CN101970679B - 氨基转移酶和氧化还原酶核酸和多肽和使用方法 - Google Patents

氨基转移酶和氧化还原酶核酸和多肽和使用方法 Download PDF

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Publication number
CN101970679B
CN101970679B CN200880127576.7A CN200880127576A CN101970679B CN 101970679 B CN101970679 B CN 101970679B CN 200880127576 A CN200880127576 A CN 200880127576A CN 101970679 B CN101970679 B CN 101970679B
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Prior art keywords
seq
dat
monatin
polypeptide
sequence
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Expired - Fee Related
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CN200880127576.7A
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English (en)
Chinese (zh)
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CN101970679A (zh
Inventor
M·L.·德苏扎
P·M.·希克斯
S·R.·科尔曼
J·M.·拉普拉萨
J·M.·伦多尔夫
S·C.·麦克法伦
E·马拉斯科
牛伟
F·A.·桑切斯-列拉
C·索尔海德
D·P.·魏纳
P·卢京比尔
A·布埃诺
J·昆卡
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Cargill Inc
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Cargill Inc
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C12P13/22—Tryptophan; Tyrosine; Phenylalanine; 3,4-Dihydroxyphenylalanine
    • C12P13/227—Tryptophan
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1096—Transferases (2.) transferring nitrogenous groups (2.6)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/10—Nitrogen as only ring hetero atom

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
CN200880127576.7A 2008-01-03 2008-12-31 氨基转移酶和氧化还原酶核酸和多肽和使用方法 Expired - Fee Related CN101970679B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US1881408P 2008-01-03 2008-01-03
US61/018,814 2008-01-03
PCT/US2008/014137 WO2009088482A1 (en) 2008-01-03 2008-12-31 Aminotransferase and oxidoreductase nucleic acids and polypeptides and methods of using

Publications (2)

Publication Number Publication Date
CN101970679A CN101970679A (zh) 2011-02-09
CN101970679B true CN101970679B (zh) 2015-04-22

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CN200880127576.7A Expired - Fee Related CN101970679B (zh) 2008-01-03 2008-12-31 氨基转移酶和氧化还原酶核酸和多肽和使用方法

Country Status (8)

