CN102038744A - High-permeability environment-friendly high-efficiency skin disinfectant and preparation method thereof - Google Patents
High-permeability environment-friendly high-efficiency skin disinfectant and preparation method thereof Download PDFInfo
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- 239000000645 desinfectant Substances 0.000 title claims abstract description 28
- 238000002360 preparation method Methods 0.000 title claims abstract description 18
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 34
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 23
- DTGKSKDOIYIVQL-WEDXCCLWSA-N (+)-borneol Chemical compound C1C[C@@]2(C)[C@@H](O)C[C@@H]1C2(C)C DTGKSKDOIYIVQL-WEDXCCLWSA-N 0.000 claims abstract description 16
- NOOLISFMXDJSKH-UHFFFAOYSA-N DL-menthol Natural products CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 claims abstract description 14
- AXTGDCSMTYGJND-UHFFFAOYSA-N 1-dodecylazepan-2-one Chemical compound CCCCCCCCCCCCN1CCCCCC1=O AXTGDCSMTYGJND-UHFFFAOYSA-N 0.000 claims abstract description 12
- 239000008367 deionised water Substances 0.000 claims abstract description 11
- 239000012153 distilled water Substances 0.000 claims abstract description 11
- 239000002904 solvent Substances 0.000 claims abstract description 7
- 239000006184 cosolvent Substances 0.000 claims abstract description 6
- NOOLISFMXDJSKH-UTLUCORTSA-N (+)-Neomenthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@@H]1O NOOLISFMXDJSKH-UTLUCORTSA-N 0.000 claims abstract description 4
- 229940041616 menthol Drugs 0.000 claims abstract description 4
- 230000002421 anti-septic effect Effects 0.000 claims description 18
- 238000003756 stirring Methods 0.000 claims description 17
- 239000003795 chemical substances by application Substances 0.000 claims description 12
- 239000000463 material Substances 0.000 claims description 12
- 230000000149 penetrating effect Effects 0.000 claims description 12
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- 230000007613 environmental effect Effects 0.000 claims description 10
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- 235000019438 castor oil Nutrition 0.000 claims description 6
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 claims description 6
- 239000002738 chelating agent Substances 0.000 claims description 4
- 239000013078 crystal Substances 0.000 claims description 4
- 239000000284 extract Substances 0.000 claims description 4
- 239000007788 liquid Substances 0.000 claims description 4
- 150000003242 quaternary ammonium salts Chemical class 0.000 claims description 4
- UEUXEKPTXMALOB-UHFFFAOYSA-J tetrasodium;2-[2-[bis(carboxylatomethyl)amino]ethyl-(carboxylatomethyl)amino]acetate Chemical compound [Na+].[Na+].[Na+].[Na+].[O-]C(=O)CN(CC([O-])=O)CCN(CC([O-])=O)CC([O-])=O UEUXEKPTXMALOB-UHFFFAOYSA-J 0.000 claims description 4
- 238000002425 crystallisation Methods 0.000 claims description 3
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- 238000004659 sterilization and disinfection Methods 0.000 abstract description 7
- 230000001954 sterilising effect Effects 0.000 abstract description 5
- 239000011148 porous material Substances 0.000 abstract description 4
- 230000036407 pain Effects 0.000 abstract description 2
- REPVLJRCJUVQFA-UHFFFAOYSA-N (-)-isopinocampheol Natural products C1C(O)C(C)C2C(C)(C)C1C2 REPVLJRCJUVQFA-UHFFFAOYSA-N 0.000 abstract 2
- 229940116229 borneol Drugs 0.000 abstract 2
- CKDOCTFBFTVPSN-UHFFFAOYSA-N borneol Natural products C1CC2(C)C(C)CC1C2(C)C CKDOCTFBFTVPSN-UHFFFAOYSA-N 0.000 abstract 2
- 235000019864 coconut oil Nutrition 0.000 abstract 2
- 239000003240 coconut oil Substances 0.000 abstract 2
- DTGKSKDOIYIVQL-UHFFFAOYSA-N dl-isoborneol Natural products C1CC2(C)C(O)CC1C2(C)C DTGKSKDOIYIVQL-UHFFFAOYSA-N 0.000 abstract 2
- 239000002994 raw material Substances 0.000 abstract 2
- 206010061218 Inflammation Diseases 0.000 abstract 1
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- 230000003467 diminishing effect Effects 0.000 abstract 1
- 230000004054 inflammatory process Effects 0.000 abstract 1
- 244000052769 pathogen Species 0.000 abstract 1
- HOKBIQDJCNTWST-UHFFFAOYSA-N phosphanylidenezinc;zinc Chemical compound [Zn].[Zn]=P.[Zn]=P HOKBIQDJCNTWST-UHFFFAOYSA-N 0.000 abstract 1
- 210000004243 sweat Anatomy 0.000 abstract 1
- 230000002195 synergetic effect Effects 0.000 abstract 1
- 238000012360 testing method Methods 0.000 description 24
- 238000000034 method Methods 0.000 description 9
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- 230000000694 effects Effects 0.000 description 7
