CN101821317A - 用于转染目的的线性聚乙烯亚胺(pei)的制造方法和用此方法得到的线性pei - Google Patents

用于转染目的的线性聚乙烯亚胺(pei)的制造方法和用此方法得到的线性pei Download PDF

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Publication number
CN101821317A
CN101821317A CN200880104653A CN200880104653A CN101821317A CN 101821317 A CN101821317 A CN 101821317A CN 200880104653 A CN200880104653 A CN 200880104653A CN 200880104653 A CN200880104653 A CN 200880104653A CN 101821317 A CN101821317 A CN 101821317A
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peox
pei
monomer
oxazoline
linear
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Chinese (zh)
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A·阿迪布
F·斯多克
P·埃尔巴彻
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Polyplus Transfection SA
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Polyplus Transfection SA
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    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G73/00—Macromolecular compounds obtained by reactions forming a linkage containing nitrogen with or without oxygen or carbon in the main chain of the macromolecule, not provided for in groups C08G12/00 - C08G71/00
    • C08G73/02—Polyamines
    • C08G73/0233—Polyamines derived from (poly)oxazolines, (poly)oxazines or having pendant acyl groups
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
CN200880104653A 2007-07-31 2008-07-31 用于转染目的的线性聚乙烯亚胺(pei)的制造方法和用此方法得到的线性pei Pending CN101821317A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US95299307P 2007-07-31 2007-07-31
US60/952,993 2007-07-31
PCT/IB2008/002339 WO2009016507A2 (en) 2007-07-31 2008-07-31 Method for manufacturing linear polyethylenimine (pei) for transfection purpose and linear pei obtained with such method

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CN101821317A true CN101821317A (zh) 2010-09-01

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CN200880104653A Pending CN101821317A (zh) 2007-07-31 2008-07-31 用于转染目的的线性聚乙烯亚胺(pei)的制造方法和用此方法得到的线性pei

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US (1) US20100197888A1 (https=)
EP (1) EP2183297A2 (https=)
JP (1) JP2010535264A (https=)
KR (1) KR20100050523A (https=)
CN (1) CN101821317A (https=)
CA (1) CA2694610A1 (https=)
WO (1) WO2009016507A2 (https=)

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102399267A (zh) * 2011-11-22 2012-04-04 上海海洋大学 一种双功能肽修饰的基因载体及其制备方法
CN106832270A (zh) * 2017-01-18 2017-06-13 南京工业大学 一种聚（2‑r‑噁唑啉）嵌段聚（乙撑亚胺）的制备方法
CN109794175A (zh) * 2018-12-26 2019-05-24 浙江大学 具有pH响应性的氧化石墨烯复合膜及其制备方法和用途
CN110638690A (zh) * 2019-03-01 2020-01-03 上海澄穆生物科技有限公司 一种人工外泌体复合物的制备方法及应用
US11559477B2 (en) 2019-03-01 2023-01-24 Shanghai Cheermore Biological Technology Co., Ltd. Preparation method and use of artificial exosome complex
CN116490540A (zh) * 2020-10-22 2023-07-25 索理思科技开曼公司 噁唑啉聚合物溶液的低临界溶液温度纯化
CN116854908A (zh) * 2023-07-10 2023-10-10 中国科学院长春应用化学研究所 一种阳离子聚合物、其制备方法及应用
CN118891306A (zh) * 2022-02-25 2024-11-01 宝利普拉斯生物转染公司 用于纯化、检测和定量残留的基于pei的转染试剂的方法

Families Citing this family (9)

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EP2464388B1 (en) * 2009-08-11 2017-05-10 Agency for Science, Technology and Research Particulate hyaluronic acid formulations for cellular delivery of bioactive agents
CA2851617A1 (en) * 2011-10-14 2013-04-18 University Of Georgia Research Foundation, Inc. Synthesis and application reactive antimicrobial copolymers for textile fibers
WO2014053245A1 (en) 2012-10-05 2014-04-10 Lipocalyx Gmbh Hydroxylated polyamine derivatives as transfection reagents
AU2013329889B2 (en) 2012-10-08 2018-03-08 Biontech Delivery Technologies Gmbh Carboxylated polyamine derivatives as transfection reagents
US8937650B2 (en) 2013-03-15 2015-01-20 Orcam Technologies Ltd. Systems and methods for performing a triggered action
CN106687504A (zh) * 2014-07-11 2017-05-17 建新公司 主链型聚胺
CN107075115B (zh) * 2014-07-18 2020-05-29 根特大学 一种用于制备均匀的高摩尔质量环亚氨醚聚合物的方法
IT202000012055A1 (it) 2020-05-22 2021-11-22 Milano Politecnico Dispositivo, metodo e composizione per la trasfezione di cellule con acidi nucleici
IT202100000149A1 (it) * 2021-01-05 2022-07-05 Themis S R L Sistema e metodo per il tracciamento e per garantire la qualità di materie prime

