CN101879297A - Prostate recovery capsules of Chinese medicinal compound preparation, preparation process and application thereof - Google Patents

Abstract

The invention relates to prostate recovery capsules of a Chinese medicinal compound preparation, a preparation process and application thereof. The prostate recovery capsules are prepared from the following raw materials: honeysuckle, raw rehmannia root, root of red-rooted salvia, epimedium brevicornum, hiraute shiny bugleweed herb, spreading hedyotis herb, mongolian dandelion herb, honey-fried pangolin scales, liquorice root, Chinese angelica, rhizoma anemarrhenae, white paeony root, red paeony root, cortex phellodendri, panax ginseng, common threewingnut root, philippine violet herb, Indian buead, Chinese wolfberry, cortex magnoliae officinalis, immature bitter orange, european verbena, longhairy antenoron herb, lalang grass rhizome, common lophatherum herb, cluster mallow fruit, radix curcumae, incised notopterygium rhizome and weeping forsythia. The preparation method comprises the following steps of: grinding the root of red-rooted salvia and the honey-fried pangolin scales into fine powder, decocting the medicaments except for the root of red-rooted salvia and the honey-fried pangolin scales in water twice, wherein the medicaments are decocted for 2 hours every time, merging decoction, and standing the decoction for 48 hours; and filtering the decoction, concentrating filter liquor until the density is between 1.23 and 1.27 (measuring at the temperature of 80 DEG C), adding the fine powder of the medicinal materials, mixing uniformly, drying, pulverizing and subpackaging to form 1,000 capsules, namely the prostate recovery capsules. The prostate recovery capsules of the Chinese medicinal compound preparation have the inhibitory effect on benign prostatic hyperplasia.

Description

Compound Chinese medicinal preparation prostate recovery capsules and preparation technology thereof and application

Technical field

The present invention relates to a kind of compound Chinese medicinal preparation and preparation technology thereof and application, particularly a kind of compound Chinese medicinal preparation prostate recovery capsules and preparation technology and application.

Background technology

At present, the Chinese medicine of traditional treatment chronic prostate mostly is the prescription that prescription handed down from one's ancestors among the people or hospital dispose voluntarily, is the Chinese medicine of the treatment chronic prostatitis of monarch drug but Flos Lonicerae, Radix Rehmanniae, Radix Salviae Miltiorrhizae are not arranged as yet.

Summary of the invention

The object of the present invention is to provide compound Chinese medicinal preparation prostate recovery capsules and preparation technology thereof and application, compound Chinese medicinal preparation prostate recovery capsules has the prostatitic effect of good curing in this.

Technical scheme of the present invention is as follows:

The compound Chinese medicinal preparation prostate recovery capsules, it is the compound Chinese medicinal preparation of being made by the following weight proportion raw material: Flos Lonicerae 171 grams, Radix Rehmanniae 171 grams, Radix Salviae Miltiorrhizae 171 grams, Herba Epimedii 114 grams, Herba Lycopi's 114 grams, Herba Hedyotidis Diffusae 114 grams, Herba Taraxaci 114 grams, stir-baked SQUAMA MANITIS 57 grams, Radix Glycyrrhizae 85 grams, Radix Angelicae Sinensis 57 grams, the Rhizoma Anemarrhenae 57 grams, the Radix Paeoniae Alba 57 grams, Radix Paeoniae Rubra 57 grams, Cortex Phellodendri 57 grams.Method for making: get Radix Salviae Miltiorrhizae, that stir-baked SQUAMA MANITIS is ground into powder is thin, all the other all medicines decoct with water secondary, and each 2 hours collecting decoctions left standstill 48 hours.Filter, it is 1.23-1.27 (80 degree are surveyed) that filtrate is concentrated into relative density, adds the thin mixing of above-mentioned medical material powder, and drying is pulverized, and is distributed into 1000 capsules, promptly.

The compound Chinese medicinal preparation prostate recovery capsules, it is the compound Chinese medicinal preparation of being made by the following weight proportion raw material: Flos Lonicerae 171 grams, Radix Rehmanniae 171 grams, Radix Salviae Miltiorrhizae 171 grams, Herba Epimedii 114 grams, Herba Lycopi's 114 grams, Herba Hedyotidis Diffusae 114 grams, Herba Taraxaci 114 grams, stir-baked SQUAMA MANITIS 57 grams, Radix Glycyrrhizae 85 grams, Radix Angelicae Sinensis 57 grams, the Rhizoma Anemarrhenae 57 grams, the Radix Paeoniae Alba 57 grams, Radix Paeoniae Rubra 57 grams, Cortex Phellodendri 57 grams, Radix Ginseng 57 grams, Radix Tripterygii Wilfordii 171 grams, Herba Violae 171 grams, Poria 114 grams, Fructus Lycii 114 grams, Cortex Magnoliae Officinalis 114 grams, Fructus Aurantii Immaturus 57 grams, Herba Verbenae 57 grams, Herba Lysimachiae 57 grams, Rhizoma Imperatae 57 grams, Herba Lophatheri 57 grams, Semen Abutili 57 grams, Radix Curcumae 57 grams, Rhizoma Et Radix Notopterygii 57 grams, Fructus Forsythiae 114 grams.Method for making: get Radix Salviae Miltiorrhizae, that stir-baked SQUAMA MANITIS is ground into powder is thin, all the other all medicines decoct with water secondary, and each 2 hours collecting decoctions left standstill 48 hours.Filter, it is 1.23-1.27 (80 degree are surveyed) that filtrate is concentrated into relative density, adds the thin mixing of above-mentioned medical material powder, and drying is pulverized, and is distributed into 1000 capsules, promptly.

Using method, consumption, the course of treatment: oral, one time 5,3 times on the one.One month is a course of treatment.

Clearing away heat-damp and promoting diuresis of the present invention, blood circulation promoting and blood stasis dispelling.Be used for diseases such as frequent micturition that prostatic hyperplasia and prostatitis cause, urgent micturition, dysurea, urine retention.Treatment frequent micturition, heat and pain in the penis, or not smooth not well, constipation with dry stool is exerted and is earned, and the urine yellow skin is turbid, weighs down pain between few abdomen and two the moon; Or urine amount is little, drop and go out the very then inaccessible obstructed disease of waiting.

Advantage of the present invention is: full side's compatibility is rigorous, medicine letter and imitate grandly, and medication is single-minded, drives straight on to prostate, and the antiinflammatory that gets rid of illness reduces prostatic hyperplasia, alleviates prostate pain, improves patients ' life quality.

Drug matching and the mechanism of curing the disease:

Compatibility: we are clinical experience side, and function clearing away heat-damp and promoting diuresis blood circulation promoting and blood stasis dispelling cures mainly diseases such as urgent micturition that prostatitis and prostatic hyperplasia cause, frequent micturition, dysurea, urine retention.Motherland's medical science does not have names of disease such as prostatitis adenitis, prostate hyperplasia.To belong to stranguria caused by overstrain, stranguria marked by chyluria, turbid urine, the difficulty in urination and sexual impotence category according to its clinical manifestation more.For the etiology and pathogenesis of disease, with pointing out for a long time for Chao Yuanfang (550-630 A.D.) " General Treatise on the Cause and Symptoms of Diseases ": " Zhu Linzhe, so bladder heat is also by suffering from a deficiency of the kidney." Yuan Dynasty Zhu Dan small stream " danxi's experiential therapy " also thinks: " pouring has five, all belongs to heat." " General Treatise on the Cause and Symptoms of Diseases " point out again: " so urinary obstruction all has heat also by bladder and kidney." generation of primary disease, how, lead to damp and hot by cloudy unclean, foul heresy down; Or have a liking for the hot delicious food of food, or have a liking for and spill too, make damp-heat flowing down to the urinary bladder; Or indulge in sensual pleasures excessively, intemperate sexual intercourse is ground the gas that is impairment of the kidney, instability of kidney-QI; Or body is weak always, the functioning of bladder event, and stagnant heat is long-pending for a long time, does not draw and drown.Based on above-mentioned, the primary disease pathogenesis mainly is the damp-heat accumulation part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels, or the internal resistance of stasis of blood poison, causes that functioning of bladder is unfavorable to form.

Treatment to primary disease should be with clearing away heat-damp and promoting diuresis, eliminating toxic substances to remove stasis for controlling.Reuse the Flos Lonicerae heat-clearing and toxic substances removing in the side, the Radix Salviae Miltiorrhizae blood circulation promoting and blood stasis dispelling, the Radix Rehmanniae heat clearing and blood cooling is monarch drug altogether.Herba Taraxaci, Herba Hedyotidis Diffusae principal drug assistance heat-clearing and toxic substances removing, dampness removing is treating stranguria; Herba Lycopi, Radix Paeoniae Rubra principal drug assistance clearing away heat-fire, YIN nourishing hold concurrently sharp damp-heat in lower-JIAO its for ministerial drug.In addition with Radix Angelicae Sinensis, Radix Paeoniae Alba blood-supplementing blood-nourishing, the Herba Epimedii enriching kidney essence, the roasted SQUAMA MANITIS into puffy with sand collateral dredging is invigorated blood circulation, and treating both the principal and secondary aspects of a disease is adjuvant drug.The Radix Glycyrrhizae coordinating the actions of various ingredients in a prescription is messenger drug.All medicines share, and play the merit of clearing away heat-damp and promoting diuresis, blood circulation promoting and blood stasis dispelling altogether.Can be used for treating frequent micturition, heat and pain in the penis, or not smooth not well, constipation with dry stool is exerted and is earned, and the urine yellow skin is turbid, weighs down pain between few abdomen and two the moon; Or urine amount is little, drop and go out the very then inaccessible obstructed disease of waiting.

