BRPI0808503B8 - composto, uso de um composto, e, composição farmacêutica - Google Patents

composto, uso de um composto, e, composição farmacêutica

Info

Publication number
BRPI0808503B8
BRPI0808503B8 BRPI0808503A BRPI0808503A BRPI0808503B8 BR PI0808503 B8 BRPI0808503 B8 BR PI0808503B8 BR PI0808503 A BRPI0808503 A BR PI0808503A BR PI0808503 A BRPI0808503 A BR PI0808503A BR PI0808503 B8 BRPI0808503 B8 BR PI0808503B8
Authority
BR
Brazil
Prior art keywords
compound
relates
alzheimer
disease
compositions
Prior art date
Application number
BRPI0808503A
Other languages
English (en)
Inventor
Swahn Britt-Marie
Wensbo David
Arzel Erwan
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of BRPI0808503A2 publication Critical patent/BRPI0808503A2/pt
Publication of BRPI0808503B1 publication Critical patent/BRPI0808503B1/pt
Publication of BRPI0808503B8 publication Critical patent/BRPI0808503B8/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/443—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with oxygen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Hospice & Palliative Care (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Furan Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

a presente invenção refere-se a novos derivados de benzotiofeno substituídos por 2-heteroarila, precursores destes e usos terapêuticos de tais compostos tendo a fórmula estrutural (1a) abaixo: e aos seus sais farmaceuticamente aceitáveis , composições e métodos de usos. além disso, a invenção refere-se a novos derivados de benzotiofeno e benzofurano substituídos por 2-heteroarila que são adequados para formação de imagem de depósitos de amilóide em pacientes vivos, suas composições , métodos de uso e processos para fabricar tais compostos. mais especificamente , a presente invenção refere-se a um método de formação de imagem de depósitos de amilóide no cérebro in vivo para permitir o diagnóstico anterior á morte do mal de alzheimer bem como a medição da eficácia clinica de agentes terapêuticos para o mal de alzheimer.
BRPI0808503A 2007-03-06 2008-03-05 composto, uso de um composto, e, composição farmacêutica BRPI0808503B8 (pt)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US89314907P 2007-03-06 2007-03-06
US60/893,149 2007-03-06
US60/893149 2007-03-06
PCT/SE2008/050243 WO2008108730A1 (en) 2007-03-06 2008-03-05 Novel 2-heteroaryl substituted benzothiophenes and benzofuranes 709

Publications (3)

Publication Number Publication Date
BRPI0808503A2 BRPI0808503A2 (pt) 2014-08-19
BRPI0808503B1 BRPI0808503B1 (pt) 2020-09-29
BRPI0808503B8 true BRPI0808503B8 (pt) 2021-05-25

Family

ID=39738510

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0808503A BRPI0808503B8 (pt) 2007-03-06 2008-03-05 composto, uso de um composto, e, composição farmacêutica

Country Status (23)

