CN101912472B - Chinese medicinal composition for treating habitual constipation and preparation method thereof - Google Patents
Chinese medicinal composition for treating habitual constipation and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a Chinese medicinal composition for treating habitual constipation and a preparation method thereof. The Chinese medicinal composition comprises the following raw materials: garden burnet, fructus evodiae, crude bighead atractylodes rhizome, skunk bugbane, Chinese goldthread, tangkuei tail and licorice root. The experimental observation of the clinical therapeutic effect shows that the Chinese medicinal composition has an obvious therapeutic effect on various constipation, and particularly has the optimal therapeutic effect on the habitual constipation. The Chinese medicinal composition of the invention has the advantages of high safety and no toxic or side effect through clinical observation.
Description
Technical field
The present invention relates to a kind of medicine of treating constipation, relate in particular to Chinese medicine composition of treatment habitual constipation and preparation method thereof, belong to the treatment by Chinese herbs field of constipation.
Background technology
The main performance of constipation is that times of defecation reduces, and prolong blanking time, or normal, but excrement matter is dry, discharges difficulty; Or excrement matter is dried, discharges not smooth.Can accompany and see abdominal distention, stomachache, loss of appetite, heating installation regurgitation, diseases such as stool band blood.Often can lay one's hand on and the visible peristalsis visible intestinal peristalsis of excrement piece or spasm at left lower quadrant.
Habitual constipation is meant secular, chronic functional constipation is mainly in the old people.Habitual constipation is claimed functional constipation again, is meant that weekly defecation is less than 3 times, or defecation is often felt difficulty.The people of constipation not only can make the toxin hyperabsorption because stool is detained, and also discharges slow cholesterol than normal person hyperabsorption because of stool.Therefore, the people of prolonged constipation, complexion dusk is dim, too fat to move, demonstrates a kind of unusual ill face.Habitual constipation is common in constitutional enterokinesia dysfunction, and stool wriggling is carried and delayed etc.
The people of prolonged constipation, enteral is prone to gather harmful gas, produces intestinal tympanites, and venous return is obstructed, and obstacle appears in digestive function; Can cause the glutted discomfort of upper abdomen, loss of appetite, belch, feel sick, stomachache, borborygmus, wind are many etc.; Also can make health poisoning symptom occur,, spirit indifferent, bitter taste weak, vexedly be prone to diseases such as hot-tempered like dizziness.
Prolonged constipation possibly cause following complication: 1. anus is tied the rectum complication.Secular constipation can make intestinal bacteria ferment and the carcinogen stimulation intestinal mucosa epithelial cell of generation, causes special-shaped hyperplasia, is prone to bring out canceration.Constipation causes perianal such as proctitis, anal fissure, hemorrhoid etc., and because of constipation, difficult defecation, feces are dry, can directly cause or increase the weight of the anal orifice and rectal intestine illness.Harder excrement piece blocks enteric cavity makes stenosis of bowel and compressing pelvic circumference structure, has hindered colonic peristalsis, makes rectum or colon pressurized and causes disturbance of blood circulation, also can form fecal ulcer, and severe patient can cause intestinal perforation.It is (many etc. like inappetence, abdominal part distension, belch, bitter taste, passage of gas by anus that colonic diverticula, intestinal obstruction, gastrointestinal nerve dysfunction also can take place.) 2. parenteral complication: like apoplexy, influence brain function (hypomnesis, distractibility, bradyphrenia), sexual life obstacle etc.In the generation of diseases such as hepatic encephalopathy, mastopathy, Alzheimer, important effect is arranged also.Clinically about because of constipation firmly increases abdominal pressure, the cardiovascular disease outbreak that the defecation with strength of holding one's breath causes has and increases trend year by year, as brings out angina pectoris, the myocardial infarction outbreak.
The traditional Chinese medical science thinks that constipation is mainly caused by dryness-heat stagnating in the interior, depression and stagnation of QI, deficiency of body fluid and spleen-kidney vacuity cold.
The existing medicine that is used to treat constipation mainly contains following several kinds:
Osmotic laxative: be also referred to as Epsom salts,,, make the capacity increase of stool, play the catharsis effect so can in intestinal, absorb large quantity of moisture because of it is not absorbed by intestinal wall and water-soluble.The main representative medicine of such cathartic is a magnesium sulfate.But because it can not make colon tension force increase, so should not be used for the slow patient of those intestinal movements.
Irritant laxative: effect is fast, effectiveness is strong, and medicine or its metabolic product can produce stimulation to intestinal wall, and enterokinesia is increased.Such medicine mainly contains: phenolphthalein, Oleum Ricini, Radix Et Rhizoma Rhei, Folium Sennae etc.But be noted that this type of medicine because stimulate intestinal mucosa and intestinal wall plexus nervorum, and possibly cause the large intestine myasthenia, form drug dependence, thereby be mainly used in and need rapid relieving constipation person, should not prolonged application.
Emollient laxative: claim stool softener again, the major function of this type of medicine is lubricated intestinal wall, and softening stool makes and is convenient to greatly discharge, like liquid paraffin etc.The main shortcoming of this type medicine is that mouthfeel is poor, and a little less than the effect, prolonged application can cause fatsoluble vitamin malabsorption.
