CN101817761B - 苯甲酸酯类衍生物及制备方法和应用 - Google Patents

苯甲酸酯类衍生物及制备方法和应用 Download PDF

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Publication number
CN101817761B
CN101817761B CN201010103089.6A CN201010103089A CN101817761B CN 101817761 B CN101817761 B CN 101817761B CN 201010103089 A CN201010103089 A CN 201010103089A CN 101817761 B CN101817761 B CN 101817761B
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China
Prior art keywords
benzoate derivatives
compound
acid
benzene
senile dementia
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CN201010103089.6A
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English (en)
Chinese (zh)
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CN101817761A (zh
Inventor
戚建华
罗燕
向兰
高丽娟
孙恺悦
李金优
韩峰
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Hangzhou Ivy Leaf Medical Technology Co Ltd
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Zhejiang University ZJU
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Priority to CN201010103089.6A priority Critical patent/CN101817761B/zh
Publication of CN101817761A publication Critical patent/CN101817761A/zh
Priority to CN2010800626231A priority patent/CN103118677A/zh
Priority to PCT/CN2010/079918 priority patent/WO2011091692A1/fr
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/235—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/075—Ethers or acetals
    • A61K31/085—Ethers or acetals having an ether linkage to aromatic ring nuclear carbon
    • A61K31/09—Ethers or acetals having an ether linkage to aromatic ring nuclear carbon having two or more such linkages
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A61K31/222—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin with compounds having aromatic groups, e.g. dipivefrine, ibopamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/60—Salicylic acid; Derivatives thereof
    • A61K31/609—Amides, e.g. salicylamide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/60—Salicylic acid; Derivatives thereof
    • A61K31/618—Salicylic acid; Derivatives thereof having the carboxyl group in position 1 esterified, e.g. salsalate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Emergency Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CN201010103089.6A 2010-01-29 2010-01-29 苯甲酸酯类衍生物及制备方法和应用 Active CN101817761B (zh)

Priority Applications (3)

Application Number Priority Date Filing Date Title
CN201010103089.6A CN101817761B (zh) 2010-01-29 2010-01-29 苯甲酸酯类衍生物及制备方法和应用
CN2010800626231A CN103118677A (zh) 2010-01-29 2010-12-17 苯甲酸酯及其衍生物的应用
PCT/CN2010/079918 WO2011091692A1 (fr) 2010-01-29 2010-12-17 Utilisation d'un benzoate et de ses dérivés

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201010103089.6A CN101817761B (zh) 2010-01-29 2010-01-29 苯甲酸酯类衍生物及制备方法和应用

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN201210138453.1A Division CN102816082B (zh) 2010-01-29 2010-01-29 苯甲酰胺类衍生物及制备方法和应用

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CN101817761A CN101817761A (zh) 2010-09-01
CN101817761B true CN101817761B (zh) 2014-06-25

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CN2010800626231A Pending CN103118677A (zh) 2010-01-29 2010-12-17 苯甲酸酯及其衍生物的应用

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CN (2) CN101817761B (fr)
WO (1) WO2011091692A1 (fr)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101817761B (zh) * 2010-01-29 2014-06-25 浙江大学 苯甲酸酯类衍生物及制备方法和应用
CN103340880B (zh) * 2013-05-13 2014-12-24 杭州耐奇睿生物医药科技有限公司 2,3-二羟基苯甲酸酯类化合物在制备治疗糖尿病的食品和药物中的应用
CN105085348B (zh) * 2014-05-20 2017-07-25 浙江大学 一种苯甲酸硫酯类化合物及其应用
CN106608824B (zh) * 2015-10-21 2019-12-20 复旦大学 芳酸酯类化合物及其制备方法和用途
CN108553456B (zh) * 2016-12-29 2020-09-15 天津中医药大学 苯甲酸及其衍生物的用途
CN109422858A (zh) * 2017-08-19 2019-03-05 中国铁道科学研究院铁道建筑研究所 一种接枝紫外吸收剂分子的多元醇
CN114292192A (zh) * 2022-01-17 2022-04-08 山东泓瑞医药科技股份公司 一种3,4-二甲氧基苯甲酸甲酯的合成方法
CN114956971A (zh) * 2022-05-24 2022-08-30 浙江禾本科技股份有限公司 一种制备灭螨醌中间体2-月桂酰基-1-萘酚及其类似物的方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3729563A (en) * 1970-12-08 1973-04-24 Ciba Geigy Corp Method of treating movement disorders
YU213587A (en) * 1986-11-28 1989-06-30 Orion Yhtymae Oy Process for obtaining new pharmacologic active cateholic derivatives
IL117629A (en) * 1995-04-03 2000-08-13 Centaur Pharmaceuticals Inc Pharmaceutical compositions containing a benzamide derivative and methods for the preparation thereof
ITMI962356A1 (it) * 1996-11-13 1998-05-13 Uni Degli Studi Di Brescia D I Uso di composti derivati da molecole ad attivita' antinfiammatoria di tipo non steroideo per la prevenzione e il trattamento di
WO2004080377A2 (fr) * 2003-03-11 2004-09-23 Neurosearch A/S Nouveaux composes modulant le canal kcnq et leur utilisation
EP2030615A3 (fr) * 2007-08-13 2009-12-02 ELFORD, Howard L. Inhibiteurs de la ribonucleotide reductase pour leur utilisation dans le traitement ou la prévention de maladies neuro-inflammatoires ou auto-immunes
ES2402562T3 (es) * 2008-07-04 2013-05-06 Kissei Pharmaceutical Co., Ltd. Derivado de catecol y su uso
CN101817761B (zh) * 2010-01-29 2014-06-25 浙江大学 苯甲酸酯类衍生物及制备方法和应用

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Publication number Publication date
CN103118677A (zh) 2013-05-22
WO2011091692A1 (fr) 2011-08-04
CN101817761A (zh) 2010-09-01

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Effective date of registration: 20180604

Address after: 311100 721, room 7, 970-1 Gao Jiao Road, Yuhang District, Hangzhou, Zhejiang.

Patentee after: Hangzhou carry forward science and technology limited company

Address before: 310027 No. 38, Zhejiang Road, Hangzhou, Zhejiang, Xihu District

Patentee before: Zhejiang University

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Effective date of registration: 20190211

Address after: 311100 Room 708, Building 970-1, Wuchang Street Higher Education Road, Yuhang District, Hangzhou City, Zhejiang Province

Patentee after: Hangzhou Ivy Leaf Medical Technology Co., Ltd.

Address before: 311100 721, room 7, 970-1 Gao Jiao Road, Yuhang District, Hangzhou, Zhejiang.

Patentee before: Hangzhou carry forward science and technology limited company

TR01 Transfer of patent right