CA2721644C - Indolesulfonyl protecting groups for protection of guanidino and amino groups - Google Patents

Indolesulfonyl protecting groups for protection of guanidino and amino groups Download PDF

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Publication number
CA2721644C
CA2721644C CA2721644A CA2721644A CA2721644C CA 2721644 C CA2721644 C CA 2721644C CA 2721644 A CA2721644 A CA 2721644A CA 2721644 A CA2721644 A CA 2721644A CA 2721644 C CA2721644 C CA 2721644C
Authority
CA
Canada
Prior art keywords
compound
arg
mis
formula
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CA2721644A
Other languages
English (en)
French (fr)
Other versions
CA2721644A1 (en
Inventor
Matthieu Giraud
Fernando Albericio
Albert Isidro Llobet
Mercedes Alvarez Domingo
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Polypeptide Laboratories Holding (ppl) AB
Original Assignee
Lonza AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lonza AG filed Critical Lonza AG
Publication of CA2721644A1 publication Critical patent/CA2721644A1/en
Application granted granted Critical
Publication of CA2721644C publication Critical patent/CA2721644C/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Indole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CA2721644A 2008-05-05 2009-05-05 Indolesulfonyl protecting groups for protection of guanidino and amino groups Active CA2721644C (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP08008418 2008-05-05
EP08008418.9 2008-05-05
US9570908P 2008-09-10 2008-09-10
US61/095,709 2008-09-10
PCT/EP2009/003210 WO2009135645A1 (en) 2008-05-05 2009-05-05 Indolesulfonyl protecting groups for protection of guanidino and amino groups

Publications (2)

Publication Number Publication Date
CA2721644A1 CA2721644A1 (en) 2009-11-12
CA2721644C true CA2721644C (en) 2013-10-15

Family

ID=39772857

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2721644A Active CA2721644C (en) 2008-05-05 2009-05-05 Indolesulfonyl protecting groups for protection of guanidino and amino groups

Country Status (16)

Country Link
US (1) US8431720B2 (https=)
EP (2) EP2280942A1 (https=)
JP (2) JP5567004B2 (https=)
KR (2) KR101493554B1 (https=)
CN (1) CN102026971B (https=)
AU (1) AU2009243730B2 (https=)
BR (1) BRPI0912355A2 (https=)
CA (1) CA2721644C (https=)
CO (1) CO6390068A2 (https=)
DK (1) DK2420489T3 (https=)
EA (1) EA022476B1 (https=)
ES (1) ES2477590T3 (https=)
IL (1) IL208930A (https=)
MX (1) MX2010012113A (https=)
WO (1) WO2009135645A1 (https=)
ZA (1) ZA201007614B (https=)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103626996B (zh) * 2013-11-29 2016-04-27 沈阳药科大学 胍基化的含二硫键聚氨基胺类聚合物及其制备和应用
EP3305780A1 (en) 2016-10-05 2018-04-11 Lonza Ltd Method for the preparation of h-arg(mis)-oh
EP3523278A4 (en) * 2016-10-09 2020-07-15 Polypeptide Laboratories Holding (PPL) AB METHOD FOR PRODUCING H-ARG (MIS) -OH
EP3315490A1 (en) 2016-10-31 2018-05-02 Polypeptide Laboratories Holding (PPL) AB Method for the preparation of h-arg(mis)-oh

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10004572A1 (de) * 2000-02-02 2001-08-09 Boehringer Ingelheim Pharma Neue positive allosterische AMPA-Rezeptor Modulatoren (PAARM), Verfahren zu deren Herstellung und deren Verwendung als Arzneimittel
CA2473803A1 (en) 2002-02-01 2003-08-07 Robert Greenhouse Substituted indoles as alpha-1 agonists
CN100453537C (zh) * 2004-05-08 2009-01-21 上海依福瑞实业有限公司 一种双保护氨基酸的制备方法
EP2031098B1 (en) * 2007-08-28 2019-05-29 Rohm and Haas Electronic Materials LLC Composition and corresponding method for the electrodeposition of indium composites

Also Published As

Publication number Publication date
JP5985534B2 (ja) 2016-09-06
IL208930A (en) 2014-07-31
EP2280942A1 (en) 2011-02-09
EA201001738A1 (ru) 2011-06-30
EP2420489A1 (en) 2012-02-22
JP2014193872A (ja) 2014-10-09
EP2420489B1 (en) 2014-04-23
BRPI0912355A2 (pt) 2015-07-28
ES2477590T3 (es) 2014-07-17
HK1154860A1 (en) 2012-05-04
AU2009243730B2 (en) 2013-07-18
CA2721644A1 (en) 2009-11-12
KR101493554B1 (ko) 2015-02-16
US8431720B2 (en) 2013-04-30
US20110060125A1 (en) 2011-03-10
EA022476B1 (ru) 2016-01-29
WO2009135645A1 (en) 2009-11-12
ZA201007614B (en) 2011-07-27
CN102026971B (zh) 2014-10-29
CO6390068A2 (es) 2012-02-29
CN102026971A (zh) 2011-04-20
JP5567004B2 (ja) 2014-08-06
MX2010012113A (es) 2010-12-01
JP2011519884A (ja) 2011-07-14
KR20110014167A (ko) 2011-02-10
AU2009243730A1 (en) 2009-11-12
KR101521400B1 (ko) 2015-05-18
DK2420489T3 (da) 2014-07-21
IL208930A0 (en) 2011-01-31
KR20140061548A (ko) 2014-05-21

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