CN101677597A - 反刍动物的鼓胀症防除剂 - Google Patents
反刍动物的鼓胀症防除剂 Download PDFInfo
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- CN101677597A CN101677597A CN200880019243A CN200880019243A CN101677597A CN 101677597 A CN101677597 A CN 101677597A CN 200880019243 A CN200880019243 A CN 200880019243A CN 200880019243 A CN200880019243 A CN 200880019243A CN 101677597 A CN101677597 A CN 101677597A
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- cashew nut
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Abstract
本发明提供一种反刍动物的鼓胀症防除剂，其特征在于，含有腰果壳油。
Description
技术领域
本发明涉及含有腰果壳油的鼓胀症的防除剂。
背景技术
家畜的感染症使家畜的体重减少，或引起各种各样的症状等，会使其商品价值显著降低。如，金黄色葡萄球菌(Staphylococcus aureus)是牛、羊、山羊的乳腺炎、皮下肿瘤、脓血症、马的发疹、猪、鸡的关节炎，皮肤炎，败血症的原因菌。此外猪链球菌(Streptococcus suis)是猪的脑膜炎、败血症、心内膜炎、关节炎的原因菌，牛链球菌(Streptococcus bovis)是牛的鼓胀症的原因菌。
鼓胀症处于如下状态，由于第一胃内容液为泡沫状而导致气体和液体没有分离，而滞留的气体又不能以打嗝儿的方式排除体外，压迫心脏和肺，如果就这样的话会死亡。喂粗饲料少、而喂食玉米等富含淀粉的饲料的话，瘤胃内牛链球菌增加，由于产生的粘性物质，瘤胃液变成泡沫状。
已知腰果壳油有抗菌作用(非专利文献1)、减轻双孢子球虫症作用(专利文献1)。
又，有报告称腰果壳油对金黄色葡萄球菌(Staphylococcos aureus)、变形链球菌(Streptococcus mutans)、枯草芽孢杆菌(Bacillus subtilis)、产氨芽孢杆菌(Bacillus ammoniagenes)这样的革兰氏阳性菌有抗菌作用，对大肠杆菌(Escherichia coli)、产气肠杆菌(Enterobacter aerogenes)、绿脓杆菌(Pseudomonas aeruginosa)这样的革兰氏阴性细菌及酿酒酵母(Saccharomycescerevisiae)、产朊假丝酵母(Candida utilis)、产黄青霉(Penichilliumchrysogenum)这样的真菌没有抗菌作用(非专利文献2)，但不知道腰果壳油对牛链球菌(S.bovis)的抗菌作用，完全没有关于鼓胀症预防效果的报告。
专利文献1日本专利特开平8-231410号公报
非专利文献1Muroi，H.et al.Bioorganic&Medicinal Chemistry 12，583-587(2004)
非专利文献2Himejima M.and KuboI.，J.Agric.Food Chem.，39，418-421(1991)
发明内容
本发明的课题为抑制反刍动物的鼓胀症。
本发明人为了解决上述课题进行了认真仔细的研究，结果发现腰果壳油可以用于鼓胀症的防除，从而完成了本发明。
也就是，本发明如下。
(1)一种反刍动物的鼓胀症防除剂，其特征在于，含有腰果壳油。
(2)根据(1)所述的鼓胀症防除剂，鼓胀症由于牛链球菌(Streptococcusbovis)引起。
(3)一种鼓胀症防除用饲料用组合物，其特征在于，含有(1)或(2)所述的鼓胀症防除剂。
(4)一种鼓胀症防除用饲料，其特征在于，含有(3)所述的饲料用组合物。
(5)一种鼓胀症防除用饲料用组合物，其特征在于，含有腰果壳油。
(6)一种鼓胀症防除用饲料，其特征在于，含有腰果壳油。
(7)一种反刍动物的鼓胀症的防除方法，其特征在于，将腰果壳油投与反刍动物。
(8)一种腰果壳油的使用，用于制造反刍动物的鼓胀症防除剂。
(9)一种腰果壳油的使用，用于制造鼓胀症防除用饲料用组合物。
(10)一种腰果壳油的使用，用于制造鼓胀症防除用饲料。
