CN101861311A - 5-吡啶酮取代的吲唑 - Google Patents
5-吡啶酮取代的吲唑 Download PDFInfo
- Publication number
- CN101861311A CN101861311A CN200880107571A CN200880107571A CN101861311A CN 101861311 A CN101861311 A CN 101861311A CN 200880107571 A CN200880107571 A CN 200880107571A CN 200880107571 A CN200880107571 A CN 200880107571A CN 101861311 A CN101861311 A CN 101861311A
- Authority
- CN
- China
- Prior art keywords
- compound
- phenyl
- base
- indazole
- pyridine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/08—Bridged systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Diabetes (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Child & Adolescent Psychology (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Gastroenterology & Hepatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Saccharide Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US95120107P | 2007-07-21 | 2007-07-21 | |
US60/951,201 | 2007-07-21 | ||
PCT/US2008/070535 WO2009015037A2 (fr) | 2007-07-21 | 2008-07-18 | Indazoles substitués par du 5-pyridinone |
Publications (1)
Publication Number | Publication Date |
---|---|
CN101861311A true CN101861311A (zh) | 2010-10-13 |
Family
ID=40282093
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN200880107571A Pending CN101861311A (zh) | 2007-07-21 | 2008-07-18 | 5-吡啶酮取代的吲唑 |
Country Status (13)
Country | Link |
---|---|
US (1) | US8273770B2 (fr) |
EP (1) | EP2176251B1 (fr) |
JP (1) | JP2010534248A (fr) |
KR (1) | KR20100044225A (fr) |
CN (1) | CN101861311A (fr) |
AT (1) | ATE544759T1 (fr) |
AU (1) | AU2008279321B2 (fr) |
BR (1) | BRPI0814772A2 (fr) |
CA (1) | CA2693377A1 (fr) |
ES (1) | ES2382982T3 (fr) |
HK (1) | HK1142608A1 (fr) |
NZ (1) | NZ582586A (fr) |
WO (1) | WO2009015037A2 (fr) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103987842A (zh) * | 2011-09-30 | 2014-08-13 | 葛兰素史密斯克莱有限责任公司 | 治疗癌症的方法 |
CN107011283A (zh) * | 2017-05-31 | 2017-08-04 | 湖南华腾制药有限公司 | 一种甲硫基取代苯并[d]恶唑衍生物的制备方法 |
CN111032656A (zh) * | 2017-08-22 | 2020-04-17 | 捷思英达医药技术(上海)有限公司 | 杂环化合物激酶抑制剂及其药物组合物和应用 |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MX2009007337A (es) * | 2007-01-10 | 2009-07-15 | Albany Molecular Res Inc | Indazoles sustituidos con 5-piridinona. |
CN101861311A (zh) | 2007-07-21 | 2010-10-13 | 阿尔巴尼分子研究公司 | 5-吡啶酮取代的吲唑 |
CA2727055C (fr) | 2008-01-11 | 2016-12-20 | Albany Molecular Research, Inc. | Pyridoindoles (1-azinone)-substitues en tant qu'antagonistes mch |
WO2011003012A1 (fr) | 2009-07-01 | 2011-01-06 | Albany Molecular Research, Inc. | Antagonistes de mch-1 azapolycycles substitués par azinone, leurs procédés de fabrication et leur utilisation |
US9073925B2 (en) | 2009-07-01 | 2015-07-07 | Albany Molecular Research, Inc. | Azinone-substituted azabicycloalkane-indole and azabicycloalkane-pyrrolo-pyridine MCH-1 antagonists, methods of making, and use thereof |
WO2011003007A1 (fr) | 2009-07-01 | 2011-01-06 | Albany Molecular Research, Inc. | Antagonistes de mch-1 dazabicycloalcane-indole et dazabicycloalcane-pyrrolo-pyridine, procédés de préparation, et utilisation de ceux-ci |
EP2448585B1 (fr) * | 2009-07-01 | 2014-01-01 | Albany Molecular Research, Inc. | Antagonistes de mch-1 d azépino[b]indole et pyrido-pyrrolo-azépine azinone-substitué, procédés de préparation, et utilisation de ceux-ci |
US8993765B2 (en) | 2010-12-21 | 2015-03-31 | Albany Molecular Research, Inc. | Tetrahydro-azacarboline MCH-1 antagonists, methods of making, and uses thereof |
