NZ587069A - Substituted arylamide diazepinopyrimidone derivatives for the treatment of neurodegenerative diseases caused by abnormal activity of gsk3-beta - Google Patents
Substituted arylamide diazepinopyrimidone derivatives for the treatment of neurodegenerative diseases caused by abnormal activity of gsk3-betaInfo
- Publication number
- NZ587069A NZ587069A NZ587069A NZ58706909A NZ587069A NZ 587069 A NZ587069 A NZ 587069A NZ 587069 A NZ587069 A NZ 587069A NZ 58706909 A NZ58706909 A NZ 58706909A NZ 587069 A NZ587069 A NZ 587069A
- Authority
- NZ
- New Zealand
- Prior art keywords
- group
- triaza
- oxo
- methoxy
- pyrimidin
- Prior art date
Links
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- 125000002088 tosyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1C([H])([H])[H])S(*)(=O)=O 0.000 description 1
- 150000003852 triazoles Chemical class 0.000 description 1
- OVCXRBARSPBVMC-UHFFFAOYSA-N triazolopyridine Chemical compound C=1N2C(C(C)C)=NN=C2C=CC=1C=1OC=NC=1C1=CC=C(F)C=C1 OVCXRBARSPBVMC-UHFFFAOYSA-N 0.000 description 1
- YWBFPKPWMSWWEA-UHFFFAOYSA-O triazolopyrimidine Chemical compound BrC1=CC=CC(C=2N=C3N=CN[N+]3=C(NCC=3C=CN=CC=3)C=2)=C1 YWBFPKPWMSWWEA-UHFFFAOYSA-O 0.000 description 1
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 1
- 230000004614 tumor growth Effects 0.000 description 1
- 230000036967 uncompetitive effect Effects 0.000 description 1
- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
- 239000008158 vegetable oil Substances 0.000 description 1
- 238000010626 work up procedure Methods 0.000 description 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
- C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
- C07D243/08—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 not condensed with other rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
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Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP08290074A EP2090578A1 (en) | 2008-01-29 | 2008-01-29 | Substituted arylamide diazepinopyrimidone derivatives for the treatment of neurodegenerative diseases caused by abnormal activity of GSK3-beta |
| PCT/IB2009/000324 WO2009095789A1 (en) | 2008-01-29 | 2009-01-27 | Substituted arylamide diazepinopyrimidone derivatives for the treatment of neurodegenerative diseases caused by abnormal activity of gsk3-beta |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NZ587069A true NZ587069A (en) | 2011-12-22 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
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| NZ587069A NZ587069A (en) | 2008-01-29 | 2009-01-27 | Substituted arylamide diazepinopyrimidone derivatives for the treatment of neurodegenerative diseases caused by abnormal activity of gsk3-beta |
Country Status (16)
| Country | Link |
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| US (1) | US8507476B2 (enExample) |
| EP (2) | EP2090578A1 (enExample) |
| JP (1) | JP5611836B2 (enExample) |
| KR (1) | KR20100116592A (enExample) |
| CN (1) | CN101981032A (enExample) |
| AR (1) | AR070274A1 (enExample) |
| AU (1) | AU2009208728A1 (enExample) |
| BR (1) | BRPI0906618A2 (enExample) |
| CA (1) | CA2713256A1 (enExample) |
| EA (1) | EA201070896A1 (enExample) |
| IL (1) | IL207193A0 (enExample) |
| MX (1) | MX2010008363A (enExample) |
| NZ (1) | NZ587069A (enExample) |
| TW (1) | TW200936589A (enExample) |
| WO (1) | WO2009095789A1 (enExample) |
| ZA (1) | ZA201005384B (enExample) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
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| EP2090579A1 (en) * | 2008-01-29 | 2009-08-19 | Sanofi-Aventis | Substituted heteroarylamide diazepinopyrimidone derivatives |
| EP2085399A1 (en) * | 2008-01-29 | 2009-08-05 | Sanofi-Aventis | substituted arylamide oxazepinopyrimidone derivatives |
| EP2085400A1 (en) * | 2008-01-29 | 2009-08-05 | Sanofi-Aventis | Substituted heteroarylamide oxazepinopyrimidone derivatives |
| EP2138494A1 (en) * | 2008-06-26 | 2009-12-30 | Sanofi-Aventis | Substituted alkyl pyrimidin-4-one derivatives |
| WO2011107494A1 (de) | 2010-03-03 | 2011-09-09 | Sanofi | Neue aromatische glykosidderivate, diese verbindungen enthaltende arzneimittel und deren verwendung |
| US8530413B2 (en) | 2010-06-21 | 2013-09-10 | Sanofi | Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments |
| TW201221505A (en) | 2010-07-05 | 2012-06-01 | Sanofi Sa | Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament |
| TW201215388A (en) | 2010-07-05 | 2012-04-16 | Sanofi Sa | (2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments |
| TW201215387A (en) | 2010-07-05 | 2012-04-16 | Sanofi Aventis | Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament |
| WO2013037390A1 (en) | 2011-09-12 | 2013-03-21 | Sanofi | 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
| EP2760862B1 (en) | 2011-09-27 | 2015-10-21 | Sanofi | 6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
| EA201891620A1 (ru) * | 2016-02-05 | 2019-02-28 | Денали Терапьютикс Инк. | Ингибиторы взаимодействующей с рецептором протеинкиназы 1 |
| PL3552017T3 (pl) | 2016-12-09 | 2022-08-08 | Denali Therapeutics Inc. | Związki użyteczne jako inhibitory RIPK1 |
| CN107987090A (zh) * | 2017-12-19 | 2018-05-04 | 杨文思 | 一种用于治疗疟疾的恶性疟原虫糖原合成酶激酶-3抑制剂的合成方法 |
| US11382889B2 (en) * | 2018-04-19 | 2022-07-12 | Institut D'investigació Biomèdica De Bellvitge (Idibell) | NRF2 activators for the prevention and/or treatment of axonal degeneration |
| CN112516337B (zh) * | 2020-12-11 | 2022-08-12 | 南京邮电大学 | 近红外二区有机共轭聚合物荧光探针的制备方法及其应用 |
| MX2024008648A (es) | 2022-01-12 | 2024-09-23 | Denali Therapeutics Inc | Formas cristalinas de (s)-5-bencil-n-(5-metil-4-oxo-2,3,4,5-tetrah idropirido [3,2- b][1,4]oxacepin-3-il)-4h-1,2,4-triazol-3-carboxam ida. |
| CN116102488B (zh) * | 2023-01-05 | 2025-06-17 | 宁夏医科大学 | 3位具有不同氨基的2,3-二氨基丙酸衍生物的制备方法 |
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| EG13192A (en) | 1976-02-10 | 1982-12-31 | Rhone Poulenc Ind | Nouveaux derives du dithiole-1,2 leur preparation et les compositions qui les contiennent |
| US5629322A (en) | 1994-11-15 | 1997-05-13 | Merck & Co., Inc. | Cyclic amidine analogs as inhibitors of nitric oxide synthase |
| JP3188715B2 (ja) | 1995-11-01 | 2001-07-16 | メルク エンド カンパニー インコーポレーテッド | 一酸化窒素シンターゼの阻害物質としてのヘキサヒドロ−５−イミノ−１，４−ヘテロアゼピン誘導体 |
