CN101981032A - 用于治疗由GSK3-β的异常活性引起的神经变性疾病的取代的芳基酰胺二氮杂并嘧啶酮衍生物 - Google Patents

用于治疗由GSK3-β的异常活性引起的神经变性疾病的取代的芳基酰胺二氮杂并嘧啶酮衍生物 Download PDF

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Publication number
CN101981032A
CN101981032A CN2009801107249A CN200980110724A CN101981032A CN 101981032 A CN101981032 A CN 101981032A CN 2009801107249 A CN2009801107249 A CN 2009801107249A CN 200980110724 A CN200980110724 A CN 200980110724A CN 101981032 A CN101981032 A CN 101981032A
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oxo
triaza
methoxy
pyrimidin
benzocyclohepten
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Pending
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CN2009801107249A
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Chinese (zh)
Inventor
奥德·法约尔
阿利斯太尔·洛克黑德
莫拉德·萨迪
朱利恩·韦切
菲利普·亚切
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Sanofi Aventis France
Mitsubishi Tanabe Pharma Corp
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Sanofi Aventis France
Mitsubishi Tanabe Pharma Corp
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CN2009801107249A 2008-01-29 2009-01-27 用于治疗由GSK3-β的异常活性引起的神经变性疾病的取代的芳基酰胺二氮杂并嘧啶酮衍生物 Pending CN101981032A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP08290074A EP2090578A1 (en) 2008-01-29 2008-01-29 Substituted arylamide diazepinopyrimidone derivatives for the treatment of neurodegenerative diseases caused by abnormal activity of GSK3-beta
EP08290074.7 2008-01-29
PCT/IB2009/000324 WO2009095789A1 (en) 2008-01-29 2009-01-27 Substituted arylamide diazepinopyrimidone derivatives for the treatment of neurodegenerative diseases caused by abnormal activity of gsk3-beta

Publications (1)

Publication Number Publication Date
CN101981032A true CN101981032A (zh) 2011-02-23

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CN2009801107249A Pending CN101981032A (zh) 2008-01-29 2009-01-27 用于治疗由GSK3-β的异常活性引起的神经变性疾病的取代的芳基酰胺二氮杂并嘧啶酮衍生物

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Country Link
US (1) US8507476B2 (enExample)
EP (2) EP2090578A1 (enExample)
JP (1) JP5611836B2 (enExample)
KR (1) KR20100116592A (enExample)
CN (1) CN101981032A (enExample)
AR (1) AR070274A1 (enExample)
AU (1) AU2009208728A1 (enExample)
BR (1) BRPI0906618A2 (enExample)
CA (1) CA2713256A1 (enExample)
EA (1) EA201070896A1 (enExample)
IL (1) IL207193A0 (enExample)
MX (1) MX2010008363A (enExample)
NZ (1) NZ587069A (enExample)
TW (1) TW200936589A (enExample)
WO (1) WO2009095789A1 (enExample)
ZA (1) ZA201005384B (enExample)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107987090A (zh) * 2017-12-19 2018-05-04 杨文思 一种用于治疗疟疾的恶性疟原虫糖原合成酶激酶-3抑制剂的合成方法
CN109071504A (zh) * 2016-02-05 2018-12-21 戴纳立制药公司 受体相互作用蛋白激酶1的抑制剂
CN112516337A (zh) * 2020-12-11 2021-03-19 南京邮电大学 近红外二区有机共轭聚合物荧光探针的制备方法及其应用
CN116102488A (zh) * 2023-01-05 2023-05-12 宁夏医科大学 3位具有不同氨基的2,3-二氨基丙酸衍生物的制备方法

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EP2085399A1 (en) * 2008-01-29 2009-08-05 Sanofi-Aventis substituted arylamide oxazepinopyrimidone derivatives
EP2090579A1 (en) * 2008-01-29 2009-08-19 Sanofi-Aventis Substituted heteroarylamide diazepinopyrimidone derivatives
EP2085400A1 (en) * 2008-01-29 2009-08-05 Sanofi-Aventis Substituted heteroarylamide oxazepinopyrimidone derivatives
EP2138494A1 (en) * 2008-06-26 2009-12-30 Sanofi-Aventis Substituted alkyl pyrimidin-4-one derivatives
WO2011107494A1 (de) 2010-03-03 2011-09-09 Sanofi Neue aromatische glykosidderivate, diese verbindungen enthaltende arzneimittel und deren verwendung
US8530413B2 (en) 2010-06-21 2013-09-10 Sanofi Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments
TW201215387A (en) 2010-07-05 2012-04-16 Sanofi Aventis Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament
TW201221505A (en) 2010-07-05 2012-06-01 Sanofi Sa Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament
TW201215388A (en) 2010-07-05 2012-04-16 Sanofi Sa (2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments
WO2013037390A1 (en) 2011-09-12 2013-03-21 Sanofi 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
WO2013045413A1 (en) 2011-09-27 2013-04-04 Sanofi 6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
PL3552017T3 (pl) 2016-12-09 2022-08-08 Denali Therapeutics Inc. Związki użyteczne jako inhibitory RIPK1
US11382889B2 (en) * 2018-04-19 2022-07-12 Institut D'investigació Biomèdica De Bellvitge (Idibell) NRF2 activators for the prevention and/or treatment of axonal degeneration
IL314082A (en) 2022-01-12 2024-09-01 Denali Therapeutics Inc Crystal forms of (S)-5-benzyl-N-(5-methyl-4-oxo-2,3,4,5-tetrahydropyrido[3,2-b][1,4]oxazapin-3-yl)- H4- 1,2,4-triazole-3-carboxamide