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US3640909A (en) * 1969-02-17 1972-02-08 Dow Chemical Co Substituted acylated polyimine resins
JPS5223000B2 (https=) * 1971-08-21 1977-06-21
US4857599A (en) * 1988-02-08 1989-08-15 The Dow Chemical Company Modified dense star polymers
JPH02255725A (ja) * 1989-03-29 1990-10-16 Kao Corp ポリ（ｎ―アシルエチレンイミン）系重合体の製造方法
US5017644A (en) * 1989-05-22 1991-05-21 Xerox Corporation Ink jet ink compositions
US6025104A (en) * 1992-07-29 2000-02-15 Xerox Corporation Toner and developer compositions with polyoxazoline resin particles
US5919442A (en) * 1995-08-11 1999-07-06 Dendritech, Inc. Hyper comb-branched polymer conjugates
DE19743135A1 (de) * 1997-09-30 1999-04-01 Hoechst Marion Roussel De Gmbh Biologisch verträgliche niedermolekular Polyethylenimine
CN101041079A (zh) * 1999-12-30 2007-09-26 诺瓦提斯公司 用于基因治疗的新的胶体合成载体
CN1479632A (zh) * 2000-10-09 2004-03-03 用于将核酸导入细胞的复合物
US20050038197A1 (en) * 2003-08-13 2005-02-17 Tomalia Donald A. Ultra_high molecular weight hybrid dendrigraft architectures
WO2005075527A1 (en) * 2004-01-30 2005-08-18 The General Hospital Corporation Hyperbranched polymers
US20070231392A1 (en) * 2006-01-23 2007-10-04 Ernst Wagner CHEMICALLY MODIFIED POLYCATION POLYMER FOR siRNA DELIVERY

Cited By (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102399267B (zh) * 2011-11-22 2013-06-12 上海海洋大学 一种双功能肽修饰的基因载体及其制备方法
CN102399267A (zh) * 2011-11-22 2012-04-04 上海海洋大学 一种双功能肽修饰的基因载体及其制备方法
CN106832270A (zh) * 2017-01-18 2017-06-13 南京工业大学 一种聚（2‑r‑噁唑啉）嵌段聚（乙撑亚胺）的制备方法
CN109794175A (zh) * 2018-12-26 2019-05-24 浙江大学 具有pH响应性的氧化石墨烯复合膜及其制备方法和用途
AU2020235305B2 (en) * 2019-03-01 2025-07-03 Shanghai Cheermore Industrial Development Co., Ltd. Preparation method and use for artificial exocrine complex
CN110638690A (zh) * 2019-03-01 2020-01-03 上海澄穆生物科技有限公司 一种人工外泌体复合物的制备方法及应用
WO2020182226A1 (zh) * 2019-03-01 2020-09-17 上海澄穆生物科技有限公司 一种人工外泌体复合物的制备方法及应用
CN110638690B (zh) * 2019-03-01 2021-06-04 上海澄穆生物科技有限公司 一种人工外泌体复合物的制备方法及应用
US11559477B2 (en) 2019-03-01 2023-01-24 Shanghai Cheermore Biological Technology Co., Ltd. Preparation method and use of artificial exosome complex
CN116490540A (zh) * 2020-10-22 2023-07-25 索理思科技开曼公司 噁唑啉聚合物溶液的低临界溶液温度纯化
CN116490540B (zh) * 2020-10-22 2026-04-17 索理思科技开曼公司 噁唑啉聚合物溶液的低临界溶液温度纯化
CN118891306A (zh) * 2022-02-25 2024-11-01 宝利普拉斯生物转染公司 用于纯化、检测和定量残留的基于pei的转染试剂的方法
CN118891306B (zh) * 2022-02-25 2025-09-12 宝利普拉斯生物转染公司 用于纯化、检测和定量残留的基于pei的转染试剂的方法
US12510541B2 (en) 2022-02-25 2025-12-30 Polyplus Transfection Methods for purification, detection and quantification of residual PEI-based transfection reagents
CN116854908A (zh) * 2023-07-10 2023-10-10 中国科学院长春应用化学研究所 一种阳离子聚合物、其制备方法及应用
CN116854908B (zh) * 2023-07-10 2026-02-13 中国科学院长春应用化学研究所 一种阳离子聚合物、其制备方法及应用

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Publication number Publication date
WO2009016507A2 (en) 2009-02-05
WO2009016507A3 (en) 2009-09-03
US20100197888A1 (en) 2010-08-05
CA2694610A1 (en) 2009-02-05
EP2183297A2 (en) 2010-05-12
KR20100050523A (ko) 2010-05-13
JP2010535264A (ja) 2010-11-18

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