AU2007333147B2 - Oligonucleotides containing high concentrations of guanine monomers - Google Patents

Oligonucleotides containing high concentrations of guanine monomers Download PDF

Info

Publication number
AU2007333147B2
AU2007333147B2 AU2007333147A AU2007333147A AU2007333147B2 AU 2007333147 B2 AU2007333147 B2 AU 2007333147B2 AU 2007333147 A AU2007333147 A AU 2007333147A AU 2007333147 A AU2007333147 A AU 2007333147A AU 2007333147 B2 AU2007333147 B2 AU 2007333147B2
Authority
AU
Australia
Prior art keywords
oligonucleotide
solvent
seq
coupling
nucleoside
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
AU2007333147A
Other languages
English (en)
Other versions
AU2007333147A1 (en
Inventor
Brian Stephen Sproat
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kuros US LLC
Original Assignee
Kuros US LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kuros US LLC filed Critical Kuros US LLC
Publication of AU2007333147A1 publication Critical patent/AU2007333147A1/en
Assigned to CYTOS BIOTECHNOLOGY AG reassignment CYTOS BIOTECHNOLOGY AG Request for Assignment Assignors: INTEGRATED DNA TECHNOLOGIES, INC.
Priority to AU2013204442A priority Critical patent/AU2013204442A1/en
Application granted granted Critical
Publication of AU2007333147B2 publication Critical patent/AU2007333147B2/en
Assigned to KUROS BIOSCIENCES AG reassignment KUROS BIOSCIENCES AG Request to Amend Deed and Register Assignors: CYTOS BIOTECHNOLOGY AG
Assigned to KUROS US LLC reassignment KUROS US LLC Request for Assignment Assignors: KUROS BIOSCIENCES AG
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C07H1/06—Separation; Purification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/02—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AU2007333147A 2006-12-12 2007-12-12 Oligonucleotides containing high concentrations of guanine monomers Active AU2007333147B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2013204442A AU2013204442A1 (en) 2006-12-12 2013-04-12 Oligonucleotides Containing High Concentrations of Guanine Monomers

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US86958806P 2006-12-12 2006-12-12
US60/869,588 2006-12-12
PCT/US2007/087183 WO2008073960A2 (en) 2006-12-12 2007-12-12 Oligonucleotides containing high concentrations of guanine monomers

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2013204442A Division AU2013204442A1 (en) 2006-12-12 2013-04-12 Oligonucleotides Containing High Concentrations of Guanine Monomers

Publications (2)

Publication Number Publication Date
AU2007333147A1 AU2007333147A1 (en) 2008-06-19
AU2007333147B2 true AU2007333147B2 (en) 2013-12-19

Family

ID=39456527

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2007333147A Active AU2007333147B2 (en) 2006-12-12 2007-12-12 Oligonucleotides containing high concentrations of guanine monomers

Country Status (7)

Country Link
US (3) US8586728B2 (enExample)
EP (1) EP2125854B1 (enExample)
JP (1) JP5389662B2 (enExample)
CN (1) CN101611048B (enExample)
AU (1) AU2007333147B2 (enExample)
CA (1) CA2671873C (enExample)
WO (1) WO2008073960A2 (enExample)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102008063490B4 (de) * 2008-12-17 2023-06-15 Merck Patent Gmbh Organische Elektrolumineszenzvorrichtung und Verfahren zum Einstellen des Farbortes einer weiß emittierenden Elektrolumineszenzvorrichtung
WO2012059510A1 (en) 2010-11-02 2012-05-10 Girindus America, Inc. Back pressure control during solid-phase synthesis on polymeric supports
US10040048B1 (en) 2014-09-25 2018-08-07 Synthego Corporation Automated modular system and method for production of biopolymers
CA2972757A1 (en) 2014-12-31 2016-07-07 Arthur M. Krieg Combination tumor immunotherapy
WO2017005818A1 (en) * 2015-07-08 2017-01-12 Kuros Biosciences Ag Guanine-rich oligonucleotides
EP3436066A1 (en) 2016-04-01 2019-02-06 Checkmate Pharmaceuticals, Inc. Fc receptor-mediated drug delivery
US20190076814A1 (en) 2017-09-11 2019-03-14 Synthego Corporation Biopolymer synthesis system and method
WO2019080704A1 (zh) * 2017-10-25 2019-05-02 深圳华大生命科学研究院 用于核酸合成的微流控芯片
EP3752194A4 (en) 2018-02-13 2022-03-16 Checkmate Pharmaceuticals, Inc. COMPOSITIONS AND METHODS FOR TUMOR IMMUNOTHERAPY
EP3775218A1 (en) 2018-04-09 2021-02-17 Checkmate Pharmaceuticals Packaging oligonucleotides into virus-like particles
MX2021002745A (es) * 2018-09-11 2021-05-12 Amgen Inc Metodos de purificacion de oligonucleotidos ricos en guanina.
BR112021007527A2 (pt) * 2018-10-30 2021-08-03 Toray Industries, Inc. inibidor de ligação não específica para ácido nucleico, reagente de hibridização para ácido nucleico, métodos de hibridização de ácido nucleico e de detecção de um ácido nucleico e uso de um ácido nucleico
WO2020093322A1 (zh) * 2018-11-08 2020-05-14 深圳华大生命科学研究院 一种微流控芯片及其制备方法和dna合成方法
US12202848B2 (en) * 2019-10-18 2025-01-21 Fujifilm Wako Pure Chemical Corporation Phosphoramidite activator
US20230322842A1 (en) * 2020-04-14 2023-10-12 Sumitomo Chemical Company, Limited Composition containing nucleic acid oligomer
CN114425443B (zh) * 2020-10-29 2025-10-31 江苏金斯瑞生物科技有限公司 一种寡核苷酸合成催化剂
GB202114688D0 (en) 2021-10-14 2021-12-01 Exactmer Ltd Solution phase polymer synthesis