Below be the introduction of part primary raw material:

1. Flos Lonicerae: the Flos Lonicerae chemical constituent mainly contains volatile oil, flavonoid, triterpenes and organic acid etc.Volatile oil is one of effective ingredient of Flos Lonicerae, isolates compositions such as linalool, Flos Lonicerae alcohol, Palmic acid, dihydro carveol, tetracosa carbon acid methyl ester, octadecadienoic ethyl ester, ethyl palmitate, 1,1 ' bicyclohexyl by gas chromatography mass spectrometry.Flavone compound mainly contain luteolin, xylostein, luteolin-7-O-alpha-D-glucose glycosides, luteolin-7-O-β-D-galactoside, Quercetin-3-O-β-D-glucoside, hyperin, corymbosin and 5-hydroxyl-3 ', 4 ', 7-trimethyl flavone.Chlorogenic acid chemical compound in the organic acid is the main effective ingredient of Flos Lonicerae, comprises chlorogenic acid and isochlorogenic acid, and wherein isochlorogenic acid is a mixture.Other organic acid also has caffeic acid and Palmic acid.In addition, Flos Lonicerae also contains triterpenes and 15 kinds of trace element ^[1]

The pharmacological action of Flos Lonicerae mainly is antibiotic, antiinflammation.The external bacteriostatic experiment of oral pathology pathogenic microorganism shows, the Flos Lonicerae aqueous extract to the Streptococcus mutans that causes gingival disease, radiate Bacillus adhaerens and cause the bacteroides melanogenicus of periodontal disease, gingivitis bacillus and half unwrapping wire haemophilus all show stronger bacteriostatic activity.Wherein its bacteriostasis rate is 87.5% under the 6.25mg/ml situation ^[2]With Flos Lonicerae extractive solution variable concentrations serotype distortion coccus is experimentized, the result shows that minimum inhibitory concentration accounts for 95.8% the following person of 25mg/ml, and minimum bactericidal concentration is generally apparently higher than Mlc ^[3]Experimental studies results such as analgesic, antiinflammatory, immunity show, Flos Lonicerae water decoction, oral liquid and injection on Carrageenan, triple vaccine pyrogenicity have antipyretic effect in various degree, edema due to Ovum Gallus domesticus album, carrageenin, the dimethylbenzene there is in various degree inhibitory action, can also obviously improve phagocytic percentage and the phagocytic index that Turnover of Mouse Peritoneal Macrophages is engulfed megalocyte in addition, thereby prove and clinically mainly realize by regulating body's immunity as the fever, detoxicating and treating infectious disease ^[4]In addition, Flos Lonicerae also has and protects the liver and anastalsis etc.

2. Radix Salviae Miltiorrhizae: Radix Salviae Miltiorrhizae contains diterpene quinones and phenolic constituent.The diterpene quinones is a fat-soluble compound, mainly contains tanshinone: TANSHINONES, TANSHINONES A, TANSHINONES-B, hydroxyl TANSHINONES-A, cryptotanshinone, saivianic acid A fat, iso tanshinone, iso tanshinone-A, different cryptotanshinone, miltirone etc.; Phenolic constituent is that water solublity mainly contains the derivant of catechu aldehyde, salviol, salviol, carnosol and catechol such as danshensu and so on etc.In recent years obtained 2 tanshinone compounds domestic the separation first from the dichloromethane extract of Radix Salviae Miltiorrhizae tissue culture: neotanshinone B R0-09-0680 ^[5]

Radix Salviae Miltiorrhizae Injection can make the decreased heart rate of Cavia porcellus and rabbit isolated heart, contractility that of short duration inhibition is arranged earlier, then strengthens gradually.Exsomatize and to look forward or upwards the experiment of bufonid toad cardiac perfusion and show that the low concentration liquid salvia can suppress myocardial contraction, reduce energy expenditure and injury of myocardium not.In the experiment of ligation left anterior descending branch tremulous pulse dog, quiet notes tanshinone sodium sulfonate accumulated dose 8mg/kg (dividing 4 times), the result does not have obvious influence to blood pressure, heart rate and myocardium keto consumption index, but damage has good action to left ventricular function.In the dirty perfusion of guinea-pig heart,, increase the weight of to suppress the heart contraction amplitude with concentration with sodium tanshinon IIA silate injection 0.5-20ug/ml perfusion 20min.Effect Radix Salviae Miltiorrhizae decoct, Radix Salviae Miltiorrhizae Injection, Salvia miltiorrhiza f. injection to blood vessel and blood pressure are given anesthetized dog or the quiet notes of rabbit, all the hypotensive effect of showed different.The tanshinone sodium sulfonate blood pressure then occurs and slightly raises.The pressure reduction effect of Radix Salviae Miltiorrhizae Injection can be blocked by atropine, but can not influence the effect of epinephrine or isoproterenol.To the influence of coronary flow, anesthetized dog or cat, quiet Radix Salviae Miltiorrhizae Injection 3-4g/kg, coronary flow obviously increases, and coronary resistance obviously descends, but myocardial oxygen consumption increases to some extent.To experimental acute myocardial infarction dog and cat, the coronary artery of exsomatize cat, pig, constant speed perfusion danshensu be coronary artery dilator obviously, coronary flow is significantly increased, and can resist the arteria coronaria effect that contracts of morphine, Propranolol (propranolol).And sodium tanshinon IIA silate injection, protocatechualdehyde etc. significantly shrink isolated coronary, and the different monomers chemical compound of prompting Radix Salviae Miltiorrhizae is not the same to effect coronarius.To the effect of myocardial ischemia and myocardial infarction, to rabbit or the Acute Myocardial Ischemia in Rats that the lobus posterior hypophyseos index rises, Radix Salviae Miltiorrhizae decoct, compound Salviae Miltiorrhizae (Radix Salviae Miltiorrhizae, Lignum Dalbergiae Odoriferae) injection, danshensu can improve or resist that it is cardiac electrical unusual.Give rats by intraperitoneal injection Radix Salviae Miltiorrhizae water extract, the acute myocardial ischemia that causes for the ligation coronary artery has tangible preventive effect, and left chamber myocardial ischemia area significantly dwindles ^[6]Radix Salviae Miltiorrhizae particularly has stronger antibacterial action to staphylococcus aureus to gram-positive cocci ^[7]Its antibiotic live part is the total tanshinone that extracts from root, and the cryptotanshinone effect is the strongest ^[8]Simultaneously, TANSHINONES has tangible anti-inflammatory effect.Capillary permeability due to the histamine increased the obvious suppression effect, and acute swollen joint due to Ovum Gallus domesticus album, carrageenin and the dextran and exudative formaldehyde peritonitis are had inhibitory action; Leukoplania and subacute formaldehyde swollen joint to white mice due to the gelatin have inhibitory action significantly; But to granuloma induced by implantation of cotton pellets experiment unrestraint effect ^[9]Radix Salviae Miltiorrhizae also has pharmacological actions such as blood fat reducing, atherosclerosis, anticoagulant, antithrombotic formation, anticoagulation, fibrinolysis enhancing ^[9]

3. Radix Glycyrrhizae: the main chemical compositions of Radix Glycyrrhizae is triterpenes and flavonoid, and triterpenes mainly contains glycyrrhizic acid, 24-hydroxyl enoxolone etc., and flavonoid mainly contains licoflavone, isoliquiritigenin, glycyrrhizin, isoliquiritigenin etc. ^[10-13]Antiinflammatory is the topmost pharmacological action of Radix Glycyrrhizae acids, reports such as Huang Nenghui ^[14]The monoammonium glycyrrhizinate intraperitoneal injection increases mice chemical auricle redness, abdominal cavity capillary permeability and to have remarkable inhibitory action, red, swollen, heat symptom-complex shape in the time of can obviously alleviating acute inflammatory response.Also have obvious inhibitory action to rat granuloma is swollen simultaneously, antiphlogistic effects and dexamethasone are approaching.Chen Jianxiong etc. ^[15]Observed the bacillary bronchitic preventive effect of monoammonium glycyrrhizinate salt pair Cavia porcellus, adopted intraperitoneal injection after G days, can obviously suppress the generation of guinea pig bronchial asthma, shown as the reduction of breathing heavily the bacterial endotoxin reaction, drawn the time of breathing heavily obviously to prolong drawing.The Radix Glycyrrhizae acids has the nonspecific immunity regulating action, and it mainly is to strengthen immunization of cell, can strengthen the M phagocytic function, eliminates the inhibition activity of inhibition M, also optionally strengthens lymphocytic multiplication capacity of complementary A and activity ^[16]Discover that in recent years glycyrrhizic acid energy inducing mouse hepatomicrosome oxidase makes its content and active increasing.Diao Yaying etc. ^[17]The research mice is to the metabolism self-induction effect of glycyrrhizic acid, and the relation of being somebody's turn to do effect and different way of administration.Experimental result shows that glycyrrhizic acid really can be induced himself metabolism, but the effect of being somebody's turn to do is relevant with the route of administration of glycyrrhizic acid, and glycyrrhizic acid is irritated stomach can produce the self-induction effect, and lumbar injection is invalid.Radix Glycyrrhizae has antivirus action, and the diammonium glycyrrhizinate pharmaceutically active is stronger, has stronger antiinflammatory, protects liver plasma membrane and improves the liver function effect, and multiple hepatotoxic agent is caused hepar damnification preventive and therapeutic effect, and dose dependent is arranged.Practice shows that the Serum ALT that diammonium glycyrrhizinate can obviously stop galactosamine, carbon tetrachloride etc. to cause increases, the also corresponding improvement of hepatic tissue infringement ^[18]To the chronic hepatic injury of mice that compound virulence factor causes, can obviously improve survival rate and improve liver function.Song Xinghong ^[19]Made glycyrrhizin treatment chronic viral hepatitis B observation of curative effect, shown that glycyrrhizin has tangible curative effect in indexs such as reducing ALT, hepatitis B virus.