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- 241000894006 Bacteria Species 0.000 description 4
- 238000001914 filtration Methods 0.000 description 4
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- 241000588724 Escherichia coli Species 0.000 description 3
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- 244000052616 bacterial pathogen Species 0.000 description 3
- 150000002632 lipids Chemical class 0.000 description 3
- 239000011550 stock solution Substances 0.000 description 3
- 238000007920 subcutaneous administration Methods 0.000 description 3
- 241000222122 Candida albicans Species 0.000 description 2
- 241000233866 Fungi Species 0.000 description 2
- 241000589517 Pseudomonas aeruginosa Species 0.000 description 2
- 241000191940 Staphylococcus Species 0.000 description 2
- 241000191967 Staphylococcus aureus Species 0.000 description 2
- 241000194017 Streptococcus Species 0.000 description 2
- 230000000202 analgesic effect Effects 0.000 description 2
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- 239000003085 diluting agent Substances 0.000 description 2
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- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 231100000252 nontoxic Toxicity 0.000 description 2
- 230000003000 nontoxic effect Effects 0.000 description 2
- 238000001228 spectrum Methods 0.000 description 2
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 description 1
- 102000004877 Insulin Human genes 0.000 description 1
- 108090001061 Insulin Proteins 0.000 description 1
- 206010067482 No adverse event Diseases 0.000 description 1
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- 230000008499 blood brain barrier function Effects 0.000 description 1
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- 229910052801 chlorine Inorganic materials 0.000 description 1
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- MEYZYGMYMLNUHJ-UHFFFAOYSA-N tunicamycin Natural products CC(C)CCCCCCCCCC=CC(=O)NC1C(O)C(O)C(CC(O)C2OC(C(O)C2O)N3C=CC(=O)NC3=O)OC1OC4OC(CO)C(O)C(O)C4NC(=O)C MEYZYGMYMLNUHJ-UHFFFAOYSA-N 0.000 description 1
Landscapes
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
The invention relates to the technical field of a disinfectant, in particular to a high-permeability environment-friendly high-efficiency skin disinfectant and a preparation method thereof. The skin disinfectant is compounded from the following components in percentage by weight: a) 0.1-1% of environment-friendly high-efficiency disinfectant prepared by using coconut oil as a basic raw material; b) 0.1-0.5% of menthol; c) 0.1-0.5% of borneol; d) 0.05-0.5% of complexing agent; e) 0.2-1% of solubilizer; f) 5-10% of cosolvent and penetrant; g) 0.5-2.5% of penetrant; and h) balance of distilled water or de-ionized water. By adding the menthol, the borneol, ethanol, azone and other components to the original environment-friendly high-efficiency disinfectant prepared by using coconut oil as a basic raw material, the invention can fast kill pathogens on the skin surface, in sweat pores and under the skin based on the synergetic effect of the components, thereby achieving the purposes of transdermal sterilization, inflammation diminishing and pain relieving.
Description
Technical field:
The present invention relates to the disinfectant technical field, refer in particular to a kind of high osmosis environment-friendly highly efficient skin antiseptic and preparation method thereof.
Background technology:
At present the traditional most number average of disinfectant of China contains compositions such as chlorine, alcohols, aldehydes, iodine class, peroxide, organic phenolic compounds, and it all has in various degree influence to environment, apparatus, human body.Epoch now, people press for a kind of environment-friendly type, efficient, wide spectrum, are not subject to the interferential ideal disinfectant of external condition.At above-mentioned situation, the inventor once developed " environmental protection efficient disinfectant that with the Oleum Cocois is the basic material preparation " [seeing Chinese invention patent application number 200710113995.2], its product nonhazardous, non-stimulated, no burn into easily degrade, pollution-free and have wide spectrum, a bactericidal effect efficiently, but because it is a macromole, penetrating power a little less than, can not accomplish well to kill to pathogenic bacterium hiding in the subcutaneous and pore.