Country Link
US (1) US8785162B2 (enExample)
EP (1) EP2225390A4 (enExample)
JP (2) JP5683962B2 (enExample)
CN (1) CN101970679B (enExample)
AU (1) AU2008347048B2 (enExample)
BR (1) BRPI0822219A2 (enExample)
CA (1) CA2726928A1 (enExample)
WO (1) WO2009088482A1 (enExample)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8372989B2 (en) 2002-04-23 2013-02-12 Cargill, Incorporated Polypeptides and biosynthetic pathways for the production of monatin and its precursors
US7572607B2 (en) * 2002-04-23 2009-08-11 Cargill, Incorporated Polypeptides and biosynthetic pathways for the production of monatin and its precursors
US20050112260A1 (en) * 2003-08-01 2005-05-26 Cargill, Inc. Monatin tabletop sweetener compositions and methods of making same
ATE360370T1 (de) * 2003-08-14 2007-05-15 Cargill Inc Monatinhaltige kaugummizusammensetzungen und verfahren zu ihrer herstellung
US20050106305A1 (en) * 2003-08-25 2005-05-19 Cargill, Inc. Beverage compositions comprising monatin and methods of making same
CN1890377B (zh) * 2003-10-21 2013-06-05 嘉吉有限公司 生产莫纳甜和莫纳甜前体
US8158389B2 (en) * 2005-04-20 2012-04-17 Cargill, Incorporated Products and methods for in vivo secretion of monatin
WO2006113897A2 (en) * 2005-04-20 2006-10-26 Cargill, Incorporated Products and methods for in vivo secretion of monatin
US8076108B2 (en) * 2005-04-26 2011-12-13 Cargill, Incorporated Polypeptides and biosynthetic pathways for the production of stereoisomers of monatin and their precursors
EP2112227B1 (en) * 2006-03-07 2013-05-15 Cargill, Incorporated Aldolases, nucleic acids encoding them and methods for making and using them
US20090198072A1 (en) * 2006-05-24 2009-08-06 Cargill, Incorporated Methods and systems for increasing production of equilibrium reactions
US10332562B2 (en) * 2007-04-17 2019-06-25 Sirius-Beta Corporation System and method for space-time annotation-capable media scrubbing
US8003361B2 (en) * 2007-10-01 2011-08-23 Cargill Incorporated Production of monatin enantiomers
US8076107B2 (en) * 2007-10-01 2011-12-13 Cargill, Incorporated Production of monatin stereoisomers
US8367847B2 (en) * 2007-10-01 2013-02-05 Cargill, Incorporated Production of monatin enantiomers
EP2238242B9 (en) * 2008-01-03 2015-06-10 BASF Enzymes LLC Transferases and oxidoreductases, nucleic acids encoding them and methods for making and using them
WO2012124639A1 (ja) * 2011-03-11 2012-09-20 株式会社カネカ 改変型アミノ基転移酵素、その遺伝子、およびそれらを利用した光学活性アミノ化合物の製造方法
US9029321B2 (en) 2011-03-30 2015-05-12 Board Of Regents Of The University Of Texas Methods and compositions for targeting adipose cells in mammals
HUE042206T2 (hu) * 2013-02-28 2019-06-28 Codexis Inc Módosított transzamináz polipeptidek ipari biokatalízishez
US11191555B2 (en) 2017-05-12 2021-12-07 Covidien Lp Retrieval of material from vessel lumens
CN120795059A (zh) 2018-08-27 2025-10-17 瑞泽恩制药公司 拉曼光谱在下游纯化中的应用
US10889790B2 (en) 2019-03-11 2021-01-12 Aldevron, Llc Growth of bacterial host cells in gas permeable low-density polyethylene bags for production of plasmid DNA or recombinant molecules
MX2024003753A (es) * 2021-09-29 2024-04-16 Ionis Pharmaceuticals Inc Oligonucleotidos conjugados y usos de estos.
CN114317629B (zh) * 2021-12-31 2024-08-27 山西大学 一种转氨酶连续化反应制备手性胺的方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007133183A2 (en) * 2006-04-26 2007-11-22 Cargill, Incorporated Polypeptides and biosynthetic pathways for the production of stereoisomers of monatin and their precursors

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6099848A (en) * 1997-11-18 2000-08-08 The Trustees Of The University Of Pennsylvania Immunogenic compositions comprising DAL/DAT double-mutant, auxotrophic, attenuated strains of Listeria and their methods of use
US7572607B2 (en) * 2002-04-23 2009-08-11 Cargill, Incorporated Polypeptides and biosynthetic pathways for the production of monatin and its precursors
CA2483126C (en) * 2002-04-23 2014-05-20 Cargill, Incorporated Polypeptides and biosynthetic pathways for the production of monatin
WO2004085624A2 (en) * 2003-03-24 2004-10-07 Diversa Corporation Transaminases, deaminases and aminomutases and compositions and methods for enzymatic detoxification
US20050106305A1 (en) * 2003-08-25 2005-05-19 Cargill, Inc. Beverage compositions comprising monatin and methods of making same
US8076108B2 (en) 2005-04-26 2011-12-13 Cargill, Incorporated Polypeptides and biosynthetic pathways for the production of stereoisomers of monatin and their precursors
CN101490249A (zh) 2006-05-24 2009-07-22 嘉吉公司 提高平衡反应的产量的方法和系统

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007133183A2 (en) * 2006-04-26 2007-11-22 Cargill, Incorporated Polypeptides and biosynthetic pathways for the production of stereoisomers of monatin and their precursors

Also Published As

Publication number Publication date
BRPI0822219A2 (pt) 2014-11-04
WO2009088482A1 (en) 2009-07-16
US8785162B2 (en) 2014-07-22
CN101970679A (zh) 2011-02-09
AU2008347048B2 (en) 2014-06-05
CA2726928A1 (en) 2009-07-16
JP2011508602A (ja) 2011-03-17
US20110020882A1 (en) 2011-01-27
AU2008347048A1 (en) 2009-07-16
JP5683962B2 (ja) 2015-03-11
JP2015091231A (ja) 2015-05-14
EP2225390A4 (en) 2012-05-09
EP2225390A1 (en) 2010-09-08

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