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005014110A1 (en) * 2003-07-22 2005-02-17 Cytos Biotechnology Ag Cpg-packaged liposomes
EP1719778A1 (en) * 2004-02-25 2006-11-08 Japan Science and Technology Agency 3'-terminal nucleoside unit containing phosphoramidite

Family Cites Families (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS60500817A (ja) * 1983-06-01 1985-05-30 ベツクマン・インストルメンツ・インコ−ポレ−テツド ヌクレオシド・ホスホルアミダイト中間体の製造方法
US20030050263A1 (en) 1994-07-15 2003-03-13 The University Of Iowa Research Foundation Methods and products for treating HIV infection
ATE292980T1 (de) 1996-10-11 2005-04-15 Univ California Immunostimulierende oligonucleotidekonjugate
AU7350798A (en) 1997-04-29 1998-11-24 Universiteit Utrecht Corona virus-like particles as tools for vaccination and therapy
AU750702B2 (en) 1997-05-01 2002-07-25 Chiron Corporation Use of virus-like particles as adjuvants
US6171591B1 (en) 1997-12-08 2001-01-09 Pentamer Pharmaceuticals, Inc. Recombinant nodavirus compositions and methods
US6541438B1 (en) 1998-05-01 2003-04-01 The Procter & Gamble Company Laundry detergent and/or fabric care compositions comprising a modified cellulase
AU770802B2 (en) 1998-10-21 2004-03-04 Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The Virus-like particles for the induction of autoantibodies
ES2317711T3 (es) 1998-11-30 2009-04-16 Cytos Biotechnology Ag Presentacion molecular de alergenos, metodos de preparacion y uso.
JP2003520568A (ja) 1999-02-02 2003-07-08 バイオカシェ ファーマシューティカルズ， インコーポレイテッド 高度な抗原提示プラットフォーム
JP2002537102A (ja) 1999-02-26 2002-11-05 カイロン コーポレイション 吸着された高分子および微粒子を有するミクロエマルジョン
UA77152C2 (en) 1999-09-25 2006-11-15 Method for stimulation of immune response using nucleic acid-containing immunostimulating compositions, method for treatment of cancer and method for treatment or prophylaxis of allergy or asthma
JP2003510290A (ja) 1999-09-27 2003-03-18 コーリー ファーマシューティカル グループ，インコーポレイテッド 免疫刺激核酸誘導インターフェロンに関する方法
US6949520B1 (en) 1999-09-27 2005-09-27 Coley Pharmaceutical Group, Inc. Methods related to immunostimulatory nucleic acid-induced interferon
JP2003511420A (ja) 1999-10-13 2003-03-25 カイロン コーポレイション タンパク質から細胞性免疫応答を得る方法
AU1928201A (en) 1999-11-24 2001-06-04 Chiron Corporation Hbv/hcv virus-like particle
AT409085B (de) 2000-01-28 2002-05-27 Cistem Biotechnologies Gmbh Pharmazeutische zusammensetzung zur immunmodulation und herstellung von vakzinen
WO2001062275A1 (en) 2000-02-24 2001-08-30 The Board Of Trustees Of The Leland Stanford Junior University Adjuvant treatment by in vivo activation of dendritic cells
AU2002248185A1 (en) 2000-12-14 2002-07-16 Coley Pharmaceutical Group, Inc. Inhibition of angiogenesis by nucleic acids
US20030050268A1 (en) 2001-03-29 2003-03-13 Krieg Arthur M. Immunostimulatory nucleic acid for treatment of non-allergic inflammatory diseases
EP1425040A2 (en) 2001-09-14 2004-06-09 Cytos Biotechnology AG In vivo activation of antigen presenting cells for enhancement of immune responses induced by virus like particles
ATE447967T1 (de) 2001-09-14 2009-11-15 Cytos Biotechnology Ag Verpackung von immunstimulierendem cpg in virusähnlichen partikeln: herstellungsverfahren und verwendung
US7524950B2 (en) 2001-10-31 2009-04-28 Agilent Technologies, Inc. Uses of cationic salts for polynucleotide synthesis
ATE489969T1 (de) 2002-06-20 2010-12-15 Cytos Biotechnology Ag Verpackte virusartige partikel in kombination mit cpg zur verwendung als adjuvantien mit allergenen. herstellungsverfahren und verwendung
JP5022028B2 (ja) 2003-03-26 2012-09-12 サイトス・バイオテクノロジー・アクチェンゲゼルシャフト メラン−ａペプチドアナログ−ウイルス様粒子コンジュゲート
US7537767B2 (en) 2003-03-26 2009-05-26 Cytis Biotechnology Ag Melan-A- carrier conjugates
US20060210588A1 (en) 2003-03-26 2006-09-21 Cytos Biotechnology Ag Hiv-peptide-carrier-conjugates
CA2527102A1 (en) 2003-07-10 2005-01-20 Cytos Biotechnology Ag Packaged virus-like particles
EP1789460B1 (en) * 2004-09-02 2013-01-09 Isis Pharmaceuticals, Inc. Polymeric beads for oligonucleotide synthesis
BRPI0516953A (pt) 2004-09-21 2008-09-30 Cytos Biotechnology Ag partìculas do tipo vìrus compreendendo uma proteìna de fusão da proteìna de revestimento de ap205 e um polipeptìdeo antigênico
EP1973608A1 (en) 2005-12-14 2008-10-01 Cytos Biotechnology AG Immunostimulatory nucleic acid packaged particles for the treatment of hypersensitivity

