CN101967179A - 一种将含巯基肽从树脂上切落的试剂及切落方法 - Google Patents
一种将含巯基肽从树脂上切落的试剂及切落方法 Download PDFInfo
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- CN101967179A CN101967179A CN2010102728759A CN201010272875A CN101967179A CN 101967179 A CN101967179 A CN 101967179A CN 2010102728759 A CN2010102728759 A CN 2010102728759A CN 201010272875 A CN201010272875 A CN 201010272875A CN 101967179 A CN101967179 A CN 101967179A
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- 108090000765 processed proteins & peptides Proteins 0.000 title claims abstract description 107
- 239000011347 resin Substances 0.000 title claims abstract description 76
- 229920005989 resin Polymers 0.000 title claims abstract description 76
- 102000004196 processed proteins & peptides Human genes 0.000 title claims abstract description 56
- 239000003153 chemical reaction reagent Substances 0.000 title claims abstract description 48
- 238000000034 method Methods 0.000 title claims abstract description 27
- 238000005520 cutting process Methods 0.000 title claims abstract description 22
- 229920001184 polypeptide Polymers 0.000 claims abstract description 53
- DTQVDTLACAAQTR-UHFFFAOYSA-N Trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F DTQVDTLACAAQTR-UHFFFAOYSA-N 0.000 claims abstract description 50
- ZGYICYBLPGRURT-UHFFFAOYSA-N tri(propan-2-yl)silicon Chemical compound CC(C)[Si](C(C)C)C(C)C ZGYICYBLPGRURT-UHFFFAOYSA-N 0.000 claims abstract description 20
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 20
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 claims abstract description 19
- DKIDEFUBRARXTE-UHFFFAOYSA-N 3-mercaptopropanoic acid Chemical compound OC(=O)CCS DKIDEFUBRARXTE-UHFFFAOYSA-N 0.000 claims abstract description 18
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims description 88
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- 239000002253 acid Substances 0.000 claims description 13
- 239000012043 crude product Substances 0.000 claims description 11
- 238000001291 vacuum drying Methods 0.000 claims description 10
- PMNLUUOXGOOLSP-UHFFFAOYSA-N alpha-mercaptopropionic acid Natural products CC(S)C(O)=O PMNLUUOXGOOLSP-UHFFFAOYSA-N 0.000 claims description 7
- 239000002244 precipitate Substances 0.000 claims description 7
- CWERGRDVMFNCDR-UHFFFAOYSA-N thioglycolic acid Chemical compound OC(=O)CS CWERGRDVMFNCDR-UHFFFAOYSA-N 0.000 claims description 5
- 239000000706 filtrate Substances 0.000 claims description 2
- LXXNWCFBZHKFPT-UHFFFAOYSA-N Ethyl 2-mercaptopropionate Chemical compound CCOC(=O)C(C)S LXXNWCFBZHKFPT-UHFFFAOYSA-N 0.000 claims 1
- 239000012535 impurity Substances 0.000 claims 1
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- DHBXNPKRAUYBTH-UHFFFAOYSA-N 1,1-ethanedithiol Chemical compound CC(S)S DHBXNPKRAUYBTH-UHFFFAOYSA-N 0.000 abstract description 5
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- 239000002699 waste material Substances 0.000 abstract description 3
- 238000009776 industrial production Methods 0.000 abstract 2
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- 229960004468 eptifibatide Drugs 0.000 description 6
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- 108010068072 salmon calcitonin Proteins 0.000 description 6
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- NHXLMOGPVYXJNR-ATOGVRKGSA-N somatostatin Chemical compound C([C@H]1C(=O)N[C@H](C(N[C@@H](CO)C(=O)N[C@@H](CSSC[C@@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CC=2C3=CC=CC=C3NC=2)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N1)[C@@H](C)O)NC(=O)CNC(=O)[C@H](C)N)C(O)=O)=O)[C@H](O)C)C1=CC=CC=C1 NHXLMOGPVYXJNR-ATOGVRKGSA-N 0.000 description 5
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- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 2
