CN102056485A - 用于局部治疗免疫相关疾病的局部lfa-1拮抗剂 - Google Patents
用于局部治疗免疫相关疾病的局部lfa-1拮抗剂 Download PDFInfo
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- CN102056485A CN102056485A CN2009801216301A CN200980121630A CN102056485A CN 102056485 A CN102056485 A CN 102056485A CN 2009801216301 A CN2009801216301 A CN 2009801216301A CN 200980121630 A CN200980121630 A CN 200980121630A CN 102056485 A CN102056485 A CN 102056485A
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- lfa
- antagonist
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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- A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
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- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Dermatology (AREA)
- Ophthalmology & Optometry (AREA)
- Pulmonology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Rheumatology (AREA)
- Gastroenterology & Hepatology (AREA)
- Pain & Pain Management (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Transplantation (AREA)
- Endocrinology (AREA)
- Diabetes (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610115732.4A CN105943534A (zh) | 2008-04-15 | 2009-04-15 | 用于局部治疗免疫相关疾病的局部lfa-1拮抗剂 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US4524008P | 2008-04-15 | 2008-04-15 | |
| US61/045,240 | 2008-04-15 | ||
| PCT/US2009/002389 WO2009128934A1 (en) | 2008-04-15 | 2009-04-15 | Topical lfa-1 antagonists for use in localized treatment of immune related disorders |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610115732.4A Division CN105943534A (zh) | 2008-04-15 | 2009-04-15 | 用于局部治疗免疫相关疾病的局部lfa-1拮抗剂 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN102056485A true CN102056485A (zh) | 2011-05-11 |
Family
ID=41164200
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2009801216301A Pending CN102056485A (zh) | 2008-04-15 | 2009-04-15 | 用于局部治疗免疫相关疾病的局部lfa-1拮抗剂 |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US20090258070A1 (https=) |
| EP (2) | EP3632444A3 (https=) |
| JP (2) | JP2011521896A (https=) |
| CN (1) | CN102056485A (https=) |
| ES (1) | ES2763703T3 (https=) |
| WO (1) | WO2009128934A1 (https=) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115707698A (zh) * | 2021-08-18 | 2023-02-21 | 辽宁何氏医学院 | 5,7-二氯-1,2,3,4-四氢异喹啉-6-甲酰胺类化合物及其制备方法和应用 |
| WO2025223511A1 (zh) * | 2024-04-25 | 2025-10-30 | 上海翊石医药科技有限公司 | 一类苯甲酰基甘氨酸衍生物及其制备方法和应用 |
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| CA2544678C (en) | 2003-11-05 | 2013-12-31 | Sunesis Pharmaceuticals, Inc. | Modulators of cellular adhesion |
| DK2444079T3 (en) | 2005-05-17 | 2017-01-30 | Sarcode Bioscience Inc | Compositions and Methods for the Treatment of Eye Diseases |
| CA2617637C (en) | 2005-08-02 | 2017-07-18 | Xbiotech Inc. | Diagnosis, treatment, and prevention of vascular disorders using il-1.alpha. autoantibodies |
| ES2830024T3 (es) | 2007-10-19 | 2021-06-02 | Novartis Ag | Composiciones y métodos para el tratamiento del edema macular |
| US20090257957A1 (en) * | 2008-04-15 | 2009-10-15 | John Burnier | Aerosolized LFA-1 antagonists for use in localized treatment of immune related disorders |
| WO2009128932A1 (en) * | 2008-04-15 | 2009-10-22 | Sarcode Corporation | Delivery of lfa-1 antagonists to the gastrointestinal system |
| EP2285409B1 (en) | 2008-05-30 | 2016-04-20 | XBiotech, Inc | Il-1 alpha antibodies |
