HUE044398T2 - Flexibilis oldalláncokat tartalmazó maláriaellenes vegyületek - Google Patents

Flexibilis oldalláncokat tartalmazó maláriaellenes vegyületek

Info

Publication number
HUE044398T2
HUE044398T2 HUE08837766A HUE044398T2 HU E044398 T2 HUE044398 T2 HU E044398T2 HU E08837766 A HUE08837766 A HU E08837766A HU E044398 T2 HUE044398 T2 HU E044398T2
Authority
HU
Hungary
Prior art keywords
chains
flexible side
antimalarial compounds
antimalarial
compounds
Prior art date
Application number
Other languages
English (en)
Hungarian (hu)
Inventor
Yongyuth Yuthavong
Tirayut Vilavain
Sumalee Kamchonwongpaisan
Bongkoch Tarchompoo
Chawanee Thongpanchang
Penchit Chitnumsub
Jirundon Yuvaniyama
David Matthews
Susan Charman
William Charman
Livia Vivas
Sanjay Katiyar
Original Assignee
Medicines For Malaria Venture Mmv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Medicines For Malaria Venture Mmv filed Critical Medicines For Malaria Venture Mmv
Publication of HUE044398T2 publication Critical patent/HUE044398T2/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/06—Antimalarials
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/48—Two nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
HUE08837766 2007-10-08 2008-10-08 Flexibilis oldalláncokat tartalmazó maláriaellenes vegyületek HUE044398T2 (hu)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US97837507P 2007-10-08 2007-10-08

Publications (1)

Publication Number Publication Date
HUE044398T2 true HUE044398T2 (hu) 2019-10-28

Family

ID=40534843

Family Applications (1)

Application Number Title Priority Date Filing Date
HUE08837766 HUE044398T2 (hu) 2007-10-08 2008-10-08 Flexibilis oldalláncokat tartalmazó maláriaellenes vegyületek

Country Status (22)

Country Link
US (1) US8530491B2 (enExample)
EP (2) EP3546452A1 (enExample)
JP (1) JP5603775B2 (enExample)
KR (1) KR101578949B1 (enExample)
CN (1) CN101820879B (enExample)
AU (1) AU2008310898B2 (enExample)
BR (1) BRPI0818618B8 (enExample)
CA (1) CA2700880C (enExample)
CY (1) CY1121598T1 (enExample)
DK (1) DK2194985T3 (enExample)
ES (1) ES2727015T3 (enExample)
HR (1) HRP20190589T1 (enExample)
HU (1) HUE044398T2 (enExample)
LT (1) LT2194985T (enExample)
MX (1) MX2010003739A (enExample)
PL (1) PL2194985T3 (enExample)
PT (1) PT2194985T (enExample)
RU (1) RU2485107C2 (enExample)
SI (1) SI2194985T1 (enExample)
TR (1) TR201904913T4 (enExample)
UA (1) UA105759C2 (enExample)
WO (1) WO2009048957A1 (enExample)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012108845A1 (en) * 2011-02-09 2012-08-16 National Science And Technology Development Agency A bacterial surrogate for testing of antimalarials: thya knockout and fola knockout bacteria for testing of inhibition of malarial dihydrofolate reductase-thymidylate synthase
US9000003B2 (en) * 2011-03-10 2015-04-07 National Science And Technology Development Agency Anti-folate antimalarials with dual-binding modes and their preparation
WO2015047199A2 (en) 2013-09-30 2015-04-02 National Science And Technology Development Agency A bacterial surrogate for testing of antimalarials: thya knockout, fola knockout, folp knockout, and folk knockout bacteria for testing of inhibition of antifolate pathway
CN104593406A (zh) * 2015-01-08 2015-05-06 山西医科大学 pIRES/TgDHFR-TS真核表达重组质粒及其构建和应用
WO2017052479A1 (en) * 2015-09-23 2017-03-30 National Science And Technology Development Agency 2,4-diamino-6-ethylpyrimidine derivatives with antimalarial activities against plasmodium falciparum
CN106083742A (zh) * 2016-05-31 2016-11-09 广东工业大学 一种2,4‑二胺基喹唑啉衍生物及其制备方法和应用
WO2021155748A1 (en) * 2020-02-04 2021-08-12 Tsinghua University Inhibitors of malarial and plasmodium falciparum hexose transporter and uses thereof
CN112961106A (zh) * 2021-03-13 2021-06-15 德州学院 一种4-羟基-6氯喹啉合成新工艺
EP4438596A1 (en) * 2023-03-28 2024-10-02 Université de Lille Diaminopyrimidine derivatives as hdac and dhfr dual-targeting inhibitors and use thereof in preventing and treating malaria
WO2025053796A1 (en) * 2023-09-04 2025-03-13 National Science And Technology Development Agency Hybrid molecules between pyrimidine derivatives and idasanutlin

