CN101778846B - 作为食欲素拮抗剂的1,2-二酰氨基-乙烯衍生物 - Google Patents

作为食欲素拮抗剂的1,2-二酰氨基-乙烯衍生物 Download PDF

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CN101778846B
CN101778846B CN2008801035335A CN200880103533A CN101778846B CN 101778846 B CN101778846 B CN 101778846B CN 2008801035335 A CN2008801035335 A CN 2008801035335A CN 200880103533 A CN200880103533 A CN 200880103533A CN 101778846 B CN101778846 B CN 101778846B
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methyl
amino
thiazole
carbonyl
ethyl
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CN101778846A (zh
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汗默德·艾萨维
克里斯托弗·博斯
马库斯·古德
拉尔夫·科贝尔施泰因
蒂埃里·西弗朗
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Actelion Pharmaceuticals Ltd
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    • C07—ORGANIC CHEMISTRY
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    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
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CN2008801035335A 2007-08-15 2008-08-14 作为食欲素拮抗剂的1,2-二酰氨基-乙烯衍生物 Expired - Fee Related CN101778846B (zh)

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IB2007053249 2007-08-15
WOPCT/IB2007/053249 2007-08-15
PCT/IB2008/053264 WO2009022311A2 (en) 2007-08-15 2008-08-14 1,2-diamido-ethylene derivatives as orexin antagonists

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CN101778846A CN101778846A (zh) 2010-07-14
CN101778846B true CN101778846B (zh) 2012-11-14

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US (1) US20110263662A1 (enExample)
EP (1) EP2188282B1 (enExample)
JP (1) JP2010536740A (enExample)
KR (1) KR20100055464A (enExample)
CN (1) CN101778846B (enExample)
AU (1) AU2008288151A1 (enExample)
BR (1) BRPI0815079A2 (enExample)
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US8084601B2 (en) 2008-09-11 2011-12-27 Royal Holloway And Bedford New College Royal Holloway, University Of London Oligomers
CN102164896A (zh) * 2008-10-14 2011-08-24 埃科特莱茵药品有限公司 苯乙基酰胺衍生物及其杂环类似物
US8653263B2 (en) 2009-10-23 2014-02-18 Janssen Pharmaceutica Disubstituted octahydropyrrolo[3,4-c]pyrroles as orexin receptor modulators
US9062044B2 (en) 2009-10-23 2015-06-23 Janssen Pharmaceutica Nv Disubstituted octahydropyrrolo[3,4-c]pyrroles as orexin receptor modulators
US8680275B2 (en) 2009-10-23 2014-03-25 Janssen Pharmaceutica Nv Fused heterocyclic compounds as orexin receptor modulators
WO2011073316A1 (en) * 2009-12-18 2011-06-23 Novartis Ag 4-aryl-butane-1,3-diamides
US9242970B2 (en) * 2010-11-10 2016-01-26 Actelion Pharmaceuticals Ltd. Lactam derivatives useful as orexin receptor antagonists
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AU2008288151A1 (en) 2009-02-19
CN101778846A (zh) 2010-07-14
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KR20100055464A (ko) 2010-05-26
US20110263662A1 (en) 2011-10-27
WO2009022311A2 (en) 2009-02-19
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