CN102008707B - 一种治疗高血压含喹那普利的复方制剂 - Google Patents
一种治疗高血压含喹那普利的复方制剂 Download PDFInfo
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- CN102008707B CN102008707B CN 201010231039 CN201010231039A CN102008707B CN 102008707 B CN102008707 B CN 102008707B CN 201010231039 CN201010231039 CN 201010231039 CN 201010231039 A CN201010231039 A CN 201010231039A CN 102008707 B CN102008707 B CN 102008707B
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- levamlodipine
- quinapril
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- 206010020772 Hypertension Diseases 0.000 title claims abstract description 24
- 150000001875 compounds Chemical class 0.000 title claims abstract description 19
- HTIQEAQVCYTUBX-KRWDZBQOSA-N (S)-amlodipine Chemical compound CCOC(=O)C1=C(COCCN)NC(C)=C(C(=O)OC)[C@@H]1C1=CC=CC=C1Cl HTIQEAQVCYTUBX-KRWDZBQOSA-N 0.000 claims abstract description 23
- 229950008554 levamlodipine Drugs 0.000 claims abstract description 23
- JSDRRTOADPPCHY-HSQYWUDLSA-N quinapril Chemical compound C([C@@H](C(=O)OCC)N[C@@H](C)C(=O)N1[C@@H](CC2=CC=CC=C2C1)C(O)=O)CC1=CC=CC=C1 JSDRRTOADPPCHY-HSQYWUDLSA-N 0.000 claims abstract description 19
- 229960001455 quinapril Drugs 0.000 claims abstract description 19
- JZUFKLXOESDKRF-UHFFFAOYSA-N Chlorothiazide Chemical compound C1=C(Cl)C(S(=O)(=O)N)=CC2=C1NCNS2(=O)=O JZUFKLXOESDKRF-UHFFFAOYSA-N 0.000 claims abstract description 13
- 229960002003 hydrochlorothiazide Drugs 0.000 claims abstract description 13
- 150000003839 salts Chemical class 0.000 claims abstract description 11
- 239000000203 mixture Substances 0.000 claims description 7
- 239000003826 tablet Substances 0.000 claims description 5
- 239000002552 dosage form Substances 0.000 claims description 4
- 239000002775 capsule Substances 0.000 claims description 3
- 239000003795 chemical substances by application Substances 0.000 claims description 3
- 239000008187 granular material Substances 0.000 claims description 3
- 239000007924 injection Substances 0.000 claims description 3
- 238000002347 injection Methods 0.000 claims description 3
- 239000002075 main ingredient Substances 0.000 claims description 3
- 239000000843 powder Substances 0.000 claims description 3
- 239000007901 soft capsule Substances 0.000 claims description 3
- 238000013270 controlled release Methods 0.000 claims description 2
- 239000003814 drug Substances 0.000 abstract description 22
- 230000000694 effects Effects 0.000 abstract description 18
- 230000036772 blood pressure Effects 0.000 abstract description 16
- 229940079593 drug Drugs 0.000 abstract description 8
- 239000000890 drug combination Substances 0.000 abstract description 4
- 230000007246 mechanism Effects 0.000 abstract description 2
- 206010067484 Adverse reaction Diseases 0.000 abstract 1
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- 239000003937 drug carrier Substances 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 238000009472 formulation Methods 0.000 description 5
- 238000011282 treatment Methods 0.000 description 5
- 239000002671 adjuvant Substances 0.000 description 4
- 230000001631 hypertensive effect Effects 0.000 description 4
- 239000002220 antihypertensive agent Substances 0.000 description 3
- 229940127088 antihypertensive drug Drugs 0.000 description 3
- 230000001225 therapeutic effect Effects 0.000 description 3
- 230000003276 anti-hypertensive effect Effects 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 238000007796 conventional method Methods 0.000 description 2
- 210000000088 lip Anatomy 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 230000002265 prevention Effects 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 238000002560 therapeutic procedure Methods 0.000 description 2
- 239000005541 ACE inhibitor Substances 0.000 description 1
