CN101965221A - 用于改进的质谱分析的组合物和方法 - Google Patents

用于改进的质谱分析的组合物和方法 Download PDF

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Publication number
CN101965221A
CN101965221A CN2009801088642A CN200980108864A CN101965221A CN 101965221 A CN101965221 A CN 101965221A CN 2009801088642 A CN2009801088642 A CN 2009801088642A CN 200980108864 A CN200980108864 A CN 200980108864A CN 101965221 A CN101965221 A CN 101965221A
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analyte
adduct
additive
mass spectrum
matrix
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Chinese (zh)
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T·贝克
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Biological Science Products Co ltd
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Sequenom Inc
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Priority to CN201610753002.7A priority Critical patent/CN106404879B/zh
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869—Methods for sequencing
    • C12Q1/6872—Methods for sequencing involving mass spectrometry
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6848—Methods of protein analysis involving mass spectrometry
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6848—Methods of protein analysis involving mass spectrometry
    • G01N33/6851—Methods of protein analysis involving laser desorption ionisation mass spectrometry
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/14—Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
    • Y10T436/142222—Hetero-O [e.g., ascorbic acid, etc.]
    • Y10T436/143333—Saccharide [e.g., DNA, etc.]
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/24—Nuclear magnetic resonance, electron spin resonance or other spin effects or mass spectrometry
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
    • Y10T436/25125—Digestion or removing interfering materials

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Microbiology (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Cell Biology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Organic Chemistry (AREA)
  • Optics & Photonics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
CN2009801088642A 2008-01-15 2009-01-14 用于改进的质谱分析的组合物和方法 Pending CN101965221A (zh)

Priority Applications (1)

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Applications Claiming Priority (3)

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US12/014,671 2008-01-15
US12/014,671 US7888127B2 (en) 2008-01-15 2008-01-15 Methods for reducing adduct formation for mass spectrometry analysis
PCT/US2009/031020 WO2009091841A2 (en) 2008-01-15 2009-01-14 Compositions and processes for improved mass spectrometry analysis

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US (6) US7888127B2 (enExample)
EP (2) EP3138623B1 (enExample)
JP (3) JP5400799B2 (enExample)
KR (1) KR101733248B1 (enExample)
CN (2) CN106404879B (enExample)
AU (2) AU2009205404B2 (enExample)
CA (1) CA2711943C (enExample)
EA (1) EA017342B1 (enExample)
ES (2) ES2697408T3 (enExample)
WO (1) WO2009091841A2 (enExample)

Cited By (10)

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CN105324831A (zh) * 2013-03-13 2016-02-10 基纳生物技术有限公司 针对maldi质谱的制备强化和使用方法
US9873912B2 (en) 2008-01-15 2018-01-23 Agena Bioscience, Inc. Compositions and processes for improved mass spectrometry analysis
CN107884466A (zh) * 2017-10-31 2018-04-06 北京毅新博创生物科技有限公司 校正质谱检测微生物样品的准确率的方法及产品
CN107907585A (zh) * 2017-11-09 2018-04-13 广州禾信康源医疗科技有限公司 靶板及其制作方法
CN108008002A (zh) * 2017-10-31 2018-05-08 北京毅新博创生物科技有限公司 校正质谱检测核酸样品的准确率的方法及产品
CN108008003A (zh) * 2017-10-31 2018-05-08 北京毅新博创生物科技有限公司 改善质谱检测核酸结晶的方法及产品
CN108051503A (zh) * 2017-10-31 2018-05-18 北京毅新博创生物科技有限公司 改善质谱检测微生物结晶的方法及产品
CN108845023A (zh) * 2018-03-30 2018-11-20 清华大学 一种激光解吸附离子化质谱检测方法
CN110129893A (zh) * 2019-03-25 2019-08-16 为康（苏州）基因科技有限公司 一种芯片的制备方法及其应用
CN116297805A (zh) * 2023-02-28 2023-06-23 厦门金诺花生物技术有限公司 用于maldi-ms的核酸基质溶液及其制备

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CN106483191B (zh) * 2016-10-27 2019-03-08 吉林大学 一种通过消除甜点效应提高质谱检测重复性的方法
CN109541012A (zh) * 2018-11-23 2019-03-29 杭州汇健科技有限公司 一种用于质谱分析的通用型纳米芯片及其制备方法与应用
KR102410207B1 (ko) * 2020-03-06 2022-06-20 주식회사 우성제약 고성능 액체 크래마토그래피-질량분석기를 이용한 타우린아미드의 정량 분석 방법
CN112316847A (zh) * 2020-11-11 2021-02-05 吉林大学 一种磷氮化合物的高温高压合成方法
CN113447560B (zh) * 2021-05-24 2022-12-09 上海交通大学 一种基于金属离子加成的小分子代谢物碎裂控制方法及应用
CN116660359A (zh) * 2023-05-19 2023-08-29 中元汇吉生物技术股份有限公司 一种质谱分析用组合物、芯片及其应用
CN117074509B (zh) * 2023-07-31 2024-04-23 广东省农业科学院农业生物基因研究中心 一种基于核壳纳米材料检测类胡萝卜素的质谱方法
CN117368300B (zh) * 2023-11-14 2024-08-09 浙江迪谱诊断技术有限公司 核酸质谱基质的试剂组合及其制备方法和应用
WO2025144071A1 (ru) * 2023-12-28 2025-07-03 Общество с ограниченной ответственностью "Ионоскоп" Времяпролетный масс-анализатор

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