The permeability caccagogue: like lactulose, it is not absorbed by the body, and works at colon through discharging organic acid after the bacterial decomposition.Especially be suitable for old people, pregnant and lying-in women, child and postoperative constipation person.The careful usefulness of diabetic.The major defect of this type of medicine is to produce gas at the bacterial action bottom fermentation, causes senses of discomfort such as abdominal distention.
Comprehensive above visible, the existing medicine that is used to treat constipation mostly in various degree have defectives such as weak curative effect, side effect are bigger, have much room for improvement.
Summary of the invention
Technical problem to be solved by this invention is the deficiency that overcomes prior art, and a kind of Chinese medicine composition of evident in efficacy, the treatment constipation that has no side effect basically is provided;
Technical problem to be solved by this invention realizes through following technical scheme:
A kind of Chinese medicine composition of treating constipation comprises that each crude drug processes: Radix Sanguisorbae, Fructus Evodiae, Rhizoma Atractylodis Macrocephalae, Rhizoma Cimicifugae, Rhizoma Coptidis, Radix Angelicae Sinensis and Radix Glycyrrhizae;
Preferably, the weight portion of each crude drug is: Radix Sanguisorbae 13-18 part, Fructus Evodiae 6-12 part, Rhizoma Atractylodis Macrocephalae 5-10 part, Rhizoma Cimicifugae 4-10 part, Rhizoma Coptidis 1-4 part, Radix Angelicae Sinensis 2-8 part, Radix Glycyrrhizae 2-6 part;
Preferred, the weight portion of each crude drug is: Radix Sanguisorbae 13-15 part, Fructus Evodiae 8-10 part, Rhizoma Atractylodis Macrocephalae 8-10 part, Rhizoma Cimicifugae 4-8 part, Rhizoma Coptidis 2-4 part, Radix Angelicae Sinensis 4-6 part, Radix Glycyrrhizae 4-6 part.
Radix Sanguisorbae (formal name used at school: Radix Sanguisorbae) be the plant of Rosaceae burnet.Property of medicine picric acid; Cold; Nontoxic returning through liver; Lung; Kidney; Large intestine channel.Effect: cooling blood for hemostasis, heat-clearing and toxic substances removing, skin ulcer is held back in detumescence.
Atractylodes, Alias: Mountain thistle, Young serrata thistle, surgery, Hill mustard, sky thistle, Alpinia, MOUNTAIN, troll, kilima gamma, winter Atractylodes; Meridian: stomach through; bitter; Gan; warm.
Effect: invigorating the spleen and benefiting QI; The dampness diuretic; Hidroschesis; Antiabortive.The concocting method of Rhizoma Atractylodis Macrocephalae is following: choose clean impurity, be soaked in water, soak time should suitably be grasped according to season, climate change and Rhizoma Atractylodis Macrocephalae size, pulls out behind the bubble, runs through, and section is dried.
Fructus Evodiae (formal name used at school Tetradium ruticarpum, original name Euodia ruticarpa), another name Fructus Evodiae, tea is peppery, lacquer spicy, smelly spicy tree, the deep and remote son of Zuo Lichun, rice spicy etc.Its bitter in the mouth hot in nature is cold, and the merit of heat radiation pain relieving, stopping nausea and vomiting by lowering the adverse flow of QI is arranged, and is used to treat that the liver insufficiency of stomach is cold, diseases such as the headache due to the cloudy turbid superinverse or stomach wrist pain.
Rhizoma Cimicifugae: these article are the dry rhizome of the big SANYE Rhizoma Cimicifugae of ranunculaceae plant Cimicifuga heracleif olia Kom., Rhizoma Cimicifugae Cimicifuga dahurica (Turcz.) Maxim. of Xingan or Rhizoma Cimicifugae Cimicifuga foetida L..Meridian distribution of property and flavor: hot, little sweet, be slightly cold.Return lung, spleen, stomach, large intestine channel.Function cures mainly: deliver rash, heat-clearing and toxic substances removing, elevate a turnable ladder yang-energy.
Rhizoma Coptidis: these article are the dry rhizome of ranunculaceae plant Rhizoma Coptidis Coptis chinensis Franch., Coptis deltoidea C.Y.Cheng et Hsiao Coptis deltoidea C.Y.Cheng et Hsiao or Coptis Teeta Wall Copt is teeta Wall..Meridian distribution of property and flavor: hardship, cold.GUIXIN, spleen, stomach, liver, gallbladder, large intestine channel.Function cures mainly: heat clearing and damp drying, eliminating fire and detoxication.
Radix Angelicae Sinensis: the supporting root of umbelliferae angelica Angelica sinensis (Oliv.) Diels.Mainly contain tonifying blood and regulating menstruation, promoting blood circulation and stopping pain, loosening bowel to relieve constipation, expansion arteria coronaria, antiinflammatory, promotion non-specific immunity, lax bronchial smooth muscle, protect the liver, multiple effects such as diuresis, anti-bacillus.
Radix Glycyrrhizae: function cures mainly: invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.Be used for weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, gastral cavity abdomen, the anxious pain of extremity contraction, carbuncle sore tumefacting virus, cushion toxicity, strong.
