LFA-1 ANTAGONISTS FOR THE USE IN THE LOCAL TREATMENT OF IMMUNE DISEASES |
| CA2726345C (en) | 2008-05-30 | 2018-08-28 | John Simard | Interleukin-1 alpha antibodies and methods of use |
| AU2009291536B2 (en) | 2008-09-12 | 2012-08-16 | Xbiotech Inc. | Targeting pathogenic monocytes |
| EP2349209A2 (en) * | 2008-09-26 | 2011-08-03 | Nanobio Corporation | Nanoemulsion therapeutic compositions and methods of using the same |
| EP2745692A1 (en) * | 2009-02-13 | 2014-06-25 | Topica Pharmaceuticals, Inc | anti-fungal formulation containing luliconazole |
| US20120022102A1 (en) * | 2010-01-20 | 2012-01-26 | Cadila Healthcare Limited | Method for preparation of pitavastatin and its pharmaceutical acceptable salts thereof |
| KR102167261B1 (ko) * | 2010-06-18 | 2020-10-20 | 엑스바이오테크, 인크. | 관절염 치료 |
| US10294296B2 (en) | 2010-08-23 | 2019-05-21 | Xbiotech, Inc. | Treatment for neoplastic diseases |
| US9724409B2 (en) | 2011-04-01 | 2017-08-08 | Xbiotech, Inc. | Treatment of inflammatory skin disease |
| ES2695102T3 (es) | 2011-09-23 | 2019-01-02 | Xbiotech Inc | Tratamiento para la caquexia |
| WO2013108644A1 (ja) * | 2012-01-20 | 2013-07-25 | 京都府公立大学法人 | レバミピドのアレルギー性結膜炎治療剤 |
| US9545441B2 (en) | 2012-09-18 | 2017-01-17 | Xbiotech, Inc. | Treatment of diabetes |
| EA028008B1 (ru) | 2012-12-19 | 2017-09-29 | Саркоуд Байосайенс Инк. | Составы ингибитора lfa-1 |
| US9688943B2 (en) | 2015-05-29 | 2017-06-27 | beauty Avenues LLC | Candle containing non-ionic emulsifer |
| EP3554477A4 (en) * | 2016-12-16 | 2020-05-27 | SARcode Bioscience Inc. | EYE AND PHARMACOKINETIC DISTRIBUTION OF LIFITEGRAST FORMULATIONS |
| CA3053231A1 (en) | 2017-02-16 | 2018-08-23 | Xbiotech Inc. | Treatment of hidradenitis suppurativa |
| CN106920239B (zh) * | 2017-03-08 | 2019-10-18 | 福建师范大学 | 一种基于改进sift算法的图像关键点检测方法 |
| WO2019065936A1 (ja) * | 2017-09-29 | 2019-04-04 | 参天製薬株式会社 | 涙液中のmuc5ac量の測定方法 |
| CA3083789A1 (en) * | 2017-11-29 | 2019-06-06 | The Rockefeller University | Combination of local and systemic therapies for enhanced treatment of dermatologic conditions |
| KR20220003555A (ko) * | 2019-04-18 | 2022-01-10 | 아주라 오프탈믹스 엘티디 | 안구 장애의 치료를 위한 화합물 및 방법 |
| AU2020315758B2 (en) | 2019-07-16 | 2024-08-01 | Donaghys Limited | Transdermal solvent system and methods of use |
| EP3797771B1 (en) * | 2019-09-03 | 2022-02-23 | Square Power Ltd | Rebamipide for use in prophylaxis and treatment of celiac disease |
| CN112494488B (zh) * | 2020-06-17 | 2022-01-18 | 中国药科大学 | 瑞巴派特的防脱发和生发用途 |
| CA3095740A1 (en) | 2020-10-07 | 2022-04-07 | Xbiotech Inc. | True human antibody specific for interleukin alpha (il-1a) |
| CA3095679A1 (en) | 2020-10-07 | 2022-04-07 | Xbiotech Inc. | True human antibody specific for interleuken 1 alpha (il-1a) |
| CA3095676A1 (en) | 2020-10-07 | 2022-04-07 | Xbiotech Inc. | True human antibody specific for interleukin 1 alpha (il-1a) |
| CA3095675A1 (en) | 2020-10-07 | 2022-04-07 | Xbiotech Inc. | True human antibody specific for interleukin 1 alpha (il-1a) |
| US12393057B2 (en) * | 2020-12-15 | 2025-08-19 | Coopervision International Limited | Oleic acid-releasing contact lens |
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| CA3216947A1 (en) * | 2021-06-14 | 2022-12-22 | Protransit Nanotherapy Llc | Cyclosporine compositions and methods of use thereof |
| WO2024058212A1 (ja) * | 2022-09-15 | 2024-03-21 | 日油株式会社 | コンタクトレンズ用溶液 |
| US12161612B2 (en) | 2023-04-14 | 2024-12-10 | Neuroderm, Ltd. | Methods and compositions for reducing symptoms of Parkinson's disease |
Citations (5)
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| US20020045582A1 (en) * | 1997-12-31 | 2002-04-18 | Alexey L. Margolin | Stabilized protein crystals formulations containing them and methods of making them |
| CN1592746A (zh) * | 2000-11-28 | 2005-03-09 | 杰南技术公司 | Lfa-1拮抗剂化合物 |
| US20060281739A1 (en) * | 2005-05-17 | 2006-12-14 | Thomas Gadek | Compositions and methods for treatment of eye disorders |
| CN1902195A (zh) * | 2003-11-05 | 2007-01-24 | 苏内西斯制药公司 | 细胞粘着调节剂 |
| US20070142317A1 (en) * | 2003-12-29 | 2007-06-21 | Qlt Usa, Inc. | Topical composition for treatment of skin disorders |
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- 2009-04-15 CN CN2009801216301A patent/CN102056485A/zh active Pending
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2013
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115707698A (zh) * | 2021-08-18 | 2023-02-21 | 辽宁何氏医学院 | 5,7-二氯-1,2,3,4-四氢异喹啉-6-甲酰胺类化合物及其制备方法和应用 |
| WO2025223511A1 (zh) * | 2024-04-25 | 2025-10-30 | 上海翊石医药科技有限公司 | 一类苯甲酰基甘氨酸衍生物及其制备方法和应用 |
Also Published As
| Publication number | Publication date |
|---|---|
| JP2011521896A (ja) | 2011-07-28 |
| WO2009128934A1 (en) | 2009-10-22 |
| EP3632444A2 (en) | 2020-04-08 |
| EP2265125A1 (en) | 2010-12-29 |
| EP2265125A4 (en) | 2011-12-28 |
| US20090258070A1 (en) | 2009-10-15 |
| EP3632444A3 (en) | 2020-08-26 |
| JP2014132032A (ja) | 2014-07-17 |
| ES2763703T3 (es) | 2020-05-29 |
| US20140051722A1 (en) | 2014-02-20 |
| EP2265125B1 (en) | 2019-08-14 |
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