CN101820879B - 具有柔性侧链的抗疟用化合物 - Google Patents

具有柔性侧链的抗疟用化合物 Download PDF

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Publication number
CN101820879B
CN101820879B CN2008801106805A CN200880110680A CN101820879B CN 101820879 B CN101820879 B CN 101820879B CN 2008801106805 A CN2008801106805 A CN 2008801106805A CN 200880110680 A CN200880110680 A CN 200880110680A CN 101820879 B CN101820879 B CN 101820879B
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China
Prior art keywords
ethyl
diamino
propoxy
pyrimidine
compound
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CN2008801106805A
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Chinese (zh)
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CN101820879A (zh
Inventor
B·塔恩卓普
Y·育他翁
T·威莱梵
P·基特纳萨布
C·童潘昌
S·甘宗翁拜杉
D·马楚斯
L·维维斯
J·尤瓦尼亚玛
S·扎曼
W·扎曼
S·B·卡蒂亚
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NATIONAL SCIENCE AND TECHNOLOGY DEVELOPMENT BUREAU
MMV Medicines for Malaria Venture
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MMV Medicines for Malaria Venture
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/06—Antimalarials
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/48—Two nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
CN2008801106805A 2007-10-08 2008-10-08 具有柔性侧链的抗疟用化合物 Active CN101820879B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US97837507P 2007-10-08 2007-10-08
US60/978,375 2007-10-08
PCT/US2008/079210 WO2009048957A1 (en) 2007-10-08 2008-10-08 Antimalarial compounds with flexible side-chains

Publications (2)

Publication Number Publication Date
CN101820879A CN101820879A (zh) 2010-09-01
CN101820879B true CN101820879B (zh) 2013-01-02

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CN2008801106805A Active CN101820879B (zh) 2007-10-08 2008-10-08 具有柔性侧链的抗疟用化合物

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US (1) US8530491B2 (enExample)
EP (2) EP3546452A1 (enExample)
JP (1) JP5603775B2 (enExample)
KR (1) KR101578949B1 (enExample)
CN (1) CN101820879B (enExample)
AU (1) AU2008310898B2 (enExample)
BR (1) BRPI0818618B8 (enExample)
CA (1) CA2700880C (enExample)
CY (1) CY1121598T1 (enExample)
DK (1) DK2194985T3 (enExample)
ES (1) ES2727015T3 (enExample)
HR (1) HRP20190589T1 (enExample)
HU (1) HUE044398T2 (enExample)
LT (1) LT2194985T (enExample)
MX (1) MX2010003739A (enExample)
PL (1) PL2194985T3 (enExample)
PT (1) PT2194985T (enExample)
RU (1) RU2485107C2 (enExample)
SI (1) SI2194985T1 (enExample)
TR (1) TR201904913T4 (enExample)
UA (1) UA105759C2 (enExample)
WO (1) WO2009048957A1 (enExample)

Families Citing this family (11)

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Publication number Priority date Publication date Assignee Title
US9611503B2 (en) 2011-02-09 2017-04-04 National Science And Technology Development Agency Escherichia coli cell line with thyA knockout and folA knockout
WO2012121682A2 (en) * 2011-03-10 2012-09-13 National Science And Technology Development Agency Anti-folate antimalarials with dual-binding modes and their preparation
WO2015047199A2 (en) 2013-09-30 2015-04-02 National Science And Technology Development Agency A bacterial surrogate for testing of antimalarials: thya knockout, fola knockout, folp knockout, and folk knockout bacteria for testing of inhibition of antifolate pathway
CN104593406A (zh) * 2015-01-08 2015-05-06 山西医科大学 pIRES/TgDHFR-TS真核表达重组质粒及其构建和应用
WO2017052479A1 (en) * 2015-09-23 2017-03-30 National Science And Technology Development Agency 2,4-diamino-6-ethylpyrimidine derivatives with antimalarial activities against plasmodium falciparum
CN106083742A (zh) * 2016-05-31 2016-11-09 广东工业大学 一种2,4‑二胺基喹唑啉衍生物及其制备方法和应用
AU2021215743B2 (en) * 2020-02-04 2024-06-13 Tsinghua University Inhibitors of malarial and Plasmodium falciparum hexose transporter and uses thereof
CN112961106A (zh) * 2021-03-13 2021-06-15 德州学院 一种4-羟基-6氯喹啉合成新工艺
EP4438596A1 (en) * 2023-03-28 2024-10-02 Université de Lille Diaminopyrimidine derivatives as hdac and dhfr dual-targeting inhibitors and use thereof in preventing and treating malaria
WO2025053796A1 (en) * 2023-09-04 2025-03-13 National Science And Technology Development Agency Hybrid molecules between pyrimidine derivatives and idasanutlin
CN117263804A (zh) * 2023-09-07 2023-12-22 中国烟草总公司郑州烟草研究院 邻羟基苯丙酸酯及其制备方法和应用