4. Herba Taraxaci: contain taraxasterol, taraxerol, φ taraxasterol, β-Amyrin, stigmasterol, sitosterol, inulin, choline, p-hydroxyphenylaceticacid, caffeic acid, Palmic acid, cerinic acid, Melissic Acid, oleic acid, linoleic acid, linolenic acid, bitter principle P, bitter principle B, fructose and a small amount of volatile oil and bitter core enzyme composition in the Radix Taraxaci, containing luteolin-7-glucoside, 20 seed amino acids in Herba Taraxaci lactone glycoside, the lucky agate acid of Herba Taraxaci glycosides, the lucky agate acid of dihydro Herba Taraxaci glycosides, the Folium Taraxacum, is many with aspartic acid, glutamic acid content; Pigment has phylloxanthin, Kui dish flavin.Antibiotic, antifungal, antiviral 50% Herba Taraxaci decoct add culture medium, and making final concentration is 10%.With the flat band method test, the result all has certain inhibitory action to escherichia coli, bacillus pyocyaneus, staphylococcus, bacterium flexneri, Salmonella paratyphi, Candida albicans etc.; 100% Herba Taraxaci decoct paper disk method test has bacteriostasis to Bacillus typhi, anti-gastric injury, and the Herba Taraxaci decoct all has in various degree protective effect to gastric mucosa injury model due to stress in rats method, pylorus ligature law stomach anabrosis disease model and the dehydrated alcohol.Herba Taraxaci water logging bubble is for tea-drinking, and the patient has therapeutical effect to gastric ulcer, and campylobacter pyloridis is turned out cloudy, the ulcer surface healing, and pain stops ^[20,21]

5. Radix Angelicae Sinensis: the Radix Angelicae Sinensis main chemical compositions is a volatile oil, mainly in its phenol oil contains carvacrol, also contains phenol, and neighbour-cresols is right-cresols, guaiacol, 2, the 3-xylenol ,-ethylphenol, 4-ethyl resorcin, 2,4-resacetophenone, isoeugenol, vanillin; The main ligustilide etc. that contains in the neutral oil; Also contain organic acid, coumarin, aminoacid etc., the organic acid composition is mainly ferulic acid, isolates positive tetradecyl alchohol again from root, Palmic acid, new angelica lactone, ligustilide, vanillic acid, ferulic acid, 6-methoxyl group-7-hydroxycoumarin, nicotinic acid, succinic acid, cupreol, daucosterol, adenine, uracil, sucrose, glucose, fructose.Also contain lysine, arginine, threonine, tyrosine, proline, glycine, alanine, cystine, proline, leucine, isoleucine, tryptophan ^[22]Modern study proves, Radix Angelicae Sinensis has the effect that promotes phagocytic function, antiallergic action, enhancing human body immunity function and hemopoietic function, and ferulic acid in the Radix Angelicae Sinensis and Radix Angelicae Sinensis polysaccharide can obviously promote mononuclear phagocyte that the Cl and the enhancing peritoneal macrophage of Congo red are engulfed erythrocytic ability ^[23,24]In addition, ferulic acid all has inhibitory action to I, II, III, type ^[25], Radix Angelicae Sinensis polysaccharide can prevent that the mice peripheral blood cells that prednisone causes from reducing ^[23]With stimulation megakaryoblast propagation ^[26]Radix Angelicae Sinensis neutral oil total acid has the human body immunity improving function too, promotes the humoral immunization effect ^[23,27]

6. the Rhizoma Anemarrhenae: Rhizoma Anemarrhenae master contains Saponin, it is respectively zhimusaponin A-I, the A-II, the A-III, the A-IV, B-I and B-II, zhimusaponin E, nonacosanol, the octacosane acid blend, cupreol, daucosterol, chinaroot greenbrier sapogenin, markogenin, zhimusaponin A III, zhimusaponin B I, zhimusaponin B III, 2,6,4 ' one trihydroxy-4-methoxyl group benzoyl ketone, precious leaves of pulse plants glycoside I, icariine-I, Mengiferin, new Mengiferin (7-O-β-D-glucosyl group Mengiferin), 7-O-glucosyl group Mengiferin, timobiose, timosaponin-B, timosaponin-B, timosaponin-B, the three kinds of materials in back are through hydrolysis, and resulting aglycon is Sarsasapogenin entirely.External influenza first-III type virus test shows: chinaroot greenbrier sapogenin, markogenin, zhimusaponin A and Mengiferin have strong active ^[28]

The long-term oral synthetic and degraded that promotes the brain m receptor simultaneously of Rhizoma Anemarrhenae water extract, to add fastoperation stronger to synthetic, and its mechanism that improves brain m receptor density when old and feeble is mainly in the generation that promotes acceptor molecule, thereby corrects the loss of equilibrium that generates and reduce.Results of study such as Fan Shi show ^[29], zhimusaponin unit (ZMS) can make the m receptor density of the former rat neurocyte of being commissioned to train foster of cultivating 9～15 days raise, but it is caused to be not that ZMS directly acts on the m receptor binding site, but because ZMS can promote the generation of m receptor.Xu Shi etc. ^[30]Studies show that, male SD rat rises during 19～20 monthly ages and add a certain amount of ZMS that extracts in feedstuff from the Rhizoma Anemarrhenae, test with the isometric Y type of three arms labyrinth during to 23～24 monthly ages, its learning and memory ability does not add the parallel control senile rat of ZMS in the feedstuff.The Rhizoma Anemarrhenae also has Accommodation to old rats cardiac muscle m receptor ^[31]Rhizoma Anemarrhenae water extract and total polysaccharides can significantly suppress the mice caused by dimethylbenzene xylene auricle edema and acetic acid causes the abdominal cavity capillary permeability, and the inhibitory action of Rhizoma Anemarrhenae water extract has dose dependent ^[32]In addition, the Rhizoma Anemarrhenae reduces the effect of hypoxic pulmonary hypertension in addition ^[33], the prevention of asthma similar outbreak to adrenal gland's glucocorticoid effect ^[34], the myocardium I/R of protection damage effect ^[35]Deng.

7. the Radix Paeoniae Alba: the Radix Paeoniae Alba contains paeoniflorin, oxypaeoniflorin, benzoylpaeoniflorin, the lucky ketone of Radix Paeoniae, hydroxypaeoniflorin etc., and wherein peoniflorin is main effective ingredient, has pharmacological actions such as analgesia, antiinflammatory ^[22]Radix Paeoniae Alba water decoction has obvious facilitation to macrophage function.Water decoction raised to the mice stomach 3-5 days continuously, and the phagocytic percentage and the phagocytic index of Turnover of Mouse Peritoneal Macrophages all are significantly improved than matched group ^[36-39]Radix Paeoniae Alba water decoction pair cell immunologic function has certain regulating action.But Radix Paeoniae Alba decocting liquid antagonism cyclophosphamide makes it to recover normal level to the lymphocytic inhibitory action of peripheral blood T, shows that the Radix Paeoniae Alba can make the cellular immune function that is in low state recover normal ^[40-44]Peoniflorin has tangible antiinflammatory action, and Radix Paeoniae Alba decocting liquid causes mice auricle swelling, acetic acid induced mice abdominal cavity inflammation and capillary permeability to Oleum Tiglii all the obvious suppression effect ^[45-47]Radix Paeoniae Alba decoct has bacteriostasis to dysentery bacterium in vitro.Radix Paeoniae Alba preserved material also has inhibitory action to some pathogenic fungus, and to pyococcus, gastrointestinal pathogen and conditioned pathogen as escherichia coli, bacillus pyocyaneus, Streptococcus viridans etc., all have antibacterial action in various degree.The Radix Paeoniae Alba has that antibacterial action is strong, the characteristics of has a broad antifungal spectrum ^[37,47]In addition, the Radix Paeoniae Alba also has pharmacological actions such as calmness, coronary dilating.

8. Herba Epimedii: Herba Epimedii mainly contains the flavone compound that isopentene group replaces, and based on epimedium flavone glycosides and epimedium flavone time glycosides, except that flavones ingredient, lignan's class, phenolic glycoside class, ionone class, sesquiterpenoids, phenethyl alcohol glycosides etc. is arranged still ^[48]In recent years, people also separate from this platymiscium first and have obtained daucosterol, P-hydroxybenzoic acid, 2,4-resorcylic acid, isoliquiritigenin, glycyrrhizin, astragaloside, kaempferide, 2-hydroxyl-3,4,6,7 tetramethoxies-9,10-dihydro phenanthrene, luteolin, emodin and 3-hydroxy-2-methyl-pyrone ^[49-51]Deng.

