TW200936589A - Substituted arylamide diazepinopyrimidone derivatives - Google Patents
Substituted arylamide diazepinopyrimidone derivatives Download PDFInfo
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- TW200936589A TW200936589A TW098103053A TW98103053A TW200936589A TW 200936589 A TW200936589 A TW 200936589A TW 098103053 A TW098103053 A TW 098103053A TW 98103053 A TW98103053 A TW 98103053A TW 200936589 A TW200936589 A TW 200936589A
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- triaza
- hexahydro
- gas
- methoxy
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- XQSNXLDLKOJJOU-UHFFFAOYSA-N pyrimido[5,4-c]diazepin-3-one Chemical class N1=NC(=O)C=CC2=NC=NC=C21 XQSNXLDLKOJJOU-UHFFFAOYSA-N 0.000 title 1
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- C07—ORGANIC CHEMISTRY
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Applications Claiming Priority (1)
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| EP08290074A EP2090578A1 (en) | 2008-01-29 | 2008-01-29 | Substituted arylamide diazepinopyrimidone derivatives for the treatment of neurodegenerative diseases caused by abnormal activity of GSK3-beta |
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| TW200936589A true TW200936589A (en) | 2009-09-01 |
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| TW098103053A TW200936589A (en) | 2008-01-29 | 2009-01-23 | Substituted arylamide diazepinopyrimidone derivatives |
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| EP (2) | EP2090578A1 (enExample) |
| JP (1) | JP5611836B2 (enExample) |
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| EP2085400A1 (en) * | 2008-01-29 | 2009-08-05 | Sanofi-Aventis | Substituted heteroarylamide oxazepinopyrimidone derivatives |
| EP2085399A1 (en) * | 2008-01-29 | 2009-08-05 | Sanofi-Aventis | substituted arylamide oxazepinopyrimidone derivatives |
| EP2090579A1 (en) * | 2008-01-29 | 2009-08-19 | Sanofi-Aventis | Substituted heteroarylamide diazepinopyrimidone derivatives |
| EP2138494A1 (en) * | 2008-06-26 | 2009-12-30 | Sanofi-Aventis | Substituted alkyl pyrimidin-4-one derivatives |
| WO2011107494A1 (de) | 2010-03-03 | 2011-09-09 | Sanofi | Neue aromatische glykosidderivate, diese verbindungen enthaltende arzneimittel und deren verwendung |
| US8530413B2 (en) | 2010-06-21 | 2013-09-10 | Sanofi | Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments |
| TW201215388A (en) | 2010-07-05 | 2012-04-16 | Sanofi Sa | (2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments |
| TW201221505A (en) | 2010-07-05 | 2012-06-01 | Sanofi Sa | Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament |
| TW201215387A (en) | 2010-07-05 | 2012-04-16 | Sanofi Aventis | Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament |
| WO2013037390A1 (en) | 2011-09-12 | 2013-03-21 | Sanofi | 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
| EP2760862B1 (en) | 2011-09-27 | 2015-10-21 | Sanofi | 6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
| US9815850B2 (en) * | 2016-02-05 | 2017-11-14 | Denali Therapeutics Inc. | Compounds, compositions and methods |
| LT3552017T (lt) | 2016-12-09 | 2022-05-10 | Denali Therapeutics Inc. | Junginiai, naudotini kaip ripk1 inhibitoriai |
| CN107987090A (zh) * | 2017-12-19 | 2018-05-04 | 杨文思 | 一种用于治疗疟疾的恶性疟原虫糖原合成酶激酶-3抑制剂的合成方法 |
| US11382889B2 (en) * | 2018-04-19 | 2022-07-12 | Institut D'investigació Biomèdica De Bellvitge (Idibell) | NRF2 activators for the prevention and/or treatment of axonal degeneration |
| CN112516337B (zh) * | 2020-12-11 | 2022-08-12 | 南京邮电大学 | 近红外二区有机共轭聚合物荧光探针的制备方法及其应用 |
| EP4463229A1 (en) | 2022-01-12 | 2024-11-20 | Denali Therapeutics Inc. | Crystalline forms of (s)-5-benzyl-n-(5-methyl-4-oxo-2, 3,4,5- tetrahydropyrido [3,2-b] [l,4]oxazepin-3-yl)-4h-l,2,4-triazole-3-carboxamide |
