CN102046166B - 用于治疗干眼症的β-转角模拟肽环状化合物 - Google Patents

用于治疗干眼症的β-转角模拟肽环状化合物 Download PDF

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Publication number
CN102046166B
CN102046166B CN2009801190689A CN200980119068A CN102046166B CN 102046166 B CN102046166 B CN 102046166B CN 2009801190689 A CN2009801190689 A CN 2009801190689A CN 200980119068 A CN200980119068 A CN 200980119068A CN 102046166 B CN102046166 B CN 102046166B
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compound
scopolamine
day
dry eye
group
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CN102046166A (zh
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G·卡姆伯利德吉
K·米罗维特施
T·拉玛
H·U·萨拉戈维
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Mimetogen Pharmaceuticals Inc
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Mimetogen Pharmaceuticals Inc
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/04—Artificial tears; Irrigation solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/12—Cyclic peptides with only normal peptide bonds in the ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/12—Cyclic peptides with only normal peptide bonds in the ring
    • C07K5/123—Tripeptides

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
CN2009801190689A 2008-04-04 2009-04-03 用于治疗干眼症的β-转角模拟肽环状化合物 Active CN102046166B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US12303608P 2008-04-04 2008-04-04
US61/123,036 2008-04-04
US20887309P 2009-02-27 2009-02-27
US61/208,873 2009-02-27
PCT/US2009/002121 WO2009123761A1 (en) 2008-04-04 2009-04-03 Beta-turn peptidomimetic cyclic compounds for treating dry eye

Publications (2)

Publication Number Publication Date
CN102046166A CN102046166A (zh) 2011-05-04
CN102046166B true CN102046166B (zh) 2012-10-17

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CN2009801190689A Active CN102046166B (zh) 2008-04-04 2009-04-03 用于治疗干眼症的β-转角模拟肽环状化合物

Country Status (9)

Country Link
US (4) US8293713B2 (OSRAM)
EP (1) EP2271337B1 (OSRAM)
JP (2) JP5480242B2 (OSRAM)
KR (1) KR101565185B1 (OSRAM)
CN (1) CN102046166B (OSRAM)
AU (1) AU2009232352B2 (OSRAM)
CA (1) CA2720141C (OSRAM)
ES (1) ES2521515T3 (OSRAM)
WO (1) WO2009123761A1 (OSRAM)

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EP2271337B1 (en) 2008-04-04 2014-09-03 Mimetogen Pharmaceuticals Inc. Beta-turn peptidomimetic cyclic compounds for treating dry eye
US9115179B2 (en) * 2012-06-22 2015-08-25 Mimetogen Pharmaceuticals Inc. Synthesis of beta-turn peptidomimetic cyclic compounds
KR20150004652A (ko) 2013-07-03 2015-01-13 삼성디스플레이 주식회사 표시 패널, 이를 포함하는 표시 장치 및 이를 이용하는 영상 표시 방법
JP6267003B2 (ja) * 2014-02-27 2018-01-24 参天製薬株式会社 ジクアホソルまたはその塩およびレバミピドまたはその塩を組み合わせたことを特徴とする涙液分泌促進剤
CA2973471A1 (en) 2015-01-12 2016-07-21 Kedalion Therapeutics, Inc. Micro-droplet delivery device and methods
EP3253433A4 (en) 2015-04-10 2018-08-22 Kedalion Therapeutics, Inc. Piezoelectric dispenser with replaceable ampoule
KR102056257B1 (ko) 2015-07-09 2019-12-16 미메토젠 파르마슈티칼스 인크. 베타-턴 펩티도미메틱 사이클릭 염의 용액상 합성 및 결정화
KR101718733B1 (ko) 2015-08-21 2017-03-22 국제약품 주식회사 레바미피드의 가용화 방법 및 이에 의해 제조된 안구건조증 치료용 액제
CA3016546A1 (en) 2016-03-04 2017-09-08 James M. Rynerson Method of treating an eye disorder by inhibiting or disrupting bacterial biofilm formation
KR102866401B1 (ko) 2017-01-20 2025-10-01 보슈 롬 아일랜드 리미티드 압전 유체 분배기
WO2019113483A1 (en) 2017-12-08 2019-06-13 Kedalion Therapeutics, Inc. Fluid delivery alignment system
CN110092799B (zh) * 2018-01-29 2021-11-12 广州丹康医药生物有限公司 一种环状化合物、其制备方法和应用
US12350194B1 (en) 2018-04-12 2025-07-08 Bausch + Lomb Ireland Limited Topical ocular delivery of fluids with controlled mass dosing and wireless communication
US20190314198A1 (en) 2018-04-12 2019-10-17 Kedalion Therapeutics, Inc. Topical Ocular Delivery Methods and Devices for Use in the Same
CA3102410A1 (en) 2018-07-03 2020-01-09 Kedalion Therapeutics, Inc. Topical ocular delivery devices and methods for using the same
US11679028B2 (en) 2019-03-06 2023-06-20 Novartis Ag Multi-dose ocular fluid delivery system
US12097145B2 (en) 2019-03-06 2024-09-24 Bausch + Lomb Ireland Limited Vented multi-dose ocular fluid delivery system
US12496218B1 (en) 2019-11-12 2025-12-16 Bausch + Lomb Ireland Limited Fractionated topical ocular drug delivery methods and devices for use in the same
US12290472B2 (en) 2020-04-17 2025-05-06 Bausch + Lomb Ireland Limited Hydrodynamically actuated preservative free dispensing system
WO2021212038A1 (en) 2020-04-17 2021-10-21 Kedalion Therapeutics, Inc. Hydrodynamically actuated preservative free dispensing system having a collapsible liquid reservoir
US11938057B2 (en) 2020-04-17 2024-03-26 Bausch + Lomb Ireland Limited Hydrodynamically actuated preservative free dispensing system
AU2021257273A1 (en) 2020-04-17 2022-11-17 Bausch + Lomb Ireland Limited Hydrodynamically actuated preservative free dispensing system
AU2022283808A1 (en) * 2021-06-02 2023-12-07 The Texas A&M University System Selective small molecule agonists and partial agonists of trk receptors
AU2022370358A1 (en) * 2021-10-20 2024-05-02 Stealth Biotherapeutics Inc. Methods and compositions comprising peptidomimitics for treating, preventing, inhibiting, ameliorating or delaying the onset of ophthalmic conditions
WO2023069255A1 (en) * 2021-10-20 2023-04-27 Stealth Biotherapeutics Inc. Methods and compositions comprising peptidomimitics for treating, preventing, inhibiting, ameliorating or delaying the onset of ophthalmic conditions