本发明的鼓胀症防除剂可以用于反刍动物的鼓胀症的防除。
具体实施方式
本发明的反刍动物的鼓胀症防除剂的特征在于，含有腰果壳油。
用于本发明的腰果壳油是腰果树(Anacardium occidentale L.)的果实的壳里所含有的油状的液体。腰果壳油含有成分槚如酸(anacardic acid)、腰果酚、腰果间二酚(cardol)。
本发明所使用的腰果壳油可以作为通过压榨腰果的壳而萃取得到的植物油获得。此外，本发明所使用的腰果壳油也可以通过加热或萃取例如对腰果壳进行干馏或者溶剂萃取而得到。此外，本发明所使用的腰果壳油可以通过日本专利开平8-231410号公报所记载的方法获得。
除此之外，本发明所使用的腰果壳油也可以是加热灭菌处理油、或将腰果的壳粉碎·破碎而得到的腰果壳油。
本发明所使用的腰果壳油也可以使用市售品。
以上述防除剂的总量为基准，从效果或成本方面考虑，本发明的鼓胀症防除剂中的腰果壳油的含量理想的是1质量％～100质量％，更理想的是5质量％～90质量，进一步理想的是10质量～80质量％。含有1质量％以上的话，可以有效地防除鼓胀症。也可以将腰果壳油的原液直接经口投与。另外，在本发明中，防除包含预防及治疗。
此外，腰果壳油由于相对于牛链球菌(Streptococcus bovis)显示抗菌活性，所以本发明的鼓胀症防除剂可以用于防除由牛链球菌(Streptococcus bovis)引起的鼓胀症。
本发明中的鼓胀症也包含豆科牧草或精饲料引起的鼓胀症，本发明的鼓胀症防除剂对这样的鼓胀症也具有效果。
此外，本发明的鼓胀症防除剂除了含有腰果壳油之外，还可以含有有效促进反刍动物的发育的成分、营养补充成分、提高保存稳定性的成分等任意成分。作为这样的任意成分，举例有肠球菌属细菌、杆菌属细菌、双叉乳杆菌等生菌剂；淀粉酶、脂肪酶等酶；L-抗坏血酸、氯化胆碱、肌醇、叶酸等的维生素；氯化钾、柠檬酸铁、氧化镁、磷酸盐类等的矿物、DL-丙氨酸、DL-蛋氨酸、L-赖氨酸等氨基酸；富马酸、丁酸、乳酸、乙酸等的有机酸以及它们的盐；乙氧基喹、二丁基羟基甲苯、丁基羟基茴香醚(anisole)、阿魏酸(ferulic acid)、维生素C、维生素E等的抗氧化剂；丙酸钙等的防霉剂；羧甲基纤维素(CMC)、酪蛋白钠、聚丙烯酸钠等的粘结剂；卵磷脂、脂肪酸甘油酯、脂肪酸脱水山梨糖醇酯等的乳化剂；虾青素、角黄素等的色素；各种酯、醚、酮类等的添香料。
本发明的鼓胀症防除剂的剂形无特别限制，例如可以作成粉末、液体、固体、片剂、胶囊剂、乳剂等任意的形态。本发明的鼓胀症防除剂可以通过将腰果壳油及根据需要添加的任意成分混合进行制剂来制造。另外，根据剂型，可以将上述腰果壳的粉碎·破碎物或者不作任何处理直接将腰果壳与其他任意成分混合来作成本发明的鼓胀症防除剂。并且，可以不与其他任意成分混合，将粉碎·破碎物本身或者腰果壳本身作成鼓胀症防除剂，也可以将上述鼓胀症防除剂本身作成饲料用组合物或饲料。
本发明的饲料用组合物的特征在于含有腰果壳油。又，也可以含有上述鼓胀症防除剂。出于效果或成本的观点，本发明的饲料用组合物中的腰果壳油的含量理想的是在每单位质量的饲料用组合物的干货中为0.5～500,000质量ppm，更理想的是5～100,000质量ppm，进一步理想的是50～50,000质量ppm。
将本发明的鼓胀症防除剂用作饲料用组合物时，可以与用于宠物食品、宠物用添加剂(以下称之为饲料)的其他饲料成分混合而作成饲料。对饲料的种类、腰果壳油以外的成分没有特别的限制。
本发明的饲料的特征在于含有腰果壳油。又，也可以含有上述饲料用组合物。
从效果或成本方面考虑，本发明的饲料中的腰果壳油的含量理想的是在每单位干货质量的饲料中为0.5～50,000质量ppm，更理想的是5～10,000质量ppm，进一步理想的是50～5,000质量ppm。
本发明的饲料可以通过将腰果壳油或含有腰果壳油的饲料用组合物直接添加到饲料成分中进行混合来制造。此时，使用粉末状、固形状的饲料用组合物时，可以将饲料用组合物作成液态或凝胶状的形态，以便容易混合。此时，可以将水、豆油、菜籽油、玉米油等植物油、液体动物油、聚乙烯醇和聚乙烯吡咯烷酮、聚丙烯酸等水溶性高分子化合物作为液体载体进行使用。此外，为了保持饲料中的腰果壳油的均一性，也优选混合藻酸、藻酸钠、苍耳烷胶、酪蛋白钠、阿拉伯胶、瓜尔豆胶、罗望子种子多糖类等水溶性多糖类。
摄取本发明的饲料的动物的种类是反刍动物。例如本发明的饲料适合于牛、山羊、羊等反刍动物的饲养。摄取饲料的量可以根据动物的种类、体重、年龄、性别、健康状态、饲料的成分等适当地调节，此时饲料所含的腰果壳油优选0.005～500g/头·天、更优选0.05～100g/头·天、进一步优选0.5～50g/头·天。