Country Link
US (1) US7772256B2 (pt)
EP (1) EP2132201B1 (pt)
JP (1) JP5631009B2 (pt)
KR (1) KR101530392B1 (pt)
CN (2) CN101675042B (pt)
AR (1) AR065599A1 (pt)
AU (1) AU2008221668B2 (pt)
BR (1) BRPI0808503B8 (pt)
CA (1) CA2680157C (pt)
CL (1) CL2008000645A1 (pt)
CO (1) CO6220965A2 (pt)
EC (1) ECSP099641A (pt)
ES (1) ES2615381T3 (pt)
IL (1) IL200524A0 (pt)
MX (1) MX2009009469A (pt)
MY (1) MY147347A (pt)
NZ (1) NZ579157A (pt)
PE (1) PE20090164A1 (pt)
SA (1) SA08290097B1 (pt)
TW (1) TW200901998A (pt)
UA (1) UA98481C2 (pt)
UY (1) UY30951A1 (pt)
WO (1) WO2008108730A1 (pt)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
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TW200901998A (en) * 2007-03-06 2009-01-16 Astrazeneca Ab Novel 2-heteroaryl substituted benzothiophenes and benzofuranes
CA2725940A1 (en) 2008-05-30 2009-12-23 Merck Sharp & Dohme Corp. Novel substituted azabenzoxazoles
AU2009278442B2 (en) 2008-08-05 2013-09-26 Daiichi Sankyo Company, Limited Imidazopyridin-2-one Derivatives
US8193363B2 (en) * 2008-08-29 2012-06-05 Astrazeneca Ab Compounds suitable as precursors to compounds that are useful for imaging amyloid deposits
KR101123178B1 (ko) * 2009-04-09 2012-06-13 (주)에스메디 2-아릴벤조싸이오펜 유도체 또는 이의 약학적으로 허용가능한 염, 이의 제조방법 및 이를 유효성분으로 함유하는 퇴행성 뇌질환의 진단 또는 치료용 약학적 조성물
WO2011059080A1 (ja) * 2009-11-16 2011-05-19 第一三共株式会社 同位体置換されたジアミン誘導体
EP2388255A1 (en) * 2010-05-11 2011-11-23 Ikerchem, S.L. Polysubstituted benzofurans and medicinal applications thereof
WO2012017891A1 (ja) * 2010-08-06 2012-02-09 国立大学法人京都大学 ピリジルベンゾフラン誘導体
KR20200118005A (ko) * 2018-02-05 2020-10-14 위니베르시떼 드 스트라스부르 통증 치료용 화합물 및 조성물
MX2022001516A (es) * 2019-08-06 2022-03-11 Domain Therapeutics Antagonistas del receptor de neuropeptido ff.

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CA2034309C (en) 1990-01-22 1997-04-01 Takashi Iwaki Mesomorphic compound, liquid crystal composition containing same, liquid crystal device using same and display apparatus
WO1995017095A1 (en) * 1993-12-21 1995-06-29 Eli Lilly And Company Methods for the treatment or prevention of conditions associated with amyloidogenic reptides
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Also Published As

Publication number Publication date
CN101675042A (zh) 2010-03-17
AU2008221668A1 (en) 2008-09-12
UY30951A1 (es) 2008-10-31
AR065599A1 (es) 2009-06-17
ECSP099641A (es) 2009-10-30
CN102617556A (zh) 2012-08-01
EP2132201A1 (en) 2009-12-16
UA98481C2 (en) 2012-05-25
US7772256B2 (en) 2010-08-10
KR20090117892A (ko) 2009-11-13
CA2680157A1 (en) 2008-09-12
ES2615381T3 (es) 2017-06-06
JP2010520276A (ja) 2010-06-10
US20080221149A1 (en) 2008-09-11
EP2132201A4 (en) 2011-05-25
CO6220965A2 (es) 2010-11-19
BRPI0808503B1 (pt) 2020-09-29
IL200524A0 (en) 2010-04-29
SA08290097B1 (ar) 2011-10-29
RU2009133257A (ru) 2011-04-20
CL2008000645A1 (es) 2008-10-24
CA2680157C (en) 2016-04-12
TW200901998A (en) 2009-01-16
CN101675042B (zh) 2012-06-13
NZ579157A (en) 2012-04-27
PE20090164A1 (es) 2009-05-03
JP5631009B2 (ja) 2014-11-26
WO2008108730A1 (en) 2008-09-12
BRPI0808503A2 (pt) 2014-08-19
MX2009009469A (es) 2009-09-15
AU2008221668B2 (en) 2011-03-31
KR101530392B1 (ko) 2015-06-22
MY147347A (en) 2012-11-30
EP2132201B1 (en) 2016-11-16

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Legal Events

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B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]

Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NO 10196/2001, QUE MODIFICOU A LEI NO 9279/96, A CONCESSAO DA PATENTE ESTA CONDICIONADA A ANUENCIA PREVIA DA ANVISA. CONSIDERANDO A APROVACAO DOS TERMOS DO PARECER NO 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL NO 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVIDENCIAS CABIVEIS.

B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 29/09/2020, OBSERVADAS AS CONDICOES LEGAIS.

B16C Correction of notification of the grant [chapter 16.3 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 05/03/2008 OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF