CN101910168B - 托烷化合物 - Google Patents
托烷化合物 Download PDFInfo
- Publication number
- CN101910168B CN101910168B CN200880122860.5A CN200880122860A CN101910168B CN 101910168 B CN101910168 B CN 101910168B CN 200880122860 A CN200880122860 A CN 200880122860A CN 101910168 B CN101910168 B CN 101910168B
- Authority
- CN
- China
- Prior art keywords
- amino
- bridge
- azabicyclo
- oct
- methyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 0 *C(CC1C23C1)CC2N3c(cc1)ncc1C(N)=O Chemical compound *C(CC1C23C1)CC2N3c(cc1)ncc1C(N)=O 0.000 description 19
- CDVMWTAGTIOTOR-UHFFFAOYSA-N Cc1c2[o]ccc2ccc1C(O)=O Chemical compound Cc1c2[o]ccc2ccc1C(O)=O CDVMWTAGTIOTOR-UHFFFAOYSA-N 0.000 description 2
- DIPOKNKRBVPHTA-UHFFFAOYSA-N Bc(cc1C(N)=O)c(C)cc1NCCC Chemical compound Bc(cc1C(N)=O)c(C)cc1NCCC DIPOKNKRBVPHTA-UHFFFAOYSA-N 0.000 description 1
- ARTSKENQKZVRQU-UHFFFAOYSA-N CC(C)(C)OC(NC(CC1CC2)CC2N1c(cc1)ncc1C(O)=O)=O Chemical compound CC(C)(C)OC(NC(CC1CC2)CC2N1c(cc1)ncc1C(O)=O)=O ARTSKENQKZVRQU-UHFFFAOYSA-N 0.000 description 1
- YWZGKSDIXLVLPQ-UHFFFAOYSA-N CC(C)C(C)Nc1cc(C(O)=O)ccc1C(N)=O Chemical compound CC(C)C(C)Nc1cc(C(O)=O)ccc1C(N)=O YWZGKSDIXLVLPQ-UHFFFAOYSA-N 0.000 description 1
- FSGHCFYJAFYQJH-UHFFFAOYSA-N CC(C1CC1)Nc(c(Cl)c(cc1)C(O)=O)c1C(N)=O Chemical compound CC(C1CC1)Nc(c(Cl)c(cc1)C(O)=O)c1C(N)=O FSGHCFYJAFYQJH-UHFFFAOYSA-N 0.000 description 1
- HUNANSGNFJZUFZ-UHFFFAOYSA-N CC(Nc1cc(C(O)=O)ccc1C(N)=O)=O Chemical compound CC(Nc1cc(C(O)=O)ccc1C(N)=O)=O HUNANSGNFJZUFZ-UHFFFAOYSA-N 0.000 description 1
- AXANILHPMDKJAD-UHFFFAOYSA-N CC(c(cc1)cnc1N(C(CC1)C2)C1C2N)=O Chemical compound CC(c(cc1)cnc1N(C(CC1)C2)C1C2N)=O AXANILHPMDKJAD-UHFFFAOYSA-N 0.000 description 1
- BSEJJGIQRPYMTF-UHFFFAOYSA-N CCC(CC)Nc(c(C([NH+]=[I-])=O)c1)cc(C(O)=O)c1F Chemical compound CCC(CC)Nc(c(C([NH+]=[I-])=O)c1)cc(C(O)=O)c1F BSEJJGIQRPYMTF-UHFFFAOYSA-N 0.000 description 1
- LKDNFZJQCLJKJH-UHFFFAOYSA-N CCCNc1cc(C(O)=O)c(C)cc1C(N)=O Chemical compound CCCNc1cc(C(O)=O)c(C)cc1C(N)=O LKDNFZJQCLJKJH-UHFFFAOYSA-N 0.000 description 1
- ACBBSXGOMIJTKZ-UHFFFAOYSA-N CCOC(NC=C)N(C(C1)C2)C1CC2N Chemical compound CCOC(NC=C)N(C(C1)C2)C1CC2N ACBBSXGOMIJTKZ-UHFFFAOYSA-N 0.000 description 1
- HLNZTFOUCOSCEN-UHFFFAOYSA-N CCOC(c(cc1)cnc1N(C(CC1)C2)C1CC2N)=O Chemical compound CCOC(c(cc1)cnc1N(C(CC1)C2)C1CC2N)=O HLNZTFOUCOSCEN-UHFFFAOYSA-N 0.000 description 1
- GWCIZIVZCVPVAY-ZCFIWIBFSA-N CC[C@@H](C)Nc1cc(C(O)=O)c(C(F)(F)F)cc1C(N)=O Chemical compound CC[C@@H](C)Nc1cc(C(O)=O)c(C(F)(F)F)cc1C(N)=O GWCIZIVZCVPVAY-ZCFIWIBFSA-N 0.000 description 1
- SBLXNKYXBHQRBT-SECBINFHSA-N CC[C@@H](C)Nc1cc(C(O)=O)c(CC)cc1C([NH+](C)[NH-])=O Chemical compound CC[C@@H](C)Nc1cc(C(O)=O)c(CC)cc1C([NH+](C)[NH-])=O SBLXNKYXBHQRBT-SECBINFHSA-N 0.000 description 1
- NVOBZOBFMIXVEZ-MRVPVSSYSA-N CC[C@@H](C)Nc1cc(C(O)=O)ccc1C(NC)=O Chemical compound CC[C@@H](C)Nc1cc(C(O)=O)ccc1C(NC)=O NVOBZOBFMIXVEZ-MRVPVSSYSA-N 0.000 description 1
- OYSGMQNCQROVAV-UHFFFAOYSA-N CN(C)CCOc1cc(Nc2cc(C(O)=O)ccc2C(N)=O)ccc1OC Chemical compound CN(C)CCOc1cc(Nc2cc(C(O)=O)ccc2C(N)=O)ccc1OC OYSGMQNCQROVAV-UHFFFAOYSA-N 0.000 description 1