In order to reach better therapeutic effect,, can in above-mentioned Chinese medicine composition, add the Radix Rehmanniae, Radix Scrophulariae, Radix Ophiopogonis, Radix Et Rhizoma Rhei and Fructus Mori when patient's constipation belongs to the deficiency of YIN when secret; The weight portion of each crude drug that preferably, is added is: Radix Rehmanniae 3-8 part, Radix Scrophulariae 1-4 part, Radix Ophiopogonis 2-8 part, Radix Et Rhizoma Rhei 2-5 part and Fructus Mori 3-8 part;
When patient's constipation belongs to yang deficiency when secret, can in above-mentioned Chinese medicine composition, add Herba Cistanches and Radix Morindae Officinalis; Preferably, the weight portion of each crude drug that is added is: Herba Cistanches 3-8 part, Radix Morindae Officinalis 2-6 part;
When the patient is just dry, can in above-mentioned Chinese medicine composition, add Semen Platycladi, Semen Lini, Semen Persicae, Semen Armeniacae Amarum, Fructus Cannabis, Semen Pruni and comet shepherd's purse; The weight portion of each crude drug that preferably, is added is: Semen Platycladi 2-6 part, Semen Lini 1-4 part, Semen Persicae 1-4 part, Semen Armeniacae Amarum 1-4 part, Fructus Cannabis 1-4 part, Semen Pruni 1-4 part, Corm Eleocharitis 2-5 part;
Semen Platycladi is the kernel of Cupressaceae plant Cacumen Platycladi Biotaorientalis (L.) End1..Semen Platycladi property is put down sweet in the mouth.The effect of tool tranquilizing by nourishing the heart, loosening bowel to relieve constipation.Control diseases such as palpitation with fear, insomnia, seminal emission, night sweat, constipation.
Semen Lini is the mature seed of Pedaliaceae plant linum.Meridian distribution of property and flavor: sweet, flat.Go into lung, spleen, liver, kidney channel.Function cures mainly: moisturize laxation, nourishing the liver and kidney.Be used for depletion of body fluid causing lack of blood, constipation, after being ill empty, the dizzy disease such as weak of body.
Semen Persicae (semenpersicae, peachseed), another name Radix Fici Hirtae core, almond core, big Semen Persicae.Seed for Folium rosae multiflorae plant peach prunuspersicabatsch.Meridian distribution of property and flavor: bitter, sweet, flat.GUIXIN, liver, large intestine channel.Function cures mainly: blood circulation promoting and blood stasis dispelling, loosening bowel to relieve constipation, relieving cough and asthma.Be used for amenorrhea, dysmenorrhea ， WEIJIA mass in the abdomen, injury from falling down, dryness of the intestine constipation.
Semen Armeniacae Amarum Almond; Sweet Almond latin name: Amygda lus Communis Vas, section's name: Rosaceae (Rosaceae).Have expelling phlegm for arresting cough, relieving asthma, intestine moistening, the effect of air to open numbness down.
Fructus Cannabis is the dry mature seed of moraceae plants Fructus Cannabis (Cannabis sativa L.), and another name is cannabis,fructus, Urtica cannabina L., hemp again.Urtica cannabina L. has cultivation in Chinese most of areas, and happiness warm and moist weather is not tight to the soil requirement, and deep with soil layer, loose fertile, well-drained sand paper soil or clayey soil are advisable.Gather during fruit maturation autumn, removes impurity, dries the back and be Fructus Cannabis.The Fructus Cannabis sweet in the mouth, property is flat, returns spleen, stomach, large intestine channel, the effect loosening bowel to relieve constipation, moisturizes parasite killing.
Semen Pruni is the kernel of strongly fragrant Lee of rosaceous plant, Prunus humilis, flowering plum, long stalk almond etc.The laxation of moisturizing is arranged, the effect of therapeutic method to keep the adverse QI flowing downwards diuretic.
When the patient receives when poor, can in above-mentioned Chinese medicine composition, add rice sprout, Fructus Hordei Germinatus, Divine Comedy and Nei Jin; Preferably, the weight portion of each bulk drug that is added is: rice sprout 3-8 part, Fructus Hordei Germinatus 3-8 part, Divine Comedy 2-6 part, interior golden 1-4 part;
When patient's abdominal distention, can in above-mentioned Chinese medicine composition, add and fry Semen Raphani, Cortex Magnoliae Officinalis, Fructus Aurantii Immaturus and Fructus Crataegi; The weight portion of each crude drug that preferably, is added is: fry Semen Raphani 2-7 part, Cortex Magnoliae Officinalis 1-5 part, Fructus Aurantii Immaturus 1-3 part, Fructus Crataegi 2-7 part.
Semen Raphani, another name: Semen Raphani, reed Fu.Pleasant relieving constipation helps digestion to remove and expands, lowering the adverse-rising QI to resolve phlegm, and certain effect of weight reducing is arranged.Be used for retention of food and drink, abdominal distention, constipation, stagnant dysentery, the expectorant heap soil or fertilizer over and around the roots is breathed with cough.
The inventor passes through clinical research for many years, in conjunction with modern achievement in research, sums up the main etiology and pathology characteristics of constipation, on this basis, in conjunction with the dialectical principle that combines with differential diagnosis of diseases, purges heat with liver heat removing, and the intestinal stasis relieving that purges heat, loosening bowel to relieve constipation are the rule of treatment, intend Fang Erding.
The used raw material of the present invention all can be bought from common Chinese medicine shop and obtain, and its specification meets industry standard.
