CN101611048B - 含有高浓度鸟嘌呤单体的寡核苷酸 - Google Patents

含有高浓度鸟嘌呤单体的寡核苷酸 Download PDF

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Publication number
CN101611048B
CN101611048B CN2007800498509A CN200780049850A CN101611048B CN 101611048 B CN101611048 B CN 101611048B CN 2007800498509 A CN2007800498509 A CN 2007800498509A CN 200780049850 A CN200780049850 A CN 200780049850A CN 101611048 B CN101611048 B CN 101611048B
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oligonucleotide
solvent
seq
coupling
synthesis
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CN101611048A (zh
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B·S·斯普罗特
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Kuros Biosciences
Kuros US LLC
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Cytos Biotechnology AG
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C07H1/06—Separation; Purification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/02—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN2007800498509A 2006-12-12 2007-12-12 含有高浓度鸟嘌呤单体的寡核苷酸 Active CN101611048B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US86958806P 2006-12-12 2006-12-12
US60/869,588 2006-12-12
PCT/US2007/087183 WO2008073960A2 (en) 2006-12-12 2007-12-12 Oligonucleotides containing high concentrations of guanine monomers

Publications (2)

Publication Number Publication Date
CN101611048A CN101611048A (zh) 2009-12-23
CN101611048B true CN101611048B (zh) 2012-11-07

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CN2007800498509A Active CN101611048B (zh) 2006-12-12 2007-12-12 含有高浓度鸟嘌呤单体的寡核苷酸

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Country Link
US (3) US8586728B2 (enExample)
EP (1) EP2125854B1 (enExample)
JP (1) JP5389662B2 (enExample)
CN (1) CN101611048B (enExample)
AU (1) AU2007333147B2 (enExample)
CA (1) CA2671873C (enExample)
WO (1) WO2008073960A2 (enExample)

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EP3752194A4 (en) 2018-02-13 2022-03-16 Checkmate Pharmaceuticals, Inc. COMPOSITIONS AND METHODS FOR TUMOR IMMUNOTHERAPY
EP3775218A1 (en) 2018-04-09 2021-02-17 Checkmate Pharmaceuticals Packaging oligonucleotides into virus-like particles
MX2021002745A (es) * 2018-09-11 2021-05-12 Amgen Inc Metodos de purificacion de oligonucleotidos ricos en guanina.
BR112021007527A2 (pt) * 2018-10-30 2021-08-03 Toray Industries, Inc. inibidor de ligação não específica para ácido nucleico, reagente de hibridização para ácido nucleico, métodos de hibridização de ácido nucleico e de detecção de um ácido nucleico e uso de um ácido nucleico
WO2020093322A1 (zh) * 2018-11-08 2020-05-14 深圳华大生命科学研究院 一种微流控芯片及其制备方法和dna合成方法
US12202848B2 (en) * 2019-10-18 2025-01-21 Fujifilm Wako Pure Chemical Corporation Phosphoramidite activator
US20230322842A1 (en) * 2020-04-14 2023-10-12 Sumitomo Chemical Company, Limited Composition containing nucleic acid oligomer
CN114425443B (zh) * 2020-10-29 2025-10-31 江苏金斯瑞生物科技有限公司 一种寡核苷酸合成催化剂
GB202114688D0 (en) 2021-10-14 2021-12-01 Exactmer Ltd Solution phase polymer synthesis

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Also Published As

Publication number Publication date
WO2008073960A2 (en) 2008-06-19
CA2671873A1 (en) 2008-06-19
US20080139797A1 (en) 2008-06-12
CN101611048A (zh) 2009-12-23
US8586728B2 (en) 2013-11-19
AU2007333147B2 (en) 2013-12-19
US9914746B2 (en) 2018-03-13
WO2008073960A3 (en) 2008-08-07
JP2010512169A (ja) 2010-04-22
AU2007333147A1 (en) 2008-06-19
US20160145293A1 (en) 2016-05-26
US20140200338A1 (en) 2014-07-17
EP2125854B1 (en) 2016-10-26
JP5389662B2 (ja) 2014-01-15
EP2125854A2 (en) 2009-12-02
CA2671873C (en) 2018-10-09

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