CN101563329B - 用于制备4，4'-（1-甲基-1，2-乙二基）-双-（2，6-哌嗪二酮）的新方法 - Google Patents

用于制备4，4'-（1-甲基-1，2-乙二基）-双-（2，6-哌嗪二酮）的新方法 Download PDF

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Publication number
CN101563329B
CN101563329B CN2007800467375A CN200780046737A CN101563329B CN 101563329 B CN101563329 B CN 101563329B CN 2007800467375 A CN2007800467375 A CN 2007800467375A CN 200780046737 A CN200780046737 A CN 200780046737A CN 101563329 B CN101563329 B CN 101563329B
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China
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compound
formula
tetraacethyl
preparation
methyl
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Expired - Fee Related
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CN2007800467375A
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English (en)
Chinese (zh)
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CN101563329A (zh
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A·考克
E·纽费尔纳
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Cyathus Exquirere Pharmaforschungs GmbH
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Cyathus Exquirere Pharmaforschungs GmbH
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/06—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members
    • C07D241/08—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/06—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton
    • C07C229/10—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings
    • C07C229/16—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings to carbon atoms of hydrocarbon radicals substituted by amino or carboxyl groups, e.g. ethylenediamine-tetra-acetic acid, iminodiacetic acids

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN2007800467375A 2006-11-24 2007-11-23 用于制备4，4'-（1-甲基-1，2-乙二基）-双-（2，6-哌嗪二酮）的新方法 Expired - Fee Related CN101563329B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
ATA1958/2006 2006-11-24
ATA1958/2006A AT504621B1 (de) 2006-11-24 2006-11-24 Neues verfahren zur herstellung von 4,4'-(1-methyl -1,2-ethandiyl)-bis-(2,6-piperazindion)
PCT/AT2007/000529 WO2008061270A1 (de) 2006-11-24 2007-11-23 Neues verfahren zur herstellung von 4,4'-(1-methyl-1,2-ethandiyl)-bis-(2,6-piperazindion)

Publications (2)

Publication Number Publication Date
CN101563329A CN101563329A (zh) 2009-10-21
CN101563329B true CN101563329B (zh) 2013-03-13

Family

ID=39048046

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CN2007800467375A Expired - Fee Related CN101563329B (zh) 2006-11-24 2007-11-23 用于制备4，4'-（1-甲基-1，2-乙二基）-双-（2，6-哌嗪二酮）的新方法

Country Status (24)

Country Link
US (1) US8455641B2 (https=)
EP (1) EP2099773B1 (https=)
JP (1) JP2010510253A (https=)
KR (1) KR20090119828A (https=)
CN (1) CN101563329B (https=)
AR (1) AR063927A1 (https=)
AT (1) AT504621B1 (https=)
AU (1) AU2007324322A1 (https=)
BR (1) BRPI0719153A2 (https=)
CA (1) CA2670282A1 (https=)
CL (1) CL2007003348A1 (https=)
CO (1) CO6220854A2 (https=)
ES (1) ES2651245T3 (https=)
IL (1) IL198908A0 (https=)
MA (1) MA31015B1 (https=)
MX (1) MX2009005423A (https=)
NO (1) NO20092076L (https=)
NZ (1) NZ577293A (https=)
PE (1) PE20081497A1 (https=)
TW (1) TWI491607B (https=)
UA (1) UA102509C2 (https=)
UY (1) UY30740A1 (https=)
WO (1) WO2008061270A1 (https=)
ZA (1) ZA200903780B (https=)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012081036A2 (en) * 2010-12-13 2012-06-21 Sequent Scientific Limited A process for preparation of 4,4'-(1-methyl-1,2-ethandiyl)-bis-(2,6-piperazinedione)
CN102952088B (zh) * 2012-06-26 2015-05-27 江苏奥赛康药业股份有限公司 右丙亚胺的制备方法
CZ2013171A3 (cs) * 2013-03-07 2014-04-30 Ústav organické chemie a biochemie Akademie věd ČR, v. v. i. Způsob výroby čistých bezvodých enantiomerů kyseliny 1,2-diaminopropan-N,N,N´,N´-tetraoctové
CN104177301B (zh) * 2013-05-22 2016-04-13 江苏奥赛康药业股份有限公司 一种右丙亚胺的制备方法
CN108250094B (zh) * 2018-03-09 2021-01-26 江苏奥赛康药业有限公司 一种哌嗪二酮类化合物的制备方法
CN110804022B (zh) * 2019-11-06 2023-01-17 扬子江药业集团有限公司 一种右丙亚胺的制备方法
CN113336661B (zh) * 2020-03-03 2022-08-05 南京正大天晴制药有限公司 一种四乙酸甲酯类化合物的制备方法