Medicine activity component of the present invention can add various adjuvants required when preparing different dosage form; For example disintegrating agent, lubricant, adhesive etc.; Method of Chinese medicinal with routine is prepared into any oral formulations commonly used; Can be pill, capsule, tablet, powder, granule or oral liquid etc. for example, be preferably capsule.
Preferably, a kind of method for preparing Chinese medicine composition of the present invention may further comprise the steps:
(1) take by weighing each raw material by following weight portion:;
(2) with the back decocte with water together of above each raw materials mix, decocting liquid leaves standstill, and filters; Filtrate decompression is condensed into clear paste, spray drying, and crushing screening adds pharmaceutical preparation adjuvant preparations shaping, promptly gets.
Preferably, the decocting that adds 3-12 times of weight after each raw material mitigation is together boiled 2-4 time, decocted 1.5-2 hour at every turn, collecting decoction leaves standstill, and filters; Filtrate decompression is concentrated into the clear paste that relative density is 1.17-1.19 (60 ℃), spray drying, and crushing screening adds pharmaceutical preparation adjuvant preparations shaping, promptly gets.
The usage of Chinese medicine composition of the present invention and consumption: the dosage of Chinese medicine composition of the present invention depends on concrete dosage form, and factor such as age of patient, body weight, health status.As guidance: capsule, oral, one time 2 (0.65g crude drug/grain), 3 times on the one; 15 days is a course of treatment.
The clinical observation on the therapeutic effect test shows that Chinese medicine composition of the present invention all has significant curative effect for all kinds constipation, especially has best therapeutic effect for habitual constipation.Chinese medicine composition safety of the present invention is good, and any toxicity is not seen in clinical observation.
The specific embodiment
Further describe the present invention below in conjunction with specific embodiment, advantage of the present invention and characteristics will be more clear along with description.But these embodiment only are exemplary, scope of the present invention are not constituted any restriction.It will be understood by those skilled in the art that and down can make amendment with form or replace without departing from the spirit and scope of the present invention, but these modifications and replacing all fall in protection scope of the present invention the details of technical scheme of the present invention.
The preparation of embodiment 1 soft capsule
Take by weighing each raw material by following weight: Radix Sanguisorbae 1300g, Fructus Evodiae 600g, Rhizoma Atractylodis Macrocephalae 500g, Rhizoma Cimicifugae 400g, Rhizoma Coptidis 100g, Radix Angelicae Sinensis 200g, Radix Glycyrrhizae 200g;
After above each crude drug mixed, add 10 times of weight decoctings and boil 2 times, 2 hours for the first time, 1.5 hours for the second time, collecting decoction left standstill, and filtered; Filtrate decompression is concentrated into the clear paste that relative density is 1.17-1.19 (60 ℃), and spray drying was pulverized 120 mesh sieves, with soybean oil, and Cera Flava, mixing is crossed colloid mill 4 times, and preparation rubber is processed soft capsule by pressing, promptly gets.
The preparation of embodiment 2 soft capsules
Take by weighing each raw material by following weight: Radix Sanguisorbae 1800g, Fructus Evodiae 1200g, Rhizoma Atractylodis Macrocephalae 1000g, Rhizoma Cimicifugae 1000g, Rhizoma Coptidis 400g, Radix Angelicae Sinensis 800g, Radix Glycyrrhizae 600g;
After above each crude drug mixed, add 8 times of weight decoctings and boil 3 times, 2 hours for the first time, 1.5 hours for the second time, 1.5 hours for the third time, collecting decoction left standstill, and filtered; Filtrate decompression is concentrated into the clear paste that relative density is 1.17-1.19 (60 ℃), and spray drying was pulverized 120 mesh sieves, with soybean oil, and Cera Flava, mixing is crossed colloid mill 3 times, and preparation rubber is processed soft capsule by pressing, promptly gets.
The preparation of embodiment 3 soft capsules
Take by weighing each raw material by following weight: Radix Sanguisorbae 1300g, Fructus Evodiae 600g, Rhizoma Atractylodis Macrocephalae 500g, Rhizoma Cimicifugae 400g, Rhizoma Coptidis 100g, Radix Angelicae Sinensis 200g, Radix Glycyrrhizae 200g, Radix Rehmanniae 300g, Radix Scrophulariae 100g, Radix Ophiopogonis 200g, Radix Et Rhizoma Rhei 200g, Fructus Mori 300g;
After above each crude drug mixed, add 12 times of weight decoctings and boil 3 times, 2 hours for the first time, 1.5 hours for the second time, 1.5 hours for the third time, collecting decoction left standstill, and filtered; Filtrate decompression is concentrated into the clear paste that relative density is 1.17-1.19 (60 ℃), and spray drying was pulverized 120 mesh sieves, with soybean oil, and Cera Flava, mixing is crossed colloid mill 3 times, and preparation rubber is processed soft capsule by pressing, promptly gets.