- RWSOTUBLDIXVET-UHFFFAOYSA-N Dihydrogen sulfide Chemical compound S RWSOTUBLDIXVET-UHFFFAOYSA-N 0.000 description 2
- BZLVMXJERCGZMT-UHFFFAOYSA-N Methyl tert-butyl ether Chemical compound COC(C)(C)C BZLVMXJERCGZMT-UHFFFAOYSA-N 0.000 description 2
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- DEQANNDTNATYII-OULOTJBUSA-N (4r,7s,10s,13r,16s,19r)-10-(4-aminobutyl)-19-[[(2r)-2-amino-3-phenylpropanoyl]amino]-16-benzyl-n-[(2r,3r)-1,3-dihydroxybutan-2-yl]-7-[(1r)-1-hydroxyethyl]-13-(1h-indol-3-ylmethyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carboxa Chemical compound C([C@@H](N)C(=O)N[C@H]1CSSC[C@H](NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](CC=2C3=CC=CC=C3NC=2)NC(=O)[C@H](CC=2C=CC=CC=2)NC1=O)C(=O)N[C@H](CO)[C@H](O)C)C1=CC=CC=C1 DEQANNDTNATYII-OULOTJBUSA-N 0.000 description 1
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- 108010016076 Octreotide Proteins 0.000 description 1
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- 150000003863 ammonium salts Chemical class 0.000 description 1
- ZZTCCAPMZLDHFM-UHFFFAOYSA-N ammonium thioglycolate Chemical compound [NH4+].[O-]C(=O)CS ZZTCCAPMZLDHFM-UHFFFAOYSA-N 0.000 description 1
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- 238000004949 mass spectrometry Methods 0.000 description 1
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- 229960002700 octreotide Drugs 0.000 description 1
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- 239000002516 radical scavenger Substances 0.000 description 1
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- 125000004213 tert-butoxy group Chemical group [H]C([H])([H])C(O*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
Images
Landscapes
- Peptides Or Proteins (AREA)
Abstract
Description
缩写 | 英文名 | 中文名 |
EDT | Ethanedithiol | 乙二硫醇 |
TFA | Trifluoroacetic acd | 三氟醋酸 |
TIS | Triisopropylsilane | 三异丙基硅烷 |
MPA | Mercaptopropionic acid | 巯基丙酸 |
MAA | Mercaptoacetic acid | 巯基乙酸 |
C6H5OH | Phenol | 苯酚 |
H2O | Water | 水 |
P2O5 | Phosphorus pentoxide | 五氧化二磷 |
Claims (9)
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CN 201010272875 CN101967179B (zh) | 2010-09-02 | 2010-09-02 | 一种将含巯基肽从树脂上切落的试剂及切落方法 |
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Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102952175A (zh) * | 2011-08-19 | 2013-03-06 | 上海苏豪逸明制药有限公司 | 固相多肽合成生长抑素的方法 |
CN113801199A (zh) * | 2020-06-15 | 2021-12-17 | 深圳翰宇药业股份有限公司 | 一种卡贝缩宫素的全固相合成方法 |
CN115572320A (zh) * | 2022-09-09 | 2023-01-06 | 中南大学湘雅医院 | 一种前列腺癌分子探针及其制备方法与应用 |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
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CN1858060A (zh) * | 2005-05-08 | 2006-11-08 | 周达明 | 固相多肽合成依非巴特的制备方法 |
CN111357937A (zh) * | 2020-03-23 | 2020-07-03 | 武汉轻工大学 | 一种水解玉米蛋白粉和解酒调味面制品及其制备方法 |
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2010
- 2010-09-02 CN CN 201010272875 patent/CN101967179B/zh active Active
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1858060A (zh) * | 2005-05-08 | 2006-11-08 | 周达明 | 固相多肽合成依非巴特的制备方法 |
CN111357937A (zh) * | 2020-03-23 | 2020-07-03 | 武汉轻工大学 | 一种水解玉米蛋白粉和解酒调味面制品及其制备方法 |
Non-Patent Citations (1)
Title |
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《现代生物医学进展》 20071231 唐宏琨等 Fmoc固相合成JFT的工艺研究 85-87 1-9 第7卷, 第1期 2 * |
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102952175A (zh) * | 2011-08-19 | 2013-03-06 | 上海苏豪逸明制药有限公司 | 固相多肽合成生长抑素的方法 |
CN113801199A (zh) * | 2020-06-15 | 2021-12-17 | 深圳翰宇药业股份有限公司 | 一种卡贝缩宫素的全固相合成方法 |
CN113801199B (zh) * | 2020-06-15 | 2024-03-05 | 深圳翰宇药业股份有限公司 | 一种卡贝缩宫素的全固相合成方法 |
CN115572320A (zh) * | 2022-09-09 | 2023-01-06 | 中南大学湘雅医院 | 一种前列腺癌分子探针及其制备方法与应用 |
CN115572320B (zh) * | 2022-09-09 | 2023-09-12 | 中南大学湘雅医院 | 一种前列腺癌分子探针及其制备方法与应用 |
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