CN101959519B - 用于玻璃体内注射的低粘度、高度絮凝的曲安奈德混悬液 - Google Patents

用于玻璃体内注射的低粘度、高度絮凝的曲安奈德混悬液 Download PDF

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Publication number
CN101959519B
CN101959519B CN2009801076823A CN200980107682A CN101959519B CN 101959519 B CN101959519 B CN 101959519B CN 2009801076823 A CN2009801076823 A CN 2009801076823A CN 200980107682 A CN200980107682 A CN 200980107682A CN 101959519 B CN101959519 B CN 101959519B
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China
Prior art keywords
suspension composite
suspension
composite
chloride
triamcinolone acetonide
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CN2009801076823A
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English (en)
Chinese (zh)
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CN101959519A (zh
Inventor
B·P·卡布拉
R·萨卡
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Novartis AG
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Alcon Research LLC
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Inorganic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Dispersion Chemistry (AREA)
  • Ophthalmology & Optometry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Materials For Medical Uses (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
CN2009801076823A 2008-03-11 2009-03-10 用于玻璃体内注射的低粘度、高度絮凝的曲安奈德混悬液 Active CN101959519B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US3545908P 2008-03-11 2008-03-11
US61/035,459 2008-03-11
PCT/US2009/036652 WO2009114521A1 (en) 2008-03-11 2009-03-10 Low viscosity, highly flocculated triamcinolone acetonide suspensions for intravitreal injection

Publications (2)

Publication Number Publication Date
CN101959519A CN101959519A (zh) 2011-01-26
CN101959519B true CN101959519B (zh) 2013-03-20

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CN2009801076823A Active CN101959519B (zh) 2008-03-11 2009-03-10 用于玻璃体内注射的低粘度、高度絮凝的曲安奈德混悬液

Country Status (21)

Country Link
US (3) US8128960B2 (enExample)
EP (1) EP2262506B1 (enExample)
JP (1) JP5581227B2 (enExample)
KR (1) KR101555293B1 (enExample)
CN (1) CN101959519B (enExample)
AR (1) AR070824A1 (enExample)
AU (1) AU2009223649B2 (enExample)
BR (1) BRPI0909630B8 (enExample)
CA (1) CA2717605C (enExample)
CL (1) CL2009000573A1 (enExample)
DK (1) DK2262506T3 (enExample)
ES (1) ES2471122T3 (enExample)
MX (1) MX2010009974A (enExample)
PL (1) PL2262506T3 (enExample)
PT (1) PT2262506E (enExample)
RU (1) RU2481842C2 (enExample)
SI (1) SI2262506T1 (enExample)
TW (1) TWI468165B (enExample)
UY (1) UY31699A1 (enExample)
WO (1) WO2009114521A1 (enExample)
ZA (1) ZA201005839B (enExample)

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KR20110099044A (ko) * 2008-12-22 2011-09-05 알콘 리서치, 리미티드 후안부에 유효농도의 활성제를 전달하기 위한 국소 안용액 조성물
WO2012051575A2 (en) 2010-10-15 2012-04-19 Iscience Interventional Corporation Device for ocular access
CN102008488B (zh) * 2010-11-24 2012-10-10 广州固志医药科技有限公司 一种曲安奈德眼用制剂及其制备方法
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AU2013342275B2 (en) * 2012-11-08 2017-11-09 Clearside Biomedical, Inc. Methods and devices for the treatment of ocular diseases in human subjects
SG10201702674PA (en) 2013-05-03 2017-06-29 Clearside Biomedical Inc Apparatus and methods for ocular injection
WO2014197317A1 (en) 2013-06-03 2014-12-11 Clearside Biomedical, Inc. Apparatus and methods for drug delivery using multiple reservoirs
WO2015196085A2 (en) 2014-06-20 2015-12-23 Clearside Biomedical, Inc. Variable diameter cannula and methods for controlling insertion depth for medicament delivery
US9694145B1 (en) 2016-03-29 2017-07-04 Joseph Onorato Auto-injector systems and method for delivering cyst medication on demand
JP2019514581A (ja) 2016-05-02 2019-06-06 クリアサイド バイオメディカル，インコーポレイテッド 眼の薬物送達のためのシステムおよび方法
US10973681B2 (en) 2016-08-12 2021-04-13 Clearside Biomedical, Inc. Devices and methods for adjusting the insertion depth of a needle for medicament delivery
WO2018204515A1 (en) 2017-05-02 2018-11-08 Georgia Tech Research Corporation Targeted drug delivery methods using a microneedle
WO2019136512A1 (en) * 2018-01-10 2019-07-18 Eye Co Pty Ltd Medical device and pharmaceutical composition for treatment of an eye disease or condition
USD893715S1 (en) 2018-11-06 2020-08-18 Joseph Onorato Measurement guide for a cyst, lesion or skin disorder
CA3136814A1 (en) * 2019-04-16 2020-10-22 Clearside Biomedical, Inc. Injectable triamcinolone formulations
US10814001B1 (en) 2019-05-06 2020-10-27 Rvl Pharmaceuticals, Inc. Oxymetazoline compositions
CN114010593A (zh) * 2021-11-23 2022-02-08 莱默(北京)药业科技有限公司 一种曲安奈德混悬注射液及制备方法
CN115969784B (zh) * 2022-12-26 2025-10-21 昆明积大制药股份有限公司 曲安奈德注射液的制备方法
WO2025114562A1 (en) * 2023-11-30 2025-06-05 Institut National de la Santé et de la Recherche Médicale Intravitreal spironolactone suspension