摄取饲料的方法以及饲养的方法可以根据动物的种类，选择通常使用的方法。
实施例
实施例1
CNSL对于牛链球菌(S.bovis)的抗菌作用
从カシユ一·トレ一デイング株式会社获得对腰果的壳进行压榨萃取出来的腰果壳油(CNSL)。
为了调查CNSL的抗菌作用，将金黄色葡萄球菌(Staphylococcus aureus)牛分离菌株、牛链球菌(S.bovis)DSM20065株、枯草芽孢杆菌(Bacillus subtilis)NBRC3009株、大肠杆菌(Escherichia coli)ATCC 11303株、绿脓杆菌(Pseudomonasaeruginosa)NBRC 12689株以及酿酒酵母(Saccharomyces cerevisiae)NBRC 10217株在脑心浸液培养基(Brain Heart Infusion Broth)(日水制药株式会社产品)中在37℃下培养1天。在添加了CNSL的脑心浸液培养基(Brain Heart Infusion Broth)中植菌10μL的上述各种菌株的培养液，在37℃下培养2天，算出最小抑菌浓度(MIC)。
结果表示于表1中。
表1
| MIC(μg/ml) | ||
| 革兰氏阳性菌 | 金黄色葡萄球菌(Staphylococcos aureus)牛分离菌 | 6.25 |
| 牛链球菌(Streptococcus bovis)DSM20065 | 9.38 | |
| 枯草芽孢杆菌(Bacillus subtilis)NBRC3009 | 6.25 | |
| 革兰氏阴性菌 | 大肠杆菌(Escherichia coli)ATCC11303 | ＞1600 |
| 绿脓杆菌(Pseudomonas aeruginosa)NBRC12689 | ＞1600 | |
| 真菌 | 酿酒酵母(Saccharomyces cerevisiae)NBRC10217 | ＞1600 |
CNSL与革兰氏阳性菌的金黄色葡萄球菌(Staphylococcos aureus)及枯草芽孢杆菌(Bacillus subtilis)一样，对牛链球菌(S.bovis)也有较高的抗菌作用。我们认为牛链球菌(S.bovis)是存在于瘤胃中的细菌中的鼓胀症的原因菌之一。因此，我们认为作为本发明的鼓胀症防除剂的作用机理之一是，通过投与CNSL，瘤胃内的牛链球菌(S.bovis)的增殖被抑制，所以可以防除鼓胀症。
实施例2
CNSL投与在体内的经时影响
(1)试样
给四只插瘤胃插管的母羊喂相当于体重的1.4质量％的饲料(精饲料∶干草＝3∶7(体积))。
在开始投与CNSL前对瘤胃内容物进行第一次的采样。CNSL投与量在目前为止的in vitro试验中为100mg/L以上时可以确认瘤胃机能的改善效果。为了使羊的瘤胃液达到100mg/L，因为在瘤胃液中会被稀释，所以需要在饲料中混合0.14～0.28质量％(1,400～2,800质量ppm)。因此，在最初的2周内，给与0.14质量％的CNSL，每周对瘤胃内容物采样2次。在接下来的2周内，给与0.28质量％的CNSL，每周对瘤胃内容物采样2次。再后面的2周不投与CNSL，只给与饲料，每周对瘤胃内容物采样2次。
(2)结果
瘤胃液的pH表示于表2中。
表2
| CNSL投与量 | pH | |
| 投与开始前 | - | 7.11±0.08 |
| 第1周 | 0.14质量％ | 6.78±0.28* |
| 第2周 | 0.14质量％ | 7.03±0.15 |
| 第3周 | 0.28质量％ | 6.98±0.11 |
| 第4周 | 0.28质量％ | 7.05±0.06 |
| 第5周 | 投与中止 | 6.86±0.10** |
| 第6周 | 投与中止 | 6.76±0.20** |
*与投与开始前比较，P＜0.10
**与投与开始前比较，P＜0.05
中止CNSL的投与的话，瘤胃液的pH下降。可知CNSL具有防止瘤胃液的pH下降的效果。即，可知CNSL具有防止使瘤胃液酸化而使瘤胃机能恶化的瘤胃酸中毒的效果。
瘤胃液的粘度(CP)、瘤胃液的起泡性(IVI(％))及泡沫稳定性(sIVI(％))表示于表3。
表3
| CNSL投与量 | CP | IVI(％) | sIVI(％) | |
| 投与开始前 | - | 4.51±0.60 | 7.67±1.15 | 6.33±1.28 |
