CN101962325A - 一种高纯度3-甲胺基-1,2-丙二醇的合成方法 - Google Patents
一种高纯度3-甲胺基-1,2-丙二醇的合成方法 Download PDFInfo
- Publication number
- CN101962325A CN101962325A CN201010272175XA CN201010272175A CN101962325A CN 101962325 A CN101962325 A CN 101962325A CN 201010272175X A CN201010272175X A CN 201010272175XA CN 201010272175 A CN201010272175 A CN 201010272175A CN 101962325 A CN101962325 A CN 101962325A
- Authority
- CN
- China
- Prior art keywords
- methylamino
- propylene glycol
- gas phase
- temperature
- weight part
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- WOMTYMDHLQTCHY-UHFFFAOYSA-N 3-methylamino-1,2-propanediol Chemical compound CNCC(O)CO WOMTYMDHLQTCHY-UHFFFAOYSA-N 0.000 title claims abstract description 5
- 238000001308 synthesis method Methods 0.000 title abstract 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims abstract description 42
- 238000006243 chemical reaction Methods 0.000 claims abstract description 40
- 238000004821 distillation Methods 0.000 claims abstract description 14
- LRWZZZWJMFNZIK-UHFFFAOYSA-N 2-chloro-3-methyloxirane Chemical compound CC1OC1Cl LRWZZZWJMFNZIK-UHFFFAOYSA-N 0.000 claims abstract description 12
- 239000003054 catalyst Substances 0.000 claims abstract description 6
- 238000001914 filtration Methods 0.000 claims abstract description 6
- BAVYZALUXZFZLV-UHFFFAOYSA-N Methylamine Chemical compound NC BAVYZALUXZFZLV-UHFFFAOYSA-N 0.000 claims description 48
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims description 24
- 238000003756 stirring Methods 0.000 claims description 20
- 239000000463 material Substances 0.000 claims description 16
- 239000007788 liquid Substances 0.000 claims description 15
- 238000010792 warming Methods 0.000 claims description 12
- 229910000831 Steel Inorganic materials 0.000 claims description 10
- DNIAPMSPPWPWGF-UHFFFAOYSA-N propylene glycol Substances CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 10
- 239000010959 steel Substances 0.000 claims description 10
- 239000000243 solution Substances 0.000 claims description 9
- 238000010189 synthetic method Methods 0.000 claims description 9
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 claims description 8
- 239000007864 aqueous solution Substances 0.000 claims description 8
- NLKNQRATVPKPDG-UHFFFAOYSA-M potassium iodide Chemical compound [K+].[I-] NLKNQRATVPKPDG-UHFFFAOYSA-M 0.000 claims description 8
- 230000007062 hydrolysis Effects 0.000 claims description 6
- 238000006460 hydrolysis reaction Methods 0.000 claims description 6
- 238000002360 preparation method Methods 0.000 claims description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 6
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical group [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 claims description 4
- 238000004176 ammonification Methods 0.000 claims description 4
- 238000001816 cooling Methods 0.000 claims description 4
- 239000008367 deionised water Substances 0.000 claims description 4
- 229910021641 deionized water Inorganic materials 0.000 claims description 4
- 230000000994 depressogenic effect Effects 0.000 claims description 4
- 238000010438 heat treatment Methods 0.000 claims description 4
- XMBWDFGMSWQBCA-UHFFFAOYSA-N hydrogen iodide Chemical compound I XMBWDFGMSWQBCA-UHFFFAOYSA-N 0.000 claims description 4
- 229910052740 iodine Inorganic materials 0.000 claims description 4
- 239000011630 iodine Substances 0.000 claims description 4
- 235000007715 potassium iodide Nutrition 0.000 claims description 4
- 229960004839 potassium iodide Drugs 0.000 claims description 2