- 102000015427 Angiotensins Human genes 0.000 description 1
- 108010064733 Angiotensins Proteins 0.000 description 1
- 229940127291 Calcium channel antagonist Drugs 0.000 description 1
- 208000024172 Cardiovascular disease Diseases 0.000 description 1
- 206010013710 Drug interaction Diseases 0.000 description 1
- 206010059866 Drug resistance Diseases 0.000 description 1
- 230000001133 acceleration Effects 0.000 description 1
- 230000032683 aging Effects 0.000 description 1
- 239000002333 angiotensin II receptor antagonist Substances 0.000 description 1
- 229940125364 angiotensin receptor blocker Drugs 0.000 description 1
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- 239000000480 calcium channel blocker Substances 0.000 description 1
- 230000008859 change Effects 0.000 description 1
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- 238000011981 development test Methods 0.000 description 1
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- 230000003203 everyday effect Effects 0.000 description 1
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- 239000005555 hypertensive agent Substances 0.000 description 1
- 206010025482 malaise Diseases 0.000 description 1
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- 239000008194 pharmaceutical composition Substances 0.000 description 1
- 230000003285 pharmacodynamic effect Effects 0.000 description 1
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Description
实施例 | 以左旋氨氯地平计为(mg/片) | 以喹那普利计为(mg/片) | 氢氯噻嗪(mg/片) |
1 | 左旋氨氯地平2.5 | 喹那普利5.0 | 氢氯噻嗪6.25 |
2 | 左旋氨氯地平2.5 | 喹那普利100.0 | 氢氯噻嗪12.5 |
3 | 左旋氨氯地平5.0 | 喹那普利80.0 | 氢氯噻嗪12.5 |
4 | 左旋氨氯地平5.0 | 喹那普利40.0 | 氢氯噻嗪25.0 |
5 | 左旋氨氯地平10.0 | 喹那普利20.0 | 氢氯噻嗪6.25 |
病例数 | 血压达标病例总数 | 血压未达标病例总数 | 平均血压达标率 |
500 | 410 | 90 | 82% |
Claims (2)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
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CN 201010231039 CN102008707B (zh) | 2009-07-14 | 2010-07-08 | 一种治疗高血压含喹那普利的复方制剂 |
Applications Claiming Priority (3)
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CN200910139997 | 2009-07-14 | ||
CN200910139997.8 | 2009-07-14 | ||
CN 201010231039 CN102008707B (zh) | 2009-07-14 | 2010-07-08 | 一种治疗高血压含喹那普利的复方制剂 |
Publications (2)
Publication Number | Publication Date |
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CN102008707A CN102008707A (zh) | 2011-04-13 |
CN102008707B true CN102008707B (zh) | 2012-12-26 |
Family
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Family Applications (9)
Application Number | Title | Priority Date | Filing Date |
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CN 201010231077 Active CN102008710B (zh) | 2009-07-14 | 2010-07-08 | 一种治疗高血压含赖诺普利的复方制剂 |
CN 201010231054 Pending CN102008491A (zh) | 2009-07-14 | 2010-07-08 | 一种治疗高血压含福辛普利的复方制剂 |
CN 201010231061 Active CN102008708B (zh) | 2009-07-14 | 2010-07-08 | 一种治疗高血压含雷米普利的复方制剂 |
CN 201010231091 Active CN102008712B (zh) | 2009-07-14 | 2010-07-08 | 一种治疗高血压含群多普利的复方制剂 |
CN 201010230019 Pending CN101984972A (zh) | 2009-07-14 | 2010-07-08 | 一种治疗高血压含苯那普利的复方制剂 |
CN 201010231082 Active CN102008711B (zh) | 2009-07-14 | 2010-07-08 | 一种治疗高血压含依那普利的复方制剂 |
CN 201010231039 Active CN102008707B (zh) | 2009-07-14 | 2010-07-08 | 一种治疗高血压含喹那普利的复方制剂 |
CN 201010230017 Pending CN101985035A (zh) | 2009-07-14 | 2010-07-08 | 一种治疗高血压含培哚普利的复方制剂 |
CN 201010231068 Active CN102008709B (zh) | 2009-07-14 | 2010-07-08 | 一种治疗高血压含美西普利的复方制剂 |
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CN 201010231077 Active CN102008710B (zh) | 2009-07-14 | 2010-07-08 | 一种治疗高血压含赖诺普利的复方制剂 |
CN 201010231054 Pending CN102008491A (zh) | 2009-07-14 | 2010-07-08 | 一种治疗高血压含福辛普利的复方制剂 |
CN 201010231061 Active CN102008708B (zh) | 2009-07-14 | 2010-07-08 | 一种治疗高血压含雷米普利的复方制剂 |