Summary of the invention:
One of purpose of the present invention is to overcome the above-mentioned weak point of prior art, and a kind of high osmosis environment-friendly highly efficient skin antiseptic is provided.
The present invention realizes that the technical scheme that its purpose adopts is: a kind of high osmosis environment-friendly highly efficient skin antiseptic, and described skin antiseptic is made by following components in weight percentage is composite:
A) with the Oleum Cocois be the environmental protection efficient disinfectant of basic material preparation: 0.1～1%
B) Mentholum: 0.1～0.5%
C) Borneolum Syntheticum: 0.1～0.5%
D) chelating agent: 0.05～0.5%
E) solubilizing agent: 0.2～1%
F) cosolvent and penetrating agent: 5～10%
G) penetrating agent: 0.5～2.5%
H) distilled water or deionized water: surplus.
In the technique scheme, described is that the environmental protection efficient disinfectant of basic material preparation is that to contain with the Oleum Cocois be the quaternary ammonium salt of basic material preparation and the disinfectant of double-chain quaternary ammonium salt with the Oleum Cocois.
Described Mentholum (menthol) is the extract of plant Herba Menthae.
Described Borneolum Syntheticum (DryobalanopsaromaticaGwaertn.f.) is that the resin and the volatile oil processed goods of Dipterocarpaceae plant Borneolum Syntheticum extracts the crystallization that obtains.
Described chelating agent is a kind of in disodiumedetate, the tetrasodium ethylenediamine tetraacetate.
Described solubilizing agent is castor oil hydrogenated (PEG-60).
Described cosolvent and penetrating agent are ethanol.
Described penetrating agent is azone (Azone).
The present invention original be on the basis of environmental protection efficient disinfectant (being Chinese invention patent application number 200710113995.2 disclosed disinfectant) of basic material preparation with the Oleum Cocois, compositions such as Mentholum, Borneolum Syntheticum, ethanol, azone have been increased, synergism by mentioned component, can kill in skin surface, the pore fast and subcutaneous pathogenic bacterium, reach the purpose of transdermal sterilization, anti-inflammatory analgesic.Its mechanism of action mainly shows in the following areas:
Mentholum: the special aroma of Herba Menthae being arranged, during topical application, blood circulation promoting and antiinflammatory, effect such as antipruritic are arranged, can be used for antiinflammatory, antipruritic, pain relieving, alleviate edema etc., also is good penetrating agent simultaneously.
Borneolum Syntheticum: extracting the crystallization that obtains by Borneolum Syntheticum resin and volatile oil processed goods, is near pure dextro Borneolum Syntheticum, and antibacterial, antiinflammatory action is arranged, and also is the good penetration agent simultaneously, can see through blood brain barrier fast when for oral administration.
Ethanol: ethanol is nontoxic and volatile, so the solvent in the administration of Chang Zuowei patch.Ethanol can see through skin rapidly, and its steady state flow is about 1mg/ (cm
2H), ethanol can be strengthened the infiltration of medicine by following several respects as cosolvent and penetrating agent: 1. as solvent, ethanol can increase the dissolubility of medicine in carrier; 2. ethanol sees through the cuticular while, has changed the characteristic of skin, thereby has improved the distribution of medicine in this tunic; In the research of using the collaborative percutaneous iontherapy promotion of penetrating agent absorption of insulin, (TGA) studies show that through thermogravimetric analyzer, and ethanol can cause the skin barrier characteristic changing; 3. ethanol can cause the minimizing of horny layer lipid, thereby prolong drug action time can increase the transdermal amount of medicine indirectly.In addition, ethanol itself also is middle effect disinfectants.
Azone: be that the oil-soluble azone becomes the efficient water soluble product through modification, all there is tangible transdermal to help the effect of oozing to oleophylic, hydrophilic medicament and active component, keratodermatitis and lipid are interacted, reduced the phase inversion temperature of active substance lipid in the horny layer gap, increased flowability, medicine or the active additive diffusional resistance in horny layer is reduced, so play the very strong short effect of oozing; And nontoxic through evidence azones such as toxicological experiment, skin and damaged skin zest, sensitization, teratogenesis, have no side effect, nonirritant.