| 第1周 | 0.14质量％ | 3.63±1.15 | 6.67±1.63 | 5.83±1.67 |
| 第2周 | 0.14质量％ | 2.77±1.05＊＊ | 3.50±1.14＊＊ | 2.83±1.00＊＊ |
| 第3周 | 0.28质量％ | 2.40±0.49＊＊ | 1.67±1.15＊＊ | 1.33±0.44＊＊ |
| 第4周 | 0.28质量％ | 2.84±0.36＊＊ | 1.83±0.33＊＊ | 1.17±1.00＊＊ |
| 第5周 | 投与中止 | 2.81±0.67＊＊ | 6.17±3.98 | 4.50±3.53 |
| 第6周 | 投与中止 | 3.64±1.55 | 6.83±4.47 | 5.00±2.91 |
*与投与开始前比较，P＜0.10
**与投与开始前比较，P＜0.05
牛的鼓胀症是一种这样的病，就是瘤胃液变成泡状，嗳气(气体)排不出，瘤胃中滞留气体，腹部鼓胀，发展成重症的话，压迫心脏或肺，而导致死亡。瘤胃液的粘度、起泡性及泡沫稳定性全都由于投与CNSL而下降，中止投与则增加。即，可知CNSL具有防止鼓胀症的效果。
产业上的可利用性
通过使反刍动物摄取腰果壳油来饲养，可以防除鼓胀症。
Claims (10)
1.一种反刍动物的鼓胀症防除剂，其特征在于，含有腰果壳油。
2.根据权利要求1所述的鼓胀症防除剂，鼓胀症由于牛链球菌引起。
3.一种鼓胀症防除用饲料用组合物，其特征在于，含有权利要求1或2所述的鼓胀症防除剂。
4.一种鼓胀症防除用饲料，其特征在于，含有权利要求3所述的饲料用组合物。
5.一种鼓胀症防除用饲料用组合物，其特征在于，含有腰果壳油。
6.一种鼓胀症防除用饲料，其特征在于，含有腰果壳油。
7.一种反刍动物的鼓胀症的防除方法，其特征在于，将腰果壳油投与反刍动物。
8.一种腰果壳油的使用，用于制造反刍动物的鼓胀症防除剂。
9.一种腰果壳油的使用，用于制造鼓胀症防除用饲料用组合物。
10.一种腰果壳油的使用，用于制造鼓胀症防除用饲料。
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| US (2) | US20100183756A1 (zh) |
| EP (2) | EP2165609B1 (zh) |
| JP (2) | JPWO2008149992A1 (zh) |
| KR (2) | KR101486611B1 (zh) |
| CN (2) | CN101677597A (zh) |
| AU (2) | AU2008260898B2 (zh) |
| BR (2) | BRPI0812886B1 (zh) |
| CA (2) | CA2689604A1 (zh) |
| CO (2) | CO6150099A2 (zh) |
| DK (1) | DK2165610T3 (zh) |
| ES (2) | ES2444442T3 (zh) |
| NZ (2) | NZ581528A (zh) |
| RU (2) | RU2009149163A (zh) |
| WO (2) | WO2008149994A1 (zh) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104288195A (zh) * | 2011-01-07 | 2015-01-21 | 出光兴产株式会社 | 反刍动物乳量和/或乳质提高剂、围产期病的预防或治疗剂及繁殖效率改善剂 |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5484340B2 (ja) * | 2008-09-29 | 2014-05-07 | 出光興産株式会社 | 反芻動物の鼓脹症治療剤 |
| WO2010053085A1 (ja) * | 2008-11-04 | 2010-05-14 | 出光興産株式会社 | 反芻動物のアシドーシス防除剤 |
| EP2397147B1 (en) * | 2008-12-12 | 2015-06-03 | Idemitsu Kosan Co., Ltd. | Feed for preventing and/or treating diseases caused by clostridium bacterium in livestock, and agent against clostridium |