- VGYLMOJQAHXYCK-UHFFFAOYSA-N CN1CNCC1 Chemical compound CN1CNCC1 VGYLMOJQAHXYCK-UHFFFAOYSA-N 0.000 description 1
- MOFSNGOPOQLJHA-NKPUCLBHSA-N C[C@@H](C1C=CC(N2CCN(C)CC2)=CC1)NC(c(cc1)cnc1N(C(C1)C2)C1C2NC(OC(C)(C)C)=O)=O Chemical compound C[C@@H](C1C=CC(N2CCN(C)CC2)=CC1)NC(c(cc1)cnc1N(C(C1)C2)C1C2NC(OC(C)(C)C)=O)=O MOFSNGOPOQLJHA-NKPUCLBHSA-N 0.000 description 1
- LGEPNRWKNPFLJQ-UHFFFAOYSA-N Cc(cc(cc1)C(N)=O)c1C(O)=O Chemical compound Cc(cc(cc1)C(N)=O)c1C(O)=O LGEPNRWKNPFLJQ-UHFFFAOYSA-N 0.000 description 1
- PBCOFAPBDVQUQZ-UHFFFAOYSA-N Cc1c2[o]ccc2ccc1C(NC(CC1CC2)CC2N1c(cc1)ncc1C(O)=O)=O Chemical compound Cc1c2[o]ccc2ccc1C(NC(CC1CC2)CC2N1c(cc1)ncc1C(O)=O)=O PBCOFAPBDVQUQZ-UHFFFAOYSA-N 0.000 description 1
- OVJWYQZAYRNOAO-UHFFFAOYSA-N Cc1c[o]c2c(C)c(C(NC(CC3CC4)C4N3c(cc3)ncc3C(N)=O)=O)ccc12 Chemical compound Cc1c[o]c2c(C)c(C(NC(CC3CC4)C4N3c(cc3)ncc3C(N)=O)=O)ccc12 OVJWYQZAYRNOAO-UHFFFAOYSA-N 0.000 description 1
- SBHJKGCZZULRSN-UHFFFAOYSA-N ICC(COC12)C1OCC21OCCO1 Chemical compound ICC(COC12)C1OCC21OCCO1 SBHJKGCZZULRSN-UHFFFAOYSA-N 0.000 description 1
- BXWSTEKVTTZMIC-UHFFFAOYSA-N NC(c(c(N1CCC1)c1)ccc1C(O)=O)=O Chemical compound NC(c(c(N1CCC1)c1)ccc1C(O)=O)=O BXWSTEKVTTZMIC-UHFFFAOYSA-N 0.000 description 1
- LDNDDJQPPUFINN-UHFFFAOYSA-O [NH3+]C(c1ccc(C(O)=O)c2c1[nH]cc2)=O Chemical compound [NH3+]C(c1ccc(C(O)=O)c2c1[nH]cc2)=O LDNDDJQPPUFINN-UHFFFAOYSA-O 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
-
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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-
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Virology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Immunology (AREA)
- Neurology (AREA)
- Molecular Biology (AREA)
- Rheumatology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Physical Education & Sports Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Biotechnology (AREA)
- Pulmonology (AREA)
- Dermatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Cardiology (AREA)
- Pain & Pain Management (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Reproductive Health (AREA)
- Endocrinology (AREA)
- Transplantation (AREA)
- Vascular Medicine (AREA)
- Diabetes (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US68707P | 2007-10-25 | 2007-10-25 | |
| US61/000,687 | 2007-10-25 | ||
| PCT/US2008/012221 WO2009055077A1 (en) | 2007-10-25 | 2008-10-27 | Tropane compounds |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN101910168A CN101910168A (zh) | 2010-12-08 |
| CN101910168B true CN101910168B (zh) | 2014-07-30 |
Family
ID=40287869
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN200880122860.5A Expired - Fee Related CN101910168B (zh) | 2007-10-25 | 2008-10-27 | 托烷化合物 |
Country Status (26)
| Country | Link |
|---|---|
| US (1) | US8012956B2 (enExample) |
| EP (1) | EP2074120B1 (enExample) |
| JP (2) | JP5476307B2 (enExample) |
| KR (1) | KR101578792B1 (enExample) |
| CN (1) | CN101910168B (enExample) |