Another object of the present invention provides a kind of preparation method of high osmosis environment-friendly highly efficient skin antiseptic, and this preparation method comprises the steps:
1) Mentholum and the Borneolum Syntheticum of measuring fixed amount are inserted in rustless steel or the glass container;
2) then the castor oil hydrogenated (PEG-60) of measuring fixed amount is joined in the container, stir, dissolve fully up to crystal and be in a liquid state;
3) add measuring fixed amount ethanol again, stir, merge fully until liquid;
4) distilled water or the deionized water of adding total amount 60% are stirred to fully and merge;
5) the adding measuring fixed amount is that the environmental protection efficient disinfectant that basic material prepares stirs with the Oleum Cocois;
6) add a kind of in the disodiumedetate, tetrasodium ethylenediamine tetraacetate of measuring fixed amount, be stirred to dissolving fully;
7) azone of adding measuring fixed amount stirs;
8) replenish distilled water or deionized water to setting total amount, leave standstill after the stirring filter to be installed.
The specific embodiment:
The present invention is further described below in conjunction with specific embodiment.
Embodiment 1
Prepare high osmosis environment-friendly highly efficient skin antiseptic as follows:
1) the 1g Mentholum is inserted in the measuring cup;
2) add the 1g Borneolum Syntheticum;
3) adding 2g castor oil hydrogenated (PEG-60) slowly is stirred to crystal and dissolves fully;
4) add 50g ethanol (concentration 95%), slowly be stirred to fully and merge;
5) add 546g distilled water or deionized water, stir;
6) add the 10g active matter content be 10%m/v be the environmental protection efficient disinfectant of basic material preparation, i.e. Chinese invention patent application number 200710113995.2 disclosed disinfectant with the Oleum Cocois;
7) add 0.5g disodiumedetate (EDTA-2Na) heated and stirred again to dissolving fully, can be heated to during stirring below 50 ℃, with convenient dissolving;
8) adding the 17g active matter content is the azone of 30%m/v, stirs;
9) distilled water or deionized water add to 1000g, slowly stir half an hour, leave standstill filter to be installed.
The properties of product and the compliance test result of high osmosis environment-friendly type disinfectant of the present invention are as follows:
(1), according to " disposable use hygienic article sanitary standard " GB15979-2002 appendix B product microorganism detection method, under the condition of 22 ℃ of temperature, relative humidity 60%, the present embodiment product is carried out microbial contamination detects testing result such as following table 1:
Table 1:(annotates: "-" expression does not detect)
| Test item | Unit | Testing result | Standard value | Conclusion |
| Total number of bacterial colonies | cfu/g | 0 | ≤200 | Qualified |
| The fungus colony sum | cfu/g | 0 | ≤100 | Qualified |
| Coliform | - | - | Qualified | |
| Bacillus pyocyaneus | - | - | Qualified | |
| Staphylococcus aureus | - | - | Qualified | |
| Hemolytic streptococcus | - | - | Qualified |
As seen from the above table, the total number of bacterial colonies of disinfectant of the present invention, fungus colony sum, coliform, bacillus pyocyaneus, staphylococcus aureus, Hemolytic streptococcus all meet the regulation of GB15979-2002.
(2), reach " disinfection technology standard " (version in 2002) (defending the method prison sends out [2002] No. 282) 2.1.11.3, as test organisms the present embodiment product carried out filtration and washing method qualification test according to " the disposable hygienic article sanitary standard of using " GB15979-2002 appendix C with escherichia coli, test is divided into 4 groups, the 1st group: test specimen+bacteria suspension; The 2nd group: test specimen+bacteria suspension+filtration and washing method is handled; The 3rd group: bacteria suspension+water+filtration and washing method is handled; The 4th group: bacteria suspension; Be 1 minute action time, repeats 3 times; Test specimen divides two kinds, is respectively present embodiment product stock solution and 50% diluent; Result of the test is respectively shown in following table 2, table 3:
Table 2 (test specimen is a stock solution):
Table 3 (test specimen is 50% diluent):
The above results shows, adopts the filtration and washing method, can effectively remove disinfectant of the present invention to colibacillary effect, and this method has no adverse effects to test organisms.
