CN101622000B - 合成glyt-1抑制剂的方法 - Google Patents
合成glyt-1抑制剂的方法 Download PDFInfo
- Publication number
- CN101622000B CN101622000B CN200880006900XA CN200880006900A CN101622000B CN 101622000 B CN101622000 B CN 101622000B CN 200880006900X A CN200880006900X A CN 200880006900XA CN 200880006900 A CN200880006900 A CN 200880006900A CN 101622000 B CN101622000 B CN 101622000B
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- CN
- China
- Prior art keywords
- formula
- alkyl
- halogen
- chemical compound
- substituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 0 *S(c(cc1)cc(C(O)=C)c1F)(=O)=O Chemical compound *S(c(cc1)cc(C(O)=C)c1F)(=O)=O 0.000 description 3
- NWXBHCBBFZOTOQ-UHFFFAOYSA-N CC(C)Oc(ccc(S(C)(=O)=O)c1)c1C(O)=O Chemical compound CC(C)Oc(ccc(S(C)(=O)=O)c1)c1C(O)=O NWXBHCBBFZOTOQ-UHFFFAOYSA-N 0.000 description 1
- ACBAHAXPEQHVHO-UHFFFAOYSA-N CS(c(cc1)cc(C(O)=O)c1F)(=O)=O Chemical compound CS(c(cc1)cc(C(O)=O)c1F)(=O)=O ACBAHAXPEQHVHO-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
- A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP07103485 | 2007-03-05 | ||
| EP07103485.4 | 2007-03-05 | ||
| PCT/EP2008/052244 WO2008107334A2 (en) | 2007-03-05 | 2008-02-25 | Process for the synthesis of glyt-1 inhibitors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN101622000A CN101622000A (zh) | 2010-01-06 |
| CN101622000B true CN101622000B (zh) | 2012-07-04 |
Family
ID=39469606
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN200880006900XA Active CN101622000B (zh) | 2007-03-05 | 2008-02-25 | 合成glyt-1抑制剂的方法 |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US7812161B2 (enExample) |
| EP (1) | EP2131843B1 (enExample) |
| JP (1) | JP4745446B2 (enExample) |
| KR (1) | KR101143073B1 (enExample) |
| CN (1) | CN101622000B (enExample) |
| AT (1) | ATE532516T1 (enExample) |
| AU (1) | AU2008223915B2 (enExample) |
| BR (1) | BRPI0808570B8 (enExample) |
| CA (1) | CA2678630C (enExample) |
| ES (1) | ES2375585T3 (enExample) |
| IL (1) | IL200323A (enExample) |
| MX (1) | MX2009009065A (enExample) |
| WO (1) | WO2008107334A2 (enExample) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5656474B2 (ja) | 2010-06-28 | 2015-01-21 | 関東化学株式会社 | 脂肪族光学活性フルオロアルコールの製造方法 |
| CN104628679B (zh) * | 2013-11-08 | 2018-02-09 | 江苏恩华药业股份有限公司 | Bitopertin的合成方法及其中间体 |
| CN106397312B (zh) * | 2015-07-31 | 2020-03-24 | 广东东阳光药业有限公司 | 一种制备glyt-1抑制剂的方法 |
| KR20220125326A (ko) | 2020-01-09 | 2022-09-14 | 디스크 메디슨, 인크. | 적혈구형성 프로토포르피린증, x-연계된 프로토포르피린증, 또는 선천성 적혈구 조혈포르피린증을 글리신 운반 억제제로 치료하는 방법 |
| KR20230088761A (ko) | 2020-10-13 | 2023-06-20 | 베링거 인겔하임 인터내셔날 게엠베하 | 재가공하는 방법 |
| WO2024042043A1 (en) | 2022-08-24 | 2024-02-29 | Boehringer Ingelheim International Gmbh | A scalable process for the preparation of a glyt-1 inhibitor |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2006061135A1 (en) * | 2004-12-09 | 2006-06-15 | F. Hoffmann-La Roche Ag | Phenyl-piperazin methanone derivatives |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3992441A (en) * | 1972-12-26 | 1976-11-16 | Pfizer Inc. | Sulfamylbenzoic acids |
| US4480102A (en) * | 1982-07-23 | 1984-10-30 | The Dow Chemical Company | 2,3-Difluoro-5-(trifluoromethyl)pyridine and methods of making and using the same |
| ES2061953T3 (es) * | 1988-11-24 | 1994-12-16 | Akzo Nv | Un procedimiento para preparar una composicion farmaceutica. |
| DE4235155A1 (de) * | 1992-10-19 | 1994-04-21 | Basf Ag | Verfahren zur Herstellung von Methylsulfonylbenzoesäuren |