Herba Epimedii is as kidney invigorating and YANG supporting Chinese medicine commonly used, and pharmacological research finds that icariin can make mouse epididymis and seminal vesicle weightening finish, points out this may be relevant with the yang invigorating functions of Herba Epimedii.Experiment in vitro shows that icariin can obviously promote rat Interstitial cell TS basal secretion, and this provides experimental basis for the treatment that Herba Epimedii is used for the low male infertility of TS level ^[52]Herba Epimedii improves significantly to " yang deficiency syndrome " due to the glucocorticoid, and it is very fast that every index is recovered.The level of " insufficiency of kidney-YANG " model testosterone and estradiol all obviously reduces due to examining with the results suggest hydrogen of measured by radioimmunoassay sex hormone level, and Herba Epimedii can improve the infringement of buck gonad, improve the content of testosterone, estradiol level increases to some extent, but not remarkable to the level of luteinizing hormone reduction, the prompting Herba Epimedii has facilitation to the function of hypophysis gonad system ^[53]Icariin (30～1000 μ g.L ^-1) follicular cell secretion estradiol there is direct stimulation, at high dose (1000 μ g.L very ^-1) time also promote adrenal cortical cell secretion corticosterone.The reinforcing the kidney and supporting YANG anti-aging effects of prompting Herba Epimedii directly stimulates the target gland secreting hormone relevant with it ^[54]Aging course is the combined process of a complexity, and its mechanism is many-sided.As influence passage, and prolong trophophase, regulate immunity and excretory system, improve organism metabolism and each organ dysfunction.Herba Epimedii total flavones can recover the function of galactose aging model mice T and bone-marrow-derived lymphocyte breeder reaction, obviously improves mouse spleen SOD activity, reduces conscience and organizes lipid peroxide to form, and the lipofuscin that reduces tissues such as conscience forms.The epimedium brevicornum polysaccharide multiphasic liposomes can obviously improve SOD in aged animal blood and the tissue, and the activity of GSHPx, and can obviously reduce the content of LPO in aged animal serum and the hepatic tissue makes that lipofuscin content reduces in the aged mouse cardiac muscle.Show that this medical instrument has antioxidation, delaying senility function ^[55]Epimedium brevicornum polysaccharide and total flavones complex can improve monoamine neurotransmitter level in the aged male rat hypothalamus, improve old rats, learning and memory of little mouse behavior, suppress activity of cholinesterase in aged mouse brain and the whole blood.Illustrate that senile variation has tangible retarding action to Herba Epimedii to naturally-aged animal hypothalamus neurotransmitter ^[56]Most index reflection Herba Epimedii have the anti-ageing life-prolonging effect.Epimedium brevicornum polysaccharide has the effect of immunostimulation sample, can cause thymus again and dwindle.It promotes thymus to discharge mature cell is that it causes one of mechanism that thymus dwindles, and also is the important mechanisms of its enhancing body cellular immune function ^[57]Icariin can significantly promote spleen lymphocyte proliferation in the inductive mice body of canavaline, can significantly promote mouse spleen lymphocyte to produce colony stimulating factor sample activity simultaneously under ConA induces, and the prompting icariin can raise immunity ^[58]In addition, can also work in coordination with PHA and induce the almond mononuclear cell to produce interleukin II, 3,6, and be dose-dependence, the prompting icariin has the biological respinse regulating action ^[59]

9. Radix Rehmanniae: the chemical constituent of the Radix Rehmanniae is mainly iridoid glycosides, cupreol, mannitol etc., and wherein iridoid glycosides has 23 kinds of catalpol, dihydro catalpol, aucubin, monomelittosides etc.The traditional Chinese medical science thinks that Radix Rehmanniae has the effect of nourishing YIN and clearing away heat, cooling blood for hemostasis, and modern pharmacology confirms: Radix Rehmanniae has the effect of tangible immunological enhancement and protection body's immunity ^[60,61]Radix Rehmanniae water decoction and pure preserved material 10g/kg gavage every day, continuous 5 days, rat experiment formaldehyde arthritis is had significant detumescence effect, and the test tube experiment shows that Radix Rehmanniae water logging agent has inhibitory action to multiple fungi growth such as trichophyton mentagrophytes, Gypsum Fibrosum sample microspore tinea bacterium and ulotrichy microspore tinea bacterium ^[62]

10. Radix Paeoniae Rubra: mainly contain in the Radix Paeoniae Rubra peoniflorin and peonin, paeonol and lactone glucoside of Radix Paeoniae, oxypaeoniflorin, benzoylpaeoniflorin, lacdtlorin, the lucky ketone of Radix Paeoniae and (Z)-(1S, 5R)-nopinene-1-O is for β-common vetch glucosides etc.Other contains tannins such as benzoic acid, catechin, gallic acid, progallin A ^[63]In addition, also contain volatile oil.Peoniflorin is the main effective ingredient of Radix Paeoniae Rubra.Pharmacological research proves that Radix Paeoniae Rubra has antiinflammatory, anti-allergic effects, and oral aqueous extract can suppress mice by floating the bursting of the sufficient sole of the foot that carrageenin causes, also can suppress the acetic acid twisting reaction.This effect is that Radix Paeoniae compatibility Radix Glycyrrhizae has stronger synergism.Also also have report can suppress the mouse peritoneal mastocyte and impel histamine's release action by compound 48/80.Oral aqueous extract can suppress the dermoreaction that mouse ear contacts bitter chlorine.Suppress passive cutaneous anaphylaxis, PCA and the rat assist agent arthritis effect of arteries and veins Mus ^[64]Peoniflorin and with Radix Glycyrrhizae FM ₁₀₀Also be significant analgesia and synergic antalgic effect; For the flat flesh of intestinal, peoniflorin all has significant spasmolytic effect ^[65]The rat stress ulcer peoniflorin there is obvious preventive and therapeutic effect, peoniflorin and Radix Glycyrrhizae FM ₁₀₀The collaborative gastric secretion effect that suppresses is arranged when share ^[66]In addition, Radix Paeoniae Rubra also has certain antiplatelet aggregation ^[67], blood sugar lowering ^[68]Reach effects such as arteriosclerosis ^[69,70]

11. Squama Manis: aminoacid is the main component of Squama Manis, account for more than 60%, 17 kinds of aspartic acid, threonine, serine, glutamic acid, sweet nitronic acid, third nitronic acid, cystine, valine, methionine, leucine, isoleucine, tyrosine, phenylalanine, histidine, lysine, arginine, proline etc. are wherein arranged.Still contain organic/inorganic substance zinc (Zn), copper (Cu), manganese (Mn), cobalt (Co), ferrum (Fe), aluminum (Mo), plumbous (Pb), potassium (K), magnesium (Mg), calcium (Ca), nickel (Ni), cadmium (Cd), boron (B), titanium (Ti), chromium (Cr), silicon (Si), phosphorus (P), vanadium (V) etc.Wherein the content with potassium (K) is the highest.And in the micro elements needed by human with zinc (Zn) content for the highest.In addition, also contain volatile oil, water-soluble alkaloid, stearic acid, cholesterol, two tridecanoyl butane, L-silk-L cheese ring dipeptides and D-silk-L-cheese ring dipeptides, also having two carbon numbers in addition is 26 and 29 aliphatic amide ^[71]

Squama Manis is an activating blood and removing stasis drug commonly used simply, and modern age, pharmacological research showed, the effect that it has blood viscosity lowering and prolongs clotting time.Irritate stomach with Squama Manis sheet decocting liquid and equivalent normal saline respectively to rat, rechallenge behind the 1h, inject sodium pentobarbital anesthesia then, the Mus tail is got blood relatively slide clotting time, blood capillary clotting time and blood capillary height, and the result shows that Squama Manis can significantly reduce rat blood viscosity and prolong clotting time.Respectively with Squama Manis sheet decocting liquid and equivalent normal saline gastric infusion, 3d posterior orbit venous plexus is got blood to mice, measures with the blood capillary method, and the result shows the effect that Squama Manis sheet decocting liquid also has blood viscosity lowering and prolongs clotting time mice.Irritate stomach with the normal saline of Squama Manis alcohol extract, water extract and equivalent respectively to mice, after 1 week mice left side ear positive and negative is coated with Oleum Tiglii, make its inflammation swelling, behind the 4h mice is put to death, cut two ears rapidly, calculate the difference and the swelling percentage rate of two ear weight.Experimental result shows that Squama Manis alcohol extract, water extract all have the effect of the mice ear inflammation that obvious anti-Oleum Tiglii causes ^[72]Compound recipe Squama Manis oral liquid clinical treatment male chronic prostatitis is evident in efficacy.Pharmacological research shows, mice ear degree due to compound recipe Squama Manis oral liquid (Squama Manis, Fructus Schisandrae Chinensis, Fructus Lycii, Poria, the Rhizoma Alismatis etc.) xylol and the reaction of the active chronic inflammation of rat Oleum Terebinthinae air bag granulation hyperplasia all have the obvious suppression effect, show that it has certain antiinflammatory action, the analgesic experiment of hot plate method and writhing method shows that also it has certain analgesic activity ^[73]With the compound recipe Squama Manis castrated rats is carried out the tonifying YANG experiment, the result shows that compound recipe Squama Manis 100mg/kg, 200mg/kg, 400mg/kg can obviously improve the organ index of castrated rats genitals such as prostate, seminal vesicle etc., and can shorten the incubation period of electricity irritation castrated rats erection ^[74]In addition, L-silk in the Squama Manis sheet-L-cheese ring dipeptides and D-silk-L-cheese ring dipeptides can improve the tolerance of mice normobaric hypoxia ^[75]

12. Herba Lycopi: herb contains volatile oil, glycoside, tannin and resin, also contains flavonoid glycoside, phenols, aminoacid, organic acid, Saponin, glucose, galactose, Herba Lycopi's sugar, sucrose, Raffinose, stachyose, fructose.Lacceric acid, cupreol, belulinic acid Betulinic acid, ursolic acid.Identify 51 compositions from lycopus lucidus volatile oil, wherein the high-load composition is myrcene, humulene, transcaryophyllene, cymol, V-terpinene, australene, nopinene ^[76]

