CN101616909B - 作为Rho-激酶抑制剂的被取代的异喹啉和异喹啉酮衍生物 - Google Patents

作为Rho-激酶抑制剂的被取代的异喹啉和异喹啉酮衍生物 Download PDF

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CN101616909B
CN101616909B CN2007800485477A CN200780048547A CN101616909B CN 101616909 B CN101616909 B CN 101616909B CN 2007800485477 A CN2007800485477 A CN 2007800485477A CN 200780048547 A CN200780048547 A CN 200780048547A CN 101616909 B CN101616909 B CN 101616909B
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alkyl
alkylene
halogen
heterocyclyl
aryl
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CN101616909A (zh
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O·普来登伯格
A·霍夫迈斯特
J·布伦德尔
M·勒恩
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Sanofi SRL
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Sanofi Aventis SpA
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/472—Non-condensed isoquinolines, e.g. papaverine
    • A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

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CN2007800485477A 2006-12-27 2007-12-19 作为Rho-激酶抑制剂的被取代的异喹啉和异喹啉酮衍生物 Expired - Fee Related CN101616909B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP06026898.4 2006-12-27
EP06026898 2006-12-27
PCT/EP2007/011163 WO2008077550A1 (en) 2006-12-27 2007-12-19 Substituted isoquinoline and isoquinolinone derivatives as inhibitors of rho-kinase

Publications (2)

Publication Number Publication Date
CN101616909A CN101616909A (zh) 2009-12-30
CN101616909B true CN101616909B (zh) 2013-09-11

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CN2007800485477A Expired - Fee Related CN101616909B (zh) 2006-12-27 2007-12-19 作为Rho-激酶抑制剂的被取代的异喹啉和异喹啉酮衍生物

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US (2) US8278294B2 (https=)
EP (1) EP2102187B1 (https=)
JP (1) JP5421783B2 (https=)
KR (1) KR101517154B1 (https=)
CN (1) CN101616909B (https=)
AR (1) AR064533A1 (https=)
AU (1) AU2007338406B2 (https=)
BR (1) BRPI0720862A2 (https=)
CA (1) CA2673916C (https=)
CL (1) CL2007003822A1 (https=)
CO (1) CO6321138A2 (https=)
CR (1) CR10812A (https=)
DO (1) DOP2009000163A (https=)
EC (1) ECSP099466A (https=)
IL (1) IL199541A (https=)
MA (1) MA31021B1 (https=)
MX (1) MX2009005825A (https=)
MY (1) MY150746A (https=)
NI (1) NI200900107A (https=)
NO (1) NO20092421L (https=)
NZ (1) NZ577981A (https=)
RU (1) RU2455302C2 (https=)
TN (1) TN2009000270A1 (https=)
TW (1) TWI435723B (https=)
UY (1) UY30840A1 (https=)
WO (1) WO2008077550A1 (https=)
ZA (1) ZA200903550B (https=)

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