CN101553565B - 从血液特别是外周血扩增成体干细胞的方法及在医药领域的相关应用 - Google Patents

从血液特别是外周血扩增成体干细胞的方法及在医药领域的相关应用 Download PDF

Info

Publication number
CN101553565B
CN101553565B CN200780034935.XA CN200780034935A CN101553565B CN 101553565 B CN101553565 B CN 101553565B CN 200780034935 A CN200780034935 A CN 200780034935A CN 101553565 B CN101553565 B CN 101553565B
Authority
CN
China
Prior art keywords
stem cells
cells
blood
mcsf
treatment
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CN200780034935.XA
Other languages
English (en)
Chinese (zh)
Other versions
CN101553565A (zh
Inventor
A·加巴科塔
M·普莱蒂尼
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Thankstem Srl
Original Assignee
SALES ENGINEERING AG
Sanxtom Liability Co ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SALES ENGINEERING AG, Sanxtom Liability Co ltd filed Critical SALES ENGINEERING AG
Publication of CN101553565A publication Critical patent/CN101553565A/zh
Application granted granted Critical
Publication of CN101553565B publication Critical patent/CN101553565B/zh
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0662—Stem cells
    • C12N5/0665—Blood-borne mesenchymal stem cells, e.g. from umbilical cord blood
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/20—Cytokines; Chemokines
    • C12N2501/22—Colony stimulating factors (G-CSF, GM-CSF)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Rheumatology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Reproductive Health (AREA)
  • Neurology (AREA)
  • Cell Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Dermatology (AREA)
  • Virology (AREA)
  • Tropical Medicine & Parasitology (AREA)
CN200780034935.XA 2006-09-20 2007-09-11 从血液特别是外周血扩增成体干细胞的方法及在医药领域的相关应用 Active CN101553565B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IT000498A ITRM20060498A1 (it) 2006-09-20 2006-09-20 Metodo di espansione di cellule staminali adulte da sangue periferico e relativi usi in campo medico
ITRM2006A000498 2006-09-20
PCT/EP2007/059531 WO2008034740A1 (en) 2006-09-20 2007-09-11 Expansion method for adult stem cells from blood, particularly peripheral blood, and relative application in medical field

Publications (2)

Publication Number Publication Date
CN101553565A CN101553565A (zh) 2009-10-07
CN101553565B true CN101553565B (zh) 2015-05-06

Family

ID=38126399

Family Applications (1)

Application Number Title Priority Date Filing Date
CN200780034935.XA Active CN101553565B (zh) 2006-09-20 2007-09-11 从血液特别是外周血扩增成体干细胞的方法及在医药领域的相关应用

Country Status (20)