WO2012088038A2 (fr) | 2010-12-21 | 2012-06-28 | Albany Molecular Research, Inc. | Antagonistes de mch-1 consistant en tétrahydro-carbolines substituées par pipérazinone, leurs procédés de fabrication et utilisations |
WO2020169058A1 (fr) * | 2019-02-21 | 2020-08-27 | 杭州阿诺生物医药科技有限公司 | Composé antagoniste de pd-l1 |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2005018557A2 (fr) * | 2003-08-13 | 2005-03-03 | Pharmacia Corporation | Pyridinones substitues |
EP1741703A1 (fr) * | 2004-03-05 | 2007-01-10 | Banyu Pharmaceutical Co., Ltd. | Derive pyridone |
WO2007029847A1 (fr) * | 2005-09-07 | 2007-03-15 | Banyu Pharmaceutical Co., Ltd. | Dérivé de pyridone substitué aromatique bicylique |
Family Cites Families (66)
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US1A (en) | 1836-07-13 | John Ruggles | Locomotive steam-engine for rail and other roads | |
US5225565A (en) * | 1988-09-15 | 1993-07-06 | The Upjohn Company | Antibacterial 3-(fused-ring substituted)phenyl-5β-amidomethyloxazolidin-2-ones |
US5182403A (en) * | 1988-09-15 | 1993-01-26 | The Upjohn Company | Substituted 3(5'indazolyl) oxazolidin-2-ones |
WO1990009781A1 (fr) | 1989-02-23 | 1990-09-07 | Rorer International (Holdings), Inc. | Compositions aerosol therapeutiques |
US5393735A (en) * | 1990-08-09 | 1995-02-28 | Rohm And Haas Company | Herbicidal glutarimides |
GB8921222D0 (en) | 1989-09-20 | 1989-11-08 | Riker Laboratories Inc | Medicinal aerosol formulations |
JPH03253852A (ja) | 1990-03-05 | 1991-11-12 | Fuji Photo Film Co Ltd | ハロゲン化銀写真感光材料の処理方法及び最終処理組成物 |
DE4017211A1 (de) * | 1990-05-29 | 1991-12-05 | Merck Patent Gmbh | Oxazolidinone |
DE4018830A1 (de) | 1990-06-12 | 1991-12-19 | Langhals Heinz | Synthese und verwendung von nicht-symmetrisch substituierten perylen-fluoreszenzfarbstoffen |
US5292499A (en) | 1990-09-11 | 1994-03-08 | University Of Wales College Of Cardiff | Method of preparing medical aerosol formulations including drug dissolved in reverse micelles |
US5230884A (en) | 1990-09-11 | 1993-07-27 | University Of Wales College Of Cardiff | Aerosol formulations including proteins and peptides solubilized in reverse micelles and process for making the aerosol formulations |
US6632456B1 (en) | 1993-06-24 | 2003-10-14 | Astrazeneca Ab | Compositions for inhalation |
TW279860B (fr) * | 1993-11-12 | 1996-07-01 | Ciba Geigy Ag | |
DE4338784A1 (de) | 1993-11-12 | 1995-05-18 | Langhals Heinz | Perylen-3,4-dicarbonsäureimide - neue hoch lichtechte Fluoreszenzfarbstoffe |
US6524557B1 (en) | 1994-12-22 | 2003-02-25 | Astrazeneca Ab | Aerosol formulations of peptides and proteins |
CH689139A5 (de) | 1995-04-03 | 1998-10-30 | Cerbios Pharma Sa | Verfahren zur Herstellung einer liposomalen, in Wasser dispergierbaren, oral zu verabreichenden, festen, trockenen therapeutischen Formulierung. |
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JP2006508077A (ja) | 2002-10-04 | 2006-03-09 | ミレニアム・ファーマシューティカルズ・インコーポレイテッド | 炎症疾患を治療するためのpgd2レセプタアンタゴニスト |
MXPA05010859A (es) | 2003-04-11 | 2005-12-14 | Smithkline Beecham Corp | Antagonistas mchr1 heterociclicos. |
WO2004112719A2 (fr) | 2003-06-19 | 2004-12-29 | Smithkline Beecham Corporation | Composes chimiques |
US7390820B2 (en) * | 2003-08-25 | 2008-06-24 | Amgen Inc. | Substituted quinolinone derivatives and methods of use |
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WO2005042541A1 (fr) | 2003-10-23 | 2005-05-12 | Glaxo Group Limited | Derives de 3-(4-aminophenyl)-thienopyrimid-4-one utilises comme antagonistes de mch r1 pour le traitement de l'obesite, du diabete, de la depression et de l'anxiete |