CN 201010231091 Active CN102008712B (zh) | 2009-07-14 | 2010-07-08 | 一种治疗高血压含群多普利的复方制剂 |
CN 201010230019 Pending CN101984972A (zh) | 2009-07-14 | 2010-07-08 | 一种治疗高血压含苯那普利的复方制剂 |
CN 201010231082 Active CN102008711B (zh) | 2009-07-14 | 2010-07-08 | 一种治疗高血压含依那普利的复方制剂 |
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CN 201010230017 Pending CN101985035A (zh) | 2009-07-14 | 2010-07-08 | 一种治疗高血压含培哚普利的复方制剂 |
CN 201010231068 Active CN102008709B (zh) | 2009-07-14 | 2010-07-08 | 一种治疗高血压含美西普利的复方制剂 |
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CN (9) | CN102008710B (zh) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
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CN102342948B (zh) * | 2011-07-14 | 2012-12-05 | 海南锦瑞制药股份有限公司 | 一种全新口服固体药用组合物及其制备方法 |
CN102319252B (zh) * | 2011-07-22 | 2012-10-10 | 海南锦瑞制药股份有限公司 | 一种氨氯地平与福辛普利钠的药用组合物及其制备方法 |
CN102423482B (zh) * | 2011-11-17 | 2013-09-25 | 南京瑞尔医药有限公司 | 复方氨氯地平赖诺普利片的制备方法 |
CN102423483A (zh) * | 2011-11-24 | 2012-04-25 | 西北农林科技大学 | 一种复方雷米普利纳米乳抗高血压药物 |
CN107029208A (zh) * | 2017-06-13 | 2017-08-11 | 江苏黄河药业股份有限公司 | 一种治疗心血管疾病的赖诺普利复方制剂及其制备方法 |
CN110755390A (zh) * | 2018-07-26 | 2020-02-07 | 北京市石景山区高血压联盟研究所 | 复方降压药物片剂及其用途 |
GR1010675B (el) * | 2023-02-17 | 2024-04-23 | Ιουλια Κλεωνος Τσετη | Τριπλος συνδυασμος αντι-υπερτασικων φαρμακων αναστολεα μεα, ανταγωνιστη ασβεστιου και διουρητικης ενωσης για ταυτοχρονη απο του στοματος χορηγηση |
Citations (1)
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CN101137367A (zh) * | 2003-10-20 | 2008-03-05 | 诺瓦提斯公司 | 用于降低心血管发病率的贝那普利和氨氯地平 |
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CN1237966C (zh) * | 2003-09-12 | 2006-01-25 | 启东盖天力药业有限公司 | 一种复方降压制剂 |
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- 2010-07-08 CN CN 201010231077 patent/CN102008710B/zh active Active
- 2010-07-08 CN CN 201010231054 patent/CN102008491A/zh active Pending
- 2010-07-08 CN CN 201010231061 patent/CN102008708B/zh active Active
- 2010-07-08 CN CN 201010231091 patent/CN102008712B/zh active Active
- 2010-07-08 CN CN 201010230019 patent/CN101984972A/zh active Pending
- 2010-07-08 CN CN 201010231082 patent/CN102008711B/zh active Active
- 2010-07-08 CN CN 201010231039 patent/CN102008707B/zh active Active
- 2010-07-08 CN CN 201010230017 patent/CN101985035A/zh active Pending
- 2010-07-08 CN CN 201010231068 patent/CN102008709B/zh active Active
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CN101137367A (zh) * | 2003-10-20 | 2008-03-05 | 诺瓦提斯公司 | 用于降低心血管发病率的贝那普利和氨氯地平 |
Also Published As
Publication number | Publication date |
---|---|
CN102008709B (zh) | 2012-12-26 |
CN102008708B (zh) | 2013-02-20 |
CN102008710B (zh) | 2013-02-20 |
CN102008491A (zh) | 2011-04-13 |
CN102008711A (zh) | 2011-04-13 |
CN102008710A (zh) | 2011-04-13 |
CN102008712B (zh) | 2012-12-26 |
CN102008707A (zh) | 2011-04-13 |
CN102008708A (zh) | 2011-04-13 |
CN102008709A (zh) | 2011-04-13 |
CN102008711B (zh) | 2012-12-26 |
CN102008712A (zh) | 2011-04-13 |
CN101985035A (zh) | 2011-03-16 |
CN101984972A (zh) | 2011-03-16 |
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Owner name: INNER MONGOLIA YUANHE PHARMACEUTICAL CO., LTD. Free format text: FORMER OWNER: WU LINXIANG Effective date: 20130911 Free format text: FORMER OWNER: WU LINYUN Effective date: 20130911 |
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Address after: The 010080 the Inner Mongolia Autonomous Region economic and Technological Development Zone of Hohhot district two gold Patentee after: YUANHE PHARMACEUTICAL CO., LTD. Address before: Jinchuan District 010080 the Inner Mongolia Autonomous Region Hohhot economic and Technological Development Zone gold two Patentee before: Inner Mongolia Yuanhe Pharmaceutical Co., Ltd. |
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