KR20100116592A - Ｇｓｋ３-베타의 비정상적인 활성에 의해 야기되는 신경퇴행성 질환의 치료를 위한 치환된 아릴아미드 디아제피노피리미돈 유도체 - Google Patents
Ｇｓｋ３-베타의 비정상적인 활성에 의해 야기되는 신경퇴행성 질환의 치료를 위한 치환된 아릴아미드 디아제피노피리미돈 유도체 Download PDFInfo
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- KR20100116592A KR20100116592A KR1020107016906A KR20107016906A KR20100116592A KR 20100116592 A KR20100116592 A KR 20100116592A KR 1020107016906 A KR1020107016906 A KR 1020107016906A KR 20107016906 A KR20107016906 A KR 20107016906A KR 20100116592 A KR20100116592 A KR 20100116592A
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- DDXXAXFVICOMLN-UHFFFAOYSA-N thieno[3,2-d]triazine Chemical compound N1=NC=C2SC=CC2=N1 DDXXAXFVICOMLN-UHFFFAOYSA-N 0.000 description 1
- 229940125670 thienopyridine Drugs 0.000 description 1
- 239000002175 thienopyridine Substances 0.000 description 1
- 229930192474 thiophene Natural products 0.000 description 1
- 125000002088 tosyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1C([H])([H])[H])S(*)(=O)=O 0.000 description 1
- 150000003852 triazoles Chemical class 0.000 description 1
- OVCXRBARSPBVMC-UHFFFAOYSA-N triazolopyridine Chemical compound C=1N2C(C(C)C)=NN=C2C=CC=1C=1OC=NC=1C1=CC=C(F)C=C1 OVCXRBARSPBVMC-UHFFFAOYSA-N 0.000 description 1
- YWBFPKPWMSWWEA-UHFFFAOYSA-O triazolopyrimidine Chemical compound BrC1=CC=CC(C=2N=C3N=CN[N+]3=C(NCC=3C=CN=CC=3)C=2)=C1 YWBFPKPWMSWWEA-UHFFFAOYSA-O 0.000 description 1
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 1
- 230000004614 tumor growth Effects 0.000 description 1
- 238000010798 ubiquitination Methods 0.000 description 1
- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
- 239000008158 vegetable oil Substances 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
- 238000010626 work up procedure Methods 0.000 description 1
Classifications
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
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- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
- C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
- C07D243/08—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 not condensed with other rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
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- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Physical Education & Sports Medicine (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Psychiatry (AREA)
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- Urology & Nephrology (AREA)
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- Emergency Medicine (AREA)
- Child & Adolescent Psychology (AREA)
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- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP08290074A EP2090578A1 (en) | 2008-01-29 | 2008-01-29 | Substituted arylamide diazepinopyrimidone derivatives for the treatment of neurodegenerative diseases caused by abnormal activity of GSK3-beta |
| EP08290074.7 | 2008-01-29 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR20100116592A true KR20100116592A (ko) | 2010-11-01 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020107016906A Withdrawn KR20100116592A (ko) | 2008-01-29 | 2009-01-27 | Ｇｓｋ３-베타의 비정상적인 활성에 의해 야기되는 신경퇴행성 질환의 치료를 위한 치환된 아릴아미드 디아제피노피리미돈 유도체 |
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| Country | Link |
