CN101849008A - 用于减少RNAi中的脱靶表型效应的siRNA的不依赖于序列的修饰形式和其稳定形式 - Google Patents

用于减少RNAi中的脱靶表型效应的siRNA的不依赖于序列的修饰形式和其稳定形式 Download PDF

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CN101849008A
CN101849008A CN200880113683A CN200880113683A CN101849008A CN 101849008 A CN101849008 A CN 101849008A CN 200880113683 A CN200880113683 A CN 200880113683A CN 200880113683 A CN200880113683 A CN 200880113683A CN 101849008 A CN101849008 A CN 101849008A
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sirna
modified
nucleotide
passenger
oligonucleotide
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N·普瑞
I·查尔斯
S·马格达雷诺
A·乌拉索夫
C·博内特
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Applied Biosystems Inc
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Applera Corp
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CN200880113683A 2007-09-19 2008-09-17 用于减少RNAi中的脱靶表型效应的siRNA的不依赖于序列的修饰形式和其稳定形式 Pending CN101849008A (zh)

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Application Number Priority Date Filing Date Title
US97354807P 2007-09-19 2007-09-19
US60/973,548 2007-09-19
PCT/US2008/076675 WO2009039173A2 (en) 2007-09-19 2008-09-17 SiRNA SEQUENCE-INDEPENDENT MODIFICATION FORMATS FOR REDUCING OFF-TARGET PHENOTYPIC EFFECTS IN RNAi, AND STABILIZED FORMS THEREOF

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CN101849008A true CN101849008A (zh) 2010-09-29

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US (6) US8524681B2 (https=)
EP (2) EP2195428B1 (https=)
JP (2) JP5723154B2 (https=)
CN (1) CN101849008A (https=)
DK (2) DK2548962T3 (https=)
WO (1) WO2009039173A2 (https=)

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CN114402074A (zh) * 2019-07-16 2022-04-26 国立大学法人东京大学 Rna分子、嵌合体型na分子、双链rna分子及双链嵌合体型na分子

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