The preparation of embodiment 4 soft capsules
Take by weighing each raw material by following weight: Radix Sanguisorbae 1800g, Fructus Evodiae 1200g, Rhizoma Atractylodis Macrocephalae 1000g, Rhizoma Cimicifugae 1000g, Rhizoma Coptidis 400g, Radix Angelicae Sinensis 800g, Radix Glycyrrhizae 600g, Radix Rehmanniae 800g, Radix Scrophulariae 400g, Radix Ophiopogonis 800g, Radix Et Rhizoma Rhei 500g, Fructus Mori 800g;
After above each crude drug mixed, add 12 times of weight decoctings and boil 3 times, 2 hours for the first time, 1.5 hours for the second time, 1.5 hours for the third time, collecting decoction left standstill, and filtered; Filtrate decompression is concentrated into the clear paste that relative density is 1.17-1.19 (60 ℃), and spray drying was pulverized 120 mesh sieves, with soybean oil, and Cera Flava, mixing is crossed colloid mill 3 times, and preparation rubber is processed soft capsule by pressing, promptly gets.
The preparation of embodiment 5 soft capsules
Take by weighing each raw material by following weight: Radix Sanguisorbae 1300g, Fructus Evodiae 600g, Rhizoma Atractylodis Macrocephalae 500g, Rhizoma Cimicifugae 400g, Rhizoma Coptidis 100g, Radix Angelicae Sinensis 200g, Radix Glycyrrhizae 200g, Herba Cistanches 300g, Radix Morindae Officinalis 200g;
After above each crude drug mixed, add 12 times of weight decoctings and boil 3 times, 2 hours for the first time, 1.5 hours for the second time, 1.5 hours for the third time, collecting decoction left standstill, and filtered; Filtrate decompression is concentrated into the clear paste that relative density is 1.17-1.19 (60 ℃), and spray drying was pulverized 120 mesh sieves, with soybean oil, and Cera Flava, mixing is crossed colloid mill 3 times, and preparation rubber is processed soft capsule by pressing, promptly gets.
The preparation of embodiment 6 soft capsules
Take by weighing each raw material by following weight: Radix Sanguisorbae 1800g, Fructus Evodiae 1200g, Rhizoma Atractylodis Macrocephalae 1000g, Rhizoma Cimicifugae 1000g, Rhizoma Coptidis 400g, Radix Angelicae Sinensis 800g, Radix Glycyrrhizae 600g, Herba Cistanches 800g, Radix Morindae Officinalis 600g;
After above each crude drug mixed, add 12 times of weight decoctings and boil 3 times, 2 hours for the first time, 1.5 hours for the second time, 1.5 hours for the third time, collecting decoction left standstill, and filtered; Filtrate decompression is concentrated into the clear paste that relative density is 1.17-1.19 (60 ℃), and spray drying was pulverized 120 mesh sieves, with soybean oil, and Cera Flava, mixing is crossed colloid mill 3 times, and preparation rubber is processed soft capsule by pressing, promptly gets.
The preparation of embodiment 7 soft capsules
Take by weighing each raw material by following weight: Radix Sanguisorbae 1300g, Fructus Evodiae 600g, Rhizoma Atractylodis Macrocephalae 500g, Rhizoma Cimicifugae 400g, Rhizoma Coptidis 100g, Radix Angelicae Sinensis 200g, Radix Glycyrrhizae 200g, Semen Platycladi 200g, Semen Lini 100g, Semen Persicae 100g, Semen Armeniacae Amarum 100g, Fructus Cannabis 100g, Semen Pruni 100g, Corm Eleocharitis 200;
After above each crude drug mixed, add 10 times of weight decoctings and boil 2 times, 2 hours for the first time, 1.5 hours for the second time, collecting decoction left standstill, and filtered; Filtrate decompression is concentrated into the clear paste that relative density is 1.17-1.19 (60 ℃), and spray drying was pulverized 120 mesh sieves, with soybean oil, and Cera Flava, mixing is crossed colloid mill 4 times, and preparation rubber is processed soft capsule by pressing, promptly gets.
The preparation of embodiment 8 soft capsules
Take by weighing each raw material by following weight: Radix Sanguisorbae 1800g, Fructus Evodiae 1200g, Rhizoma Atractylodis Macrocephalae 1000g, Rhizoma Cimicifugae 1000g, Rhizoma Coptidis 400g, Radix Angelicae Sinensis 800g, Radix Glycyrrhizae 600g, Semen Platycladi 600g, Semen Lini 400g, Semen Persicae 400g, Semen Armeniacae Amarum 400g, Fructus Cannabis 400g, Semen Pruni 400g, Corm Eleocharitis 500g;
After above each crude drug mixed, add 8 times of weight decoctings and boil 3 times, 2 hours for the first time, 1.5 hours for the second time, 1.5 hours for the third time, collecting decoction left standstill, and filtered; Filtrate decompression is concentrated into the clear paste that relative density is 1.17-1.19 (60 ℃), and spray drying was pulverized 120 mesh sieves, with soybean oil, and Cera Flava, mixing is crossed colloid mill 3 times, and preparation rubber is processed soft capsule by pressing, promptly gets.
The preparation of embodiment 9 soft capsules
Take by weighing each raw material by following weight: Radix Sanguisorbae 1300g, Fructus Evodiae 600g, Rhizoma Atractylodis Macrocephalae 500g, Rhizoma Cimicifugae 400g, Rhizoma Coptidis 100g, Radix Angelicae Sinensis 200g, Radix Glycyrrhizae 200g, Fructus Setariae Germinatus 300g, Fructus Hordei Germinatus 300g, Massa Medicata Fermentata 200g, Endothelium corneum 100g;
After above each crude drug mixed, add 10 times of weight decoctings and boil 2 times, 2 hours for the first time, 1.5 hours for the second time, collecting decoction left standstill, and filtered; Filtrate decompression is concentrated into the clear paste that relative density is 1.17-1.19 (60 ℃), and spray drying was pulverized 120 mesh sieves, with soybean oil, and Cera Flava, mixing is crossed colloid mill 4 times, and preparation rubber is processed soft capsule by pressing, promptly gets.