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005014110A1 (en) * 2003-07-22 2005-02-17 Cytos Biotechnology Ag Cpg-packaged liposomes
EP1719778A1 (en) * 2004-02-25 2006-11-08 Japan Science and Technology Agency 3'-terminal nucleoside unit containing phosphoramidite

Also Published As

Publication number Publication date
WO2008073960A2 (en) 2008-06-19
CA2671873A1 (en) 2008-06-19
US20080139797A1 (en) 2008-06-12
CN101611048A (zh) 2009-12-23
US8586728B2 (en) 2013-11-19
US9914746B2 (en) 2018-03-13
WO2008073960A3 (en) 2008-08-07
JP2010512169A (ja) 2010-04-22
AU2007333147A1 (en) 2008-06-19
US20160145293A1 (en) 2016-05-26
US20140200338A1 (en) 2014-07-17
EP2125854B1 (en) 2016-10-26
JP5389662B2 (ja) 2014-01-15
EP2125854A2 (en) 2009-12-02
CN101611048B (zh) 2012-11-07
CA2671873C (en) 2018-10-09

Similar Documents

Publication Publication Date Title
AU2007333147B2 (en) Oligonucleotides containing high concentrations of guanine monomers
Bonora et al. Large scale, liquid phase synthesis of oligonucleotides by the phosphoramidite approach
JP7377228B2 (ja) グアニンリッチオリゴヌクレオチド
EP2332954A2 (en) Process for the preparation of phosphorothionate oligonucleotides
JP2010248084A (ja) 新規洗浄溶媒を用いるオリゴヌクレオチド合成法
KR20160150051A (ko) Rna 올리고뉴클레오티드 절단 방법
AU2022224306A1 (en) Process for the de-tritylation of oligonucleotides
CA2494150A1 (en) Process for separating and deprotecting oligonucleotides
AU2013204442A1 (en) Oligonucleotides Containing High Concentrations of Guanine Monomers
KR20200035267A (ko) 이메텔스타트를 제조하기 위한 향상된 공정
JP2000342265A (ja) オリゴヌクレオチド類の精製方法
WO2023067038A1 (en) Process for oligonucleotide purification
WO2025028656A1 (ja) オリゴヌクレオチドを製造する方法
ES2741025T3 (es) Oligonucleótidos ricos en guanina
CN119855824A (zh) 核酸的制造方法、杂质的去除方法以及杂质少的核酸
EP4041741A1 (en) Method for the production of a catalytically active dna molecule having improved activity and its use in a method of treating asthma

Legal Events

Date Code Title Description
PC1 Assignment before grant (sect. 113)

Owner name: CYTOS BIOTECHNOLOGY AG

Free format text: FORMER APPLICANT(S): INTEGRATED DNA TECHNOLOGIES, INC.

FGA Letters patent sealed or granted (standard patent)
HB Alteration of name in register

Owner name: KUROS BIOSCIENCES AG

Free format text: FORMER NAME(S): CYTOS BIOTECHNOLOGY AG

PC Assignment registered

Owner name: KUROS US LLC

Free format text: FORMER OWNER(S): KUROS BIOSCIENCES AG