CN101543468B - Liquorice whitening moisturizing lotion and preparation method thereof - Google Patents
Liquorice whitening moisturizing lotion and preparation method thereof Download PDFInfo
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Abstract
The invention relates to a liquorice whitening moisturizing lotion and a preparation method thereof, which belong to technology of preparing cosmetics by natural substances. The liquorice whitening moisturizing lotion is prepared by an effective active component of a liquorice cell extract with liquorice whitening effect, and comprises octodecyl alcohol, white oil, monoglyceride, an emulsifier-tween 80, span 80, glycerol, triethanolamine, a lilac compound, 2-methyl-4-isothiazoline-3-ketone, 5-chloro-2-methyl-4-isothiazoline-3-ketone and the effective active component of the liquorice cell extract. The preparation method comprises the combined extraction process of an effective liquorice component and the step of preparing the liquorice whitening moisturizing lotion from components such as the effective liquorice component, deionized water and the like. The liquorice cell whitening moisturizing lotion has high content of effective components, can better inhibit the formation of melanin, and achieve good whitening effect; in addition, the product does not contain other pharmaceutical ingredients, and has simple extraction and preparation processes.
Description
Technical field
The present invention relates to a kind of liquorice whitening moisturizing lotion and preparation method thereof, is the whitening moisturizing lotion that is made by licorice cell extract effective active composition, belongs to natural goods preparing cosmetics technology.
Background technology
Radix Glycyrrhizae (Glycyrrhiza uralensis Fisch.) is the pulse family herbaceos perennial, is one of the most frequently used Chinese medicine, and saying of " ten sides, nine grass " always just arranged.Radix Glycyrrhizae is not only Chinese medicine simply, all is widely used in fields such as the medicine in modern times, food, cosmetics, and market is very big to the demand of Radix Glycyrrhizae, and present wild Radix Glycyrrhizae resource is on the verge of exhaustion.One of effective method that solves the Radix Glycyrrhizae shortage of resources is to produce valuable active substance (licorice cell extract effective active composition) by the mode of cell culture.Its main active component of Radix Glycyrrhizae---glycyrrhizin and liquirtin (glucoside of glycyrrhizin) belongs to flavanone, it is the active ingredient in Radix Glycyrrhizae (Gluralensis) and light Radix Glycyrrhizae (Glglabra) rhizome, general flavone content accounts for 3%, and is wherein the highest with liquirtin content.Radix Glycyrrhizae have antioxygen, antiallergic, antifungal, prevents skin aging and effectively removes effects such as superoxide ion.Liquirtin has antiinflammatory, anti-cutaneous tumor and effectively dispels the effect of skin splash.Glycyrrhizin and liquirtin can both effectively reduce the activity of tryrosinase, the melanic formation in the skin of can slowing down of the liquirtin of 20 μ g/mg in cosmetics, can be made into protective skin cream, QUBAN SHUANG, senior pearl cream etc., existing beautifying skin-protection function can be treated dermatosis etc. again.Glycyrrhizic acid is a triterpene saponin, have antiinflammatory, antioxygen, antibacterial, treatment wound, effectively remove superoxide ion and hydroxyl radical free radical, significantly suppress the effect of liposome peroxidation thing.Glycyrrhizic acid has compatibility widely in cosmetics, normal and other activating agents are shared, can quicken skin to they absorption and potentiation, can be used for sun-proof, brighten, conditioning, antipruritic and hair-growing and hair care etc.Glycyrrhizin is the lyotropic salt made from glycyrrhizic acid (being generally ammonium salt, sodium salt or potassium salt), has high sugariness, low heat energy, and foaming characteristic and haemolysis are very low, safety non-toxic and stronger medicinal health care function.In cosmetics, can be made into protective skin cream, QUBAN SHUANG, senior pearl cream etc., existing beautifying skin-protection function can be treated dermatosis etc. again.
The cosmetics of white-skinned face function are a lot of in the market, and traditional skin-whitening agents often adopts hydrogen peroxide, ammoniated mercury and various phenol derivatives, and these chemical compounds can make melanin organize rapidly to disintegrate, reach the effect of whitening fast.But because of its corrosivity, cytotoxicity and anaphylaxis, make it have great danger, in the hygienic practice of many countries, forbid skin.Still there is certain hidden danger in safety evaluatio to the whitening function cosmetics at present, a large amount of survey results show, there are serious problems in the whitening product of beauty parlor, and the hydrargyrum disqualification rate is up to 43.8%, and skin care item cause mercury accumulation or chronic mercury poisoning also more and more to use that clean skin is whitened etc.