Country Link
US (2) US8263400B2 (cg-RX-API-DMAC7.html)
EP (1) EP2076588B1 (cg-RX-API-DMAC7.html)
JP (1) JP5340941B2 (cg-RX-API-DMAC7.html)
KR (1) KR101570446B1 (cg-RX-API-DMAC7.html)
CN (1) CN101553565B (cg-RX-API-DMAC7.html)
AU (1) AU2007299043B2 (cg-RX-API-DMAC7.html)
BR (1) BRPI0715036A2 (cg-RX-API-DMAC7.html)
CA (1) CA2663072C (cg-RX-API-DMAC7.html)
DK (1) DK2076588T3 (cg-RX-API-DMAC7.html)
EA (1) EA019305B1 (cg-RX-API-DMAC7.html)
ES (1) ES2435080T3 (cg-RX-API-DMAC7.html)
HR (1) HRP20131104T1 (cg-RX-API-DMAC7.html)
IL (1) IL197575A (cg-RX-API-DMAC7.html)
IT (1) ITRM20060498A1 (cg-RX-API-DMAC7.html)
MX (1) MX2009003059A (cg-RX-API-DMAC7.html)
PL (1) PL2076588T3 (cg-RX-API-DMAC7.html)
RS (1) RS53039B (cg-RX-API-DMAC7.html)
SI (1) SI2076588T1 (cg-RX-API-DMAC7.html)
WO (1) WO2008034740A1 (cg-RX-API-DMAC7.html)
ZA (1) ZA200901748B (cg-RX-API-DMAC7.html)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9132116B2 (en) * 2004-08-02 2015-09-15 Willowcroft Pharm Inc. Mast cell stabilizers to prevent or treat laminitis
ITUD20080058A1 (it) * 2008-03-18 2009-09-19 Thankstem S R L Kit per la raccolta di sangue, preferibilmente periferico, per la produzione di cellule staminali
WO2010126544A1 (en) * 2009-04-29 2010-11-04 Willowcroft Pharm, Llc Mast cell stabilizers to prevent or treat laminitis
KR101202836B1 (ko) * 2010-08-27 2012-11-20 서울대학교산학협력단 세포응집을 이용한 인간 혈액 유래 혈구 세포괴의 유도와 이를 이용한 혈중 성체줄기세포 및 전구세포의 증폭방법 및 상기의 방법에 의해 제조된 줄기세포
CA2863556A1 (en) * 2011-01-31 2012-08-09 Henry E. Young Pluripotent stem cells and method of stimulating and extracting non-embryonic pluripotent stem cells from mammal blood and using reconstituted pluripotent stem cells to treat diseases including chronic obstructive pulmonary disease
BE1020480A5 (nl) 2012-10-01 2013-11-05 Global Stem Cell Technology Werkwijze voor de isolatie van mesenchymale stamcellen uit bloed van zoogdieren, en gebruik ervan.
ES2690253T3 (es) * 2014-05-09 2018-11-20 Thankstem S.R.L. Método para expandir células madre adultas a partir de sangre entera
RU2644650C2 (ru) 2014-12-01 2018-02-13 Общество с ограниченной ответственностью "Т-Хелпер Клеточные Технологии" Материал стволовых клеток и способ его получения
WO2016204230A1 (ja) * 2015-06-17 2016-12-22 仁幸 小林 幹細胞投与方法、競走馬または競技馬の症状改善方法、注射用容器および幹細胞注射セット
RU2708329C2 (ru) 2016-05-31 2019-12-05 Общество с ограниченной ответственностью "Т-Хелпер Клеточные Технологии" Материал стволовых клеток, композиции и способы применения
AU2017281631B2 (en) * 2016-06-23 2023-06-15 Tithon Biotech, Inc. Cells expressing parathyroid hormone 1 receptor and uses thereof
US11103537B2 (en) 2016-06-23 2021-08-31 Tithon Biotech Inc. Cells expressing parathyroid hormone 1 receptor and uses thereof
WO2020234910A1 (en) * 2019-05-22 2020-11-26 Thankstem S.R.L. Method for expanding adult stem cells from whole blood

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1436843A (zh) * 2002-02-08 2003-08-20 刘颉 脐血造血干细胞的制作方法
CN1667119A (zh) * 2004-03-11 2005-09-14 中国人民解放军第二军医大学 一种成体干细胞及其培养方法和用途

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI288779B (en) * 2002-03-28 2007-10-21 Blasticon Biotech Forschung Dedifferentiated, programmable stem cells of monocytic origin, and their production and use
WO2004043990A2 (en) * 2002-11-07 2004-05-27 University Of Chicago Human stem cell materials and methods

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1436843A (zh) * 2002-02-08 2003-08-20 刘颉 脐血造血干细胞的制作方法
CN1667119A (zh) * 2004-03-11 2005-09-14 中国人民解放军第二军医大学 一种成体干细胞及其培养方法和用途

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
A human peripheral blood monocyte-derived subset acts as pluripotent stem cells;Yong Zhao et al;《PNAS》;20030304;第100卷(第4期);p2426-2431 *

Also Published As

Publication number Publication date
KR101570446B1 (ko) 2015-11-27
ITRM20060498A1 (it) 2008-03-21
IL197575A0 (en) 2011-08-01
ES2435080T3 (es) 2013-12-18
EA200970294A1 (ru) 2009-10-30
IL197575A (en) 2013-06-27
HK1138315A1 (en) 2010-08-20
ZA200901748B (en) 2010-03-31
KR20090074044A (ko) 2009-07-03
CN101553565A (zh) 2009-10-07
US20100068189A1 (en) 2010-03-18
CA2663072C (en) 2016-01-19
WO2008034740A1 (en) 2008-03-27
AU2007299043A1 (en) 2008-03-27
JP5340941B2 (ja) 2013-11-13
US8263400B2 (en) 2012-09-11
RS53039B (sr) 2014-04-30
US20120308535A1 (en) 2012-12-06
EP2076588A1 (en) 2009-07-08
MX2009003059A (es) 2009-04-01
AU2007299043B2 (en) 2013-06-27
HRP20131104T1 (hr) 2013-12-20
BRPI0715036A2 (pt) 2013-05-28
PL2076588T3 (pl) 2014-01-31
CA2663072A1 (en) 2008-03-27
DK2076588T3 (da) 2013-11-11
EA019305B1 (ru) 2014-02-28
SI2076588T1 (sl) 2013-12-31
JP2010504083A (ja) 2010-02-12
EP2076588B1 (en) 2013-08-21