| CA2737056C (en) | 2008-09-12 | 2018-10-30 | Xbiotech Inc. | Targeting pathogenic monocytes |
| CN102223876A (zh) * | 2008-09-26 | 2011-10-19 | 纳米生物公司 | 纳米乳剂治疗性组合物及其使用方法 |
| US8193232B2 (en) * | 2009-02-13 | 2012-06-05 | Topica Pharmaceuticals, Inc. | Anti-fungal formulation |
| JP2013516459A (ja) * | 2010-01-20 | 2013-05-13 | カディラ・ヘルスケア・リミテッド | ピタバスタチン及び医薬として許容可能なそれらの塩の製造方法 |
| EP2582391B1 (en) * | 2010-06-18 | 2018-10-03 | XBiotech, Inc | Arthritis treatment |
| KR101910760B1 (ko) | 2010-08-23 | 2018-10-22 | 엑스바이오테크, 인크. | 종양성 질병들에 대한 치료 |
| US9724409B2 (en) | 2011-04-01 | 2017-08-08 | Xbiotech, Inc. | Treatment of inflammatory skin disease |
| CN108404127B (zh) | 2011-09-23 | 2025-12-12 | 埃克斯生物科技公司 | 恶病质治疗 |
| WO2013108644A1 (ja) * | 2012-01-20 | 2013-07-25 | 京都府公立大学法人 | レバミピドのアレルギー性結膜炎治療剤 |
| US9545441B2 (en) | 2012-09-18 | 2017-01-17 | Xbiotech, Inc. | Treatment of diabetes |
| BR112015014367B1 (pt) | 2012-12-19 | 2022-11-22 | Novartis Ag | Composição inibidora de lfa-1, método para estabilizar a dita composição e uso da mesma para tratar uma doença ocular |
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| EP3582813A4 (en) | 2017-02-16 | 2020-12-30 | XBiotech, Inc | TREATMENT OF SUPPURATIVE HIDRADENITIS |
| CN106920239B (zh) * | 2017-03-08 | 2019-10-18 | 福建师范大学 | 一种基于改进sift算法的图像关键点检测方法 |
| WO2019065936A1 (ja) * | 2017-09-29 | 2019-04-04 | 参天製薬株式会社 | 涙液中のmuc5ac量の測定方法 |
| WO2019108814A1 (en) * | 2017-11-29 | 2019-06-06 | The Rockefeller University | Combination of local and systemic therapies for enhanced treatment of dermatologic conditions |
| JP7700045B2 (ja) * | 2019-04-18 | 2025-06-30 | アズーラ オフサルミックス エルティーディー. | 眼障害を処置するための化合物および方法 |
| AU2020315758B2 (en) | 2019-07-16 | 2024-08-01 | Donaghys Limited | Transdermal solvent system and methods of use |
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Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20020045582A1 (en) * | 1997-12-31 | 2002-04-18 | Alexey L. Margolin | Stabilized protein crystals formulations containing them and methods of making them |
| CN1592746A (zh) * | 2000-11-28 | 2005-03-09 | 杰南技术公司 | Lfa-1拮抗剂化合物 |
| US20060281739A1 (en) * | 2005-05-17 | 2006-12-14 | Thomas Gadek | Compositions and methods for treatment of eye disorders |
| CN1902195A (zh) * | 2003-11-05 | 2007-01-24 | 苏内西斯制药公司 | 细胞粘着调节剂 |
| US20070142317A1 (en) * | 2003-12-29 | 2007-06-21 | Qlt Usa, Inc. | Topical composition for treatment of skin disorders |
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| US3989816A (en) * | 1975-06-19 | 1976-11-02 | Nelson Research & Development Company | Vehicle composition containing 1-substituted azacycloheptan-2-ones |
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| CN115707698A (zh) * | 2021-08-18 | 2023-02-21 | 辽宁何氏医学院 | 5,7-二氯-1,2,3,4-四氢异喹啉-6-甲酰胺类化合物及其制备方法和应用 |
| WO2025223511A1 (zh) * | 2024-04-25 | 2025-10-30 | 上海翊石医药科技有限公司 | 一类苯甲酰基甘氨酸衍生物及其制备方法和应用 |
Also Published As
| Publication number | Publication date |
|---|---|
| US20140051722A1 (en) | 2014-02-20 |
| ES2763703T3 (es) | 2020-05-29 |
| EP2265125A1 (en) | 2010-12-29 |
| EP3632444A3 (en) | 2020-08-26 |
| EP3632444A2 (en) | 2020-04-08 |
| JP2011521896A (ja) | 2011-07-28 |
| JP2014132032A (ja) | 2014-07-17 |
| US20090258070A1 (en) | 2009-10-15 |
| EP2265125B1 (en) | 2019-08-14 |
| WO2009128934A1 (en) | 2009-10-22 |
| EP2265125A4 (en) | 2011-12-28 |
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