As seen, there is certain problem in traditional skin-lightening cosmetic, and " green " is the theme of 21 century cosmetics, and the natural activity cosmetics are complied with the trend that goes back to nature and people's consumer psychology.Safely, the whitening product that has no side effect arises at the historic moment, some Chinese herbal medicine with good whitening effect more and more are subjected to the favor of consumer at present, such as Radix Glycyrrhizae.And generally make by multiple medicinal plants in the Chinese herbal medicine cosmetics by Radix Glycyrrhizae extract (flavones ingredient) preparation at present, its preparation process complexity, Radix Glycyrrhizae extract flavones ingredient content is lower in addition, and is undesirable thereby it stops melanic formation, antioxygen, antiallergic, prevents skin aging and effectively removes effect such as superoxide ion.
Summary of the invention
The purpose of this invention is to provide a kind of liquorice whitening moisturizing lotion and preparation method thereof, it is to be made by licorice cell extract effective active composition, the effective liquorice content height that prepared whitening moisturizing lotion contains, and preparation process is simple.
The quality of a kind of liquorice whitening emollient cream provided by the invention is formed and is comprised: octadecanol 1.3～3%, white oil 4～6%, monoglyceride acid glyceride 1～3%, emulsifier tween 80 be 1～5% and span 80 be 0.5～5%, glycerol 2～5%, contain licorice cell extract effective active composition 1～4%, triethanolamine 0.2～0.4%, deionized water 60～75%, lilac compound 0.1～0.6%, 2-methyl-4-isothiazoline-3-ketone: 0.02～0.03%, 5-chloro-2-methyl-4-isothiazoline-3-ketone: 0.02～0.03%.Each component percentage composition sum is absolutely.
The step that liquorice whitening moisturizing lotion preparation method provided by the invention comprises:
1. licorice cell extract effective active composition unites extraction
Dry cell weight is counted the Glycyrrhiza cell suspension of 15～40g/L, with 4000r/min centrifugalize 15～20min, obtain centrifugal sediment, with precipitate in 50～60 ℃ of dryings of temperature, obtain block through pulverizing, sieve and obtain powder body, add distilled water and carry out hot dipping, addition is 15 times of dry cell weight, the sodium hydrate aqueous solution that with concentration is 0.2mol/L is 2: 5 mixed by the volume ratio with solvent, carrying out hot dipping 80 ℃ of temperature extracted 1.5 hours, extracting solution after filtration, obtain 1 filtrate and filtering residue, by the ratio of filtering residue quality gram number and solvent solution volume ml vol is that 1: 10 mixed is carried out hot dipping and extracted, the sodium hydrate aqueous solution that with concentration is 0.2mol/L is 3: 10 mixed by the volume ratio with solvent, carrying out hot dipping in 80 ℃ of temperature extracted 1 hour, extracting solution after filtration, obtain 2 filtrate and filtering residue, by the ratio of filtering residue quality gram number and solvent solution volume ml vol is that 1: 5 mixed is carried out the 3rd hot dipping and extracted, the sodium hydrate aqueous solution that with concentration is 0.2mol/L is 1: 5 mixed by the volume ratio with solvent, in 80 ℃ of temperature, carry out hot dipping and extract half an hour, extracting solution after filtration, obtain 3 filtrate and filtering residue, 3 filtrates of gained are carried out centrifugalize under the 4000r/min rotating speed, disgorging, get supernatant, adding mass concentration in supernatant is 3% hydrochloric acid adjust pH to 1～2.5, centrifugalize under the rotating speed of 4000r/min, get precipitate, remove supernatant, precipitate promptly gets licorice cell extract effective active composition in 50～60 ℃ of dryings of temperature.