US7071182B2 (en) * | 2003-12-23 | 2006-07-04 | Abbott Laboratories | Antagonists of melanin concentrating hormone effects on the melanin concentrating hormone receptor |
US7049307B2 (en) * | 2003-12-23 | 2006-05-23 | Abbott Laboratories | Antagonists of melanin concentrating hormone effects on the melanin concentrating hormone receptor |
US20050137243A1 (en) * | 2003-12-23 | 2005-06-23 | Souers Andrew J. | Antagonists of melanin concentrating hormone effects on the melanin concentrating hormone receptor |
US7632831B2 (en) * | 2004-05-07 | 2009-12-15 | Memory Pharmaceuticals Corporation | 1H-indazoles, benzothiazoles, 1,2-benzoisoxazoles, 1,2-benzoisothiazoles, and chromones and preparation and uses thereof |
WO2006017257A2 (fr) | 2004-07-12 | 2006-02-16 | Phenomix Corporation | Derives d'acetidinone |
KR20090097214A (ko) * | 2007-01-10 | 2009-09-15 | 알바니 몰레큘라 리써치, 인크. | 5-푸로피리디논 치환된 인다졸 |
MX2009007337A (es) | 2007-01-10 | 2009-07-15 | Albany Molecular Res Inc | Indazoles sustituidos con 5-piridinona. |
CN101861311A (zh) | 2007-07-21 | 2010-10-13 | 阿尔巴尼分子研究公司 | 5-吡啶酮取代的吲唑 |
-
2008
- 2008-07-18 CN CN200880107571A patent/CN101861311A/zh active Pending
- 2008-07-18 NZ NZ582586A patent/NZ582586A/en not_active IP Right Cessation
- 2008-07-18 WO PCT/US2008/070535 patent/WO2009015037A2/fr active Application Filing
- 2008-07-18 JP JP2010518311A patent/JP2010534248A/ja active Pending
- 2008-07-18 ES ES08796320T patent/ES2382982T3/es active Active
- 2008-07-18 EP EP08796320A patent/EP2176251B1/fr not_active Not-in-force
- 2008-07-18 AU AU2008279321A patent/AU2008279321B2/en not_active Ceased
- 2008-07-18 KR KR1020107003768A patent/KR20100044225A/ko not_active Application Discontinuation
- 2008-07-18 CA CA2693377A patent/CA2693377A1/fr not_active Abandoned
- 2008-07-18 AT AT08796320T patent/ATE544759T1/de active
- 2008-07-18 BR BRPI0814772-8A2A patent/BRPI0814772A2/pt not_active IP Right Cessation
- 2008-07-18 US US12/176,144 patent/US8273770B2/en not_active Expired - Fee Related
-
2010
- 2010-09-24 HK HK10109173.8A patent/HK1142608A1/xx not_active IP Right Cessation
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2005018557A2 (fr) * | 2003-08-13 | 2005-03-03 | Pharmacia Corporation | Pyridinones substitues |
EP1741703A1 (fr) * | 2004-03-05 | 2007-01-10 | Banyu Pharmaceutical Co., Ltd. | Derive pyridone |
WO2007029847A1 (fr) * | 2005-09-07 | 2007-03-15 | Banyu Pharmaceutical Co., Ltd. | Dérivé de pyridone substitué aromatique bicylique |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103987842A (zh) * | 2011-09-30 | 2014-08-13 | 葛兰素史密斯克莱有限责任公司 | 治疗癌症的方法 |
CN107011283A (zh) * | 2017-05-31 | 2017-08-04 | 湖南华腾制药有限公司 | 一种甲硫基取代苯并[d]恶唑衍生物的制备方法 |
CN111032656A (zh) * | 2017-08-22 | 2020-04-17 | 捷思英达医药技术(上海)有限公司 | 杂环化合物激酶抑制剂及其药物组合物和应用 |
CN111032656B (zh) * | 2017-08-22 | 2022-12-02 | 捷思英达医药技术(上海)有限公司 | 杂环化合物激酶抑制剂及其药物组合物和应用 |
Also Published As
Publication number | Publication date |
---|---|
NZ582586A (en) | 2011-12-22 |
AU2008279321A1 (en) | 2009-01-29 |
HK1142608A1 (en) | 2010-12-10 |
US20090082359A1 (en) | 2009-03-26 |
WO2009015037A3 (fr) | 2009-04-30 |
US8273770B2 (en) | 2012-09-25 |
AU2008279321B2 (en) | 2013-08-01 |
JP2010534248A (ja) | 2010-11-04 |
ES2382982T3 (es) | 2012-06-15 |
ATE544759T1 (de) | 2012-02-15 |
WO2009015037A2 (fr) | 2009-01-29 |
EP2176251A2 (fr) | 2010-04-21 |
KR20100044225A (ko) | 2010-04-29 |
CA2693377A1 (fr) | 2009-01-29 |
BRPI0814772A2 (pt) | 2015-03-03 |
EP2176251B1 (fr) | 2012-02-08 |
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