The preparation of embodiment 10 soft capsules
Take by weighing each raw material by following weight: Radix Sanguisorbae 1800g, Fructus Evodiae 1200g, Rhizoma Atractylodis Macrocephalae 1000g, Rhizoma Cimicifugae 1000g, Rhizoma Coptidis 400g, Radix Angelicae Sinensis 800g, Radix Glycyrrhizae 600g, Fructus Setariae Germinatus 800g, Fructus Hordei Germinatus 800g, Massa Medicata Fermentata 600g, Endothelium corneum 400g;
After above each crude drug mixed, add 8 times of weight decoctings and boil 3 times, 2 hours for the first time, 1.5 hours for the second time, 1.5 hours for the third time, collecting decoction left standstill, and filtered; Filtrate decompression is concentrated into the clear paste that relative density is 1.17-1.19 (60 ℃), and spray drying was pulverized 120 mesh sieves, with soybean oil, and Cera Flava, mixing is crossed colloid mill 3 times, and preparation rubber is processed soft capsule by pressing, promptly gets.
The preparation of embodiment 11 soft capsules
Take by weighing each raw material by following weight: Radix Sanguisorbae 1300g, Fructus Evodiae 600g, Rhizoma Atractylodis Macrocephalae 500g, Rhizoma Cimicifugae 400g, Rhizoma Coptidis 100g, Radix Angelicae Sinensis 200g, Radix Glycyrrhizae 200g, stir-fry Semen Raphani 200g, Cortex Magnoliae Officinalis 100g, Fructus Aurantii Immaturus 100g, Fructus Crataegi 200g;
After above each crude drug mixed, add 10 times of weight decoctings and boil 2 times, 2 hours for the first time, 1.5 hours for the second time, collecting decoction left standstill, and filtered; Filtrate decompression is concentrated into the clear paste that relative density is 1.17-1.19 (60 ℃), and spray drying was pulverized 120 mesh sieves, with soybean oil, and Cera Flava, mixing is crossed colloid mill 4 times, and preparation rubber is processed soft capsule by pressing, promptly gets.
The preparation of embodiment 12 soft capsules
Take by weighing each raw material by following weight: Radix Sanguisorbae 1800g, Fructus Evodiae 1200g, Rhizoma Atractylodis Macrocephalae 1000g, Rhizoma Cimicifugae 1000g, Rhizoma Coptidis 400g, Radix Angelicae Sinensis 800g, Radix Glycyrrhizae 600g, stir-fry Semen Raphani 700g, Cortex Magnoliae Officinalis 500g, Fructus Aurantii Immaturus 300g, Fructus Crataegi 700g;
After above each crude drug mixed, add 8 times of weight decoctings and boil 3 times, 2 hours for the first time, 1.5 hours for the second time, 1.5 hours for the third time, collecting decoction left standstill, and filtered; Filtrate decompression is concentrated into the clear paste that relative density is 1.17-1.19 (60 ℃), and spray drying was pulverized 120 mesh sieves, with soybean oil, and Cera Flava, mixing is crossed colloid mill 3 times, and preparation rubber is processed soft capsule by pressing, promptly gets.
The preparation of embodiment 13 granules
Take by weighing each raw material by following weight: Radix Sanguisorbae 1300g, Fructus Evodiae 800g, Rhizoma Atractylodis Macrocephalae 800g, Rhizoma Cimicifugae 400g, Rhizoma Coptidis 200g, Radix Angelicae Sinensis 400g, Radix Glycyrrhizae 400g;
After above each crude drug mixing, add 12 times of weight decoctings and boil 2 times, 2 hours for the first time, 1.5 hours for the second time, collecting decoction left standstill, and filtered; Filtrate decompression is concentrated into the clear paste that relative density is 1.17-1.19 (60 ℃), and spray drying was pulverized 120 mesh sieves, adds suitable excipient (like dextrin, starch, sucrose), granulation, dry, granulate, and granule is processed in packing, promptly gets.
The preparation of embodiment 14 tablets
Take by weighing each raw material by following weight: Radix Sanguisorbae 1500g, Fructus Evodiae 1000g, Rhizoma Atractylodis Macrocephalae 1000g, Rhizoma Cimicifugae 800g, Rhizoma Coptidis 400g, Radix Angelicae Sinensis 600g, Radix Glycyrrhizae 600g;
After each crude drug mixing, add 12 times of weight decoctings of water and boil 2 times, 2 hours for the first time, 1.5 hours for the second time, collecting decoction left standstill, and filtered; Filtrate decompression is concentrated into the clear paste that relative density is 1.17-1.19 (60 ℃), and spray drying was pulverized 120 mesh sieves, adds suitable excipient (like dextrin, starch, sucrose etc.), granulation, dry, granulate, and tabletting, coating are processed tablet, promptly get.
The preparation of embodiment 15 oral liquids
Take by weighing each raw material by following weight: Radix Sanguisorbae 1400g, Fructus Evodiae 900g, Rhizoma Atractylodis Macrocephalae 900g, Rhizoma Cimicifugae 600g, Rhizoma Coptidis 300g, Radix Angelicae Sinensis 500g, Radix Glycyrrhizae 500g;
After each crude drug mixing, add 12 times of weight decoctings and boil 2 times, 2 hours for the first time, 1.5 hours for the second time, collecting decoction left standstill, and filtered; Add ethanol in the filtrating and make and contain the alcohol amount and reach 70-80%, left standstill 24 hours, get supernatant, add syrup after, add water to 10000ml, filter, fill, sterilization promptly gets.
The clinical observation on the therapeutic effect test of Test Example 1 traditional Chinese medicine composition for treating constipation of the present invention
One, clinical data
Accept habitual constipation patient's 256 examples altogether for medical treatment, at 24～82 years old age, 52 years old mean age, be the out-patient; Wherein secret type constipation patient 46 examples of the deficiency of Yin, secret type constipation patient 54 examples of the deficiency of yang; Just dry type constipation patient 78 examples are received poor type constipation patient 42 examples, belly constipation patient 36 examples that expand;
Two, trial drug
Embodiment of the invention 1-15 drug prepared.
Three, Therapeutic Method
(1) the secret type 46 routine constipation patients of the deficiency of YIN are divided into 1 group of test and 2 groups of tests at random, every group of each 23 example are tested 1 group and are adopted the prepared soft capsule treatment of embodiment 1, test 2 groups and adopt the prepared soft capsules treatment of embodiment 3;
Oral, one time 2 (0.65g crude drug/grain), 3 times on the one, 15 days is a course of treatment, treats 3 courses of treatment altogether; Period in a medicine is withdrawn other related drugs and other treatment.
(2) the secret type 54 routine constipation patients of yang deficiency are divided into 3 groups of tests and 4 groups of tests at random, every group of each 27 example are tested 3 groups and are adopted the prepared soft capsules treatment of embodiment 2, test 4 groups and adopt the prepared soft capsules treatment of embodiment 5;
Oral, one time 2 (0.65g crude drug/grain), 3 times on the one, 15 days is a course of treatment, treats 3 courses of treatment altogether; Period in a medicine is withdrawn other related drugs and other treatment.
(3) the just dry constipation patient of 78 examples is divided into 5 groups of tests and 6 groups of tests at random, every group of each 39 example are tested 5 groups and are adopted the prepared soft capsule treatment of embodiment 1, test 6 groups and adopt the prepared soft capsules treatment of embodiment 7;
Oral, one time 2 (0.65g crude drug/grain), 3 times on the one, 15 days is a course of treatment, treats 3 courses of treatment altogether; Period in a medicine is withdrawn other related drugs and other treatment.
(4) 42 examples being received poor constipation patient is divided into 7 groups of tests and 8 groups of tests at random, and every group of each 21 example are tested 7 groups and adopted the prepared soft capsule treatment of embodiment 1, tests 8 groups and adopts the prepared soft capsules treatment of embodiment 9;
Oral, one time 2 (0.65g crude drug/grain), 3 times on the one, 15 days is a course of treatment, treats 3 courses of treatment altogether; Period in a medicine is withdrawn other related drugs and other treatment.
(5) the 36 routine abdominal paries constipation patient that expands is divided into 9 groups of tests and 10 groups of tests at random, every group of each 18 example are tested 9 groups and are adopted the prepared soft capsule treatment of embodiment 1, test 10 groups and adopt the prepared soft capsules treatment of embodiment 11;
Oral, one time 2 (0.65g crude drug/grain), 3 times on the one, 15 days is a course of treatment, treats 3 courses of treatment altogether; Period in a medicine is withdrawn other related drugs and other treatment.
Four, efficacy assessment standard
(1) recovery from illness: clinical symptom disappearance.
(2) produce effects: clinical symptoms obviously alleviates.
(3) effective: clinical symptoms takes a turn for the better to some extent.
(4) invalid: the clinical symptoms no change.
Five, clinical observation result
Observed result is seen table 1.
The clinical observation on the therapeutic effect result of the test of table 1 medicine composite for curing all kinds of the present invention constipation
Clinical observation on the therapeutic effect is the result show, Chinese medicine composition of the present invention has significant curative effect for various types of constipation; Safety observe to be found, does not observe any clinical adverse, show Chinese medicine composition clinical practice of the present invention safely, have no side effect.
Claims (10)
1. a Chinese medicine composition of treating constipation is characterized in that, is processed by each crude drug of following weight portion: Radix Sanguisorbae 13-18 part, Fructus Evodiae 6-12 part, Rhizoma Atractylodis Macrocephalae 5-10 part, Rhizoma Cimicifugae 4-10 part, Rhizoma Coptidis 1-4 part, Radix Angelicae Sinensis 2-8 part and Radix Glycyrrhizae 2-6 part.
2. according to the described Chinese medicine composition of claim 1, it is characterized in that the weight portion of each crude drug is: Radix Sanguisorbae 13-15 part, Fructus Evodiae 8-10 part, Rhizoma Atractylodis Macrocephalae 8-10 part, Rhizoma Cimicifugae 4-8 part, Rhizoma Coptidis 2-4 part, Radix Angelicae Sinensis 4-6 part, Radix Glycyrrhizae 4-6 part.
3. Chinese medicine composition of treating constipation; It is characterized in that, process by each crude drug of following weight portion: Radix Sanguisorbae 13-18 part, Fructus Evodiae 6-12 part, Rhizoma Atractylodis Macrocephalae 5-10 part, Rhizoma Cimicifugae 4-10 part, Rhizoma Coptidis 1-4 part, Radix Angelicae Sinensis 2-8 part, Radix Glycyrrhizae 2-6 part, Radix Rehmanniae 3-8 part, Radix Scrophulariae 1-4 part, Radix Ophiopogonis 2-8 part, Radix Et Rhizoma Rhei 2-5 part and Fructus Mori 3-8 part.
4. Chinese medicine composition of treating constipation; It is characterized in that, process: Radix Sanguisorbae 13-18 part, Fructus Evodiae 6-12 part, Rhizoma Atractylodis Macrocephalae 5-10 part, Rhizoma Cimicifugae 4-10 part, Rhizoma Coptidis 1-4 part, Radix Angelicae Sinensis 2-8 part, Radix Glycyrrhizae 2-6 part, Herba Cistanches 3-8 part and Radix Morindae Officinalis 2-6 part by each crude drug of following weight portion.
5. Chinese medicine composition of treating constipation; It is characterized in that, process: Radix Sanguisorbae 13-18 part, Fructus Evodiae 6-12 part, Rhizoma Atractylodis Macrocephalae 5-10 part, Rhizoma Cimicifugae 4-10 part, Rhizoma Coptidis 1-4 part, Radix Angelicae Sinensis 2-8 part, Radix Glycyrrhizae 2-6 part, Semen Platycladi 2-6 part, Semen Lini 1-4 part, Semen Persicae 1-4 part, Semen Armeniacae Amarum 1-4 part, Fructus Cannabis 1-4 part, Semen Pruni 1-4 part and Corm Eleocharitis 2-5 part by each crude drug of following weight portion.
6. Chinese medicine composition of treating constipation; It is characterized in that, process: Radix Sanguisorbae 13-18 part, Fructus Evodiae 6-12 part, Rhizoma Atractylodis Macrocephalae 5-10 part, Rhizoma Cimicifugae 4-10 part, Rhizoma Coptidis 1-4 part, Radix Angelicae Sinensis 2-8 part, Radix Glycyrrhizae 2-6 part, Fructus Setariae Germinatus 3-8 part, Fructus Hordei Germinatus 3-8 part, Massa Medicata Fermentata 2-6 part and Endothelium corneum 1-4 part by each crude drug of following weight portion.
7. Chinese medicine composition of treating constipation; It is characterized in that, process: Radix Sanguisorbae 13-18 part, Fructus Evodiae 6-12 part, Rhizoma Atractylodis Macrocephalae 5-10 part, Rhizoma Cimicifugae 4-10 part, Rhizoma Coptidis 1-4 part, Radix Angelicae Sinensis 2-8 part, Radix Glycyrrhizae 2-6 part, stir-fry Semen Raphani 2-7 part, Cortex Magnoliae Officinalis 1-5 part, Fructus Aurantii Immaturus 1-3 part and Fructus Crataegi 2-7 part by each crude drug of following weight portion.
8. method for preparing any one said Chinese medicine composition of claim 1-7, comprising: (1) takes by weighing each crude drug by said weight portion; (2) each crude drug is mixed the back decocte with water, decocting liquid leaves standstill, and filters; Filtrate decompression is condensed into clear paste, spray drying, and crushing screening adds pharmaceutical preparation adjuvant preparations shaping, promptly gets.
9. any one said Chinese medicine composition of claim 1-7 is treated the purposes in the constipation medicine in preparation.
10. according to the described purposes of claim 9, it is characterized in that: described constipation comprises habitual constipation.
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| CN102488759B (en) * | 2011-12-12 | 2013-03-13 | 张明生 | Medicine for curing senile habitual constipation |
| CN102697952B (en) * | 2012-06-15 | 2013-10-02 | 李良 | Polygonum multiflorum traditional Chinese medicine decoction for treating astriction and preparation method for decoction |
| CN103432504B (en) * | 2013-07-24 | 2015-05-20 | 江苏苏南药业实业有限公司 | Traditional Chinese medicine granules for treating children's constipation and preparation method thereof |
| CN105362558A (en) * | 2015-12-15 | 2016-03-02 | 王金国 | Herbal extract applied for treating constipation and preparation method of herbal extract |
| CN105998594A (en) * | 2016-06-27 | 2016-10-12 | 吕伟 | Medicine for treating habitual constipation |
| CN106038820A (en) * | 2016-06-30 | 2016-10-26 | 王季馨 | Edible and medicinal traditional Chinese medicine composition for improving functional constipation and preparation method thereof |
| CN106109799A (en) * | 2016-08-04 | 2016-11-16 | 太仓优活生物技术有限公司 | One moisturizes laxation Chinese herbal medicine |
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| CN101411808B (en) * | 2008-12-01 | 2010-12-22 | 戴桂兰 | Method for preparing Chinese medicine for treating heat intestine and stomach type constipation |
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