CN102026971B - 用于保护胍基和氨基基团的吲哚磺酰基保护性基团 - Google Patents

用于保护胍基和氨基基团的吲哚磺酰基保护性基团 Download PDF

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Publication number
CN102026971B
CN102026971B CN200980118481.3A CN200980118481A CN102026971B CN 102026971 B CN102026971 B CN 102026971B CN 200980118481 A CN200980118481 A CN 200980118481A CN 102026971 B CN102026971 B CN 102026971B
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CN
China
Prior art keywords
compound
peptide compound
alkyl
protected
hydrogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN200980118481.3A
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English (en)
Chinese (zh)
Other versions
CN102026971A (zh
Inventor
马蒂厄·吉罗
费尔南多·阿尔贝利西欧
阿尔韦特·伊西德罗·略韦特
梅赛德斯·阿尔瓦雷斯·多明戈
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Polypeptide Laboratory Ppl Holding Co
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Lonza AG
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Publication date
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Publication of CN102026971A publication Critical patent/CN102026971A/zh
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Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Indole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN200980118481.3A 2008-05-05 2009-05-05 用于保护胍基和氨基基团的吲哚磺酰基保护性基团 Expired - Fee Related CN102026971B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP08008418 2008-05-05
EP08008418.9 2008-05-05
US9570908P 2008-09-10 2008-09-10
US61/095,709 2008-09-10
PCT/EP2009/003210 WO2009135645A1 (en) 2008-05-05 2009-05-05 Indolesulfonyl protecting groups for protection of guanidino and amino groups

Publications (2)

Publication Number Publication Date
CN102026971A CN102026971A (zh) 2011-04-20
CN102026971B true CN102026971B (zh) 2014-10-29

Family

ID=39772857

Family Applications (1)

Application Number Title Priority Date Filing Date
CN200980118481.3A Expired - Fee Related CN102026971B (zh) 2008-05-05 2009-05-05 用于保护胍基和氨基基团的吲哚磺酰基保护性基团

Country Status (16)

Country Link
US (1) US8431720B2 (https=)
EP (2) EP2280942A1 (https=)
JP (2) JP5567004B2 (https=)
KR (2) KR101493554B1 (https=)
CN (1) CN102026971B (https=)
AU (1) AU2009243730B2 (https=)
BR (1) BRPI0912355A2 (https=)
CA (1) CA2721644C (https=)
CO (1) CO6390068A2 (https=)
DK (1) DK2420489T3 (https=)
EA (1) EA022476B1 (https=)
ES (1) ES2477590T3 (https=)
IL (1) IL208930A (https=)
MX (1) MX2010012113A (https=)
WO (1) WO2009135645A1 (https=)
ZA (1) ZA201007614B (https=)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103626996B (zh) * 2013-11-29 2016-04-27 沈阳药科大学 胍基化的含二硫键聚氨基胺类聚合物及其制备和应用
EP3305780A1 (en) 2016-10-05 2018-04-11 Lonza Ltd Method for the preparation of h-arg(mis)-oh
EP3523278A4 (en) * 2016-10-09 2020-07-15 Polypeptide Laboratories Holding (PPL) AB METHOD FOR PRODUCING H-ARG (MIS) -OH
EP3315490A1 (en) 2016-10-31 2018-05-02 Polypeptide Laboratories Holding (PPL) AB Method for the preparation of h-arg(mis)-oh

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1693305A (zh) * 2004-05-08 2005-11-09 上海依福瑞实业有限公司 一种双保护氨基酸的制备方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10004572A1 (de) * 2000-02-02 2001-08-09 Boehringer Ingelheim Pharma Neue positive allosterische AMPA-Rezeptor Modulatoren (PAARM), Verfahren zu deren Herstellung und deren Verwendung als Arzneimittel
CA2473803A1 (en) 2002-02-01 2003-08-07 Robert Greenhouse Substituted indoles as alpha-1 agonists
EP2031098B1 (en) * 2007-08-28 2019-05-29 Rohm and Haas Electronic Materials LLC Composition and corresponding method for the electrodeposition of indium composites

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1693305A (zh) * 2004-05-08 2005-11-09 上海依福瑞实业有限公司 一种双保护氨基酸的制备方法

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
Louis A. Carpino,et al..The 2,2,4,6,7-Pentamethyldihydrobenzofuran-5-sulfonyl Group (Pbf) as Arginine Side Chain Protectant.《Tetrahedron Letters》.1993,第34卷(第49期),7829-7832. *
The 2,2,4,6,7-Pentamethyldihydrobenzofuran-5-sulfonyl Group (Pbf) as Arginine Side Chain Protectant;Louis A. Carpino,et al.;《Tetrahedron Letters》;19931231;第34卷(第49期);7829-7832 *

Also Published As

Publication number Publication date
JP5985534B2 (ja) 2016-09-06
IL208930A (en) 2014-07-31
EP2280942A1 (en) 2011-02-09
EA201001738A1 (ru) 2011-06-30
EP2420489A1 (en) 2012-02-22
JP2014193872A (ja) 2014-10-09
EP2420489B1 (en) 2014-04-23
BRPI0912355A2 (pt) 2015-07-28
CA2721644C (en) 2013-10-15
ES2477590T3 (es) 2014-07-17
HK1154860A1 (en) 2012-05-04
AU2009243730B2 (en) 2013-07-18
CA2721644A1 (en) 2009-11-12
KR101493554B1 (ko) 2015-02-16
US8431720B2 (en) 2013-04-30
US20110060125A1 (en) 2011-03-10
EA022476B1 (ru) 2016-01-29
WO2009135645A1 (en) 2009-11-12
ZA201007614B (en) 2011-07-27
CO6390068A2 (es) 2012-02-29
CN102026971A (zh) 2011-04-20
JP5567004B2 (ja) 2014-08-06
MX2010012113A (es) 2010-12-01
JP2011519884A (ja) 2011-07-14
KR20110014167A (ko) 2011-02-10
AU2009243730A1 (en) 2009-11-12
KR101521400B1 (ko) 2015-05-18
DK2420489T3 (da) 2014-07-21
IL208930A0 (en) 2011-01-31
KR20140061548A (ko) 2014-05-21

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