Similar Documents

Publication Publication Date Title
CN101553565B (zh) 从血液特别是外周血扩增成体干细胞的方法及在医药领域的相关应用
JP2010504083A5 (cg-RX-API-DMAC7.html)
Chang et al. Regenerative therapy for stroke
Liao et al. Exogenous neural stem cell transplantation for cerebral ischemia
Xiong et al. Transplantation of hematopoietic stem cells promotes functional improvement associated with NT-3-MEK-1 activation in spinal cord-transected rats
Wang et al. Combination Therapy of Bone Marrow Mesenchymal Stem Cell Transplantation and Electroacupuncture for the Repair of Intrauterine Adhesions in Rats: Mechanisms and Functional Recovery
Sugai et al. Stem cell therapies for spinal cord injury in humans: A review of recent clinical research
AU2010306868B2 (en) Stem cells for musculoskeletal tissue repair
Zhang et al. Therapeutic effects of dental pulp stem cells on vascular dementia in rat models
HK1138315B (en) Expansion method for adult stem cells from blood, particularly peripheral blood, and relative application in medical field
CN113069472B (zh) 肝脏前体细胞、其制备方法以及在抑郁症治疗中的用途
Bakhtiary et al. Combination of stem cell mobilized by granulocyte-colony stimulating factor and human umbilical cord matrix stem cell: therapy of traumatic brain injury in rats
KR20130023797A (ko) 자연살해세포 억제제 및 간엽줄기세포를 유효성분으로 포함하는 이식편대숙주질환의 예방 또는 치료를 위한 세포치료제 조성물
US20230405054A1 (en) Novel nr1 es-derived neural stem cells having a normal karyotype and uses thereof
Martín López Cervical spinal cord injury Treatment with iPSC-derived NSCS: preclinical Studies
CN120064653A (zh) 一种鉴定脐带间充质干细胞心肌修复特性的方法
JP2022113019A (ja) Ｐｔｘ－３、ｔｉｍｐ１、およびｂｄｎｆを発現する間葉系幹細胞を有効成分として含む、炎症性疾患または疼痛の予防または治療のための医薬組成物
May A treatment for SCI: From regeneration and plasticity to rehabilitative training
Chen et al. Synergistic actions of olomoucine and bone morphogenetic protein-4 in axonal repair after acute spinal cord contusion
WO2013069861A1 (ko) 지방조직유래줄기세포에 ｃｂｍ－１０７８을 처리함으로써 분화 유도된 ｇａｂａ성 신경세포를 유효성분으로 포함하는 신경성 통증 예방 및 치료용 약학적 조성물
US20120070418A1 (en) Stem cells for musculoskeletal tissue repair
Prajzlerova et al. www. ibimapublishing. com
UA119730C2 (uk) Спосіб комплексного лікування розсіяного склерозу мегадозами фетальних стовбурових клітин у поєднанні з екстрактами фетальних тканин
WO2018162722A1 (en) Dpp-4 inhibitors for use in treating bone fractures

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
REG Reference to a national code

Ref country code: HK

Ref legal event code: DE

Ref document number: 1138315

Country of ref document: HK

ASS Succession or assignment of patent right

Owner name: SANGKE SITEMU CO., LTD.

Free format text: FORMER OWNER: THANKSTEM S. R. L.

Effective date: 20110906

C41 Transfer of patent application or patent right or utility model
TA01 Transfer of patent application right

Effective date of registration: 20110906

Address after: Italy Udine

Applicant after: THANKSTEM SRL

Address before: Zurich

Applicant before: Thankstem S. R. L.

C14 Grant of patent or utility model
GR01 Patent grant
REG Reference to a national code

Ref country code: HK

Ref legal event code: GR

Ref document number: 1138315

Country of ref document: HK