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| US (1) | US8507476B2 (enExample) |
| EP (2) | EP2090578A1 (enExample) |
| JP (1) | JP5611836B2 (enExample) |
| KR (1) | KR20100116592A (enExample) |
| CN (1) | CN101981032A (enExample) |
| AR (1) | AR070274A1 (enExample) |
| AU (1) | AU2009208728A1 (enExample) |
| BR (1) | BRPI0906618A2 (enExample) |
| CA (1) | CA2713256A1 (enExample) |
| EA (1) | EA201070896A1 (enExample) |
| IL (1) | IL207193A0 (enExample) |
| MX (1) | MX2010008363A (enExample) |
| NZ (1) | NZ587069A (enExample) |
| TW (1) | TW200936589A (enExample) |
| WO (1) | WO2009095789A1 (enExample) |
| ZA (1) | ZA201005384B (enExample) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2090579A1 (en) * | 2008-01-29 | 2009-08-19 | Sanofi-Aventis | Substituted heteroarylamide diazepinopyrimidone derivatives |
| EP2085399A1 (en) * | 2008-01-29 | 2009-08-05 | Sanofi-Aventis | substituted arylamide oxazepinopyrimidone derivatives |
| EP2085400A1 (en) * | 2008-01-29 | 2009-08-05 | Sanofi-Aventis | Substituted heteroarylamide oxazepinopyrimidone derivatives |
| EP2138494A1 (en) * | 2008-06-26 | 2009-12-30 | Sanofi-Aventis | Substituted alkyl pyrimidin-4-one derivatives |
| WO2011107494A1 (de) | 2010-03-03 | 2011-09-09 | Sanofi | Neue aromatische glykosidderivate, diese verbindungen enthaltende arzneimittel und deren verwendung |
| US8530413B2 (en) | 2010-06-21 | 2013-09-10 | Sanofi | Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments |
| TW201221505A (en) | 2010-07-05 | 2012-06-01 | Sanofi Sa | Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament |
| TW201215388A (en) | 2010-07-05 | 2012-04-16 | Sanofi Sa | (2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments |
| TW201215387A (en) | 2010-07-05 | 2012-04-16 | Sanofi Aventis | Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament |
| WO2013037390A1 (en) | 2011-09-12 | 2013-03-21 | Sanofi | 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
| EP2760862B1 (en) | 2011-09-27 | 2015-10-21 | Sanofi | 6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
| EA201891620A1 (ru) * | 2016-02-05 | 2019-02-28 | Денали Терапьютикс Инк. | Ингибиторы взаимодействующей с рецептором протеинкиназы 1 |
| PL3552017T3 (pl) | 2016-12-09 | 2022-08-08 | Denali Therapeutics Inc. | Związki użyteczne jako inhibitory RIPK1 |
| CN107987090A (zh) * | 2017-12-19 | 2018-05-04 | 杨文思 | 一种用于治疗疟疾的恶性疟原虫糖原合成酶激酶-3抑制剂的合成方法 |
| US11382889B2 (en) * | 2018-04-19 | 2022-07-12 | Institut D'investigació Biomèdica De Bellvitge (Idibell) | NRF2 activators for the prevention and/or treatment of axonal degeneration |
| CN112516337B (zh) * | 2020-12-11 | 2022-08-12 | 南京邮电大学 | 近红外二区有机共轭聚合物荧光探针的制备方法及其应用 |
| MX2024008648A (es) | 2022-01-12 | 2024-09-23 | Denali Therapeutics Inc | Formas cristalinas de (s)-5-bencil-n-(5-metil-4-oxo-2,3,4,5-tetrah idropirido [3,2- b][1,4]oxacepin-3-il)-4h-1,2,4-triazol-3-carboxam ida. |
| CN116102488B (zh) * | 2023-01-05 | 2025-06-17 | 宁夏医科大学 | 3位具有不同氨基的2,3-二氨基丙酸衍生物的制备方法 |
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| EG13192A (en) | 1976-02-10 | 1982-12-31 | Rhone Poulenc Ind | Nouveaux derives du dithiole-1,2 leur preparation et les compositions qui les contiennent |
| US5629322A (en) | 1994-11-15 | 1997-05-13 | Merck & Co., Inc. | Cyclic amidine analogs as inhibitors of nitric oxide synthase |