2. Glycyrrhiza cell whitening moisturizing lotion preparation
(1) mass percent that will contain licorice cell extract effective active composition, glycerol, this dish, tween and deionized water by metering is respectively 1～4%, 2～5%, 0.5～5% and 60～75% and takes by weighing each amount of substance and mix, and stirring makes the A component;
(2) by metering the mass percent of octadecanol, white oil, glyceryl monostearate is respectively 1.3～3%, 4～6%, 1～3% and takes by weighing each amount of substance and mix, stirring makes the B component;
(3) the A component is heated to 100 ℃, keep 1～2min sterilization, be cooled to 30～40 ℃ standby, the B component is heated to 85 ℃, low whipping speed is under the condition of 250～300r/min, the A component slowly added in the B component go into homogeneous phase, keep stirring, when temperature is reduced to 80 ℃, the unlatching vacuum pump (vacuum-0.085～-0.1MPa), when temperature is reduced to 40 ℃, be 0.1～0.6% adding lilac compound with mass percent according to metering, is 0.02～0.03 adding 2-methyl-4-isothiazoline-3-ketone according to metering with mass percent, according to mass percent is 0.02～0.03 adding 5-chloro-2-methyl-4-isothiazoline-3-ketone, transfers pH to 6.1, discharging when being cooled to 40～30 ℃ again with triethanolamine, through the sterilization of cobalt 60-radiation gamma, promptly get liquorice whitening moisturizing lotion.
Advantage of the present invention: the liquorice whitening moisturizing lotion of the present invention's preparation, the effective active component content height of licorice cell extract can suppress melanic formation preferably, reaches good whitening effect.This product does not contain the other medicines composition in addition, and it is simple to extract preparation process.
The specific embodiment
Example one:
To count Glycyrrhiza cell suspension (preparation method the is seen CN 200810053014.4) 4L of 40g/L with dry cell weight, with 4000r/min centrifugalize 15min, obtain centrifugal sediment 600g, with precipitate in 60 ℃ of dryings of temperature, obtain block through pulverizing, sieve and obtain powder body 60g, in powder body, add distilled water 900ml and carry out hot dipping, adding concentration is the sodium hydrate aqueous solution 360ml mixing of 0.2mol/L, carrying out hot dipping 80 ℃ of temperature extracted 1.5 hours, extracting solution after filtration, obtain 1 filtrate and filtering residue, in filtering residue, add distilled water 600ml again and carry out hot dipping, adding concentration is the sodium hydrate aqueous solution 180ml mixing of 0.2mol/L, carrying out hot dipping in 80 ℃ of temperature extracted 1 hour, extracting solution after filtration, obtain 2 filtrate and filtering residue, in filtering residue, add distilled water 300ml again and carry out hot dipping, adding concentration is the sodium hydrate aqueous solution 60ml mixing of 0.2mol/L, in 80 ℃ of temperature, carry out hot dipping and extract half an hour, extracting solution after filtration, obtain 3 filtrate and filtering residue, 3 filtrates of gained are total to 2.4L under the 4000r/min rotating speed, carry out centrifugalize, disgorging, get supernatant, adding mass concentration in supernatant is 3% hydrochloric acid adjust pH to 1～2.5, centrifugalize under the rotating speed of 4000r/min, get precipitate, remove supernatant, precipitate promptly gets and contains licorice cell extract effective active composition 10g in 50～60 ℃ of dryings of temperature.
The weighing following compounds: mainly contain licorice cell extract effective active composition: 2g, glycerol: 1g, tween 80 0.85g, Span-80 0.5g, deionized water: 65g mixes to stir obtaining the A component at normal temperatures.
Weighing following compounds: octadecanol: 0.65g, white oil: 2g, glyceryl monostearate: 0.5g mixes to stir obtaining the B component at normal temperatures.
The A component is heated to 100 ℃, keep 1～2% sterilization, be cooled to 30～40 ℃ standby, the B component is heated to 85 ℃, low whipping speed is under the condition of 250～300r/min, the A component slowly added in the B component go, keep stirring, when temperature is reduced to 80 ℃ into homogeneous phase, the unlatching vacuum pump (vacuum-0.085～-0.1MPa), when temperature is reduced to 40 ℃, add lilac compound 0.5g, add 2-methyl-4-isothiazoline-3-ketone and 5-chloro-2-methyl-4-isothiazoline-3-ketone 0.02g respectively, transfer pH to 6.1 with triethanolamine, discharging when being cooled to 40～30 ℃ again through the sterilization of cobalt 60-radiation gamma, promptly gets liquorice whitening moisturizing lotion.
