CN101848925A - 有生物学活性的、含c-端精氨酸的肽 - Google Patents

有生物学活性的、含c-端精氨酸的肽 Download PDF

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Publication number
CN101848925A
CN101848925A CN200880114757A CN200880114757A CN101848925A CN 101848925 A CN101848925 A CN 101848925A CN 200880114757 A CN200880114757 A CN 200880114757A CN 200880114757 A CN200880114757 A CN 200880114757A CN 101848925 A CN101848925 A CN 101848925A
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peptide
host cell
peptone
cell
arginine
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CN200880114757A
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English (en)
Chinese (zh)
Inventor
詹姆斯·威尔金斯
马萨鲁·K·希拉托里
蒂姆·布里斯
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Genentech Inc
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Genentech Inc
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Priority to CN201510249486.7A priority Critical patent/CN104844690B/zh
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    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0018—Culture media for cell or tissue culture
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/20—Partition-, reverse-phase or hydrophobic interaction chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
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    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
    • C07K5/06043—Leu-amino acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
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    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
    • C07K5/06052—Val-amino acid
    • C—CHEMISTRY; METALLURGY
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    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/0606—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing heteroatoms not provided for by C07K5/06086 - C07K5/06139, e.g. Ser, Met, Cys, Thr
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
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    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • C—CHEMISTRY; METALLURGY
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    • C07K5/06—Dipeptides
    • C07K5/06104—Dipeptides with the first amino acid being acidic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
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    • C07K5/06—Dipeptides
    • C07K5/06104—Dipeptides with the first amino acid being acidic
    • C07K5/06113—Asp- or Asn-amino acid
    • C—CHEMISTRY; METALLURGY
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    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • C07K5/0806—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
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    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • C07K5/0808—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
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    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • C07K5/081—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing O or S as heteroatoms, e.g. Cys, Ser
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0812—Tripeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0819—Tripeptides with the first amino acid being acidic
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/998—Proteins not provided for elsewhere
    • C—CHEMISTRY; METALLURGY
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    • C12N2510/00—Genetically modified cells
    • C12N2510/02—Cells for production

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  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Analytical Chemistry (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
CN200880114757A 2007-09-05 2008-09-05 有生物学活性的、含c-端精氨酸的肽 Pending CN101848925A (zh)

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US96764407P 2007-09-05 2007-09-05
US60/967,644 2007-09-05
PCT/US2008/075403 WO2009033024A1 (en) 2007-09-05 2008-09-05 Biologically active c-terminal arginine-containing peptides

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CN201510249486.7A Expired - Fee Related CN104844690B (zh) 2007-09-05 2008-09-05 有生物学活性的、含c-端精氨酸的肽

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EP (1) EP2207790B1 (enExample)
JP (1) JP5734653B2 (enExample)
CN (2) CN101848925A (enExample)
CA (1) CA2697519C (enExample)
CY (1) CY1114618T1 (enExample)
DK (1) DK2207790T3 (enExample)
ES (1) ES2434829T3 (enExample)
HR (1) HRP20131108T1 (enExample)
PL (1) PL2207790T3 (enExample)
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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109575106A (zh) * 2019-01-07 2019-04-05 无限极（中国）有限公司 一种从大米多肽中制备抗氧化三肽的方法及应用
CN116444610A (zh) * 2022-11-30 2023-07-18 内蒙古伊利实业集团股份有限公司 乳源活性肽dasaqfir及其制备方法与应用

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HRP20131108T1 (hr) * 2007-09-05 2014-01-31 Genentech, Inc. Biološki aktivan arginin koji na c-završetku sadrži peptide
DE102010001983A1 (de) * 2010-02-16 2011-08-18 peptides&elephants GmbH, 14558 Verfahren zur Erzeugung eines Peptidreinigungsmaterials auf Graphitbasis und Verfahren zur Peptidaufreinigung
EP2611904A2 (en) * 2010-08-31 2013-07-10 Friesland Brands B.V. Culture medium for eukaryotic cells
JP6517692B2 (ja) * 2012-09-19 2019-05-22 ジェムバックス アンド カエル カンパニー，リミティド 細胞透過性ペプチド、それを含んだコンジュゲート、及びそれを含んだ組成物
WO2017178193A1 (en) * 2016-04-14 2017-10-19 MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. Method for the identification of random polynucleotide or polypeptide sequences with biological activity
JP7166039B1 (ja) * 2020-12-22 2022-11-07 株式会社マルハチ村松 ペプチド、細胞増殖促進剤、タンパク質産生促進剤、培地、該ペプチドを用いた細胞増殖方法、及び、該ペプチドを用いたタンパク質産生方法

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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109575106A (zh) * 2019-01-07 2019-04-05 无限极（中国）有限公司 一种从大米多肽中制备抗氧化三肽的方法及应用
CN116444610A (zh) * 2022-11-30 2023-07-18 内蒙古伊利实业集团股份有限公司 乳源活性肽dasaqfir及其制备方法与应用
CN116444610B (zh) * 2022-11-30 2024-05-17 内蒙古伊利实业集团股份有限公司 乳源活性肽dasaqfir及其制备方法与应用

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SG190602A1 (en) 2013-06-28
SI2207790T1 (sl) 2013-11-29
EP2207790A1 (en) 2010-07-21
US20090143248A1 (en) 2009-06-04
JP2010538089A (ja) 2010-12-09
DK2207790T3 (da) 2013-10-28
HK1213916A1 (zh) 2016-07-15
CN104844690A (zh) 2015-08-19
JP5734653B2 (ja) 2015-06-17
PL2207790T3 (pl) 2014-01-31
EP2207790B1 (en) 2013-08-21
SG10201803541TA (en) 2018-06-28
ES2434829T3 (es) 2013-12-17
HRP20131108T1 (hr) 2014-01-31
US20210163880A1 (en) 2021-06-03
PT2207790E (pt) 2013-11-04
CY1114618T1 (el) 2016-10-05
US20170321187A1 (en) 2017-11-09
WO2009033024A1 (en) 2009-03-12
US20110183413A1 (en) 2011-07-28
CA2697519A1 (en) 2009-03-12
US20170088813A1 (en) 2017-03-30
CN104844690B (zh) 2019-08-16

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