CN101631780A - 用于抗病毒治疗的吩噻嗪衍生物 - Google Patents

用于抗病毒治疗的吩噻嗪衍生物 Download PDF

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Publication number
CN101631780A
CN101631780A CN200880008338A CN200880008338A CN101631780A CN 101631780 A CN101631780 A CN 101631780A CN 200880008338 A CN200880008338 A CN 200880008338A CN 200880008338 A CN200880008338 A CN 200880008338A CN 101631780 A CN101631780 A CN 101631780A
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CN
China
Prior art keywords
compound
virus
replaces
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hydrogen
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Pending
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CN200880008338A
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English (en)
Chinese (zh)
Inventor
V·林格帕
J·普莱特尼尔
C·克莱尔
B·弗瑞曼
W·汉森
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Prosetta Bioconformatics Inc
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Prosetta Bioconformatics Inc
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Publication date
Application filed by Prosetta Bioconformatics Inc filed Critical Prosetta Bioconformatics Inc
Publication of CN101631780A publication Critical patent/CN101631780A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D279/10—1,4-Thiazines; Hydrogenated 1,4-thiazines
    • C07D279/14—1,4-Thiazines; Hydrogenated 1,4-thiazines condensed with carbocyclic rings or ring systems
    • C07D279/18—[b, e]-condensed with two six-membered rings

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Plural Heterocyclic Compounds (AREA)
CN200880008338A 2007-04-03 2008-04-03 用于抗病毒治疗的吩噻嗪衍生物 Pending CN101631780A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US90992807P 2007-04-03 2007-04-03
US60/909,928 2007-04-03

Publications (1)

Publication Number Publication Date
CN101631780A true CN101631780A (zh) 2010-01-20

Family

ID=39718949

Family Applications (1)

Application Number Title Priority Date Filing Date
CN200880008338A Pending CN101631780A (zh) 2007-04-03 2008-04-03 用于抗病毒治疗的吩噻嗪衍生物

Country Status (7)

Country Link
US (1) US8227459B2 (enExample)
EP (1) EP2137172A1 (enExample)
JP (1) JP2010523591A (enExample)
CN (1) CN101631780A (enExample)
AU (1) AU2008237276A1 (enExample)
CA (1) CA2686513C (enExample)
WO (1) WO2008124550A1 (enExample)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2016202982B2 (en) * 2009-09-24 2017-09-21 TauRx Therapeutics Management Ltd Crystalline methylthionium chloride (methylene blue) hydrates
BR122019022612B8 (pt) * 2009-09-24 2021-07-27 Wista Lab Ltd forma e de mono-hidrato de cloreto de metiltionínio, seu processo de preparação, e composição farmacêutica
US8809317B2 (en) * 2011-03-29 2014-08-19 Prosetta Antiviral Inc. Antiviral compounds
CN102958525B (zh) * 2010-04-30 2017-05-24 普罗瑟塔抗病毒股份有限公司 抗病毒化合物
WO2012125983A1 (en) 2011-03-17 2012-09-20 Prosetta Antiviral Inc. Antiviral treatments
WO2012145567A1 (en) 2011-04-20 2012-10-26 Prosetta Antiviral Inc. Antiviral compounds
US20120301904A1 (en) 2011-04-26 2012-11-29 Prosetta Antiviral, Inc Multiprotein assemblies
US10153510B2 (en) 2014-06-23 2018-12-11 University Of Kentucky Research Foundation Non-aqueous redox flow batteries including 3,7-perfluoroalkylated phenothiazine derivatives
US10195189B2 (en) * 2014-12-15 2019-02-05 Prosetta Antiviral, Inc. 2-phenethenyltetrahydro isoquinolines useful as anti-HIV compounds
CN114605267B (zh) * 2022-03-18 2024-02-23 北京格林凯默科技有限公司 2-溴-n,n-二甲基苯胺的制备方法
AU2024224306A1 (en) * 2023-02-21 2025-09-11 Prosetta Biosciences, Inc. Phenothiazinyl compounds and uses

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19640758C2 (de) * 1996-10-02 1999-11-04 Rafael Lachky Mittel zur Behandlung von Diskusfischen
GB0113121D0 (en) * 2001-05-30 2001-07-18 Univ Leeds Biologically active photosensitisers
BRPI0416928A (pt) * 2003-11-28 2007-01-16 Photopharmica Ltd desenvolvimento de derivados biologicamente ativos de azul de metileno
US20080166304A1 (en) * 2004-09-17 2008-07-10 The General Hospital Corpoartion Inactivation of Microorganisms With Multidrug Resistance Inhibitors and Phenothiaziniums
GB0420888D0 (en) * 2004-09-20 2004-10-20 Photopharmica Ltd Compounds and uses
EP1799662B1 (en) * 2004-09-23 2013-04-17 Wista Laboratories Ltd. Methods of chemical synthesis and purification of diaminophenothiazinium compounds including methylthioninium chloride (mtc)
DE602007008550D1 (de) * 2006-03-29 2010-09-30 Wista Lab Ltd 3,7-diamino-10h-phenothiazinsalze und ihre verwendung

Also Published As

Publication number Publication date
AU2008237276A1 (en) 2008-10-16
US20110178071A1 (en) 2011-07-21
WO2008124550A1 (en) 2008-10-16
CA2686513A1 (en) 2008-10-16
EP2137172A1 (en) 2009-12-30
CA2686513C (en) 2017-06-13
US8227459B2 (en) 2012-07-24
JP2010523591A (ja) 2010-07-15

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C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C02 Deemed withdrawal of patent application after publication (patent law 2001)
WD01 Invention patent application deemed withdrawn after publication

Application publication date: 20100120