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2428353A (en) * 1943-06-21 1947-10-07 Frederick C Bersworth Lower aliphatic esters of ethylene-and propylene-diamine n,n'-tetracetic acids
GB961065A (en) * 1961-01-19 1964-06-17 Geigy Ag J R Manufacture of new poly-n-diacetic acid imides
US3196153A (en) * 1961-01-19 1965-07-20 Geigy Chem Corp Poly(3, 5-diketo-piperazinyl-1) compounds
EP0330381A1 (en) * 1988-02-17 1989-08-30 Erbamont, Inc. Process for preparing bis (3,5-dioxopiperazinyl) alkanes or alkenes

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3941790A (en) * 1967-07-03 1976-03-02 National Research Development Corporation Bis diketopiperazines
JP2556026B2 (ja) * 1986-04-03 1996-11-20 日産化学工業株式会社 アルカリ廃水からの有用なカルボン酸の回収方法
US4764614A (en) * 1987-03-23 1988-08-16 Monsanto Company Process for preparing (S)(+)-4,4'(methyl-1,2-ethanediyl)-bis(2,6-piperazinedione)
JPS63243060A (ja) * 1987-03-31 1988-10-07 Nippon Mining Co Ltd エステル化物の回収方法
GB9122677D0 (en) * 1991-10-25 1991-12-11 Eurocetus Bv Process for preparing(s)(+)-4,4'-(1-methyl-1,2-ethanediyl)-bis(2,6-piperazinedione)
JPH11343267A (ja) * 1998-05-28 1999-12-14 Daikin Ind Ltd 含ハロゲンカルボン酸エステルの製造方法
WO2007053415A2 (en) * 2005-11-01 2007-05-10 Novartis Vaccines And Diagnostics Inc. Agents for the treatment of cardiac arrhythmias

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2428353A (en) * 1943-06-21 1947-10-07 Frederick C Bersworth Lower aliphatic esters of ethylene-and propylene-diamine n,n'-tetracetic acids
GB961065A (en) * 1961-01-19 1964-06-17 Geigy Ag J R Manufacture of new poly-n-diacetic acid imides
US3196153A (en) * 1961-01-19 1965-07-20 Geigy Chem Corp Poly(3, 5-diketo-piperazinyl-1) compounds
EP0330381A1 (en) * 1988-02-17 1989-08-30 Erbamont, Inc. Process for preparing bis (3,5-dioxopiperazinyl) alkanes or alkenes

Also Published As

Publication number Publication date
CL2007003348A1 (es) 2008-06-06
ES2651245T3 (es) 2018-01-25
MA31015B1 (fr) 2009-12-01
JP2010510253A (ja) 2010-04-02
PE20081497A1 (es) 2008-10-30
AU2007324322A1 (en) 2008-05-29
TW200825068A (en) 2008-06-16
EP2099773B1 (de) 2017-07-05
US8455641B2 (en) 2013-06-04
US20100152447A1 (en) 2010-06-17
AR063927A1 (es) 2009-02-25
CN101563329A (zh) 2009-10-21
EP2099773A1 (de) 2009-09-16
UY30740A1 (es) 2008-07-03
NO20092076L (no) 2009-08-17
TWI491607B (zh) 2015-07-11
WO2008061270A1 (de) 2008-05-29
UA102509C2 (uk) 2013-07-25
ZA200903780B (en) 2014-11-26
NZ577293A (en) 2011-12-22
RU2009123980A (ru) 2010-12-27
BRPI0719153A2 (pt) 2014-02-04
KR20090119828A (ko) 2009-11-20
AT504621A1 (de) 2008-06-15
AT504621B1 (de) 2014-08-15
MX2009005423A (es) 2009-07-17
HK1133001A1 (en) 2010-03-12
CA2670282A1 (en) 2008-05-29
CO6220854A2 (es) 2010-11-19
IL198908A0 (en) 2010-02-17

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