| JP3188715B2 (ja) | 1995-11-01 | 2001-07-16 | メルク エンド カンパニー インコーポレーテッド | 一酸化窒素シンターゼの阻害物質としてのヘキサヒドロ−５−イミノ−１，４−ヘテロアゼピン誘導体 |
| US20030096813A1 (en) * | 2001-04-20 | 2003-05-22 | Jingrong Cao | Compositions useful as inhibitors of GSK-3 |
| CN1247586C (zh) * | 2001-09-21 | 2006-03-29 | 赛诺菲安万特 | 治疗神经退化性疾病的取代的2－嘧啶基－6,7,8,9－四氢嘧啶并[1,2－a]嘧啶－4－酮及7－嘧啶基－2,3－二氢咪唑并[1,2－a]嘧啶－5(1h)酮衍生物 |
| EP1557417B1 (en) | 2003-12-19 | 2007-03-07 | Sanofi-Aventis | Substituted 8'-pyri(mi)dinyl-dihydrospiro-[cycloalkylamine]-pyrimido[1,2-a] pyrimidin-6-one derivatives |
| EP1790649A1 (en) * | 2005-11-21 | 2007-05-30 | Sanofi-Aventis | Substituted bicyclic pyrimidone derivatives |
| EP2090579A1 (en) * | 2008-01-29 | 2009-08-19 | Sanofi-Aventis | Substituted heteroarylamide diazepinopyrimidone derivatives |
| EP2085399A1 (en) * | 2008-01-29 | 2009-08-05 | Sanofi-Aventis | substituted arylamide oxazepinopyrimidone derivatives |
| EP2085400A1 (en) * | 2008-01-29 | 2009-08-05 | Sanofi-Aventis | Substituted heteroarylamide oxazepinopyrimidone derivatives |
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2008
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2009
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- 2009-01-27 CA CA2713256A patent/CA2713256A1/en not_active Abandoned
- 2009-01-27 KR KR1020107016906A patent/KR20100116592A/ko not_active Withdrawn
- 2009-01-27 EA EA201070896A patent/EA201070896A1/ru unknown
- 2009-01-27 MX MX2010008363A patent/MX2010008363A/es not_active Application Discontinuation
- 2009-01-27 NZ NZ587069A patent/NZ587069A/en not_active IP Right Cessation
- 2009-01-27 EP EP09706634.4A patent/EP2238141B1/en active Active
- 2009-01-27 AU AU2009208728A patent/AU2009208728A1/en not_active Abandoned
- 2009-01-27 JP JP2010544814A patent/JP5611836B2/ja not_active Expired - Fee Related
- 2009-01-27 BR BRPI0906618-7A patent/BRPI0906618A2/pt not_active IP Right Cessation
- 2009-01-27 WO PCT/IB2009/000324 patent/WO2009095789A1/en not_active Ceased
- 2009-01-28 AR ARP090100257A patent/AR070274A1/es unknown
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2010
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- 2010-07-27 US US12/844,278 patent/US8507476B2/en not_active Expired - Fee Related
- 2010-07-28 ZA ZA2010/05384A patent/ZA201005384B/en unknown
Also Published As
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|---|---|
| US20110039835A1 (en) | 2011-02-17 |
| NZ587069A (en) | 2011-12-22 |
| EA201070896A1 (ru) | 2011-02-28 |
| BRPI0906618A2 (pt) | 2015-07-14 |
| EP2090578A1 (en) | 2009-08-19 |
| US8507476B2 (en) | 2013-08-13 |
| TW200936589A (en) | 2009-09-01 |
| MX2010008363A (es) | 2010-08-30 |
| EP2238141A1 (en) | 2010-10-13 |
| WO2009095789A1 (en) | 2009-08-06 |
| JP5611836B2 (ja) | 2014-10-22 |
| IL207193A0 (en) | 2010-12-30 |
| ZA201005384B (en) | 2011-10-26 |
| AU2009208728A1 (en) | 2009-08-06 |
| CA2713256A1 (en) | 2009-08-06 |
| AR070274A1 (es) | 2010-03-25 |
| EP2238141B1 (en) | 2015-01-14 |
| CN101981032A (zh) | 2011-02-23 |
| JP2011510970A (ja) | 2011-04-07 |
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|
| PG1501 | Laying open of application | ||
| PC1203 | Withdrawal of no request for examination | ||
| WITN | Application deemed withdrawn, e.g. because no request for examination was filed or no examination fee was paid |