- HEQCDGCRHOZAOV-UHFFFAOYSA-N 1-(methylamino)propane-1,2,3-triol Chemical compound CNC(O)C(O)CO HEQCDGCRHOZAOV-UHFFFAOYSA-N 0.000 abstract description 13
- 238000004519 manufacturing process Methods 0.000 abstract description 12
- 238000000199 molecular distillation Methods 0.000 abstract description 4
- 230000035484 reaction time Effects 0.000 abstract description 3
- 230000018044 dehydration Effects 0.000 abstract description 2
- 238000006297 dehydration reaction Methods 0.000 abstract description 2
- 238000005576 amination reaction Methods 0.000 abstract 2
- 230000003301 hydrolyzing effect Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 description 10
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 4
- DGAIEPBNLOQYER-UHFFFAOYSA-N iopromide Chemical compound COCC(=O)NC1=C(I)C(C(=O)NCC(O)CO)=C(I)C(C(=O)N(C)CC(O)CO)=C1I DGAIEPBNLOQYER-UHFFFAOYSA-N 0.000 description 3
- 229960002603 iopromide Drugs 0.000 description 3
- 230000008569 process Effects 0.000 description 3
- 238000002601 radiography Methods 0.000 description 3
- CTKINSOISVBQLD-UHFFFAOYSA-N Glycidol Chemical compound OCC1CO1 CTKINSOISVBQLD-UHFFFAOYSA-N 0.000 description 2
- 238000004458 analytical method Methods 0.000 description 2
- 238000002583 angiography Methods 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- XENVCRGQTABGKY-ZHACJKMWSA-N chlorohydrin Chemical compound CC#CC#CC#CC#C\C=C\C(Cl)CO XENVCRGQTABGKY-ZHACJKMWSA-N 0.000 description 2
- 230000007797 corrosion Effects 0.000 description 2
- 238000005260 corrosion Methods 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 238000005194 fractionation Methods 0.000 description 2
- 235000011187 glycerol Nutrition 0.000 description 2
- 230000006872 improvement Effects 0.000 description 2
- 238000012423 maintenance Methods 0.000 description 2
- 239000003690 nonionic contrast media Substances 0.000 description 2
- 238000005070 sampling Methods 0.000 description 2
- MQDLKAADJTYKRH-UHFFFAOYSA-N 1-aminopropane-1,2,3-triol Chemical group NC(O)C(O)CO MQDLKAADJTYKRH-UHFFFAOYSA-N 0.000 description 1
- 239000003513 alkali Substances 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 238000010612 desalination reaction Methods 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 230000008676 import Effects 0.000 description 1
- 238000009776 industrial production Methods 0.000 description 1
- 238000002697 interventional radiology Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 238000007487 urography Methods 0.000 description 1
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Description
Claims (5)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201010272175XA CN101962325B (zh) | 2010-09-06 | 2010-09-06 | 一种3-甲胺基-1,2-丙二醇的合成方法 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201010272175XA CN101962325B (zh) | 2010-09-06 | 2010-09-06 | 一种3-甲胺基-1,2-丙二醇的合成方法 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN101962325A true CN101962325A (zh) | 2011-02-02 |
CN101962325B CN101962325B (zh) | 2013-12-11 |
Family
ID=43515410
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201010272175XA Expired - Fee Related CN101962325B (zh) | 2010-09-06 | 2010-09-06 | 一种3-甲胺基-1,2-丙二醇的合成方法 |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN101962325B (zh) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103601734A (zh) * | 2013-11-19 | 2014-02-26 | 沈阳化工大学 | 利用环氧氯丙烷水解产物合成含氯螺环原碳酸酯的方法 |
CN108373401A (zh) * | 2018-01-23 | 2018-08-07 | 宜兴市阳洋塑料助剂有限公司 | 一种新型氨基甘油的生产工艺 |
CN111875507A (zh) * | 2020-08-03 | 2020-11-03 | 宜兴市阳洋塑料助剂有限公司 | 一种环保型3-甲胺基甘油及其制备方法 |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0839802A2 (en) * | 1996-10-23 | 1998-05-06 | Daicel Chemical Industries, Ltd. | A process for the preparation of a dihydroxyamino compound |
