CN101675042B - 新的2-杂芳基取代的苯并噻吩和苯并呋喃709 - Google Patents
新的2-杂芳基取代的苯并噻吩和苯并呋喃709 Download PDFInfo
- Publication number
- CN101675042B CN101675042B CN2008800149945A CN200880014994A CN101675042B CN 101675042 B CN101675042 B CN 101675042B CN 2008800149945 A CN2008800149945 A CN 2008800149945A CN 200880014994 A CN200880014994 A CN 200880014994A CN 101675042 B CN101675042 B CN 101675042B
- Authority
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- China
- Prior art keywords
- alkyl
- fluoroalkyl
- compound
- alkylene
- nhc
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 0 CC(C*(*)C(*)=*(*)*)C1=Cc2cc(I)c(*)cc2*1 Chemical compound CC(C*(*)C(*)=*(*)*)C1=Cc2cc(I)c(*)cc2*1 0.000 description 4
- SYXJZMVDSCLULC-UHFFFAOYSA-N CC(C)(C)OC(Nc(c(F)c1)ncc1Br)=O Chemical compound CC(C)(C)OC(Nc(c(F)c1)ncc1Br)=O SYXJZMVDSCLULC-UHFFFAOYSA-N 0.000 description 1
- YOQRASPYXLBVOK-UHFFFAOYSA-N CNc(nc1)ccc1-c1cc2cc(O)ccc2[o]1 Chemical compound CNc(nc1)ccc1-c1cc2cc(O)ccc2[o]1 YOQRASPYXLBVOK-UHFFFAOYSA-N 0.000 description 1
- PQCXZHFSSVHSPI-UHFFFAOYSA-N CNc(ncc(-c1cc2cc(O)ccc2[o]1)c1)c1F Chemical compound CNc(ncc(-c1cc2cc(O)ccc2[o]1)c1)c1F PQCXZHFSSVHSPI-UHFFFAOYSA-N 0.000 description 1
- MYNQXTDIPMCJCR-UHFFFAOYSA-N CNc1ccc(-c2cc3cc(O)ccc3[o]2)c(F)n1 Chemical compound CNc1ccc(-c2cc3cc(O)ccc3[o]2)c(F)n1 MYNQXTDIPMCJCR-UHFFFAOYSA-N 0.000 description 1
- QYJIKULJTMICLA-UHFFFAOYSA-N Nc(ccc(Br)n1)c1F Chemical compound Nc(ccc(Br)n1)c1F QYJIKULJTMICLA-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/443—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with oxygen as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Furan Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US89314907P | 2007-03-06 | 2007-03-06 | |
| US60/893,149 | 2007-03-06 | ||
| PCT/SE2008/050243 WO2008108730A1 (en) | 2007-03-06 | 2008-03-05 | Novel 2-heteroaryl substituted benzothiophenes and benzofuranes 709 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2012100933476A Division CN102617556A (zh) | 2007-03-06 | 2008-03-05 | 新的2-杂芳基取代的苯并噻吩和苯并呋喃709 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN101675042A CN101675042A (zh) | 2010-03-17 |
| CN101675042B true CN101675042B (zh) | 2012-06-13 |
Family
ID=39738510
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2008800149945A Active CN101675042B (zh) | 2007-03-06 | 2008-03-05 | 新的2-杂芳基取代的苯并噻吩和苯并呋喃709 |
| CN2012100933476A Pending CN102617556A (zh) | 2007-03-06 | 2008-03-05 | 新的2-杂芳基取代的苯并噻吩和苯并呋喃709 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2012100933476A Pending CN102617556A (zh) | 2007-03-06 | 2008-03-05 | 新的2-杂芳基取代的苯并噻吩和苯并呋喃709 |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US7772256B2 (https=) |
| EP (1) | EP2132201B1 (https=) |
| JP (1) | JP5631009B2 (https=) |
| KR (1) | KR101530392B1 (https=) |
| CN (2) | CN101675042B (https=) |
| AR (1) | AR065599A1 (https=) |