| WO2010071222A1 (ja) * | 2008-12-20 | 2010-06-24 | 味の素株式会社 | 反芻動物用メタン生成抑制剤および飼料組成物 |
| WO2011013592A1 (ja) * | 2009-07-30 | 2011-02-03 | 出光興産株式会社 | コート製剤 |
| ES2757844T3 (es) * | 2010-06-03 | 2020-04-30 | Idemitsu Kosan Co | Aceite de cáscara de anacardo con estabilidad mejorada |
| FR2966603B1 (fr) * | 2010-10-21 | 2012-11-16 | Valorex Sa | Procede d'evaluation de la quantite de methane produite par un ruminant laitier |
| CA2816635A1 (en) * | 2010-11-05 | 2012-05-10 | Idemitsu Kosan Co., Ltd. | Cashew nut shell liquid with improved stability |
| AU2016204291B2 (en) * | 2011-01-07 | 2016-12-22 | Sds Biotech K.K. | Agent for improving milk yield and/or milk quality of ruminants, preventive or therapeutic agent for perinatal disease, and agent for improving reproductive efficiency |
| US20130224320A1 (en) * | 2012-02-23 | 2013-08-29 | Joan Torrent Campmany | Process to improve feed efficiency and carcass characteristics of animals |
| EA038483B1 (ru) * | 2014-02-14 | 2021-09-03 | Геа Фарм Технолоджиз Гмбх | Способ и устройство для контроля кормления, прежде всего ферментации в рубце желудка жвачного животного |
| US10588331B2 (en) | 2014-11-26 | 2020-03-17 | River Road Research, Inc. | Method for converting food waste and other biological waste into invertebrate feed |
| CN106387353A (zh) * | 2016-08-31 | 2017-02-15 | 广州市义和化工有限公司 | 一种饲料用组合物及其制造方法 |
| AR120346A1 (es) | 2019-10-31 | 2022-02-09 | Idemitsu Kosan Co | Agente para suprimir la resistencia a la insulina en rumiantes |
| JP7519661B2 (ja) | 2019-12-03 | 2024-07-22 | 株式会社エス・ディー・エス バイオテック | 腸管細胞の炎症抑制剤 |
| BR112023024751A2 (pt) | 2021-05-28 | 2024-02-15 | Sds Biotech Corp | Agente anti-inflamatório para células intestinais de animal doméstico |
| WO2024075706A1 (ja) * | 2022-10-03 | 2024-04-11 | 株式会社エス・ディー・エス バイオテック | 反芻動物のメタン産生抑制剤 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2317611A (en) * | 1939-12-07 | 1943-04-27 | Harvel Corp | Cashew nut shell liquid material compositions and bases carrying the same |