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EG13192A (en) 1976-02-10 1982-12-31 Rhone Poulenc Ind Nouveaux derives du dithiole-1,2 leur preparation et les compositions qui les contiennent
US5629322A (en) 1994-11-15 1997-05-13 Merck & Co., Inc. Cyclic amidine analogs as inhibitors of nitric oxide synthase
EP0861238A4 (en) 1995-11-01 2000-03-01 Merck & Co Inc HEXAHYDRO-5-IMINO-1,4-HETEROAZEPINE DERIVATIVES AS INHIBITORS OF NITROGEN OXIDE SYTHASE
WO2002085909A1 (en) * 2001-04-20 2002-10-31 Vertex Pharmaceuticals Incorporated 9-deazaguanine derivatives as inhibitors of gsk-3
EA009456B1 (ru) * 2001-09-21 2007-12-28 Санофи-Авентис ПРОИЗВОДНЫЕ ПИРИМИДОНА В КАЧЕСТВЕ ПРОМЕЖУТОЧНЫХ СОЕДИНЕНИЙ ДЛЯ ПОЛУЧЕНИЯ ИНГИБИТОРОВ GSK3β ИЛИ GSK3β И CDK5/P25
EP1557417B1 (en) 2003-12-19 2007-03-07 Sanofi-Aventis Substituted 8'-pyri(mi)dinyl-dihydrospiro-[cycloalkylamine]-pyrimido[1,2-a] pyrimidin-6-one derivatives
EP1790649A1 (en) * 2005-11-21 2007-05-30 Sanofi-Aventis Substituted bicyclic pyrimidone derivatives
EP2085400A1 (en) * 2008-01-29 2009-08-05 Sanofi-Aventis Substituted heteroarylamide oxazepinopyrimidone derivatives
EP2085399A1 (en) * 2008-01-29 2009-08-05 Sanofi-Aventis substituted arylamide oxazepinopyrimidone derivatives
EP2090579A1 (en) * 2008-01-29 2009-08-19 Sanofi-Aventis Substituted heteroarylamide diazepinopyrimidone derivatives

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109071504A (zh) * 2016-02-05 2018-12-21 戴纳立制药公司 受体相互作用蛋白激酶1的抑制剂
CN109071504B (zh) * 2016-02-05 2022-03-08 戴纳立制药公司 受体相互作用蛋白激酶1的抑制剂
CN107987090A (zh) * 2017-12-19 2018-05-04 杨文思 一种用于治疗疟疾的恶性疟原虫糖原合成酶激酶-3抑制剂的合成方法
CN112516337A (zh) * 2020-12-11 2021-03-19 南京邮电大学 近红外二区有机共轭聚合物荧光探针的制备方法及其应用
CN116102488A (zh) * 2023-01-05 2023-05-12 宁夏医科大学 3位具有不同氨基的2,3-二氨基丙酸衍生物的制备方法
CN116102488B (zh) * 2023-01-05 2025-06-17 宁夏医科大学 3位具有不同氨基的2,3-二氨基丙酸衍生物的制备方法

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EA201070896A1 (ru) 2011-02-28
AR070274A1 (es) 2010-03-25
NZ587069A (en) 2011-12-22
KR20100116592A (ko) 2010-11-01
BRPI0906618A2 (pt) 2015-07-14
ZA201005384B (en) 2011-10-26
IL207193A0 (en) 2010-12-30
JP2011510970A (ja) 2011-04-07
US20110039835A1 (en) 2011-02-17
WO2009095789A1 (en) 2009-08-06
EP2238141B1 (en) 2015-01-14
EP2238141A1 (en) 2010-10-13
AU2009208728A1 (en) 2009-08-06
TW200936589A (en) 2009-09-01
JP5611836B2 (ja) 2014-10-22
CA2713256A1 (en) 2009-08-06
EP2090578A1 (en) 2009-08-19
MX2010008363A (es) 2010-08-30
US8507476B2 (en) 2013-08-13

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