| AU (1) | AU2008221668B2 (https=) |
| BR (1) | BRPI0808503B8 (https=) |
| CA (1) | CA2680157C (https=) |
| CL (1) | CL2008000645A1 (https=) |
| CO (1) | CO6220965A2 (https=) |
| EC (1) | ECSP099641A (https=) |
| ES (1) | ES2615381T3 (https=) |
| IL (1) | IL200524A0 (https=) |
| MX (1) | MX2009009469A (https=) |
| MY (1) | MY147347A (https=) |
| NZ (1) | NZ579157A (https=) |
| PE (1) | PE20090164A1 (https=) |
| SA (1) | SA08290097B1 (https=) |
| TW (1) | TW200901998A (https=) |
| UA (1) | UA98481C2 (https=) |
| UY (1) | UY30951A1 (https=) |
| WO (1) | WO2008108730A1 (https=) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102617556A (zh) * | 2007-03-06 | 2012-08-01 | 阿斯利康(瑞典)有限公司 | 新的2-杂芳基取代的苯并噻吩和苯并呋喃709 |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2009260519A1 (en) | 2008-05-30 | 2009-12-23 | Merck Sharp & Dohme Corp. | Novel substituted azabenzoxazoles |
| BRPI0917540A2 (pt) | 2008-08-05 | 2015-11-17 | Daiichi Sankyo Co Ltd | composto, sal farmacologicamente aceitavél, composição farmacêutica, e, uso de um composto ou sal farmacologicamente aceitável |
| US8193363B2 (en) * | 2008-08-29 | 2012-06-05 | Astrazeneca Ab | Compounds suitable as precursors to compounds that are useful for imaging amyloid deposits |
| KR101123178B1 (ko) * | 2009-04-09 | 2012-06-13 | (주)에스메디 | 2-아릴벤조싸이오펜 유도체 또는 이의 약학적으로 허용가능한 염, 이의 제조방법 및 이를 유효성분으로 함유하는 퇴행성 뇌질환의 진단 또는 치료용 약학적 조성물 |
| WO2011059080A1 (ja) * | 2009-11-16 | 2011-05-19 | 第一三共株式会社 | 同位体置換されたジアミン誘導体 |
| EP2388255A1 (en) * | 2010-05-11 | 2011-11-23 | Ikerchem, S.L. | Polysubstituted benzofurans and medicinal applications thereof |
| JP5825608B2 (ja) * | 2010-08-06 | 2015-12-02 | 国立大学法人京都大学 | ピリジルベンゾフラン誘導体 |
| CA3086668A1 (en) * | 2018-02-05 | 2019-08-08 | Universite De Strasbourg | Compounds and compositions for the treatment of pain |
| KR20220044721A (ko) * | 2019-08-06 | 2022-04-11 | 도메인 테라퓨틱스 | 신경펩타이드 ff 수용체 길항제로서의 5-헤테로아릴-피리딘-2-아민 화합물 |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1995017095A1 (en) * | 1993-12-21 | 1995-06-29 | Eli Lilly And Company | Methods for the treatment or prevention of conditions associated with amyloidogenic reptides |
| WO2003051859A1 (en) * | 2001-12-19 | 2003-06-26 | Amersham Plc | Compounds for imaging alzheimer's disease |
Family Cites Families (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU523040B2 (en) | 1978-05-15 | 1982-07-08 | Kanebo Limited | Calcium -antagonistic composition |
| GB8305245D0 (en) | 1983-02-25 | 1983-03-30 | Fujisawa Pharmaceutical Co | Imidazo-heterocyclic compounds |
| CA2034309C (en) | 1990-01-22 | 1997-04-01 | Takashi Iwaki | Mesomorphic compound, liquid crystal composition containing same, liquid crystal device using same and display apparatus |
| US5518713A (en) | 1995-02-13 | 1996-05-21 | 3V Inc. | Benzoxazole derivatives, the use thereof as sunscreens and cosmetic compositions containing them |
