CN1015457B - 5-(3-烷基-5-叔丁基-4-羟基苯基)-2-氨基-6h-1，3，4-噻二嗪的制备方法 - Google Patents
5-(3-烷基-5-叔丁基-4-羟基苯基)-2-氨基-6h-1，3，4-噻二嗪的制备方法Info
- Publication number
- CN1015457B CN1015457B CN88100519A CN88100519A CN1015457B CN 1015457 B CN1015457 B CN 1015457B CN 88100519 A CN88100519 A CN 88100519A CN 88100519 A CN88100519 A CN 88100519A CN 1015457 B CN1015457 B CN 1015457B
- Authority
- CN
- China
- Prior art keywords
- alkyl
- carbon
- substituted
- butyl
- tert
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
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- 229910052799 carbon Inorganic materials 0.000 claims description 27
- -1 carbon alkane Chemical class 0.000 claims description 13
- 238000000034 method Methods 0.000 claims description 12
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 11
- 229910052760 oxygen Inorganic materials 0.000 claims description 11
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- 229910052757 nitrogen Inorganic materials 0.000 claims description 8
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- 125000005843 halogen group Chemical group 0.000 claims description 2
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- ZWEHNKRNPOVVGH-UHFFFAOYSA-N 2-Butanone Chemical compound CCC(C)=O ZWEHNKRNPOVVGH-UHFFFAOYSA-N 0.000 description 3
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
- C07D285/01—Five-membered rings
- C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
- C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
- C07D285/12—1,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
- C07D285/15—Six-membered rings
- C07D285/16—Thiadiazines; Hydrogenated thiadiazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pain & Pain Management (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Lubricants (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DEP3702756.5 | 1987-01-30 | ||
| DE19873702756 DE3702756A1 (de) | 1987-01-30 | 1987-01-30 | 5-(3-alkyl-5-tert.butyl-4-hydroxyphenyl)-2- amino-6h-1,3,4-thiadiazine, verfahren zu ihrer herstellung, die sie enthaltenden arzneimittel und ihre verwendung |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN88100519A CN88100519A (zh) | 1988-12-28 |
| CN1015457B true CN1015457B (zh) | 1992-02-12 |
Family
ID=6319854
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN88100519A Expired CN1015457B (zh) | 1987-01-30 | 1988-01-29 | 5-(3-烷基-5-叔丁基-4-羟基苯基)-2-氨基-6h-1，3，4-噻二嗪的制备方法 |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US4940790A (index.html) |
| EP (1) | EP0276804B1 (index.html) |
| JP (1) | JPS63192765A (index.html) |
| KR (1) | KR880009003A (index.html) |
| CN (1) | CN1015457B (index.html) |
| AT (1) | ATE73785T1 (index.html) |
| AU (1) | AU602053B2 (index.html) |
| DE (2) | DE3702756A1 (index.html) |
| DK (1) | DK47688A (index.html) |
| ES (1) | ES2038216T3 (index.html) |
| FI (1) | FI880386A7 (index.html) |
| GR (1) | GR3004685T3 (index.html) |
| HU (1) | HU198195B (index.html) |
| IE (1) | IE880248L (index.html) |
| IL (1) | IL85230A0 (index.html) |
| NO (1) | NO169229C (index.html) |
| NZ (1) | NZ223335A (index.html) |
| PH (1) | PH24609A (index.html) |
| PT (1) | PT86656B (index.html) |
| ZA (1) | ZA88641B (index.html) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4768619A (en) * | 1987-11-18 | 1988-09-06 | George Darnell | Fire escape device |
| US5057534A (en) * | 1991-04-12 | 1991-10-15 | A. H. Robins Company Incorporated | 3-amino-5-arylpyrazole-4-acetic acid derivatives exhibiting therapeutic effects |
| US5510361A (en) * | 1994-10-20 | 1996-04-23 | The Procter & Gamble Company | Di-tert-butylphenol compounds with heterocyclic moiety, useful as anti-inflammatory agents |
| DE69523640T2 (de) * | 1995-12-28 | 2002-11-21 | Nauchno-Tekhnologicheskoe Predpriyatie "Ligand" (Obschestvo S Ogranichennoi Otvetstvennostju), Ekaterinburg | Substituierte 6-r-1,3,4-thiadiazin-2-amine, deren verwendung als anaesthetische, cardiovaskulare und hypometabolische mittel, und eine sie enthaltende pharmazeutische zubereitung |
| AU5127896A (en) | 1995-12-28 | 1997-07-28 | Procter & Gamble Company, The | Substituted 6-h-1,3,4-thiadiazine-2-amines, the use thereof as an aesthetising, cardiovascular and hypometabolic agents, and a pharmaceutical composition containing them |