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4033962A (en) * 1975-06-26 1977-07-05 Hoffman-La Roche Inc. 2,4-Diamino-pyrimidine derivatives and processes
GB1546937A (en) * 1976-07-29 1979-05-31 Beecham Group Ltd 2,4-diaminopyrimidine derivatives
FR2397407A2 (fr) * 1977-07-11 1979-02-09 Dick Pierre Derives de 2,4-diamino pyrimidines et leur mise en solution en association avec des sulfamides
OA07362A (fr) * 1980-10-27 1984-06-30 May & Baker Ltd Dérivés de la pyrimidine, leur procédé de préparation et les compositions les contenant.
GB2086386B (en) 1980-10-27 1984-01-18 May & Baker Ltd Pyrimidine derivatives
US5322858A (en) 1992-02-14 1994-06-21 Jacobus Pharmaceutical Co. Inc. N,N'-substituted imidodicarbonimidic diamides derived from hydroxylamines
RU95113597A (ru) 1992-12-02 1997-06-10 ФМК Корпорейшн (US) Инсектицидная композиция, способы борьбы с насекомыми
HK1042049A1 (en) 1999-05-24 2002-08-02 Sankyo Company, Limited Medicinal compositions containing anti-fas antibody
IT1317826B1 (it) * 2000-02-11 2003-07-15 Dompe Spa Ammidi, utili nell'inibizione della chemiotassi dei neutrofiliindotta da il-8.
US7371758B2 (en) * 2003-03-13 2008-05-13 National Science & Technology Development Agency Antimalarial pyrimidine derivatives and methods of making and using them

Also Published As

Publication number Publication date
TR201904913T4 (tr) 2019-05-21
JP5603775B2 (ja) 2014-10-08
WO2009048957A1 (en) 2009-04-16
CY1121598T1 (el) 2020-07-31
WO2009048957A8 (en) 2010-04-22
RU2485107C2 (ru) 2013-06-20
ES2727015T3 (es) 2019-10-11
EP2194985A1 (en) 2010-06-16
CA2700880A1 (en) 2009-04-16
AU2008310898A1 (en) 2009-04-16
PL2194985T3 (pl) 2019-12-31
EP2194985A4 (en) 2012-01-25
BRPI0818618A2 (pt) 2015-08-04
KR101578949B1 (ko) 2015-12-18
JP2010540666A (ja) 2010-12-24
SI2194985T1 (sl) 2019-04-30
CA2700880C (en) 2016-03-08
LT2194985T (lt) 2019-04-10
PT2194985T (pt) 2019-05-30
RU2010117193A (ru) 2011-11-20
EP3546452A1 (en) 2019-10-02
US20090099220A1 (en) 2009-04-16
MX2010003739A (es) 2010-04-21
CN101820879A (zh) 2010-09-01
UA105759C2 (uk) 2014-06-25
BRPI0818618B1 (pt) 2020-03-03
AU2008310898B2 (en) 2014-05-08
HRP20190589T1 (hr) 2019-05-31
KR20100094459A (ko) 2010-08-26
EP2194985B1 (en) 2019-02-20
DK2194985T3 (da) 2019-05-20
US8530491B2 (en) 2013-09-10
CN101820879B (zh) 2013-01-02
BRPI0818618B8 (pt) 2023-04-25

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