CN101553504A - Aβ抗体胃肠外制剂 - Google Patents

Aβ抗体胃肠外制剂 Download PDF

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Publication number
CN101553504A
CN101553504A CNA2007800455861A CN200780045586A CN101553504A CN 101553504 A CN101553504 A CN 101553504A CN A2007800455861 A CNA2007800455861 A CN A2007800455861A CN 200780045586 A CN200780045586 A CN 200780045586A CN 101553504 A CN101553504 A CN 101553504A
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antibody
formulation
histidine
tween
sucrose
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Pending
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CNA2007800455861A
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Chinese (zh)
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P·哥德巴赫
H·-C·马勒
R·穆勒
C·维特
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F Hoffmann La Roche AG
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F Hoffmann La Roche AG
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Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of CN101553504A publication Critical patent/CN101553504A/zh
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39591—Stabilisation, fragmentation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Mycology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Dermatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Inorganic Chemistry (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CNA2007800455861A 2006-12-11 2007-12-11 Aβ抗体胃肠外制剂 Pending CN101553504A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP06025590.8 2006-11-12
EP06025590 2006-12-11

Publications (1)

Publication Number Publication Date
CN101553504A true CN101553504A (zh) 2009-10-07

Family

ID=39190366

Family Applications (1)

Application Number Title Priority Date Filing Date
CNA2007800455861A Pending CN101553504A (zh) 2006-12-11 2007-12-11 Aβ抗体胃肠外制剂

Country Status (21)

Country Link
US (1) US20110070225A1 (https=)
EP (1) EP2094729A1 (https=)
JP (1) JP2010512356A (https=)
KR (1) KR20090104017A (https=)
CN (1) CN101553504A (https=)
AR (1) AR064220A1 (https=)
AU (1) AU2007331712A1 (https=)
BR (1) BRPI0721097A2 (https=)
CA (1) CA2671968A1 (https=)
CL (1) CL2007003583A1 (https=)
CR (1) CR10823A (https=)
EC (1) ECSP099403A (https=)
IL (1) IL198963A0 (https=)
MA (1) MA30975B1 (https=)
MX (1) MX2009006199A (https=)
NO (1) NO20092586L (https=)
PE (1) PE20081477A1 (https=)
RU (1) RU2009126420A (https=)
TW (1) TW200831133A (https=)
WO (1) WO2008071394A1 (https=)
ZA (1) ZA200904014B (https=)

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CN104023743A (zh) * 2011-10-25 2014-09-03 昂克雷夫治疗有限公司 抗体制剂和方法
CN104684933A (zh) * 2012-08-31 2015-06-03 拜尔健康护理有限责任公司 抗体和蛋白质制剂
CN104736175A (zh) * 2012-08-31 2015-06-24 拜尔健康护理有限责任公司 抗催乳素受体抗体制剂
CN104946616A (zh) * 2015-05-12 2015-09-30 骏实生物科技(上海)有限公司 一种用于体外诊断试剂的通用固体稳定剂及其使用方法
CN106199007A (zh) * 2016-08-03 2016-12-07 烟台普罗吉生物科技发展有限公司 蛋白保护剂
CN106620691A (zh) * 2015-11-04 2017-05-10 信达生物制药(苏州)有限公司 一种重组全人源抗ctla-4单克隆抗体制剂及其应用
CN106913869A (zh) * 2017-03-17 2017-07-04 信达生物制药(苏州)有限公司 一种抗ctla‑4单克隆抗体制剂及其应用
CN107998388A (zh) * 2011-05-02 2018-05-08 米伦纽姆医药公司 抗α4β7抗体的制剂
CN108025072A (zh) * 2015-09-22 2018-05-11 辉瑞公司 制备治疗用蛋白质制剂的方法和由这种方法生产的抗体制剂
CN111201037A (zh) * 2017-08-22 2020-05-26 比奥根Ma公司 含有抗β淀粉样蛋白抗体的药物组合物
CN112618482A (zh) * 2019-09-24 2021-04-09 江苏恒瑞医药股份有限公司 新型蛋白制剂
WO2021136274A1 (zh) * 2019-12-30 2021-07-08 百奥泰生物制药股份有限公司 含抗Trop2抗体-药物偶联物的制剂及其制备方法和应用
CN117088974A (zh) * 2023-08-14 2023-11-21 武汉健昊生物科技有限公司 一种抗体保存液