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WO2001052843A1 (en) * 2000-01-18 2001-07-26 Mcgill University β-TURN PEPTIDOMIMETIC CYCLIC COMPOUNDS

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EP2271337B1 (en) * 2008-04-04 2014-09-03 Mimetogen Pharmaceuticals Inc. Beta-turn peptidomimetic cyclic compounds for treating dry eye
CN102333537B (zh) * 2009-02-27 2014-08-13 米梅托根药物公司 用于治疗色素性视网膜炎的模拟肽环状化合物
US9115179B2 (en) * 2012-06-22 2015-08-25 Mimetogen Pharmaceuticals Inc. Synthesis of beta-turn peptidomimetic cyclic compounds

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WO2001052843A1 (en) * 2000-01-18 2001-07-26 Mcgill University β-TURN PEPTIDOMIMETIC CYCLIC COMPOUNDS

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A. Lambiase等.Efficacy of topical nerve growth factor treatment in dogs affected by dry eye.《Graefe’s Arch Clin Exp Ophthalmol》.2005,第243卷151–155. *

Also Published As

Publication number Publication date
CN102046166A (zh) 2011-05-04
CA2720141A1 (en) 2009-10-08
HK1152898A1 (en) 2012-03-16
US9156882B2 (en) 2015-10-13
JP5480242B2 (ja) 2014-04-23
US20120322747A1 (en) 2012-12-20
WO2009123761A1 (en) 2009-10-08
EP2271337A1 (en) 2011-01-12
JP2014080447A (ja) 2014-05-08
US9707267B2 (en) 2017-07-18
US20140274910A1 (en) 2014-09-18
KR20110010712A (ko) 2011-02-07
CA2720141C (en) 2014-01-28
EP2271337B1 (en) 2014-09-03
US8748391B2 (en) 2014-06-10
JP2011516477A (ja) 2011-05-26
AU2009232352B2 (en) 2013-09-05
JP5870348B2 (ja) 2016-02-24
US20110105410A1 (en) 2011-05-05
AU2009232352A1 (en) 2009-10-08
ES2521515T3 (es) 2014-11-12
US20160082072A1 (en) 2016-03-24
US8293713B2 (en) 2012-10-23
KR101565185B1 (ko) 2015-11-02

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Inventor after: Cumberlidge Garth

Inventor after: Meerovitch Karen

Inventor after: Lama Teresa

Inventor after: Saragovi H. Uri

Inventor before: Cumberlidge Garth

Inventor before: Meerovitch Karen

Inventor before: Lama Teresa

COR Change of bibliographic data

Free format text: CORRECT: INVENTOR; FROM: GARTH CUMBERLIDGE MIRVITESSE K. T.LARMA TO: GARTH CUMBERLIDGE MIRVITESSE K. T.LARMA URI SARAGOVI H

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