| CN116102488B (zh) * | 2023-01-05 | 2025-06-17 | 宁夏医科大学 | 3位具有不同氨基的2,3-二氨基丙酸衍生物的制备方法 |
Family Cites Families (10)
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|---|---|---|---|---|
| EG13192A (en) * | 1976-02-10 | 1982-12-31 | Rhone Poulenc Ind | Nouveaux derives du dithiole-1,2 leur preparation et les compositions qui les contiennent |
| US5629322A (en) | 1994-11-15 | 1997-05-13 | Merck & Co., Inc. | Cyclic amidine analogs as inhibitors of nitric oxide synthase |
| WO1997016430A1 (en) | 1995-11-01 | 1997-05-09 | Merck & Co., Inc. | Hexahydro-5-imino-1,4-heteroazepine derivatives as inhibitors of nitric oxide synthases |
| EP1383771A1 (en) * | 2001-04-20 | 2004-01-28 | Vertex Pharmaceuticals Incorporated | 9-deazaguanine derivatives as inhibitors of gsk-3 |
| WO2003027115A1 (en) * | 2001-09-21 | 2003-04-03 | Sanofi-Synthelabo | Substituted 2-pyrimidinyl-6,7,8,9-tetrahydropyrimido[1,2-a]pyrimidin-4-one and 7-pyrimidinyl-2,3-dihydroimidazo[1,2-a]pyrimidin-5(1h)one derivatives for neurodegenerative disorders |
| EP1557417B1 (en) | 2003-12-19 | 2007-03-07 | Sanofi-Aventis | Substituted 8'-pyri(mi)dinyl-dihydrospiro-[cycloalkylamine]-pyrimido[1,2-a] pyrimidin-6-one derivatives |
| EP1790649A1 (en) * | 2005-11-21 | 2007-05-30 | Sanofi-Aventis | Substituted bicyclic pyrimidone derivatives |
| EP2085400A1 (en) * | 2008-01-29 | 2009-08-05 | Sanofi-Aventis | Substituted heteroarylamide oxazepinopyrimidone derivatives |
| EP2085399A1 (en) * | 2008-01-29 | 2009-08-05 | Sanofi-Aventis | substituted arylamide oxazepinopyrimidone derivatives |
| EP2090579A1 (en) * | 2008-01-29 | 2009-08-19 | Sanofi-Aventis | Substituted heteroarylamide diazepinopyrimidone derivatives |
-
2008
- 2008-01-29 EP EP08290074A patent/EP2090578A1/en not_active Withdrawn
-
2009
- 2009-01-23 TW TW098103053A patent/TW200936589A/zh unknown
- 2009-01-27 MX MX2010008363A patent/MX2010008363A/es not_active Application Discontinuation
- 2009-01-27 NZ NZ587069A patent/NZ587069A/en not_active IP Right Cessation
- 2009-01-27 EA EA201070896A patent/EA201070896A1/ru unknown
- 2009-01-27 KR KR1020107016906A patent/KR20100116592A/ko not_active Withdrawn
- 2009-01-27 CA CA2713256A patent/CA2713256A1/en not_active Abandoned
- 2009-01-27 CN CN2009801107249A patent/CN101981032A/zh active Pending
- 2009-01-27 EP EP09706634.4A patent/EP2238141B1/en active Active
- 2009-01-27 BR BRPI0906618-7A patent/BRPI0906618A2/pt not_active IP Right Cessation
- 2009-01-27 WO PCT/IB2009/000324 patent/WO2009095789A1/en not_active Ceased
- 2009-01-27 JP JP2010544814A patent/JP5611836B2/ja not_active Expired - Fee Related
- 2009-01-27 AU AU2009208728A patent/AU2009208728A1/en not_active Abandoned
- 2009-01-28 AR ARP090100257A patent/AR070274A1/es unknown
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2010
- 2010-07-25 IL IL207193A patent/IL207193A0/en unknown
- 2010-07-27 US US12/844,278 patent/US8507476B2/en not_active Expired - Fee Related
- 2010-07-28 ZA ZA2010/05384A patent/ZA201005384B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP2090578A1 (en) | 2009-08-19 |
| BRPI0906618A2 (pt) | 2015-07-14 |
| IL207193A0 (en) | 2010-12-30 |
| JP5611836B2 (ja) | 2014-10-22 |
| AR070274A1 (es) | 2010-03-25 |
| EP2238141B1 (en) | 2015-01-14 |
| WO2009095789A1 (en) | 2009-08-06 |
| CN101981032A (zh) | 2011-02-23 |
| CA2713256A1 (en) | 2009-08-06 |
| ZA201005384B (en) | 2011-10-26 |
| AU2009208728A1 (en) | 2009-08-06 |
| NZ587069A (en) | 2011-12-22 |
| EP2238141A1 (en) | 2010-10-13 |
| EA201070896A1 (ru) | 2011-02-28 |
| JP2011510970A (ja) | 2011-04-07 |
| US20110039835A1 (en) | 2011-02-17 |
| US8507476B2 (en) | 2013-08-13 |
| MX2010008363A (es) | 2010-08-30 |
| KR20100116592A (ko) | 2010-11-01 |
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