| RU2152943C1 (ru) * | 1995-12-28 | 2000-07-20 | Проктер энд Гэмбл Компани | Фармацевтически приемлемые соли замещенных 6h-1,3,4-тиадиазин-2-аминов и их фармацевтические композиции |
| JP2000515118A (ja) * | 1995-12-28 | 2000-11-14 | ザ プロクター アンド ギャンブル カンパニー | 置換６ｈ―１，３，４―チアジアジン―２―アミン、麻酔剤、心臓血管剤および代謝低下剤としてのそれらの使用、およびそれらを含有する医薬組成物 |
| JP3588734B2 (ja) * | 1996-07-26 | 2004-11-17 | コニカミノルタホールディングス株式会社 | 電子写真感光体 |
| JP2001181191A (ja) * | 1999-12-24 | 2001-07-03 | Cci Corp | 慢性関節リウマチ疾患予防および治療剤 |
| EP1191024A1 (en) * | 2000-09-22 | 2002-03-27 | Harald Tschesche | Thiadiazines and their use as inhibitors of metalloproteinases |
| RU2281946C1 (ru) * | 2005-09-21 | 2006-08-20 | ГОУ ВПО Уральский государственный технический университет-УПИ | 2-циклоалкилимино-5-(4-нитрофенил)-1,3,4-тиадиазины, обладающие биологической активностью против вирусов оспы |
| DE102012020516A1 (de) | 2011-12-09 | 2013-06-13 | W.E.T. Automotive Systems Ag | Temperier-Einrichtung für eine elektrochemische Spannungsquelle |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4289767A (en) * | 1979-09-04 | 1981-09-15 | Richardson-Merrell Inc. | 5-(Chlorophenyl)-6H-1,3,4-thiadiazine-2-amines |
| US4272532A (en) * | 1979-09-04 | 1981-06-09 | Richardson-Merrell Inc. | 5-(Optionally substituted phenyl)-6H-1,3,4-thiadiazine-2-amines |
| US4636516A (en) * | 1981-02-19 | 1987-01-13 | Yamanouchi Pharmaceutical Co., Ltd. | 3,5-di-tert-butyl-4-hydroxyphenyl-substituted heterocyclic compounds |
-
1987
- 1987-01-30 DE DE19873702756 patent/DE3702756A1/de not_active Withdrawn
-
1988
- 1988-01-26 DE DE8888101055T patent/DE3869144D1/de not_active Expired - Fee Related
- 1988-01-26 AT AT88101055T patent/ATE73785T1/de active
- 1988-01-26 ES ES198888101055T patent/ES2038216T3/es not_active Expired - Lifetime
- 1988-01-26 EP EP88101055A patent/EP0276804B1/de not_active Expired - Lifetime
- 1988-01-28 PH PH36421A patent/PH24609A/en unknown
- 1988-01-28 NZ NZ223335A patent/NZ223335A/xx unknown
- 1988-01-28 FI FI880386A patent/FI880386A7/fi not_active Application Discontinuation
- 1988-01-28 HU HU88392Q patent/HU198195B/hu not_active IP Right Cessation
- 1988-01-28 US US07/149,601 patent/US4940790A/en not_active Expired - Fee Related
- 1988-01-28 PT PT86656A patent/PT86656B/pt not_active IP Right Cessation
- 1988-01-28 IL IL85230A patent/IL85230A0/xx unknown
- 1988-01-29 IE IE880248A patent/IE880248L/xx unknown
- 1988-01-29 DK DK047688A patent/DK47688A/da not_active Application Discontinuation
- 1988-01-29 AU AU10997/88A patent/AU602053B2/en not_active Ceased
- 1988-01-29 JP JP63017513A patent/JPS63192765A/ja active Pending
- 1988-01-29 CN CN88100519A patent/CN1015457B/zh not_active Expired
- 1988-01-29 NO NO880406A patent/NO169229C/no unknown
- 1988-01-29 ZA ZA88641A patent/ZA88641B/xx unknown
- 1988-01-30 KR KR1019880000826A patent/KR880009003A/ko not_active Withdrawn
-
1992
- 1992-05-22 GR GR920401016T patent/GR3004685T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| NZ223335A (en) | 1989-09-27 |
| JPS63192765A (ja) | 1988-08-10 |
| FI880386A0 (fi) | 1988-01-28 |
| HUT47263A (en) | 1989-02-28 |
| CN88100519A (zh) | 1988-12-28 |
| US4940790A (en) | 1990-07-10 |
| NO169229B (no) | 1992-02-17 |
| HU198195B (en) | 1989-08-28 |
| NO880406L (no) | 1988-08-01 |
| IE880248L (en) | 1988-07-30 |
| KR880009003A (ko) | 1988-09-13 |
| NO880406D0 (no) | 1988-01-29 |
| ZA88641B (en) | 1988-09-28 |
| EP0276804A1 (de) | 1988-08-03 |
| DK47688D0 (da) | 1988-01-29 |
| DE3869144D1 (de) | 1992-04-23 |
| DE3702756A1 (de) | 1988-08-11 |
| PH24609A (en) | 1990-08-17 |
| PT86656B (pt) | 1992-02-28 |
| ATE73785T1 (de) | 1992-04-15 |
| PT86656A (pt) | 1988-02-01 |
| FI880386A7 (fi) | 1988-07-31 |
| AU1099788A (en) | 1988-08-04 |
| DK47688A (da) | 1988-07-31 |
| IL85230A0 (en) | 1988-07-31 |
| ES2038216T3 (es) | 1993-07-16 |
| NO169229C (no) | 1992-06-10 |
| EP0276804B1 (de) | 1992-03-18 |
| GR3004685T3 (index.html) | 1993-04-28 |
| AU602053B2 (en) | 1990-09-27 |
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