| US20030096813A1 (en) * | 2001-04-20 | 2003-05-22 | Jingrong Cao | Compositions useful as inhibitors of GSK-3 |
| CN1247586C (zh) * | 2001-09-21 | 2006-03-29 | 赛诺菲安万特 | 治疗神经退化性疾病的取代的2－嘧啶基－6,7,8,9－四氢嘧啶并[1,2－a]嘧啶－4－酮及7－嘧啶基－2,3－二氢咪唑并[1,2－a]嘧啶－5(1h)酮衍生物 |
| EP1557417B1 (en) | 2003-12-19 | 2007-03-07 | Sanofi-Aventis | Substituted 8'-pyri(mi)dinyl-dihydrospiro-[cycloalkylamine]-pyrimido[1,2-a] pyrimidin-6-one derivatives |
| EP1790649A1 (en) * | 2005-11-21 | 2007-05-30 | Sanofi-Aventis | Substituted bicyclic pyrimidone derivatives |
| EP2090579A1 (en) * | 2008-01-29 | 2009-08-19 | Sanofi-Aventis | Substituted heteroarylamide diazepinopyrimidone derivatives |
| EP2085399A1 (en) * | 2008-01-29 | 2009-08-05 | Sanofi-Aventis | substituted arylamide oxazepinopyrimidone derivatives |
| EP2085400A1 (en) * | 2008-01-29 | 2009-08-05 | Sanofi-Aventis | Substituted heteroarylamide oxazepinopyrimidone derivatives |
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2008
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2009
- 2009-01-23 TW TW098103053A patent/TW200936589A/zh unknown
- 2009-01-27 CN CN2009801107249A patent/CN101981032A/zh active Pending
- 2009-01-27 CA CA2713256A patent/CA2713256A1/en not_active Abandoned
- 2009-01-27 KR KR1020107016906A patent/KR20100116592A/ko not_active Withdrawn
- 2009-01-27 EA EA201070896A patent/EA201070896A1/ru unknown
- 2009-01-27 MX MX2010008363A patent/MX2010008363A/es not_active Application Discontinuation
- 2009-01-27 NZ NZ587069A patent/NZ587069A/en not_active IP Right Cessation
- 2009-01-27 EP EP09706634.4A patent/EP2238141B1/en active Active
- 2009-01-27 AU AU2009208728A patent/AU2009208728A1/en not_active Abandoned
- 2009-01-27 JP JP2010544814A patent/JP5611836B2/ja not_active Expired - Fee Related
- 2009-01-27 BR BRPI0906618-7A patent/BRPI0906618A2/pt not_active IP Right Cessation
- 2009-01-27 WO PCT/IB2009/000324 patent/WO2009095789A1/en not_active Ceased
- 2009-01-28 AR ARP090100257A patent/AR070274A1/es unknown
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2010
- 2010-07-25 IL IL207193A patent/IL207193A0/en unknown
- 2010-07-27 US US12/844,278 patent/US8507476B2/en not_active Expired - Fee Related
- 2010-07-28 ZA ZA2010/05384A patent/ZA201005384B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US20110039835A1 (en) | 2011-02-17 |
| EA201070896A1 (ru) | 2011-02-28 |
| BRPI0906618A2 (pt) | 2015-07-14 |
| EP2090578A1 (en) | 2009-08-19 |
| US8507476B2 (en) | 2013-08-13 |
| TW200936589A (en) | 2009-09-01 |
| MX2010008363A (es) | 2010-08-30 |
| EP2238141A1 (en) | 2010-10-13 |
| WO2009095789A1 (en) | 2009-08-06 |
| JP5611836B2 (ja) | 2014-10-22 |
| IL207193A0 (en) | 2010-12-30 |
| KR20100116592A (ko) | 2010-11-01 |
| ZA201005384B (en) | 2011-10-26 |
| AU2009208728A1 (en) | 2009-08-06 |
| CA2713256A1 (en) | 2009-08-06 |
| AR070274A1 (es) | 2010-03-25 |
| EP2238141B1 (en) | 2015-01-14 |
| CN101981032A (zh) | 2011-02-23 |
| JP2011510970A (ja) | 2011-04-07 |
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| Date | Code | Title | Description |
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| PSEA | Patent sealed | ||
| LAPS | Patent lapsed |