CN101778846B - 作为食欲素拮抗剂的1,2-二酰氨基-乙烯衍生物 - Google Patents

作为食欲素拮抗剂的1,2-二酰氨基-乙烯衍生物 Download PDF

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CN101778846B
CN101778846B CN2008801035335A CN200880103533A CN101778846B CN 101778846 B CN101778846 B CN 101778846B CN 2008801035335 A CN2008801035335 A CN 2008801035335A CN 200880103533 A CN200880103533 A CN 200880103533A CN 101778846 B CN101778846 B CN 101778846B
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methyl
amino
thiazole
carbonyl
ethyl
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CN101778846A (zh
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汗默德·艾萨维
克里斯托弗·博斯
马库斯·古德
拉尔夫·科贝尔施泰因
蒂埃里·西弗朗
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Actelion Pharmaceuticals Ltd
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    • C07—ORGANIC CHEMISTRY
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    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
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    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
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CN2008801035335A 2007-08-15 2008-08-14 作为食欲素拮抗剂的1,2-二酰氨基-乙烯衍生物 Expired - Fee Related CN101778846B (zh)

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WOPCT/IB2007/053249 2007-08-15
IB2007053249 2007-08-15
PCT/IB2008/053264 WO2009022311A2 (en) 2007-08-15 2008-08-14 1,2-diamido-ethylene derivatives as orexin antagonists

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CN101778846A CN101778846A (zh) 2010-07-14
CN101778846B true CN101778846B (zh) 2012-11-14

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US (1) US20110263662A1 (enExample)
EP (1) EP2188282B1 (enExample)
JP (1) JP2010536740A (enExample)
KR (1) KR20100055464A (enExample)
CN (1) CN101778846B (enExample)
AU (1) AU2008288151A1 (enExample)
BR (1) BRPI0815079A2 (enExample)
CA (1) CA2694993A1 (enExample)
ES (1) ES2400830T3 (enExample)
MX (1) MX2010001575A (enExample)
RU (1) RU2010109455A (enExample)
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US8084601B2 (en) 2008-09-11 2011-12-27 Royal Holloway And Bedford New College Royal Holloway, University Of London Oligomers
RU2011119217A (ru) * 2008-10-14 2012-11-27 Актелион Фармасьютикалз Лтд Производные фенетиламида и их гетероциклические аналоги
ME03452B (me) 2009-10-23 2020-01-20 Janssen Pharmaceutica Nv Disupstituisani oktahi-dropirolo[3,4-c]piroli kao modulatori oreksin receptora
EP2491034B1 (en) 2009-10-23 2013-12-18 Janssen Pharmaceutica, N.V. Fused heterocyclic compounds as orexin receptor modulators
EP2491031B1 (en) 2009-10-23 2013-08-07 Janssen Pharmaceutica N.V. Fused heterocyclic compounds as orexin receptor modulators
WO2011073316A1 (en) * 2009-12-18 2011-06-23 Novartis Ag 4-aryl-butane-1,3-diamides
EP2638008B1 (en) * 2010-11-10 2015-07-01 Actelion Pharmaceuticals Ltd Lactam derivatives useful as orexin receptor antagonists
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