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CN107998388A (zh) * 2011-05-02 2018-05-08 米伦纽姆医药公司 抗α4β7抗体的制剂
CN107998388B (zh) * 2011-05-02 2023-07-14 千禧制药公司 抗α4β7抗体的制剂
CN108969469A (zh) * 2011-05-02 2018-12-11 米伦纽姆医药公司 抗α4β7抗体的制剂
CN104023743A (zh) * 2011-10-25 2014-09-03 昂克雷夫治疗有限公司 抗体制剂和方法
CN107233569B (zh) * 2011-10-25 2021-08-31 普罗西纳生物科学有限公司 抗体制剂和方法
CN107233569A (zh) * 2011-10-25 2017-10-10 普罗西纳治疗有限公司 抗体制剂和方法
CN114392353A (zh) * 2012-08-31 2022-04-26 拜尔健康护理有限责任公司 抗体和蛋白质制剂
CN104684933A (zh) * 2012-08-31 2015-06-03 拜尔健康护理有限责任公司 抗体和蛋白质制剂
CN111202843A (zh) * 2012-08-31 2020-05-29 拜尔健康护理有限责任公司 抗催乳素受体抗体制剂
CN111202844A (zh) * 2012-08-31 2020-05-29 拜尔健康护理有限责任公司 抗催乳素受体抗体制剂
CN104736175A (zh) * 2012-08-31 2015-06-24 拜尔健康护理有限责任公司 抗催乳素受体抗体制剂
CN104946616A (zh) * 2015-05-12 2015-09-30 骏实生物科技(上海)有限公司 一种用于体外诊断试剂的通用固体稳定剂及其使用方法
CN108025072A (zh) * 2015-09-22 2018-05-11 辉瑞公司 制备治疗用蛋白质制剂的方法和由这种方法生产的抗体制剂
CN106620691B (zh) * 2015-11-04 2020-08-21 信达生物制药(苏州)有限公司 一种重组全人源抗ctla-4单克隆抗体制剂及其应用
CN106620691A (zh) * 2015-11-04 2017-05-10 信达生物制药(苏州)有限公司 一种重组全人源抗ctla-4单克隆抗体制剂及其应用
CN106199007A (zh) * 2016-08-03 2016-12-07 烟台普罗吉生物科技发展有限公司 蛋白保护剂
CN106199007B (zh) * 2016-08-03 2017-04-05 烟台普罗吉生物科技发展有限公司 蛋白保护剂
CN106913869A (zh) * 2017-03-17 2017-07-04 信达生物制药(苏州)有限公司 一种抗ctla‑4单克隆抗体制剂及其应用
CN106913869B (zh) * 2017-03-17 2020-07-28 信达生物制药(苏州)有限公司 一种抗ctla-4单克隆抗体制剂及其应用
CN111201037A (zh) * 2017-08-22 2020-05-26 比奥根Ma公司 含有抗β淀粉样蛋白抗体的药物组合物
CN111201037B (zh) * 2017-08-22 2024-04-02 比奥根Ma公司 含有抗β淀粉样蛋白抗体的药物组合物
CN112618482A (zh) * 2019-09-24 2021-04-09 江苏恒瑞医药股份有限公司 新型蛋白制剂
WO2021136274A1 (zh) * 2019-12-30 2021-07-08 百奥泰生物制药股份有限公司 含抗Trop2抗体-药物偶联物的制剂及其制备方法和应用
CN117088974A (zh) * 2023-08-14 2023-11-21 武汉健昊生物科技有限公司 一种抗体保存液
CN117088974B (zh) * 2023-08-14 2024-02-13 武汉健昊生物科技有限公司 一种抗体保存液

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CA2671968A1 (en) 2008-06-19
ZA200904014B (en) 2010-04-28
RU2009126420A (ru) 2011-01-20
CR10823A (es) 2009-08-12
MX2009006199A (es) 2009-06-22
IL198963A0 (en) 2011-08-01
TW200831133A (en) 2008-08-01
AR064220A1 (es) 2009-03-18
AU2007331712A2 (en) 2009-07-30
AU2007331712A1 (en) 2008-06-19
JP2010512356A (ja) 2010-04-22
ECSP099403A (es) 2009-07-31
BRPI0721097A2 (pt) 2014-07-01
PE20081477A1 (es) 2008-10-18
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KR20090104017A (ko) 2009-10-05
US20110070225A1 (en) 2011-03-24

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