(3), according to " the disposable hygienic article sanitary standard of using " GB15979-2002 appendix C and " disinfection technology standard " (version in 2002) (defending the method prison sends out [2002] No. 282) 2.1.11.3, with golden staphylococcus and escherichia coli as test organisms to the present embodiment product sterilize, the bacteriostasis property test, 20～21 ℃ of experimental conditions, test specimen is a stock solution, be 1 minute, 2 minutes, 5 minutes and 10 minutes action time, result of the test such as following table 4:
Table 4:
The above results shows that under experimental condition, this test specimen effect 1min is 100% to golden staphylococcus and escherichia coli killing rate, and product promptly of the present invention has extremely strong sterilization, fungistatic effect.
(4), with test method, the experimental condition identical with (three), be that test organisms carries out the bactericidal property test to the present embodiment product with the Candida albicans, result of the test is: this test specimen effect 1min is 100% to the Candida albicans killing rate.
Embodiment 2
Prepare high osmosis environment-friendly highly efficient skin antiseptic as follows:
1) the 5g Mentholum is inserted in the measuring cup;
2) add the 2g Borneolum Syntheticum;
3) adding 8g castor oil hydrogenated (PEG-60) slowly is stirred to crystal and dissolves fully;
4) add 50g ethanol (concentration 95%), slowly be stirred to fully and merge;
5) add 535g distilled water or deionized water, stir;
6) add the 50g active matter content be 10%m/v be the environmental protection efficient disinfectant of basic material preparation with the Oleum Cocois;
7) add 0.5g disodiumedetate (EDTA-2Na) heated and stirred again to dissolving fully;
8) adding the 65g active matter content is the azone of 30%m/v, stirs;
9) distilled water or deionized water add to 1000g, slowly stir half an hour, leave standstill filter to be installed.
With method, the condition identical with embodiment 1 properties of product and sterilization, the fungistatic effect of present embodiment product are tested, result of the test is identical with embodiment 1.
In sum, disinfectant of the present invention can be killed in skin surface, the pore and subcutaneous pathogenic bacterium fast, reaches the purpose of transdermal sterilization, anti-inflammatory analgesic.
Certainly, the above is several simple embodiment of the present invention, and non-limiting protection scope of the present invention, allly does equivalence according to technical scheme disclosed by the invention and changes or modify, all should be within protection scope of the present invention.
Claims (9)
1. high osmosis environment-friendly highly efficient skin antiseptic, it is characterized in that: described skin antiseptic is made by following components in weight percentage is composite:
A) with the Oleum Cocois be the environmental protection efficient disinfectant of basic material preparation: 0.1～1%
B) Mentholum: 0.1～0.5%
C) Borneolum Syntheticum: 0.1～0.5%
D) chelating agent: 0.05～0.5%
E) solubilizing agent: 0.2～1%
F) cosolvent and penetrating agent: 5～10%
G) penetrating agent: 0.5～2.5%
H) distilled water or deionized water: surplus.
2. high osmosis environment-friendly highly efficient skin antiseptic according to claim 1 is characterized in that: described is that the environmental protection efficient disinfectant of basic material preparation is that to contain with the Oleum Cocois be the quaternary ammonium salt of basic material preparation and the disinfectant of double-chain quaternary ammonium salt with the Oleum Cocois.
3. high osmosis environment-friendly highly efficient skin antiseptic according to claim 1 is characterized in that: described Mentholum (menthol) is the extract of plant Herba Menthae.
4. high osmosis environment-friendly highly efficient skin antiseptic according to claim 1 is characterized in that: described Borneolum Syntheticum (DryobalanopsaromaticaGwaertn.f.) extracts the crystallization of acquisition for the resin of Dipterocarpaceae plant Borneolum Syntheticum and volatile oil processed goods.
5. high osmosis environment-friendly highly efficient skin antiseptic according to claim 1 is characterized in that: described chelating agent is a kind of in disodiumedetate, the tetrasodium ethylenediamine tetraacetate.
6. high osmosis environment-friendly highly efficient skin antiseptic according to claim 1 is characterized in that: described solubilizing agent is castor oil hydrogenated (PEG-60).
7. high osmosis environment-friendly highly efficient skin antiseptic according to claim 1 is characterized in that: described cosolvent and penetrating agent are ethanol.
