CN101547906B - 抗菌喹啉衍生物 - Google Patents

抗菌喹啉衍生物 Download PDF

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Publication number
CN101547906B
CN101547906B CN200780045128.8A CN200780045128A CN101547906B CN 101547906 B CN101547906 B CN 101547906B CN 200780045128 A CN200780045128 A CN 200780045128A CN 101547906 B CN101547906 B CN 101547906B
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China
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compound
alkyl
formula
aryl
mol
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Expired - Fee Related
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CN200780045128.8A
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English (en)
Chinese (zh)
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CN101547906A (zh
Inventor
J·E·G·吉尔蒙特
I·多兰奇
D·F·A·兰科伊斯
J·M·维拉尔戈多-索托
Y·R·F·西蒙内特
M·M·S·莫特
K·J·L·M·安德烈斯
A·考尔
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Janssen Pharmaceutica NV
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Janssen Pharmaceutica NV
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Application filed by Janssen Pharmaceutica NV filed Critical Janssen Pharmaceutica NV
Publication of CN101547906A publication Critical patent/CN101547906A/zh
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/06—Antibacterial agents for tuberculosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • C07D215/227—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CN200780045128.8A 2006-12-06 2007-12-04 抗菌喹啉衍生物 Expired - Fee Related CN101547906B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP06125545.1 2006-12-06
EP06125545 2006-12-06
PCT/EP2007/063319 WO2008068272A2 (en) 2006-12-06 2007-12-04 Antibacterial quinoline derivatives

Publications (2)

Publication Number Publication Date
CN101547906A CN101547906A (zh) 2009-09-30
CN101547906B true CN101547906B (zh) 2014-08-06

Family

ID=38048032

Family Applications (1)

Application Number Title Priority Date Filing Date
CN200780045128.8A Expired - Fee Related CN101547906B (zh) 2006-12-06 2007-12-04 抗菌喹啉衍生物

Country Status (33)

Country Link
US (1) US20100063026A1 (cg-RX-API-DMAC10.html)
EP (1) EP2099761B1 (cg-RX-API-DMAC10.html)
JP (1) JP5466013B2 (cg-RX-API-DMAC10.html)
KR (1) KR101553600B1 (cg-RX-API-DMAC10.html)
CN (1) CN101547906B (cg-RX-API-DMAC10.html)
AP (1) AP2477A (cg-RX-API-DMAC10.html)
AR (1) AR064148A1 (cg-RX-API-DMAC10.html)
AT (1) ATE486061T1 (cg-RX-API-DMAC10.html)
AU (1) AU2007328892B2 (cg-RX-API-DMAC10.html)
BR (1) BRPI0719915A2 (cg-RX-API-DMAC10.html)
CA (1) CA2668558C (cg-RX-API-DMAC10.html)
CL (1) CL2007003518A1 (cg-RX-API-DMAC10.html)
CY (1) CY1112027T1 (cg-RX-API-DMAC10.html)
DE (1) DE602007010182D1 (cg-RX-API-DMAC10.html)
DK (1) DK2099761T3 (cg-RX-API-DMAC10.html)
EA (1) EA016760B1 (cg-RX-API-DMAC10.html)
ES (1) ES2354755T3 (cg-RX-API-DMAC10.html)
HR (1) HRP20110024T1 (cg-RX-API-DMAC10.html)
IL (1) IL199082A (cg-RX-API-DMAC10.html)
JO (1) JO2683B1 (cg-RX-API-DMAC10.html)
ME (1) ME01230B (cg-RX-API-DMAC10.html)
MX (1) MX2009005906A (cg-RX-API-DMAC10.html)
MY (1) MY145940A (cg-RX-API-DMAC10.html)
NO (1) NO341984B1 (cg-RX-API-DMAC10.html)
NZ (1) NZ576862A (cg-RX-API-DMAC10.html)
PL (1) PL2099761T3 (cg-RX-API-DMAC10.html)
PT (1) PT2099761E (cg-RX-API-DMAC10.html)
RS (1) RS51582B (cg-RX-API-DMAC10.html)
SI (1) SI2099761T1 (cg-RX-API-DMAC10.html)
TW (1) TWI487526B (cg-RX-API-DMAC10.html)
UA (1) UA101307C2 (cg-RX-API-DMAC10.html)
WO (1) WO2008068272A2 (cg-RX-API-DMAC10.html)
ZA (1) ZA200903949B (cg-RX-API-DMAC10.html)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JO2970B1 (en) * 2006-12-06 2016-03-15 جانسين فارماسوتيكا ان. في Quinoline antibacterial derivatives
AU2013254670B2 (en) 2012-04-27 2017-03-30 Janssen Pharmaceutica Nv Antibacterial quinoline derivatives
ES2576491T3 (es) 2012-04-27 2016-07-07 Janssen Pharmaceutica, N.V. Derivados de quinolina antibacterianos
US20250214980A1 (en) 2022-03-14 2025-07-03 Slap Pharmaceuticals Llc Multicyclic compounds