Experimental result shows that Herba Lycopi's water decoction was irritated stomach 3 in continuous 7 days, and 9g/kg obviously prolongs clotting time of mice, and experiment in vitro 2.0,6.0,18.0mg/ml obviously suppress the rabbit platelet aggregation.Irritated stomach 3 in continuous 7 days, 9g/kg obviously alleviates rat arteriovenous thrombus weight, single is irritated stomach 15g/kg and can obviously be prolonged the multiple calcium clotting time of plasma in rabbit, prothrombin time, wash in a pan native partial thromboplastin time and thrombin time, rising blood plasma antithrombase (AT) activity in vain; But rabbit blood plasma fibrinogen content and euglobulin lysis time are not had obvious influence, vasomotoricity is not had remarkable effect.Thereby prompting Herba Lycopi function of promoting blood circulation to disperse blood clots mechanism may be with anticoagulant, act on endogenous and exogenous cruor pathway, Trombin inhibiting forms, improves AT activity, relevant to the effect of antithrombase ^[77]Herba Lycopi's alcohol extraction position, water are proposed the research that experimentizes of position, alcohol extracting-water precipitating position (L.F02) and L.F04 position, and the three all has the effect that reduces the whole blood apparent viscosity in various degree behind the result, wherein imitates best with L.F04 ^[78]Show that through further result of study L.F040.408,0.204g/kg all have significant inhibition to the obvious increase of platelet maximum agglutination rate in the inductive body of dextran model group rat ADP, and be dose-dependence; Compare with matched group, blood stasis model rats in vitro thrombosis quality obviously increases, and length only has increase trend, and the L.F04 high and low dose all has anti-thrombosis function, and the L.F04 high dose is particularly evident to alleviating of thrombosis dry mass, wet quality; The L.F04 high and low dose all has the obvious suppression effect to experimental arteriovenous shut thrombosis, and suppression ratio is respectively 27.41%, 27.14%.Thereby prompting Herba Lycopi L.F04 is anticoagulant and the inside and outside thrombosis of body significantly ^[79]The mouse writhing reaction that Herba Lycopi's Dichlorodiphenyl Acetate causes has significant inhibitory effect, the back pain in foot Herba Lycopi that hot plate is caused has obvious effect, spontaneous activity to mice has significant inhibitory effect, and the Herba Lycopi has weak facilitation to the liver cell regeneration of partially hepatectomized mice; And the Herba Lycopi has the antalgic and sedative effect of dose dependent ground, and dose,optimum is 5.0g/kg-10.0g/kg ^[80]The Herba Lycopi has hepatic cholagogic in addition ^[81], blood fat reducing ^[82]Deng pharmacological action.

13. Cortex Phellodendri: Cortex Phellodendri contains berberine, and contain a small amount of phellodendrine, magnoflorine, jateorhizine, palmatine, draw together building alkali in vain, Caulis menispermi is appointed alkali; Other contains obakulactone, obacunone.Cortex Phellodendri water decoction or pure preserved material are external all to have in various degree bacteriostasis to golden yellow, white and Staphylococcus citreus, Hemolytic streptococcus, streptococcus pneumoniae, anthrax bacillus etc., wherein the strongest to the staphylococcus inhibitory action.Cortex Phellodendri has certain antipyretic effect.The heating that infected by microbes is caused is eliminated the cause of disease causes bringing down a fever except that having antibacterial action, and the refrigeration function that also has with itself is relevant on the other hand.Contained berberine has tangible diarrhea and antiinflammatory action.Can suppress the increased capillary permeability that acetic acid or histamine cause, suppress dimethylbenzene and cause the swelling of mice auricle.Its antiinflammatory action strengthens with dosage.Cortex Phellodendri extracting solution basic species lumbar injection to anesthetized cat, dog, rabbit or anesthetized rat not, all has hypotensive effect.Berberine in a small amount can be excited myocardium, strengthens its contractility, has positive inotropic action, and effect takes place very fast.To heart failure animal and the low dose of quiet Xiao Bai alkali of patient, myocardial contraction is strengthened.Pharmacological actions such as Cortex Phellodendri also has blood sugar lowering, antitussive, eliminates the phlegm, antiplatelet aggregation ^[83]Berberine is one of main effective ingredient, and berberine is the quaternary ammonium type alkaloid, and dissolubility is big in water ^[84]

14. Herba Hedyotidis Diffusae: contain sterols, triterpenes and iridoid glycosides, wherein sterols has cupreol, cupreol-D-glycoside, clionasterol, stigmasterol; Triterpenes has maloic acid, oleanolic acid, the sub-ketone of Chinese lime, arborinol etc.; Iridoid glycosides have 6-O-right-coumaric acyl paederoside methyl ester, 6-O-be to methoxyl group cinnamyl paederoside methyl ester, 6-O-Resina Ferulae acyl paederoside methyl ester, Asperula orientalis glucoside etc.Still the 2-methyl-3-hydroxyanthraquinone, the 2-methyl-3-methoxyl group anthraquinone and 4 that contain the anthraquinone class in addition, 4 '-dimethoxy truxillic acid, 5-hydroxy tryptamine, oleanolic acid, P-coumaric acid, hentriacontane, tetramethylputrescine, polypeptide class, elements such as Fe, Mn, Al, Si, Ca, Ti ^[85]Experiment in vitro shows that this product has strong inhibitory action to acute lymphoblastic type, granulocyte type, monocyte type and chronic granulocyte type tumor cell; External have faint inhibitory action to staphylococcus aureus, dysentery bacterium; Its decoct can stimulate normal and artificial appendicitis rabbit reticuloendothelial system hypertrophy, and strengthens its leukocyte vigor of engulfing in vivo and in vitro, thus the performance antiinflammatory action ^[86]This product can promote ConA and LPS to the breeder reaction of mouse boosting cell, increases the specific antibody secretory cell number of mouse boosting cell to sheep red blood cell (SRBC), strengthens delayed hypersensitivity and T lymphocyte activity ^[87]This product can also promote radiation damage mouse boosting cell secretion interleukin-II, and this may be that it promotes one of T, B cell function Restoration Mechanism ^[88]

15 Radix Ginsengs are medicinal plants world-famous.Contain sp act matter such as panoxadiol's class, ginsenoside, panaxatriol's class, ginsenoside's oleanolic acid, ginsenoside's phenol maltol, has the hormonal effect of the secretion of promotion adrenal cortex, resistance to psychentonia is increased Strong, is promoted the anabolic effect of DNA, and can be increased erythrocyte.Leukocytic quantity.

16 Radix Tripterygii Wilfordiis, Celastraceae tripterygium plant Radix Tripterygii Wilfordii is used as medicine with root, leaf, flower and fruit.Root is adopted autumn; Leaf is adopted summer; Flower, fruit Xia Qiucai.Contain multiple alkaloid such as wilfordine, wilfordine, diterpenoid-lactone, triptonide and dulcitol etc.Have and dispel the wind, detoxifcation, parasite killing.The external treating rheumatic arthritis, skin is itched, and kills maggot, wriggler, water-snail eradication, effects such as malicious Mus.Pharmacological research proof wilfordine, wilfordine and diterpenoid-lactone, dulcitol all have tangible anti-tumor activity, and to mouse leukemia 1210, P388 and human nasopharyngeal carcinoma all have inhibitory action.

The fungus that 17 Poria belong to for the Polyporaceae transverse hole fungus, former plant is called Poria, 93% of dry product, be that to have 3 one (1-6) Glucopyranose. be (1-3) of side chain, its property is flat, the glucose polysaccharide. also have pachymaran in addition, the xylan sweet in the mouth is gone into the heart, lung, kidney, warp, pharmacological evaluation shows that Poria has the eliminating dampness by diuresis diuresis, one pachyman (one), pachyman, stomach function regulating spleen invigorating, mind tranquilizing and the heart calming, antibacterial, the effect .. of enhancing body resistance against diseases and blood sugar lowering is used for the edema oliguria, the phlegm retention vertigo and palpitation, insufficiency of the spleen lack of appetite, have loose bowels in the loose stool, irritability, diseases such as palpitation with fear insomnia.

It is very high that 18 Fructus Lycii contain abundant lycium barbarum polysaccharide, fat, protein, free amino acid, taurine, betanin, vitamin B1, B2, E, C, particularly carotenoid content.In addition, also contain a large amount of mineral elements, as potassium, sodium, calcium, magnesium, ferrum, copper, manganese, zinc, selenium etc.The research department makes eluant by DEAE-cellulose and Sephadex gel column chromatography and sodium chloride and separate four fraction such as obtaining needle-shaped crystals LBP-I, LBP-IIL BP-III and LBP-IV from the Fructus Lycii crude polysaccharides, wherein functional factor LBP-X fraction has hypoglycemic effect to diabetes, Fructus Lycii and functional factor LBPs are influential to blood fat reducing, lycium barbarum polysaccharide is the factor with antifatigue effect, slow down aging.Pharmacological evaluation shows that lycium barbarum polysaccharide can induce people's acute promyelocytic leukemia HL-60 apoptosis.Thereby reach resisting oxygen lack and regulate the immunity of organism activity.

19 Herba Violaes are bitter, hot, cold, nontoxic; GUIXIN, Liver Channel.Function cures mainly: can be used as medicine its mildly bitter flavor cold in nature, heat-clearing and toxic substances removing, removing heat from blood detumescence.

20 Cortex Magnoliae Officinalis, hardship, suffering, temperature.Return spleen, stomach, lung, large intestine channel.Function cures mainly: the dampness expectorant, the therapeutic method to keep the adverse QI flowing downwards is removed full.