| JPH11116476A (ja) | 1997-10-16 | 1999-04-27 | Sankyo Co Ltd | 縮合複素環化合物 |
| RU2324686C2 (ru) | 2000-08-24 | 2008-05-20 | Юнивесити Оф Питсбэг | ПРОИЗВОДНЫЕ ТИОФЛАВИНА, СВЯЗЫВАЮЩИЕ АМИЛОИД, СПОСОБ ОБНАРУЖЕНИЯ in vivo ОТЛОЖЕНИЙ АМИЛОИДА И СПОСОБ РАСПОЗНАВАНИЯ БОЛЕЗНИ АЛЬЦГЕЙМЕРА |
| WO2002051821A1 (en) | 2000-12-22 | 2002-07-04 | Astrazeneca Ab | Therapeutic compounds |
| JP2004520347A (ja) * | 2001-01-15 | 2004-07-08 | グラクソ グループ リミテッド | Ｌｄｌ−受容体発現のインデューサーとしてのアリールピペリジンおよびピペラジン誘導体 |
| JP4307001B2 (ja) * | 2001-03-14 | 2009-08-05 | キヤノン株式会社 | 金属配位化合物、電界発光素子及び表示装置 |
| US6596731B2 (en) | 2001-03-27 | 2003-07-22 | Hoffmann-La Roche Inc. | Substituted imidazo[1,2-A] pyridine derivatives |
| CA2444214A1 (en) | 2001-04-23 | 2002-10-31 | The Trustees Of The University Of Pennsylvania | Amyloid plaque aggregation inhibitors and diagnostic imaging agents |
| EP1460067A4 (en) | 2001-11-26 | 2005-12-07 | Takeda Pharmaceutical | BICYCLIC DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE |
| WO2003106439A1 (ja) | 2002-06-12 | 2003-12-24 | 株式会社ビーエフ研究所 | アミロイド蓄積性疾患の画像診断プローブ化合物、老人斑／びまん性老人斑染色用化合物、ならびにアミロイド蓄積性疾患の治療薬 |
| TW200401194A (en) | 2002-07-11 | 2004-01-16 | Advanced Micro Devices Inc | Method and apparatus for determining a processor state without interrupting processor operation |
| ATE425753T1 (de) | 2002-08-02 | 2009-04-15 | Genesoft Pharmaceuticals Inc | Biaryl-verbindungen mit antiinfektiver wirkung |
| JP2004250411A (ja) | 2003-02-21 | 2004-09-09 | Bf Kenkyusho:Kk | アミロイドβ蓄積性疾患の診断プローブおよび治療用化合物 |
| CA2438032C (en) | 2003-03-14 | 2013-05-07 | University Of Pittsburgh | Benzothiazole derivative compounds, compositions and uses |
| WO2004087641A1 (ja) | 2003-03-31 | 2004-10-14 | Daiichi Pharmaceutical Co., Ltd. | ヒドラゾン誘導体 |
| KR100710453B1 (ko) | 2003-05-13 | 2007-04-24 | 에프. 호프만-라 로슈 아게 | 아데노신 수용체 리간드로서의 2-이미다조-벤조싸이아졸 |
| WO2005003101A2 (en) * | 2003-07-02 | 2005-01-13 | Biofocus Discovery Limited | Pyrazine and pyridine derivatives as rho kinase inhibitors |
| GB0420722D0 (en) | 2004-09-17 | 2004-10-20 | Addex Pharmaceuticals Sa | Novel allosteric modulators |
| CA2609980C (en) | 2005-05-27 | 2015-10-13 | Queen's University At Kingston | Treatment of protein folding disorders |
| MX2007015675A (es) * | 2005-07-04 | 2008-02-20 | Novo Nordisk As | Antagonistas del receptor de histamina h3. |
| US20080219922A1 (en) | 2005-09-12 | 2008-09-11 | Goodman Mark M | Alzheimer's Disease Imaging Agents |
| CN101355940B (zh) | 2005-09-16 | 2013-03-27 | 匹兹堡大学高等教育联邦体系 | 用于检测具有至少一种促淀粉样变蛋白的淀粉样沉积物的体内或体外方法 |
| ATE539069T1 (de) | 2005-10-11 | 2012-01-15 | Univ Pittsburgh | Isotopenmarkierte benzofuranverbindungen als bilddarstellende mittel für amyloidogene proteine |
| WO2007063946A1 (ja) | 2005-11-30 | 2007-06-07 | Fujifilm Ri Pharma Co., Ltd. | アミロイドの凝集及び／又は沈着に起因する疾患の診断薬及び治療薬 |