CN101033193A (zh) * | 2007-04-11 | 2007-09-12 | 浙江大学 | 一种2-氨基丙醇的合成方法 |
CN101648881A (zh) * | 2009-09-03 | 2010-02-17 | 潍坊中业油脂有限公司 | 一种氨基甘油合成新工艺 |
CN101759574A (zh) * | 2009-12-25 | 2010-06-30 | 张中法 | 3-甲胺基-1,2-丙二醇的合成方法 |
-
2010
- 2010-09-06 CN CN201010272175XA patent/CN101962325B/zh not_active Expired - Fee Related
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0839802A2 (en) * | 1996-10-23 | 1998-05-06 | Daicel Chemical Industries, Ltd. | A process for the preparation of a dihydroxyamino compound |
EP1201644A2 (en) * | 1996-10-23 | 2002-05-02 | Daicel Chemical Industries, Ltd. | A process for the prepration of a dihydroxyamino compound |
CN101033193A (zh) * | 2007-04-11 | 2007-09-12 | 浙江大学 | 一种2-氨基丙醇的合成方法 |
CN101648881A (zh) * | 2009-09-03 | 2010-02-17 | 潍坊中业油脂有限公司 | 一种氨基甘油合成新工艺 |
CN101759574A (zh) * | 2009-12-25 | 2010-06-30 | 张中法 | 3-甲胺基-1,2-丙二醇的合成方法 |
Non-Patent Citations (1)
Title |
---|
张中法: "3-甲胺基-1,2-丙二醇的生产新工艺", 《贵州化工》 * |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103601734A (zh) * | 2013-11-19 | 2014-02-26 | 沈阳化工大学 | 利用环氧氯丙烷水解产物合成含氯螺环原碳酸酯的方法 |
CN103601734B (zh) * | 2013-11-19 | 2016-06-29 | 沈阳化工大学 | 利用环氧氯丙烷水解产物合成含氯螺环原碳酸酯的方法 |
CN108373401A (zh) * | 2018-01-23 | 2018-08-07 | 宜兴市阳洋塑料助剂有限公司 | 一种新型氨基甘油的生产工艺 |
CN111875507A (zh) * | 2020-08-03 | 2020-11-03 | 宜兴市阳洋塑料助剂有限公司 | 一种环保型3-甲胺基甘油及其制备方法 |
Also Published As
Publication number | Publication date |
---|---|
CN101962325B (zh) | 2013-12-11 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN101962325B (zh) | 一种3-甲胺基-1,2-丙二醇的合成方法 | |
CN104693038A (zh) | 一种以丙二醇和液氨为原料制备丙二胺的方法及其装置 | |
CN109456204B (zh) | γ-甲氧基丙胺的制备方法 | |
CN101759574B (zh) | 3-甲胺基-1,2-丙二醇的合成方法 | |
CN101648881B (zh) | 一种氨基甘油合成工艺 | |
CN101823968B (zh) | 一种水合肼还原1,8-二硝基萘制备1,8-二氨基萘的方法 | |
CN103012074A (zh) | 制备芳香族甲醚化合物的方法 | |
CN106631835B (zh) | 一种3-甲胺基-1,2-丙二醇的生产方法 | |
CN102382294A (zh) | 聚醚胺系列产品的制备方法 | |
WO2022134882A1 (zh) | 一种1,4-环己二酮的纯化方法 | |
CN104829466A (zh) | 一种管道反应器合成3-甲胺基-1,2-丙二醇的方法 | |
CN109456207B (zh) | 3-氨基丙醇的制备方法 | |
CN104496761A (zh) | 一种制备双酚a的方法 | |
CN109809983A (zh) | 一种氢化二聚酸的连续化合成方法及合成的氢化二聚酸 | |
CN104892365A (zh) | 一种低压合成高纯度氯代甘油的方法 | |
CN103396325B (zh) | 一种氨基甘油提纯装置及其生产方法 | |
CN113200821A (zh) | 一种月桂醇的提纯方法及聚多卡醇的合成方法 | |
CN102964586A (zh) | 一种用于聚醚胺的催化剂的制备方法 | |
CN111233788A (zh) | 一种n-羟乙基哌嗪的合成方法 | |
CN105713191A (zh) | 一种连续化临氢氨化生产聚醚胺的工艺 | |
CN205590594U (zh) | 新型磷酸三乙酯生产装置 | |
CN110563591B (zh) | 一种n,n,n′-三甲基乙二胺的绿色环保合成方法 | |
CN115677497B (zh) | 一种苯甲酸乙酯的生产方法 | |
CN101024617A (zh) | d-2-氨基丁醇-1的制造方法 | |
CN108069862A (zh) | 2-甲基-1,2-丙二胺的合成方法 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
ASS | Succession or assignment of patent right |
Owner name: WULIAN QIANGONG FINE CHEMICALS CO., LTD. Free format text: FORMER OWNER: ZHANG LIANGCHEN Effective date: 20131104 |
|
C41 | Transfer of patent application or patent right or utility model | ||
TA01 | Transfer of patent application right |
Effective date of registration: 20131104 Address after: Xu Qian Gong Meng Zhen Nanling Wulian County Fine Chemical Co. Ltd., 262315 Shandong province Rizhao City Wulian County Applicant after: Wulian Qiangong Fine-chemicals Co., Ltd. Address before: Xu Qian Gong Meng Zhen Nanling Wulian County Fine Chemical Co. Ltd., 262315 Shandong province Rizhao City Wulian County Applicant before: Zhang Liangchen |
|
C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20131211 Termination date: 20170906 |
|
CF01 | Termination of patent right due to non-payment of annual fee |