CN101965348A - 伐地那非的制备方法及其中间体 - Google Patents

伐地那非的制备方法及其中间体 Download PDF

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Publication number
CN101965348A
CN101965348A CN200780100539.2A CN200780100539A CN101965348A CN 101965348 A CN101965348 A CN 101965348A CN 200780100539 A CN200780100539 A CN 200780100539A CN 101965348 A CN101965348 A CN 101965348A
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formula
compound
mixture
reaction
ice
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CN200780100539.2A
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English (en)
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CN101965348B (zh
Inventor
田广辉
沈敬山
刘正
郑金
赵庆杰
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Shanghai Institute of Materia Medica of CAS
Topharman Shanghai Co Ltd
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Shanghai Institute of Materia Medica of CAS
Topharman Shanghai Co Ltd
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Publication of CN101965348B publication Critical patent/CN101965348B/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

本发明涉及伐地那非的制备方法及其中间体。本发明提供一种制备伐地那非的新方法，本发明还提供制备伐地那非的新中间体及其制备方法。本发明制备伐地那非的方法减少了现有某些方法中及其他步骤中的副反应，提高了反应的收率，反应条件也容易控制，具有很强的工业实用性。

Description

PCT国内申请，说明书已公开。

Claims (17)

  1. PCT国内申请，权利要求书已公开。
CN2007801005392A 2007-09-06 2007-09-06 伐地那非的制备方法及其中间体 Expired - Fee Related CN101965348B (zh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/CN2007/070648 WO2009030095A1 (en) 2007-09-06 2007-09-06 Process for preparing vardenafil and its intermediates

Publications (2)

Publication Number Publication Date
CN101965348A true CN101965348A (zh) 2011-02-02
CN101965348B CN101965348B (zh) 2013-11-13

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ID=40428446

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CN2007801005392A Expired - Fee Related CN101965348B (zh) 2007-09-06 2007-09-06 伐地那非的制备方法及其中间体

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CN (1) CN101965348B (zh)
WO (1) WO2009030095A1 (zh)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT512084A1 (de) 2011-10-20 2013-05-15 Univ Wien Tech Diazabicyclo- und diazaspiro-alkanderivate als phosphodiesterase-5 inhibitoren
CZ2011767A3 (cs) 2011-11-24 2013-06-05 Zentiva, K.S. Zpusob prípravy a izolace solí vardenafilu s kyselinami
US20160317542A1 (en) 2013-12-09 2016-11-03 Respira Therapeutics, Inc. Pde5 inhibitor powder formulations and methods relating thereto
CN109553591B (zh) * 2019-01-15 2020-12-15 山东安信制药有限公司 一种富马酸喹硫平中间体的制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE59803108D1 (de) * 1997-11-12 2002-03-21 Bayer Ag 2-phenyl-substituierte imidazotriazinone als phosphodiesterase inhibitoren
DE10063108A1 (de) * 2000-12-18 2002-06-20 Bayer Ag Verfahren zur Herstellung von Sulfonamid-substituierten Imidazotriazinonen
MXPA03010119A (es) * 2001-05-09 2005-03-07 Bayer Healthcare Ag Nuevo uso de imidazotriazinonas 2-fenilo sustituidas.
WO2006127368A2 (en) * 2005-05-20 2006-11-30 Lexicon Genetics Incorporated Methods for synthesizing imidazotriazinones

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Publication number Publication date
WO2009030095A1 (en) 2009-03-12
CN101965348B (zh) 2013-11-13

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