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4033962A (en) * 1975-06-26 1977-07-05 Hoffman-La Roche Inc. 2,4-Diamino-pyrimidine derivatives and processes
US4232023A (en) * 1977-07-11 1980-11-04 Dick Pierre R G Novel soluble derivatives of 2,4-diamino pyrimidine
US20040180913A1 (en) * 2003-03-13 2004-09-16 National Science And Technology Development Agency Antimalarial pyrimidine derivatives and methods of making and using them

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1546937A (en) * 1976-07-29 1979-05-31 Beecham Group Ltd 2,4-diaminopyrimidine derivatives
OA07362A (fr) * 1980-10-27 1984-06-30 May & Baker Ltd Dérivés de la pyrimidine, leur procédé de préparation et les compositions les contenant.
GB2086386B (en) 1980-10-27 1984-01-18 May & Baker Ltd Pyrimidine derivatives
US5322858A (en) 1992-02-14 1994-06-21 Jacobus Pharmaceutical Co. Inc. N,N'-substituted imidodicarbonimidic diamides derived from hydroxylamines
RU95113597A (ru) * 1992-12-02 1997-06-10 ФМК Корпорейшн (US) Инсектицидная композиция, способы борьбы с насекомыми
EP1180369A4 (en) 1999-05-24 2002-07-24 Sankyo Co ANTI-FAS ANTIBODY MEDICAL COMPOSITIONS
IT1317826B1 (it) * 2000-02-11 2003-07-15 Dompe Spa Ammidi, utili nell'inibizione della chemiotassi dei neutrofiliindotta da il-8.

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4033962A (en) * 1975-06-26 1977-07-05 Hoffman-La Roche Inc. 2,4-Diamino-pyrimidine derivatives and processes
US4232023A (en) * 1977-07-11 1980-11-04 Dick Pierre R G Novel soluble derivatives of 2,4-diamino pyrimidine
US20040180913A1 (en) * 2003-03-13 2004-09-16 National Science And Technology Development Agency Antimalarial pyrimidine derivatives and methods of making and using them

Also Published As

Publication number Publication date
WO2009048957A8 (en) 2010-04-22
ES2727015T3 (es) 2019-10-11
BRPI0818618A2 (pt) 2015-08-04
BRPI0818618B8 (pt) 2023-04-25
UA105759C2 (uk) 2014-06-25
CA2700880A1 (en) 2009-04-16
SI2194985T1 (sl) 2019-04-30
AU2008310898A1 (en) 2009-04-16
CA2700880C (en) 2016-03-08
US20090099220A1 (en) 2009-04-16
RU2010117193A (ru) 2011-11-20
CY1121598T1 (el) 2020-07-31
AU2008310898B2 (en) 2014-05-08
PT2194985T (pt) 2019-05-30
DK2194985T3 (da) 2019-05-20
MX2010003739A (es) 2010-04-21
BRPI0818618B1 (pt) 2020-03-03
HUE044398T2 (hu) 2019-10-28
KR101578949B1 (ko) 2015-12-18
KR20100094459A (ko) 2010-08-26
JP5603775B2 (ja) 2014-10-08
EP2194985B1 (en) 2019-02-20
HRP20190589T1 (hr) 2019-05-31
PL2194985T3 (pl) 2019-12-31
EP3546452A1 (en) 2019-10-02
EP2194985A4 (en) 2012-01-25
EP2194985A1 (en) 2010-06-16
LT2194985T (lt) 2019-04-10
RU2485107C2 (ru) 2013-06-20
TR201904913T4 (tr) 2019-05-21
CN101820879A (zh) 2010-09-01
JP2010540666A (ja) 2010-12-24
WO2009048957A1 (en) 2009-04-16
US8530491B2 (en) 2013-09-10

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Address after: Geneva, Switzerland

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