21 Fructus Aurantii Immaturuss, former plant and medical material Fructus Aurantii Immaturus, Chinese medicine name.Be the dry young fruit of rutaceae Citrus aurantium Linn. and variety or Fructus Citri sinensis, main product in Sichuan, ground such as Jiangxi, Fujian, Jiangsu.Plucking between 5～June or gather from the fruit that falls, is two halves from the middle part crosscut, dries or cold drying, and the smaller directly dries or cold drying.Time spent is clean, vexed, shave, drying.Give birth to and use or parched with bran usefulness.. " medicine justice ": " Fructus Aurantii Immaturus is specially let out excess of the stomach, convinces hard knot by patient analysis, thus the main middle part of gastric cavity to control blood system, it is full to treat the interventral reality of umbilicus, the expectorant addiction is dispelled and is cut off the water, and by dyspepsia, breaks blocked-up chest, relieving constipation is closed, non-this can not be also.If skin pruritus, because of hematocele stagnate in, can not nutrition flesh table, if diet do not think, can not fortune because of spleen pent-up, all get power that its hot hardship of loosing rushes down also.

22 Herba Verbenae, hardship, cold.Return liver, spleen channel.Function cures mainly: promoting blood circulation to remove blood stasis, preventing the attack (or recurrence) of malaria, detoxifcation, inducing diuresis to remove edema.Be used for lump in the abdomen, amenorrhea dysmenorrhea, malaria, sore throat, carbuncle, edema, pyretic stranguria.

23 Herba Lysimachiaes, sweet in the mouth, little hardship, cool in nature.Return liver, gallbladder, kidney, urinary bladder channel.Effect cures mainly: relieving stranguria by diuresis; Heat-clearing and toxic substances removing; Dissipating blood stasis for subsidence of swelling.Cure mainly liver and gall and urinary system calculus;

24 Rhizoma Imperataes are grass perennial herb Herba Imperatae (formal name used at school: rhizome Imperata cylindrica).Two seasons of spring and autumn excavate.Dry.Remove fibrous root and membranous sheath, cutting is given birth to and is used or parch to black usefulness.Another name: Rhizoma Imperatae, manage, eat root, blue root.Cure mainly: cooling blood for hemostasis, heat-clearing and toxic substances removing.

25 Herba Lophatheris, cold, sweet in the mouth, light.Function cures mainly: clearing heat and relieving fidgetness, diuresis.Be used for calentura excessive thirst, hot urination pouring pain, aphtha of the mouth and tongue.

26 Semen Abutilis, sweet, cold, function cures mainly: control constipation and anuresis, gonorrhea, edema, women's galactozemia, breast swell and pain.

27 Radix Curcumaes, hot, bitter, cold.Return liver, the heart, lung meridian.Function cures mainly: regulating qi to disperse stagnation, heart fire-clearing upset-relieving, promoting the function of the gallbladder to alleviate jaundice.Be used for the amenorrhea dysmenorrhea, chest and abdomen swelling and pain, twinge, the calentura coma, epilepsy is gone mad, the jaundice dark coloured urine.

28 Rhizoma Et Radix Notopterygiis, hot, bitter, temperature.Return bladder, kidney channel.Function cures mainly: cold expelling, dispel the wind dehumidifying, pain relieving.Be used for the anemofrigid cold headache, rheumatic arthralgia, aching pain in should and back.

29 Fructus Forsythiaes, Chinese medicine bitter in the mouth, cold nature.Heat-clearing and toxic substances removing, mass dissipating and swelling eliminating.The mongolian medicine bitter in the mouth, cool in nature." association's day " clearly, antidiarrheal.Function cures mainly: Chinese medicine is controlled calentura from the beginning of, anemopyretic cold, and heating is vexed, laryngopharynx swelling and pain, macule, erysipelas, scrofula, carbuncle pyogenic infections from tumour or sore, acute nephritis, pyretic stranguria.The mongolian medicine subcutaneous ulcer of harnessing the Yellow River, intestinal twinge, " association day " disease, intestinal heat.

The specific embodiment

Embodiment 1, the compound Chinese medicinal preparation prostate recovery capsules, it is the compound Chinese medicinal preparation of being made by the following weight proportion raw material: Flos Lonicerae 171 grams, Radix Rehmanniae 171 grams, Radix Salviae Miltiorrhizae 171 grams, Herba Epimedii 114 grams, Herba Lycopi's 114 grams, Herba Hedyotidis Diffusae 114 grams, Herba Taraxaci 114 grams, stir-baked SQUAMA MANITIS 57 grams, Radix Glycyrrhizae 85 grams, Radix Angelicae Sinensis 57 grams, the Rhizoma Anemarrhenae 57 grams, the Radix Paeoniae Alba 57 grams, Radix Paeoniae Rubra 57 grams, Cortex Phellodendri 57 grams, Radix Ginseng 57 grams, Radix Tripterygii Wilfordii 171 grams, Herba Violae 171 grams, Poria 114 grams, Fructus Lycii 114 grams, Cortex Magnoliae Officinalis 114 grams, Fructus Aurantii Immaturus 57 grams, Herba Verbenae 57 grams, Herba Lysimachiae 57 grams, Rhizoma Imperatae 57 grams, Herba Lophatheri 57 grams, Semen Abutili 57 grams, Radix Curcumae 57 grams, Rhizoma Et Radix Notopterygii 57 grams, Fructus Forsythiae 114 grams.Method for making: get Radix Salviae Miltiorrhizae, that stir-baked SQUAMA MANITIS is ground into powder is thin, all the other all medicines decoct with water secondary, and each 2 hours collecting decoctions left standstill 48 hours.Filter, it is 1.23-1.27 (80 degree are surveyed) that filtrate is concentrated into relative density, adds the thin mixing of above-mentioned medical material powder, and drying is pulverized, and is distributed into 1000 capsules, promptly.

Get this capsule and do following pharmacodynamics test research:

By the preparation that Flos Lonicerae, Radix Salviae Miltiorrhizae, stir-baked SQUAMA MANITIS etc. are made, be the chief physician of Nanchang City hospital of andrology clinical practice evident in efficacy through proved recipe, clinical use for many years confirms that this product has curative effect preferably to prostatitis and prostatic hyperplasia.This experiment is observed its inhibitory action to experimental rat and mice prostatic hyperplasia and inflammation by prostatic hyperplasia and inflammatory model, has observed the analgesia and the antibacterial action of this product simultaneously.

1 experiment material:

1.1 animal

The Wistar rat: male, body weight 280～320g, by animal housing of Jiangxi Medical College supply, the quality certification number: 021-9602.

The KM mice: male, body weight 20～24g, by Jiangxi College of Traditional Chinese Medicine animal housing supply, the quality certification number: 021-9601.

The pathogenic bacterium pearl: staphylococcus aureus, recently from clinical separation.

1.2 medicine and reagent:

Capsule: provide by the attached Nanchang City of Nanchang City Medical House andrology hospital preparation chamber, specification 0.45g/ grain, lot number: 980112 compound methods: get the prostate recovery capsules powder and add 0.5% carboxymethylcellulose sodium solution, be mixed with 24%, 12% and 7.5%, 3.75% solution for standby.

QIANLIEKANG PIAN: produce lot number: 970852 by pharmaceutical Co. Ltd of Zhejiang Kang Enbei group.Compound method: get QIANLIEKANG PIAN and add 0.5% carboxymethylcellulose sodium solution, be mixed with 12% and 3.8% solution for standby.

Androlin: produce lot number: 970402 by Shanghai the 9th pharmaceutical factory.

Hydrocortisone: produce lot number: 951103 by Hualian Pharmaceutical Co., Shanghai.

5-hydroxy tryptamine (5-HT): Switzerland's import packing

2 test methods and result:

2.1 prostate recovery capsules is to the inhibitory action of prostatic hyperplasia

Test objective: by the inhibitory action of experimental observation prostate recovery capsules to prostatic hyperplasia model rat and mice.

2.1.1 influence to the rat experiment prostatic hyperplasia

Get 50 of male and healthy rats, body weight 296.7 ± 18.34g respectively to rat ip 1% pentobarbital sodium normal saline solution, behind the rat anesthesia, extracts bilateral testes under the sterile working.After one week, take out 10 castrated rats at random, weigh earlier, then sacrificed by decapitation, getting each leaf of prostate weighs and surveys cumulative volume, the oven dry back claims dry weight, divides equally four groups at random, 10 every group to remaining 40 rats, equal sc androlin 1mg/300g body weight, once a day, continuous 30 days, blank simultaneously group ig was with the distilled water of volume; Other each groups are the medicine of the variant concentration of ig (low dose group 0.6g/kg, high dose group 1.2g/kg, QIANLIEKANG PIAN group 0.6g/kg) respectively, capacity is 0.5ml/kg, continuous 30 days (to weigh weekly during the administration once to adjust dosage), in next day with all rats back sacrificed by decapitation of weighing.Get each leaf of prostate, claim weight in wet base with weight 1mg balance, volumetric method is surveyed prostate volume, gets a gauge head leaf and claims weight in wet base and claim dry weight after 37 ℃ of oven dry, does dried/weight in wet base ratio measurement.Get the frontal lobe prostate and be fixed in routine paraffin wax flaking in 10% formalin solution, the HE microscopy.Other gets rat blood serum, measures corresponding hormonal readiness with putting the method for exempting from.The results are shown in Table 1, table 2, table 3, table 4, table 5, table 6, table 7.

The prostatic volume of castrated rats, weight in wet base and dried weight in wet base ratio before table 1 is treated (X ± S)

Table 2 prostate recovery capsules is to the influence of castrated rats prostate volume (X ± S)

Annotate: compare with the blank group ^*P＜0.05 ^*P＜0.01 time with

Table 3 prostate recovery capsules is to the influence of castrated rats prostate weight in wet base (X ± S)

Table 4 prostate recovery capsules is to the influence of castrated rats prostate one gauge head leaf dry weight (X ± S)

Table 5 prostate recovery capsules is done/influence of weight in wet base ratio (X ± S) the castrated rats prostate

Table 6 prostate recovery capsules is to the influence (%) of castrated rats prostate volume and weight in wet base rate of change (X ± S)

Annotate: rate of change=(volume or weight in wet base-administration front volume or weight in wet base after the administration)/administration front volume or weight in wet base

Table 7 prostate recovery capsules is to the endocrine influence of castrated rats gonad (X ± S)

Result of the test shows that prostate recovery capsules has the obvious suppression effect to castrated rats prostatic hyperplasia due to the androlin, simultaneously can obviously alleviate prostate weight in wet base and dry weight, reduce prostate volume, reduce the testosterone levels of rat, improve the estradiol level of rat.

2.1.2 influence to the mouse experiment prostatic hyperplasia

(1) preventive effect: get 50 of male and healthy mices, body weight 22～28g divides equally 5 groups: blank group, NS group, prostate recovery capsules big (1.88g/kg), little (1.88g/kg) dosage group and QIANLIEKANG PIAN (1.88g/kg) group at random.Large and small dosage of prostate recovery capsules and QIANLIEKANG PIAN group be the medicine of each corresponding variable concentrations of ig respectively, and the administration capacity is 0.25ml/10g, capacity NS such as blank group, NS group difference ig, continuous 21 days.Except that the blank group, all the other each groups are scTP5mg/kg simultaneously, 1 time/d.In the 21st day sacrificed by decapitation mice, get prostate and weigh, calculate the prostate index.The results are shown in Table 8.

Table 8 prostate recovery capsules is to the preventive effect of mice prostatic hyperplasia (X ± S)

Annotate: compare △ p＜0.05 △ △ p＜0.01 with the blank group; Compare with the NS group ^*P＜0.05 ^*P＜0.01.Down together.

(2) therapeutical effect: get 55 of male and healthy mices, body weight 22～28g does the normal control group except that getting 10 at random, and all the other respectively organize mice scTp5mg/kg, and 1 time/d, continuous 21 days.

From the modeling mice, extract 5 after 21 days and put to death simultaneously, cut open the real prostate of probatio inspectionem pecuoarem hypertrophy, confirm the modeling success with normal control group mice.To remain mice and divide equally 4 groups at random: blank group, prostate recovery capsules big (1.88g/kg), little (1.88g/kg) dosage group and QIANLIEKANG PIAN (1.88g/kg) group.Large and small dosage of prostate recovery capsules and QIANLIEKANG PIAN group be the medicine of each corresponding variable concentrations of ig respectively, and the administration capacity is 0.25ml/10g, capacity NS such as blank group, NS group difference ig, continuous 21 days.After the last administration, put to death whole mices in 1 hour, get prostate and weigh, and calculate the prostate index.The results are shown in Table 9.

Table 9 prostate recovery capsules is to the therapeutical effect of mice prostatic hyperplasia (X ± S)

Result of the test shows: prostate recovery capsules has tangible prevention and therapeutical effect to prostatic hyperplasia due to the androlin.

2.2 antiinflammatory action

Test objective: the inhibitory action of observing rat paw edema due to prostate recovery capsules xylol induced mice auricle edema, the 5-HT by experiment.

2.2.1 the influence of xylol induced mice auricle edema

Get 40 of male mices, divide equally 4 groups at random:: blank group, prostate recovery capsules big (1.88g/kg), little (0.94g/kg) dosage group and QIANLIEKANG PIAN (1.88g/kg) group.Large and small dosage of prostate recovery capsules and QIANLIEKANG PIAN group etc. are the medicine of each corresponding variable concentrations of ig respectively, capacity NS such as blank group ig, and successive administration twice, be 4 hours blanking time.45min evenly was coated with the dimethylbenzene with 20ul in each in ear outside, a Mus left side after the administration, put to death mice after 15 minutes, took off the auricle at ears symmetry place with diameter 8mm card punch and weighed, and represented the swelling degree with left and right sides auricle weight difference, obtained inhibitory rate of intumesce, the results are shown in Table 10.

The every capsule of table 10 prostate health is to the influence of auricle edema due to the mice dimethylbenzene (X ± S)

Result of the test shows: prostate recovery capsules xylol induced mice auricle edema has the obvious suppression effect.

2.2.2 influence to rat paw edema due to the 5-HT

Get 32 of male rats, divide equally 4 groups at random:: blank group, prostate recovery capsules big (1.2g/kg), little (0.6g/kg) dosage group and QIANLIEKANG PIAN (0.6g/kg) group.Large and small dosage of prostate recovery capsules and QIANLIEKANG PIAN group etc. are the medicine of each corresponding variable concentrations of ig respectively, capacity NS such as blank group ig, and continuous use 7 days, 30min after the last administration, the right back vola sc5-HT0.1ml of every Mus (20ug) causes inflammation.With miking cause scorching before and cause scorching back vola thickness, the results are shown in Table 11.

Table 11 prostate recovery capsules is to the influence of rat paw edema due to the 5-HT (X ± S)

Result of the test shows: the prostate recovery capsules high dose group has the obvious suppression effect to rat paw edema due to the 5-HT.

2.3 analgesic activity

Experiment purpose: observe the inhibitory action of prostate recovery capsules by experiment to hot plate and lumbar injection acetic acid induced mice pain.

2.3.1 influence to hot plate induced mice pain reaction

Get some of female mices, put into and place 55 ± 0.5 ℃ of beakers in the water-bath, licking metapedes with mice is the pain indicator reaction, choose greater than 10s, less than 20s, 40 of the mices of stable reaction are divided equally 4 groups: blank group, prostate recovery capsules big (1.88g/kg), little (0.94g/kg) dosage group and QIANLIEKANG PIAN (1.88g/kg) group at random., large and small dosage of prostate recovery capsules and QIANLIEKANG PIAN group be the medicine of each corresponding variable concentrations of ig respectively, capacity NS such as blank group ig.0.5h, 1h, 1.5h, 2h, 3h, 4h survey the threshold of pain twice respectively after the administration, get average, and the painless reaction of 60s the results are shown in Table 12 by 60s.

Table 12 prostate recovery capsules is to the influence of hot plate induced mice pain reaction (X ± S)

2.3.2 influence to lumbar injection acetic acid induced mice writhing response

Get 40 of mices, male and female half and half are divided equally 4 groups: blank group, prostate recovery capsules big (1.88g/kg), little (0.94g/kg) dosage group and QIANLIEKANG PIAN (1.88g/kg) group at random.Large and small dosage of prostate recovery capsules and QIANLIEKANG PIAN group be the medicine of each corresponding variable concentrations of ig respectively, capacity NS such as blank group ig.1h after the administration, each Mus is lumbar injection 0.6% glacial acetic acid 0.1ml/10g respectively, and first, second and third interior each Mus of 10min turned round the body number of times behind the record injection algogen, the results are shown in Table 13.

Table 13 prostate recovery capsules is to the influence of lumbar injection acetic acid induced mice pain reaction (X ± S)

Result of the test shows: prostate recovery capsules has an obvious suppression effect to hot plate and lumbar injection acetic acid are pain caused.

2.4 antibacterial tests in the body

Experiment purpose: observe the protective effect of prostate recovery capsules by experiment to infection of staphylococcus aureus.

Preparation bacterium liquid: clinical isolating staphylococcus aureus is inoculated in the Carnis Bovis seu Bubali cream soup culture medium recently, cultivates 18 hours in 37 ℃ of incubators, and it is 10 that this culture fluid is diluted with 10 times of orders successively with normal saline ^-1, 10 ^-2, 10 ^-310 ^-8Deng the bacterium liquid of variable concentrations, promptly to add 1ml bacterium liquid be 10 to the 9ml physiological saline solution ^-1, the rest may be inferred, and the bacterium liquid 1ml that draws the good variable concentrations of dilution again is put in sterilization respectively in vitro, adding 5g/dl gastric Mucin liquid again (takes by weighing gastric Mucin 5g, is put in the mortar, add a small amount of normal saline and grind, with adding water, add to 100ml with mill at last, got final product in 10 minutes in 68.95Kpa pressurization sterilization.Facing the time spent and adjust its pH value to 7.0) promptly to make concentration be 10 to 9ml ^-2, 10 ^-3, 10 ^-410 ^-9Antibacterial liquid standby.

Preliminary experiment: get 24 of mices at random, with the staphylococcus aureus suspension of variable concentrations ip respectively, 3 of every concentration groups, every 0.5ml observes the death condition in the animal 48 hours.As a result, bacterium liquid reaches 10 ^-3During concentration, mice is all dead, and bacterium liquid reaches 10 ^-4Shi Youyi is only survived.So infection concentration when selecting this concentration to be formal the experiment.

Formal test: get 50 of mices, divide equally 5 groups at random, 10 every group, male and female half and half, wherein blank is one group, in addition four groups of prostate recovery capsules groups that are respectively variant concentration.Every mice ip staphylococcus aureus gastric Mucin suspension 0.5ml infection respectively, after infecting the previous day (the upper and lower noon respectively once) and infection, reach 6 hours difference ig administration at once, blank group ig distilled water wherein, all the other each groups are the medicinal liquid of each corresponding concentration of ig respectively, and the administration capacity is 0.4ml/10g.The dosage ratio is 1: 0.7 between group, and maximum dose level is 2.74g/kg, and lowest dose level is the dose,equivalent 0.94g/kg of clinical consumption.Observe to infect response situation and death toll in the back mice 7 days.Survival mice after 3 days hair color, diet, feces, blood circulation, respiratory system recover normal gradually.The results are shown in Table 14.

Table 14 prostate recovery capsules is to the influence of infection of staphylococcus aureus

Result of the test shows that prostate recovery capsules has the certain protection effect to the infection of staphylococcus aureus mice.

Embodiment 2, compound Chinese medicinal preparation prostate recovery capsules, it is the compound Chinese medicinal preparation of being made by the following weight proportion raw material: Flos Lonicerae 171 grams, Radix Rehmanniae 171 grams, Radix Salviae Miltiorrhizae 171 grams, Herba Epimedii 114 grams, Herba Lycopi's 114 grams, Herba Hedyotidis Diffusae 114 grams, Herba Taraxaci 114 grams, stir-baked SQUAMA MANITIS 57 grams, Radix Glycyrrhizae 85 grams, Radix Angelicae Sinensis 57 grams, the Rhizoma Anemarrhenae 57 grams, the Radix Paeoniae Alba 57 grams, Radix Paeoniae Rubra 57 grams, Cortex Phellodendri 57 grams.Method for making: get Radix Salviae Miltiorrhizae, that stir-baked SQUAMA MANITIS is ground into powder is thin, all the other all medicines decoct with water secondary, and each 2 hours collecting decoctions left standstill 48 hours.Filter, it is 1.23-1.27 (80 degree are surveyed) that filtrate is concentrated into relative density, adds the thin mixing of above-mentioned medical material powder, and drying is pulverized, and is distributed into 1000 capsules, promptly gets prostate recovery capsules A.

Now the capsule that is made by embodiment 2 is called: prostate recovery capsules A.

Get the prostate recovery capsules A that makes by embodiment 2 and do following pharmacodynamics test research:

This experiment is observed its inhibitory action to the experimental rat prostatic hyperplasia by prostatic hyperplasia and inflammatory model, has observed analgesia and the antibacterial action of prostate recovery capsules A to mice simultaneously.

1 experiment material:

1.1 animal

The Wistar rat: male, body weight 280～320g is supplied by animal housing of Jiangxi Medical College.

1.2 medicine and reagent:

Prostate recovery capsules A: provide by the attached Nanchang City of Nanchang City Medical House andrology hospital preparation chamber, specification 0.45g/ grain, compound method: get the capsule powder that makes and add 0.5% carboxymethylcellulose sodium solution, be mixed with 24%, 12% and 7.5%, 3.75% solution for standby.

QIANLIEKANG PIAN: produce by pharmaceutical Co. Ltd of Zhejiang Kang Enbei group.Compound method: get QIANLIEKANG PIAN and add 0.5% carboxymethylcellulose sodium solution, be mixed with 12% and 3.8% solution for standby.

Androlin: produce by Shanghai the 9th pharmaceutical factory.

2 test methods and result:

2.1 prostate recovery capsules A is to the inhibitory action of prostatic hyperplasia

Test objective: by the inhibitory action of experimental observation prostate recovery capsules A to the prostatic hyperplasia model rat.

2.1.1 influence to the rat experiment prostatic hyperplasia

Get 50 of male and healthy rats, body weight 275.4 ± 20.15g respectively to rat ip 1% pentobarbital sodium normal saline solution, behind the rat anesthesia, extracts bilateral testes under the sterile working.After one week, take out 10 castrated rats at random, weigh earlier, then sacrificed by decapitation, getting each leaf of prostate weighs and surveys cumulative volume, the oven dry back claims dry weight, divides equally four groups at random, 10 every group to remaining 40 rats, equal sc androlin 1mg/300g body weight, once a day, continuous 30 days, blank simultaneously group ig was with the distilled water of volume; Other each groups are the medicine of the variant concentration of ig (low dose group 0.6g/kg, high dose group 1.2g/kg, QIANLIEKANG PIAN group 0.6g/kg) respectively, capacity is 0.5ml/kg, continuous 30 days (to weigh weekly during the administration once to adjust dosage), in next day with all rats back sacrificed by decapitation of weighing.Get each leaf of prostate, claim weight in wet base with weight 1mg balance, volumetric method is surveyed prostate volume, gets a gauge head leaf and claims weight in wet base and claim dry weight after 37 ℃ of oven dry, does dried/weight in wet base ratio measurement.Get the frontal lobe prostate and be fixed in routine paraffin wax flaking in 10% formalin solution, the HE microscopy.Other gets rat blood serum, measures corresponding hormonal readiness with putting the method for exempting from.The results are shown in Table 15, table 16.

The prostatic volume of castrated rats, weight in wet base and dried weight in wet base ratio before table 15 is treated (X ± S)

Table 16 prostate recovery capsules A is to the influence of castrated rats prostate volume (X ± S)

Annotate: compare with the blank group ^*P＜0.05 ^*P＜0.01 time with.

Obviously embodiment 2 technical scheme that provides and the technical scheme that embodiment 1 provides there are differences aspect the influence of castrated rats prostate volume, and the ability of the inhibition weightening finish of the technical scheme that embodiment 2 provides obviously is weaker than the ability that the inhibition of the technical scheme that embodiment 1 provides is increased weight.Through long-felt, the technical scheme effect that compound recipe flavor number is many is better.

Claims (4)

1. compound Chinese medicinal preparation prostate recovery capsules, it is characterized in that: it is the compound Chinese medicinal preparation of being made by following raw material: Flos Lonicerae, Radix Rehmanniae, Radix Salviae Miltiorrhizae, Herba Epimedii, the Herba Lycopi, Herba Hedyotidis Diffusae, Herba Taraxaci, stir-baked SQUAMA MANITIS, Radix Glycyrrhizae, Radix Angelicae Sinensis, the Rhizoma Anemarrhenae, the Radix Paeoniae Alba, Radix Paeoniae Rubra, Cortex Phellodendri, Radix Ginseng, Radix Tripterygii Wilfordii, Herba Violae, Poria, Fructus Lycii, Cortex Magnoliae Officinalis, Fructus Aurantii Immaturus, Herba Verbenae, Herba Lysimachiae, Rhizoma Imperatae, Herba Lophatheri, Semen Abutili, Radix Curcumae, Rhizoma Et Radix Notopterygii, Fructus Forsythiae.

2. compound Chinese medicinal preparation prostate recovery capsules, it is characterized in that: it is the compound Chinese medicinal preparation of being made by the following weight proportion raw material: Flos Lonicerae 171 grams, Radix Rehmanniae 171 grams, Radix Salviae Miltiorrhizae 171 grams, Herba Epimedii 114 grams, Herba Lycopi's 114 grams, Herba Hedyotidis Diffusae 114 grams, Herba Taraxaci 114 grams, stir-baked SQUAMA MANITIS 57 grams, Radix Glycyrrhizae 85 grams, Radix Angelicae Sinensis 57 grams, the Rhizoma Anemarrhenae 57 grams, the Radix Paeoniae Alba 57 grams, Radix Paeoniae Rubra 57 grams, Cortex Phellodendri 57 grams, Radix Ginseng 57 grams, Radix Tripterygii Wilfordii 171 grams, Herba Violae 171 grams, Poria 114 grams, Fructus Lycii 114 grams, Cortex Magnoliae Officinalis 114 grams, Fructus Aurantii Immaturus 57 grams, Herba Verbenae 57 grams, Herba Lysimachiae 57 grams, Rhizoma Imperatae 57 grams, Herba Lophatheri 57 grams, Semen Abutili 57 grams, Radix Curcumae 57 grams, Rhizoma Et Radix Notopterygii 57 grams, Fructus Forsythiae 114 grams.

3. the preparation method of compound Chinese medicinal preparation prostate recovery capsules, it is characterized in that: it is the compound Chinese medicinal preparation of being made by the following weight proportion raw material: Flos Lonicerae 171 grams, Radix Rehmanniae 171 grams, Radix Salviae Miltiorrhizae 171 grams, Herba Epimedii 114 grams, Herba Lycopi's 114 grams, Herba Hedyotidis Diffusae 114 grams, Herba Taraxaci 114 grams, stir-baked SQUAMA MANITIS 57 grams, Radix Glycyrrhizae 85 grams, Radix Angelicae Sinensis 57 grams, the Rhizoma Anemarrhenae 57 grams, the Radix Paeoniae Alba 57 grams, Radix Paeoniae Rubra 57 grams, Cortex Phellodendri 57 grams, Radix Ginseng 57 grams, Radix Tripterygii Wilfordii 171 grams, Herba Violae 171 grams, Poria 114 grams, Fructus Lycii 114 grams, Cortex Magnoliae Officinalis 114 grams, Fructus Aurantii Immaturus 57 grams, Herba Verbenae 57 grams, Herba Lysimachiae 57 grams, Rhizoma Imperatae 57 grams, Herba Lophatheri 57 grams, Semen Abutili 57 grams, Radix Curcumae 57 grams, Rhizoma Et Radix Notopterygii 57 grams, Fructus Forsythiae 114 grams.Method for making: get Radix Salviae Miltiorrhizae, that stir-baked SQUAMA MANITIS is ground into powder is thin, all the other all medicines decoct with water secondary, and each 2 hours collecting decoctions left standstill 48 hours.Filter, it is 1.23-1.27 (80 degree are surveyed) that filtrate is concentrated into relative density, adds the thin mixing of above-mentioned medical material powder, and drying is pulverized, and is distributed into 1000 capsules, promptly.

4. the compound Chinese medicinal preparation prostate recovery capsules is being treated the application in the inhibition of prostatic hyperplasia.