CN105017219A - 一种p53-MDM2结合抑制剂二羟基异喹啉衍生物的合成方法 - Google Patents
一种p53-MDM2结合抑制剂二羟基异喹啉衍生物的合成方法 Download PDFInfo
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- CN105017219A CN105017219A CN201510408680.5A CN201510408680A CN105017219A CN 105017219 A CN105017219 A CN 105017219A CN 201510408680 A CN201510408680 A CN 201510408680A CN 105017219 A CN105017219 A CN 105017219A
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- HNQQHFYYMCHSTK-XYPYZODXSA-N CC(C)CN[C@H]1CC[C@H](CO)CC1 Chemical compound CC(C)CN[C@H]1CC[C@H](CO)CC1 HNQQHFYYMCHSTK-XYPYZODXSA-N 0.000 description 1
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
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CN201510408680.5A CN105017219B (zh) | 2015-07-13 | 2015-07-13 | 一种p53‑MDM2结合抑制剂二羟基异喹啉衍生物的合成方法 |
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CN201510408680.5A CN105017219B (zh) | 2015-07-13 | 2015-07-13 | 一种p53‑MDM2结合抑制剂二羟基异喹啉衍生物的合成方法 |
Publications (2)
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CN105017219A true CN105017219A (zh) | 2015-11-04 |
CN105017219B CN105017219B (zh) | 2017-05-10 |
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CN201510408680.5A Active CN105017219B (zh) | 2015-07-13 | 2015-07-13 | 一种p53‑MDM2结合抑制剂二羟基异喹啉衍生物的合成方法 |
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Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN115403527A (zh) * | 2022-07-20 | 2022-11-29 | 西安近代化学研究所 | 一种还原胺化法合成杀菌剂乙嘧酚的方法 |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102770182A (zh) * | 2009-12-22 | 2012-11-07 | 诺瓦提斯公司 | 被取代的异喹啉酮类和喹唑酮类 |
WO2012175520A1 (en) * | 2011-06-20 | 2012-12-27 | Novartis Ag | Hydroxy substituted isoquinolinone derivatives |
CN103221094A (zh) * | 2010-11-19 | 2013-07-24 | 诺华有限公司 | Mdm2/4及p53相互作用抑制剂的结晶型 |
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2015
- 2015-07-13 CN CN201510408680.5A patent/CN105017219B/zh active Active
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102770182A (zh) * | 2009-12-22 | 2012-11-07 | 诺瓦提斯公司 | 被取代的异喹啉酮类和喹唑酮类 |
CN103221094A (zh) * | 2010-11-19 | 2013-07-24 | 诺华有限公司 | Mdm2/4及p53相互作用抑制剂的结晶型 |
WO2012175520A1 (en) * | 2011-06-20 | 2012-12-27 | Novartis Ag | Hydroxy substituted isoquinolinone derivatives |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN115403527A (zh) * | 2022-07-20 | 2022-11-29 | 西安近代化学研究所 | 一种还原胺化法合成杀菌剂乙嘧酚的方法 |
CN115403527B (zh) * | 2022-07-20 | 2024-03-29 | 西安近代化学研究所 | 一种还原胺化法合成杀菌剂乙嘧酚的方法 |
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Address after: 201203 Shanghai Zhangjiang High Tech Park of Pudong New Area Cailun Road Lane 720 No. 2 Room 601 Applicant after: Shanghai Haoyuan Chemexpress Bio-pharmaceutical Technology Co., Ltd. Applicant after: Shanghai Hao Yuan pharmaceutical Limited by Share Ltd Address before: 201203 Shanghai Zhangjiang High Tech Park of Pudong New Area Cailun Road Lane 720 No. 2 Room 601 Applicant before: Shanghai Haoyuan Chemexpress Bio-pharmaceutical Technology Co., Ltd. Applicant before: Shanghai Haoyuan Chemical Technology Co., Ltd. |
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Address after: 3 / F, building 8, No.15 and 16, Lane 1999, zhangheng Road, China (Shanghai) pilot Free Trade Zone, Pudong New Area, Shanghai, 201203 Patentee after: MEDCHEMEXPRESS CHINA Co.,Ltd. Patentee after: SHANGHAI HAOYUAN CHEMEXPRESS Co.,Ltd. Address before: 201203 Room 601, Lane 720, Cailun Road, Zhangjiang High-tech Park, Pudong New Area, Shanghai Patentee before: MEDCHEMEXPRESS CHINA Co.,Ltd. Patentee before: SHANGHAI HAOYUAN CHEMEXPRESS Co.,Ltd. |