CA2671873C - Oligonucleotides containing high concentrations of guanine monomers - Google Patents

Oligonucleotides containing high concentrations of guanine monomers Download PDF

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Publication number
CA2671873C
CA2671873C CA2671873A CA2671873A CA2671873C CA 2671873 C CA2671873 C CA 2671873C CA 2671873 A CA2671873 A CA 2671873A CA 2671873 A CA2671873 A CA 2671873A CA 2671873 C CA2671873 C CA 2671873C
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Prior art keywords
oligonucleotide
solvent
coupling
seq
nucleoside
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CA2671873A
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English (en)
French (fr)
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CA2671873A1 (en
Inventor
Brian Stephen Sproat
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Kuros US LLC
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Kuros Biosciences AG
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C07H1/06—Separation; Purification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/02—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CA2671873A 2006-12-12 2007-12-12 Oligonucleotides containing high concentrations of guanine monomers Active CA2671873C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US86958806P 2006-12-12 2006-12-12
US60/869,588 2006-12-12
PCT/US2007/087183 WO2008073960A2 (en) 2006-12-12 2007-12-12 Oligonucleotides containing high concentrations of guanine monomers

Publications (2)

Publication Number Publication Date
CA2671873A1 CA2671873A1 (en) 2008-06-19
CA2671873C true CA2671873C (en) 2018-10-09

Family

ID=39456527

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2671873A Active CA2671873C (en) 2006-12-12 2007-12-12 Oligonucleotides containing high concentrations of guanine monomers

Country Status (7)

Country Link
US (3) US8586728B2 (enExample)
EP (1) EP2125854B1 (enExample)
JP (1) JP5389662B2 (enExample)
CN (1) CN101611048B (enExample)
AU (1) AU2007333147B2 (enExample)
CA (1) CA2671873C (enExample)
WO (1) WO2008073960A2 (enExample)

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US10040048B1 (en) 2014-09-25 2018-08-07 Synthego Corporation Automated modular system and method for production of biopolymers
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US20190046638A1 (en) 2016-04-01 2019-02-14 Checkmate Pharmaceuticals, Inc. Fc RECEPTOR-MEDIATED DRUG DELIVERY
EP3681637A4 (en) 2017-09-11 2021-06-02 Synthego Corporation SYSTEM AND PROCEDURE FOR BIOPOLYMER SYNTHESIS
WO2019080704A1 (zh) * 2017-10-25 2019-05-02 深圳华大生命科学研究院 用于核酸合成的微流控芯片
WO2019160866A2 (en) 2018-02-13 2019-08-22 Checkmate Pharmaceuticals, Inc. Compositions and methods for tumor immunotherapy
BR112020020479A2 (pt) 2018-04-09 2021-01-12 Checkmate Pharmaceuticals Empacotamento de oligonucleotídeos em partículas similares a vírus
US12049620B2 (en) * 2018-09-11 2024-07-30 Amgen Inc. Purification methods for guanine-rich oligonucleotides
US12655470B2 (en) 2018-10-30 2026-06-16 Toray Industries, Inc. Inhibitor of non-specific binding of nucleic acid, hybridization reagent and nucleic acid hybridization method
CN112969527A (zh) * 2018-11-08 2021-06-15 深圳华大生命科学研究院 一种微流控芯片及其制备方法和dna合成方法
US12202848B2 (en) * 2019-10-18 2025-01-21 Fujifilm Wako Pure Chemical Corporation Phosphoramidite activator
US20230322842A1 (en) * 2020-04-14 2023-10-12 Sumitomo Chemical Company, Limited Composition containing nucleic acid oligomer
CN114425443B (zh) * 2020-10-29 2025-10-31 江苏金斯瑞生物科技有限公司 一种寡核苷酸合成催化剂
GB202114688D0 (en) 2021-10-14 2021-12-01 Exactmer Ltd Solution phase polymer synthesis
GB202414228D0 (en) 2024-09-27 2024-11-13 Exactmer Ltd Solvent recycling in a liquid-phase process for preparing a defined monomoer sequence polymer

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Also Published As

Publication number Publication date
AU2007333147B2 (en) 2013-12-19
US9914746B2 (en) 2018-03-13
EP2125854B1 (en) 2016-10-26
US20140200338A1 (en) 2014-07-17
WO2008073960A3 (en) 2008-08-07
CA2671873A1 (en) 2008-06-19
US8586728B2 (en) 2013-11-19
EP2125854A2 (en) 2009-12-02
CN101611048A (zh) 2009-12-23
CN101611048B (zh) 2012-11-07
WO2008073960A2 (en) 2008-06-19
US20080139797A1 (en) 2008-06-12
AU2007333147A1 (en) 2008-06-19
JP2010512169A (ja) 2010-04-22
US20160145293A1 (en) 2016-05-26
JP5389662B2 (ja) 2014-01-15

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