| AT (1) | ATE459622T1 (enExample) |
| AU (1) | AU2008317262B2 (enExample) |
| BR (1) | BRPI0818893B8 (enExample) |
| CA (1) | CA2703477C (enExample) |
| CO (1) | CO6321232A2 (enExample) |
| CY (1) | CY1110648T1 (enExample) |
| DE (1) | DE602008000754D1 (enExample) |
| DK (1) | DK2074120T3 (enExample) |
| EA (1) | EA018999B1 (enExample) |
| ES (1) | ES2342348T3 (enExample) |
| HR (1) | HRP20100292T1 (enExample) |
| IL (1) | IL205202A0 (enExample) |
| MX (1) | MX2010004493A (enExample) |
| NZ (1) | NZ585137A (enExample) |
| PL (1) | PL2074120T3 (enExample) |
| PT (1) | PT2074120E (enExample) |
| RS (1) | RS51346B (enExample) |
| SG (1) | SG2012079653A (enExample) |
| SI (1) | SI2074120T1 (enExample) |
| WO (1) | WO2009055077A1 (enExample) |
| ZA (1) | ZA201002987B (enExample) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2231666B1 (en) * | 2007-12-12 | 2015-07-29 | Rigel Pharmaceuticals, Inc. | Carboxamide, sulfonamide and amine compounds for metabolic disorders |
| FR2949467B1 (fr) | 2009-09-03 | 2011-11-25 | Sanofi Aventis | Nouveaux derives de 5,6,7,8-tetrahydroindolizine inhibiteurs d'hsp90, compositions les contenant et utilisation |
| UY32940A (es) | 2009-10-27 | 2011-05-31 | Bayer Cropscience Ag | Amidas sustituidas con halogenoalquilo como insecticidas y acaricidas |
| AU2011236933A1 (en) | 2010-04-05 | 2013-05-02 | Shionogi & Co., Ltd. | Cephem compound having catechol group |
| EP2640366A2 (en) | 2010-11-15 | 2013-09-25 | Exelixis, Inc. | Benzoxazepines as inhibitors of pi3k/mtor and methods of their use and manufacture |
| EP2740474A1 (en) | 2012-12-05 | 2014-06-11 | Instituto Europeo di Oncologia S.r.l. | Cyclopropylamine derivatives useful as inhibitors of histone demethylases kdm1a |
| WO2014107718A2 (en) * | 2013-01-07 | 2014-07-10 | H. Lee Moffitt Cancer Center And Research Institute, Inc. | Heat shock protein (hsp) inhibition and monitoring effectiveness thereof |
| CA2921294C (en) | 2013-08-21 | 2023-05-16 | Alios Biopharma, Inc. | Antiviral compounds |
| MX2016006457A (es) * | 2013-11-18 | 2017-01-06 | Del Mar Pharmaceuticals | Analisis de cromatografia liquida de alto rendimiento (hplc) de impurezas en dianhidrogalactitol. |
| MX375102B (es) | 2014-05-30 | 2025-03-06 | Ieo St Europeo Di Oncologia S R L | Compuestos de ciclopropilamina como inhibidores de histona demetilasa |
| EP2949648A1 (en) | 2014-05-30 | 2015-12-02 | IEO - Istituto Europeo di Oncologia Srl | Cyclopropylamine derivatives as histone demethylase inhibitors |
| WO2016061253A1 (en) | 2014-10-14 | 2016-04-21 | Exelixis, Inc. | Drug combination to treat melanoma |
| EP3322450A1 (en) * | 2015-07-16 | 2018-05-23 | Akuru Pharma AB | Detection and treatment of renal cell carcinoma with a slc6a3 ligand linked to a label, cytotoxic or immunomodulatory group |
| WO2018155260A1 (ja) * | 2017-02-23 | 2018-08-30 | 株式会社Ihi | Ｏｈラジカル検出プローブ、ｏｈラジカル測定装置、および、ｏｈラジカル測定方法 |
| CN108164529B (zh) * | 2017-12-25 | 2020-04-24 | 三峡大学 | 一种小分子抑制剂sld9059及其在制药中的应用 |
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