8. high osmosis environment-friendly highly efficient skin antiseptic according to claim 1 is characterized in that: described penetrating agent is azone (Azone).
9. the preparation method of a high osmosis environment-friendly highly efficient skin antiseptic, it is characterized in that: this preparation method comprises the steps:
1) Mentholum and the Borneolum Syntheticum of measuring fixed amount are inserted in rustless steel or the glass container;
2) then the castor oil hydrogenated (PEG-60) of measuring fixed amount is joined in the container, stir, dissolve fully up to crystal and be in a liquid state;
3) add measuring fixed amount ethanol again, stir, merge fully until liquid;
4) distilled water or the deionized water of adding total amount 60% are stirred to fully and merge;
5) the adding measuring fixed amount is that the environmental protection efficient disinfectant that basic material prepares stirs with the Oleum Cocois;
6) add a kind of in the disodiumedetate, tetrasodium ethylenediamine tetraacetate of measuring fixed amount, be stirred to dissolving fully;
7) azone of adding measuring fixed amount stirs;
8) replenish distilled water or deionized water to setting total amount, leave standstill after the stirring filter to be installed.
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| CN201010616170A CN102038744B (en) | 2010-12-30 | 2010-12-30 | High-permeability environment-friendly high-efficiency skin disinfectant and preparation method thereof |
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| Publication Number | Publication Date |
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| CN102038744A true CN102038744A (en) | 2011-05-04 |
| CN102038744B CN102038744B (en) | 2012-09-05 |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102861206A (en) * | 2011-07-07 | 2013-01-09 | 万绪山 | Sterilizing and disinfecting aerosol for skin mucous membrane and preparation method thereof |
| CN103316261A (en) * | 2013-06-27 | 2013-09-25 | 广西信业生物技术有限公司 | Medical antibacterial liquid and preparation method thereof |
| CN109260247A (en) * | 2018-10-23 | 2019-01-25 | 渭南新秦药物研究有限责任公司 | A kind of skin antiseptic and preparation method thereof acting on herpesviral |
| CN110150537A (en) * | 2019-06-19 | 2019-08-23 | 潍坊市毅泓泽环境工程有限公司 | A kind of sterilizing method of pigskin processing |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1226816A (en) * | 1996-08-02 | 1999-08-25 | 普拉姆开米制品股份有限公司 | Oil-in-water emulsion for use on human skin for cleansing, preserving or improving skin condition |
| CN101422149A (en) * | 2007-10-31 | 2009-05-06 | 李忠泽 | Environmental protection efficient disinfectant prepared by coconut oil as basis raw material |
-
2010
- 2010-12-30 CN CN201010616170A patent/CN102038744B/en active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1226816A (en) * | 1996-08-02 | 1999-08-25 | 普拉姆开米制品股份有限公司 | Oil-in-water emulsion for use on human skin for cleansing, preserving or improving skin condition |
| CN101422149A (en) * | 2007-10-31 | 2009-05-06 | 李忠泽 | Environmental protection efficient disinfectant prepared by coconut oil as basis raw material |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102861206A (en) * | 2011-07-07 | 2013-01-09 | 万绪山 | Sterilizing and disinfecting aerosol for skin mucous membrane and preparation method thereof |
| CN103316261A (en) * | 2013-06-27 | 2013-09-25 | 广西信业生物技术有限公司 | Medical antibacterial liquid and preparation method thereof |
| CN109260247A (en) * | 2018-10-23 | 2019-01-25 | 渭南新秦药物研究有限责任公司 | A kind of skin antiseptic and preparation method thereof acting on herpesviral |
| CN110150537A (en) * | 2019-06-19 | 2019-08-23 | 潍坊市毅泓泽环境工程有限公司 | A kind of sterilizing method of pigskin processing |
Also Published As
| Publication number | Publication date |
|---|---|
| CN102038744B (en) | 2012-09-05 |
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Effective date of registration: 20160106 Address after: 523000 Guangdong province Gaobu town Dongguan city Jiangcheng Jiangcheng Road Patentee after: Dongguan Sino Biological Technology Co., Ltd. Address before: 523086 Guangdong province Gaobu town Dongguan city Jiangcheng Jiangcheng road in Dongguan city leading Biotechnology Co. Ltd. Patentee before: Li Zhongze |