| TW201018678A (en) | 2006-01-27 | 2010-05-16 | Astrazeneca Ab | Novel heteroaryl substituted benzothiazoles |
| WO2008118122A2 (en) | 2006-05-08 | 2008-10-02 | Molecular Neuroimaging, Llc | Compounds and amyloid probes thereof for therapeutic and imaging uses |
| TW200813035A (en) | 2006-06-19 | 2008-03-16 | Astrazeneca Ab | Novel heteroaryl substituted benzoxazoles |
| WO2008091195A1 (en) | 2007-01-22 | 2008-07-31 | Astrazeneca Ab | Novel heteroaryl substituted imidazo [1,2 -a] pyridine derivatives |
| TW200901998A (en) * | 2007-03-06 | 2009-01-16 | Astrazeneca Ab | Novel 2-heteroaryl substituted benzothiophenes and benzofuranes |
-
2008
- 2008-03-03 TW TW097107378A patent/TW200901998A/zh unknown
- 2008-03-04 CL CL200800645A patent/CL2008000645A1/es unknown
- 2008-03-04 SA SA8290097A patent/SA08290097B1/ar unknown
- 2008-03-05 JP JP2009552641A patent/JP5631009B2/ja active Active
- 2008-03-05 MY MYPI20093695A patent/MY147347A/en unknown
- 2008-03-05 US US12/042,795 patent/US7772256B2/en active Active
- 2008-03-05 BR BRPI0808503A patent/BRPI0808503B8/pt active IP Right Grant
- 2008-03-05 CA CA2680157A patent/CA2680157C/en active Active
- 2008-03-05 NZ NZ579157A patent/NZ579157A/en not_active IP Right Cessation
- 2008-03-05 EP EP08724190.7A patent/EP2132201B1/en active Active
- 2008-03-05 UY UY30951A patent/UY30951A1/es not_active Application Discontinuation
- 2008-03-05 CN CN2008800149945A patent/CN101675042B/zh active Active
- 2008-03-05 WO PCT/SE2008/050243 patent/WO2008108730A1/en not_active Ceased
- 2008-03-05 CN CN2012100933476A patent/CN102617556A/zh active Pending
- 2008-03-05 AU AU2008221668A patent/AU2008221668B2/en active Active
- 2008-03-05 ES ES08724190.7T patent/ES2615381T3/es active Active
- 2008-03-05 AR ARP080100905A patent/AR065599A1/es active IP Right Grant
- 2008-03-05 KR KR1020097018603A patent/KR101530392B1/ko active Active
- 2008-03-05 PE PE2008000429A patent/PE20090164A1/es not_active Application Discontinuation
- 2008-03-05 MX MX2009009469A patent/MX2009009469A/es active IP Right Grant
- 2008-05-03 UA UAA200908596A patent/UA98481C2/ru unknown
-
2009
- 2009-08-20 IL IL200524A patent/IL200524A0/en unknown
- 2009-09-07 CO CO09095235A patent/CO6220965A2/es not_active Application Discontinuation
- 2009-09-21 EC EC2009009641A patent/ECSP099641A/es unknown
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1995017095A1 (en) * | 1993-12-21 | 1995-06-29 | Eli Lilly And Company | Methods for the treatment or prevention of conditions associated with amyloidogenic reptides |
| WO2003051859A1 (en) * | 2001-12-19 | 2003-06-26 | Amersham Plc | Compounds for imaging alzheimer's disease |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102617556A (zh) * | 2007-03-06 | 2012-08-01 | 阿斯利康(瑞典)有限公司 | 新的2-杂芳基取代的苯并噻吩和苯并呋喃709 |
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