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1671667A (zh) * 2002-07-25 2005-09-21 詹森药业有限公司 喹啉衍生物及其作为分枝杆菌抑制剂的应用

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5965572A (en) * 1996-10-28 1999-10-12 The United States Of America As Respresented By The Secretary Of The Army Methods for treating antibiotic-resistant infections
US7902225B2 (en) * 2004-01-23 2011-03-08 Janssen Pharmaceutica Nv Mycobacterial inhibitors
UA83875C2 (ru) * 2004-01-29 2008-08-26 Янссен Фармацевтика Н.В. Производные хинолина для применения в качестве микобактериальных ингибиторов
MXPA06013888A (es) * 2004-05-28 2007-01-26 Janssen Pharmaceutica Nv Uso de derivados de quinolina sustituidos para el tratamiento de enfermedades micobacterianas resistentes a los farmacos.
EE05394B1 (et) * 2004-12-24 2011-04-15 Janssen Pharmaceutica N.V. Kinoliinihendid kasutamiseks latentse tuberkuloosi ravis
CA2528849C (en) * 2005-06-08 2014-01-14 Janssen Pharmaceutica N.V. Quinoline derivatives as antibacterial agents
JO2752B1 (en) * 2005-06-28 2014-03-15 شركة جانسين فارماسوتيكا ان. في Quinoline derivatives acting as antibacterial agents
KR101329587B1 (ko) * 2005-06-28 2013-11-15 얀센 파마슈티카 엔.브이. 항균제로서의 퀴놀린 유도체
JO2952B1 (en) * 2005-08-03 2016-03-15 جانسين فارماسوتيكا ان. في Quinoline derivatives acting as antibacterial agents
JO2855B1 (en) * 2005-08-03 2015-03-15 شركة جانسين فارماسوتيكا ان. في Quinoline derivatives acting as antibacterial agents
JO2837B1 (en) * 2005-08-03 2014-09-15 جانسن فارمسيتكا ان في Quinoline derivatives acting as antibacterial agents

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1671667A (zh) * 2002-07-25 2005-09-21 詹森药业有限公司 喹啉衍生物及其作为分枝杆菌抑制剂的应用

Also Published As

Publication number Publication date
EA200970537A1 (ru) 2009-10-30
JP2010511672A (ja) 2010-04-15
CA2668558A1 (en) 2008-06-12
CA2668558C (en) 2016-06-07
CY1112027T1 (el) 2015-11-04
ZA200903949B (en) 2010-08-25
PL2099761T3 (pl) 2011-04-29
MX2009005906A (es) 2009-06-16
ES2354755T3 (es) 2011-03-17
NO20092541L (no) 2009-09-02
AP2009004873A0 (en) 2009-06-30
TW200831095A (en) 2008-08-01
DE602007010182D1 (de) 2010-12-09
NO341984B1 (no) 2018-03-05
US20100063026A1 (en) 2010-03-11
MY145940A (en) 2012-05-31
ME01230B (me) 2013-03-20
WO2008068272A2 (en) 2008-06-12
HRP20110024T1 (hr) 2011-04-30
AU2007328892B2 (en) 2013-05-16
TWI487526B (zh) 2015-06-11
JO2683B1 (en) 2013-03-03
AP2477A (en) 2012-09-27
NZ576862A (en) 2012-01-12
EA016760B1 (ru) 2012-07-30
JP5466013B2 (ja) 2014-04-09
UA101307C2 (ru) 2013-03-25
BRPI0719915A2 (pt) 2014-03-04
KR101553600B1 (ko) 2015-09-16
CN101547906A (zh) 2009-09-30
SI2099761T1 (sl) 2011-02-28
PT2099761E (pt) 2011-01-18
IL199082A (en) 2014-04-30
CL2007003518A1 (es) 2008-07-11
AU2007328892A1 (en) 2008-06-12
WO2008068272A3 (en) 2008-07-24
EP2099761A2 (en) 2009-09-16
EP2099761B1 (en) 2010-10-27
DK2099761T3 (da) 2011-02-07
HK1137437A1 (en) 2010-07-30
KR20090102778A (ko) 2009-09-30
RS51582B (sr) 2011-08-31
ATE486061T1 (de) 2010-11-15
AR064148A1 (es) 2009-03-18

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