| DE69906059D1 (de) * | 1998-04-20 | 2003-04-24 | Fujisawa Pharmaceutical Co | Anthranilsäurederivate als inhibitoren der c-gmp-phosphodiesterase |
| DE10112040A1 (de) | 2001-03-14 | 2002-10-02 | Aventis Pharma Gmbh | Verbessertes Verfahren zur Herstellung von Sulfonylcarboxamidderivaten |
| GB0227240D0 (en) * | 2002-11-21 | 2002-12-31 | Glaxo Group Ltd | Compounds |
| NZ544820A (en) * | 2003-08-11 | 2009-02-28 | Hoffmann La Roche | Piperazine with or-substituted phenyl group and their use as GlyT1 inhibitors |
| CA2593453A1 (en) * | 2005-01-06 | 2006-07-13 | F. Hoffmann-La Roche Ag | Sulfanyl substituted phenyl methanones as glycine transporter 1 (glyt-1) inhibitors for the treatment of neurological and neuropsychiatric disorders |
| ATE472327T1 (de) * | 2005-01-07 | 2010-07-15 | Hoffmann La Roche | Ä4-(heteroaryl)piperazin-1-ylü-(2,5-substituier e phenyl)methanon-derivate als glycin-transporter 1 (glyt-1) hemmer zur behandlung von neurologischen und neuropsychiatrischen erkrankungen |
| KR100946461B1 (ko) * | 2005-07-08 | 2010-03-10 | 에프. 호프만-라 로슈 아게 | 1,1,1-트라이플루오로아세톤의 비대칭 환원 |
-
2008
- 2008-02-25 CA CA2678630A patent/CA2678630C/en active Active
- 2008-02-25 CN CN200880006900XA patent/CN101622000B/zh active Active
- 2008-02-25 JP JP2009552166A patent/JP4745446B2/ja active Active
- 2008-02-25 KR KR1020097018418A patent/KR101143073B1/ko active Active
- 2008-02-25 AT AT08709206T patent/ATE532516T1/de active
- 2008-02-25 MX MX2009009065A patent/MX2009009065A/es active IP Right Grant
- 2008-02-25 WO PCT/EP2008/052244 patent/WO2008107334A2/en not_active Ceased
- 2008-02-25 BR BRPI0808570A patent/BRPI0808570B8/pt active IP Right Grant
- 2008-02-25 AU AU2008223915A patent/AU2008223915B2/en active Active
- 2008-02-25 ES ES08709206T patent/ES2375585T3/es active Active
- 2008-02-25 EP EP08709206A patent/EP2131843B1/en active Active
- 2008-02-27 US US12/038,006 patent/US7812161B2/en active Active
-
2009
- 2009-08-10 IL IL200323A patent/IL200323A/en active IP Right Grant
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2006061135A1 (en) * | 2004-12-09 | 2006-06-15 | F. Hoffmann-La Roche Ag | Phenyl-piperazin methanone derivatives |
Non-Patent Citations (2)
| Title |
|---|
| Harald Suhr.Der EinfluB der austretenden Grupppe auf die Geschwindigkeit von nucleophilen aromatischen Substitutionen.《Chemische Berichte》.1963,第97卷参见第3268-3276页. * |
| Jerry March.aromatic nucleophilic substitute.《Advanced Organic Chemistry:reactions,mechanisms, and structure》.1992,(第4版),参见第652-653页. * |
Also Published As
| Publication number | Publication date |
|---|---|
| US20080221327A1 (en) | 2008-09-11 |
| CA2678630A1 (en) | 2008-09-12 |
| JP2010520251A (ja) | 2010-06-10 |
| CN101622000A (zh) | 2010-01-06 |
| BRPI0808570B8 (pt) | 2021-05-25 |
| EP2131843B1 (en) | 2011-11-09 |
| KR20090110368A (ko) | 2009-10-21 |
| ES2375585T3 (es) | 2012-03-02 |
| US7812161B2 (en) | 2010-10-12 |
| IL200323A (en) | 2013-11-28 |
| CA2678630C (en) | 2015-04-14 |
| MX2009009065A (es) | 2009-08-31 |
| KR101143073B1 (ko) | 2012-05-08 |
| EP2131843A2 (en) | 2009-12-16 |
| ATE532516T1 (de) | 2011-11-15 |
| IL200323A0 (en) | 2010-04-29 |
| WO2008107334A3 (en) | 2008-10-23 |
| AU2008223915B2 (en) | 2013-05-02 |
| BRPI0808570B1 (pt) | 2020-09-15 |
| JP4745446B2 (ja) | 2011-08-10 |
| AU2008223915A1 (en) | 2008-09-12 |
| WO2008107334A2 (en) | 2008-09-12 |
| BRPI0808570A2 (pt) | 2014-09-02 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant |