CN101910191B - 15,16-亚甲基-17-羟基-19-去甲-21-羧酸-甾体γ-内酯衍生物、其应用以及包含所述衍生物的药物产品 - Google Patents
15,16-亚甲基-17-羟基-19-去甲-21-羧酸-甾体γ-内酯衍生物、其应用以及包含所述衍生物的药物产品 Download PDFInfo
- Publication number
- CN101910191B CN101910191B CN2008801234324A CN200880123432A CN101910191B CN 101910191 B CN101910191 B CN 101910191B CN 2008801234324 A CN2008801234324 A CN 2008801234324A CN 200880123432 A CN200880123432 A CN 200880123432A CN 101910191 B CN101910191 B CN 101910191B
- Authority
- CN
- China
- Prior art keywords
- carboxylic acid
- beta
- ketone
- pregnant
- diene
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 0 CC(*C1C2(C*)CCC(C3CC4)C1C#CC3=CC4=O)[C@@]2(C=CC*)O Chemical compound CC(*C1C2(C*)CCC(C3CC4)C1C#CC3=CC4=O)[C@@]2(C=CC*)O 0.000 description 5
- QCVKSYPDNJRVMO-UHFFFAOYSA-N O=C1OC(C(C2)C2C2C3C(CC4)=C(CCC(O[RnH])=C5)C5=CC3)(C24C=[IH])C=C1 Chemical compound O=C1OC(C(C2)C2C2C3C(CC4)=C(CCC(O[RnH])=C5)C5=CC3)(C24C=[IH])C=C1 QCVKSYPDNJRVMO-UHFFFAOYSA-N 0.000 description 1
- WFGSORLYIXSGMS-UHFFFAOYSA-N O=C1OC(C2C3C2)(C(CI)(CCC2C4CC5)C3C2C=CC4=CC5=O)C=C1 Chemical compound O=C1OC(C2C3C2)(C(CI)(CCC2C4CC5)C3C2C=CC4=CC5=O)C=C1 WFGSORLYIXSGMS-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J53/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by condensation with a carbocyclic rings or by formation of an additional ring by means of a direct link between two ring carbon atoms, including carboxyclic rings fused to the cyclopenta(a)hydrophenanthrene skeleton are included in this class
- C07J53/002—Carbocyclic rings fused
- C07J53/004—3 membered carbocyclic rings
- C07J53/008—3 membered carbocyclic rings in position 15/16
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/18—Feminine contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/26—Androgens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/28—Antiandrogens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/30—Oestrogens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/32—Antioestrogens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/34—Gestagens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
- A61P5/42—Drugs for disorders of the endocrine system of the suprarenal hormones for decreasing, blocking or antagonising the activity of mineralocorticosteroids
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Endocrinology (AREA)
- Diabetes (AREA)
- Reproductive Health (AREA)
- Gynecology & Obstetrics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Cosmetics (AREA)
Abstract
Description
Claims (14)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE102007063501.1 | 2007-12-29 | ||
DE102007063501A DE102007063501A1 (de) | 2007-12-29 | 2007-12-29 | 15, 16-Methylen-17-hydroxy-19-nor-21-carbonsäure-Steroid y-Lacton-Derivat, dessen Verwendung und das Derivat enthaltende Arzneimittel |
PCT/EP2008/011162 WO2009083269A1 (de) | 2007-12-29 | 2008-12-23 | 15,16-METHYLEN-17-HYDROXY-19-NOR-21-CARBONSÄURE-STEROID γ-LACTON-DERIVAT, DESSEN VERWENDUNG UND DAS DERIVAT ENTHALTENDE ARZNEIMITTEL |
Publications (2)
Publication Number | Publication Date |
---|---|
CN101910191A CN101910191A (zh) | 2010-12-08 |
CN101910191B true CN101910191B (zh) | 2013-07-31 |
Family
ID=40627627
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN2008801234324A Expired - Fee Related CN101910191B (zh) | 2007-12-29 | 2008-12-23 | 15,16-亚甲基-17-羟基-19-去甲-21-羧酸-甾体γ-内酯衍生物、其应用以及包含所述衍生物的药物产品 |
Country Status (25)
Country | Link |
---|---|
US (1) | US20110015162A1 (zh) |
EP (1) | EP2238150B1 (zh) |
JP (1) | JP5643107B2 (zh) |
KR (1) | KR20100094999A (zh) |
CN (1) | CN101910191B (zh) |
AR (1) | AR069965A1 (zh) |
AU (1) | AU2008342913A1 (zh) |
BR (1) | BRPI0821432A2 (zh) |
CA (1) | CA2708394C (zh) |
CL (1) | CL2008003920A1 (zh) |
CO (1) | CO6300840A2 (zh) |
DE (1) | DE102007063501A1 (zh) |
DO (1) | DOP2010000200A (zh) |
EA (1) | EA201001006A1 (zh) |
EC (1) | ECSP10010319A (zh) |
ES (1) | ES2397972T3 (zh) |
HK (1) | HK1151801A1 (zh) |
IL (1) | IL205981A0 (zh) |
NZ (1) | NZ586452A (zh) |
PA (1) | PA8809901A1 (zh) |
PE (1) | PE20091186A1 (zh) |
TW (1) | TW200938206A (zh) |
UY (1) | UY31583A1 (zh) |
WO (1) | WO2009083269A1 (zh) |
ZA (1) | ZA201005394B (zh) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2012059594A1 (en) | 2010-11-04 | 2012-05-10 | Bayer Pharma Aktiengesellschaft | Mineralcorticoid receptor antagonists for the treatment of corticoid-induced obesity |
KR200497382Y1 (ko) | 2023-05-22 | 2023-10-25 | 주식회사밀알 | 마감판 체결이 용이한 침대 프레임 구조 |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4891365A (en) * | 1984-03-21 | 1990-01-02 | Schering Aktiengesellschaft | 17-Substituted estradienes and estratrienes |
WO2006072467A1 (de) * | 2004-12-30 | 2006-07-13 | Schering Aktiengesellschaft | 18-methyl-19-nor-17-pregn-4-en-21,17-carbolactone, sowie diese enthaltende pharmazeutische präparate |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2918463A (en) | 1958-06-12 | 1959-12-22 | Searle & Co | 17-carboxyalkylated 17-hydroxy-19-norandrosten-3-ones |
DE1183500B (de) | 1962-10-12 | 1964-12-17 | Schering Ag | Verfahren zur Herstellung von alpha, beta-Methylenketonen der Steroidreihe |
US3705179A (en) | 1971-03-15 | 1972-12-05 | American Home Prod | Antiandrogenic steroids |
NL7701384A (nl) | 1977-02-10 | 1978-08-14 | Akzo Nv | Werkwijze voor het bereiden van nieuwe steroiden van de oestraanreeks. |
DE2922500A1 (de) | 1979-05-31 | 1980-12-04 | Schering Ag | 6 beta .7 beta |
DE3402329A1 (de) | 1984-01-20 | 1985-08-01 | Schering AG, 1000 Berlin und 4709 Bergkamen | 6,6-ethylen-15,16-methylen-3-oxo-17(alpha)-pregn-4-en-21,17-carbolactone, verfahren zu deren herstellung und diese enthaltende pharmazeutische praeparate |
DE19651000A1 (de) | 1996-12-01 | 1998-06-04 | Schering Ag | Oxyiminopregnancarbolactone |
-
2007
- 2007-12-29 DE DE102007063501A patent/DE102007063501A1/de not_active Ceased
-
2008
- 2008-12-23 AU AU2008342913A patent/AU2008342913A1/en not_active Abandoned
- 2008-12-23 KR KR1020107014313A patent/KR20100094999A/ko not_active Application Discontinuation
- 2008-12-23 PA PA20088809901A patent/PA8809901A1/es unknown
- 2008-12-23 JP JP2010540080A patent/JP5643107B2/ja not_active Expired - Fee Related
- 2008-12-23 EP EP08868567A patent/EP2238150B1/de not_active Not-in-force
- 2008-12-23 TW TW097150289A patent/TW200938206A/zh unknown
- 2008-12-23 AR ARP080105702A patent/AR069965A1/es unknown
- 2008-12-23 NZ NZ586452A patent/NZ586452A/en not_active IP Right Cessation
- 2008-12-23 US US12/811,002 patent/US20110015162A1/en not_active Abandoned
- 2008-12-23 CN CN2008801234324A patent/CN101910191B/zh not_active Expired - Fee Related
- 2008-12-23 WO PCT/EP2008/011162 patent/WO2009083269A1/de active Application Filing
- 2008-12-23 ES ES08868567T patent/ES2397972T3/es active Active
- 2008-12-23 BR BRPI0821432-8A patent/BRPI0821432A2/pt not_active IP Right Cessation
- 2008-12-23 EA EA201001006A patent/EA201001006A1/ru unknown
- 2008-12-23 CA CA2708394A patent/CA2708394C/en not_active Expired - Fee Related
- 2008-12-26 UY UY31583A patent/UY31583A1/es not_active Application Discontinuation
- 2008-12-29 PE PE2008002192A patent/PE20091186A1/es not_active Application Discontinuation
- 2008-12-29 CL CL2008003920A patent/CL2008003920A1/es unknown
-
2010
- 2010-05-26 IL IL205981A patent/IL205981A0/en unknown
- 2010-06-29 CO CO10078683A patent/CO6300840A2/es not_active Application Discontinuation
- 2010-06-29 EC EC2010010319A patent/ECSP10010319A/es unknown
- 2010-06-29 DO DO2010000200A patent/DOP2010000200A/es unknown
- 2010-07-28 ZA ZA2010/05394A patent/ZA201005394B/en unknown
-
2011
- 2011-06-08 HK HK11105765.9A patent/HK1151801A1/xx not_active IP Right Cessation
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4891365A (en) * | 1984-03-21 | 1990-01-02 | Schering Aktiengesellschaft | 17-Substituted estradienes and estratrienes |
WO2006072467A1 (de) * | 2004-12-30 | 2006-07-13 | Schering Aktiengesellschaft | 18-methyl-19-nor-17-pregn-4-en-21,17-carbolactone, sowie diese enthaltende pharmazeutische präparate |
Non-Patent Citations (1)
Title |
---|
Klaus Nickisch et al..Aldosterone Antagonists. 4. Synthesis and Activities of Steroidal 6,6-Et hylene- 15,16-met hylene 17-Spirolactones.《J. Med. Chem.》.1991,第34卷(第8期),2464-2468. * |
Also Published As
Publication number | Publication date |
---|---|
ES2397972T3 (es) | 2013-03-12 |
CL2008003920A1 (es) | 2010-01-22 |
JP2011507926A (ja) | 2011-03-10 |
PA8809901A1 (es) | 2009-12-16 |
EA201001006A1 (ru) | 2011-02-28 |
HK1151801A1 (en) | 2012-02-10 |
BRPI0821432A2 (pt) | 2015-06-16 |
ZA201005394B (en) | 2014-01-29 |
US20110015162A1 (en) | 2011-01-20 |
KR20100094999A (ko) | 2010-08-27 |
CA2708394C (en) | 2015-06-16 |
DE102007063501A1 (de) | 2009-07-02 |
IL205981A0 (en) | 2010-11-30 |
TW200938206A (en) | 2009-09-16 |
NZ586452A (en) | 2012-04-27 |
EP2238150A1 (de) | 2010-10-13 |
UY31583A1 (es) | 2009-08-03 |
DOP2010000200A (es) | 2010-07-31 |
CO6300840A2 (es) | 2011-07-21 |
CA2708394A1 (en) | 2009-07-09 |
AR069965A1 (es) | 2010-03-03 |
EP2238150B1 (de) | 2012-10-24 |
CN101910191A (zh) | 2010-12-08 |
WO2009083269A1 (de) | 2009-07-09 |
JP5643107B2 (ja) | 2014-12-17 |
ECSP10010319A (es) | 2010-08-31 |
PE20091186A1 (es) | 2009-09-06 |
AU2008342913A1 (en) | 2009-07-09 |
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C56 | Change in the name or address of the patentee |
Owner name: BAYER PHARMA AG Free format text: FORMER NAME: SCHERING AG |
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Address after: Berlin Patentee after: BAYER PHARMA AG Address before: Berlin Patentee before: BAYER SCHERING PHARMA AG |
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Effective date of registration: 20130730 Address after: German Monheim Patentee after: BAYER INTELLECTUAL PROPERTY GmbH Address before: Berlin Patentee before: Bayer Pharma AG |
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