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CN101119733A (zh) * 2005-02-18 2008-02-06 参天制药株式会社 减轻或避免甾族化合物副作用的方法

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WO2005107705A2 (en) * 2004-04-30 2005-11-17 Allergan, Inc. Extended therapeutic effect ocular implant treatments
CN101119733A (zh) * 2005-02-18 2008-02-06 参天制药株式会社 减轻或避免甾族化合物副作用的方法

Also Published As

Publication number Publication date
US8128960B2 (en) 2012-03-06
CN101959519A (zh) 2011-01-26
PT2262506E (pt) 2014-06-24
US20120115829A1 (en) 2012-05-10
KR20100127267A (ko) 2010-12-03
HK1146464A1 (en) 2011-06-10
EP2262506B1 (en) 2014-05-07
BRPI0909630B8 (pt) 2021-05-25
CL2009000573A1 (es) 2010-01-04
US20120116216A1 (en) 2012-05-10
TWI468165B (zh) 2015-01-11
KR101555293B1 (ko) 2015-10-06
US8211880B2 (en) 2012-07-03
BRPI0909630B1 (pt) 2019-03-26
JP5581227B2 (ja) 2014-08-27
US20090233890A1 (en) 2009-09-17
ZA201005839B (en) 2011-10-26
CA2717605C (en) 2012-05-15
JP2011513492A (ja) 2011-04-28
EP2262506A1 (en) 2010-12-22
CA2717605A1 (en) 2009-09-17
AU2009223649A1 (en) 2009-09-17
WO2009114521A1 (en) 2009-09-17
MX2010009974A (es) 2010-09-30
SI2262506T1 (sl) 2014-07-31
DK2262506T3 (da) 2014-06-10
TW200940071A (en) 2009-10-01
BRPI0909630A2 (pt) 2015-09-22
RU2010141542A (ru) 2012-04-20
PL2262506T3 (pl) 2014-09-30
UY31699A1 (es) 2009-05-29
RU2481842C2 (ru) 2013-05-20
ES2471122T3 (es) 2014-06-25
AU2009223649B2 (en) 2013-08-29
AR070824A1 (es) 2010-05-05

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SE01 Entry into force of request for substantive examination
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Effective date of registration: 20191128

Address after: Fribourg

Patentee after: ALCON, Inc.

Address before: Texas, USA

Patentee before: Alcon Research Co.,Ltd.

Effective date of registration: 20191128

Address after: Texas, USA

Patentee after: Alcon Research Co.,Ltd.

Address before: Texas, USA

Patentee before: ALCON RESEARCH, Ltd.

TR01 Transfer of patent right
TR01 Transfer of patent right

Effective date of registration: 20200824

Address after: Basel, Switzerland

Patentee after: NOVARTIS AG

Address before: Fribourg

Patentee before: ALCON, Inc.

TR01 Transfer of patent right