| JPH0781137B2 (ja) | 1990-01-24 | 1995-08-30 | 御木本製薬株式会社 | 酸化防止剤 |
| JP3217484B2 (ja) | 1992-08-17 | 2001-10-09 | 株式会社リコー | 高耐圧半導体装置 |
| JPH08231410A (ja) * | 1995-02-23 | 1996-09-10 | Takasago Internatl Corp | コクシジウム症軽減剤及びそれを含有する飼料 |
| JP4680339B2 (ja) * | 1999-11-26 | 2011-05-11 | 日清丸紅飼料株式会社 | コクシジウム症の予防および／または治療用飼料 |
| JP4783512B2 (ja) * | 2001-03-27 | 2011-09-28 | 社団法人農林水産先端技術産業振興センター | 反芻動物のメタン生成を抑制する飼料組成物 |
| SE0400996D0 (sv) | 2004-04-16 | 2004-04-16 | Alltech Ireland Inc | Use of plants, plant extracts and nature-identical components from plants to affect the rumen fermentation and to improve the energy and protein retention of ruminants |
| JP2006166853A (ja) * | 2004-12-17 | 2006-06-29 | Ajinomoto Co Inc | 反芻動物用のメタン生成抑制剤および飼料組成物 |
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- 2008-06-06 WO PCT/JP2008/060492 patent/WO2008149994A1/ja active Application Filing
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- 2008-06-06 DK DK08777112.7T patent/DK2165610T3/da active
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- 2008-06-06 JP JP2009517919A patent/JP5424401B2/ja active Active
- 2008-06-06 EP EP08777110.1A patent/EP2165609B1/en active Active
- 2008-06-06 CA CA2689641A patent/CA2689641C/en active Active
- 2008-06-06 KR KR1020107000383A patent/KR101477840B1/ko active IP Right Grant
- 2008-06-06 AU AU2008260900A patent/AU2008260900B2/en active Active
- 2008-06-06 EP EP08777112A patent/EP2165610B1/en active Active
- 2008-06-06 CN CN200880019242A patent/CN101677596A/zh active Pending
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- 2008-06-06 RU RU2009149164/13A patent/RU2009149164A/ru not_active Application Discontinuation
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104288195A (zh) * | 2011-01-07 | 2015-01-21 | 出光兴产株式会社 | 反刍动物乳量和/或乳质提高剂、围产期病的预防或治疗剂及繁殖效率改善剂 |
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