This product process heat-resistance test: 40 ℃, after 24h recovered room temperature, mastic did not have the oil-water separation phenomenon; The process freezing test :-5 ℃, after 24h recovered room temperature, mastic did not have the oil-water separation phenomenon; Measure through bacterial content: no settlement occurs after cultivating one month on the all-round culture medium.This shows that the Ben Meibai breast is a kind of cosmetics of safe, reliable, stable in properties.
Example two:
Get the Glycyrrhiza cell suspension 2L that counts 20g/L with dry cell weight, with 4000r/min centrifugalize 15min, obtain centrifugal sediment 400g, with precipitate in 60 ℃ of dryings of temperature, obtain block through pulverizing, sieve and obtain powder body 40g, in powder body, add distilled water 600ml and carry out hot dipping, adding concentration is the sodium hydrate aqueous solution 240ml mixing of 0.2mol/L, carrying out hot dipping 80 ℃ of temperature extracted 1.5 hours, extracting solution after filtration, obtain 1 filtrate and filtering residue, in filtering residue, add distilled water 400ml again and carry out hot dipping, adding concentration is the sodium hydrate aqueous solution 120ml mixing of 0.2mol/L, carrying out hot dipping in 80 ℃ of temperature extracted 1 hour, extracting solution after filtration, obtain 2 filtrate and filtering residue, in filtering residue, add distilled water 200ml again and carry out hot dipping, adding concentration is the sodium hydrate aqueous solution 40ml mixing of 0.2mol/L, in 80 ℃ of temperature, carry out hot dipping and extract half an hour, extracting solution obtains 3 filtrate and filtering residue after filtration, with 3 filtrates of gained altogether 520ml under the 4000r/min rotating speed, carry out centrifugalize, disgorging, get supernatant, adding mass concentration in supernatant is 3% hydrochloric acid adjust pH to 1～2.5, centrifugalize under the rotating speed of 4000r/min, get precipitate, remove supernatant, precipitate promptly gets and contains licorice cell extract effective active composition 3g in 50～60 ℃ of dryings of temperature.
The weighing following compounds: mainly contain licorice cell extract effective active composition: 3g, glycerol: 2g, tween 80 0.56, Span-80 0.78, deionized water: 65g mixes to stir obtaining the A component at normal temperatures.
Weighing following compounds: octadecanol: 1.2g, white oil: 3g, glyceryl monostearate: 0.7g mixes to stir obtaining the B component at normal temperatures.
The A component is heated to 100 ℃, keep 1～2% sterilization, be cooled to 30～40 ℃ standby, the B component is heated to 85 ℃, low whipping speed is under the condition of 250～300r/min, the A component slowly added in the B component go, keep stirring, when temperature is reduced to 80 ℃ into homogeneous phase, the unlatching vacuum pump (vacuum-0.085～-0.1MPa), when temperature is reduced to 40 ℃, add lilac compound 0.1g, add 2-methyl-4-isothiazoline-3-ketone and 5-chloro-2-methyl-4-isothiazoline-3-ketone 0.03g respectively, transfer pH to 6.1 with triethanolamine, discharging when being cooled to 40～30 ℃ again through the sterilization of cobalt 60-radiation gamma, promptly gets liquorice whitening moisturizing lotion 100g.
Example three:
Get the Glycyrrhiza cell suspension 3L that counts 30g/L with dry cell weight, with 4000r/min centrifugalize 15min, obtain centrifugal sediment 900g, with precipitate in 60 ℃ of dryings of temperature, obtain block through pulverizing, sieve and obtain powder body 90g, in powder body, add distilled water 1300ml and carry out hot dipping, adding concentration is the sodium hydrate aqueous solution 620ml mixing of 0.2mol/L, carrying out hot dipping 80 ℃ of temperature extracted 1.5 hours, extracting solution after filtration, obtain 1 filtrate and filtering residue, in filtering residue, add distilled water 900ml again and carry out hot dipping, adding concentration is the sodium hydrate aqueous solution 270ml mixing of 0.2mol/L, carrying out hot dipping in 80 ℃ of temperature extracted 1 hour, extracting solution after filtration, obtain 2 filtrate and filtering residue, in filtering residue, add distilled water 450ml again and carry out hot dipping, adding concentration is the sodium hydrate aqueous solution 90ml mixing of 0.2mol/L, in 80 ℃ of temperature, carry out hot dipping and extract half an hour, extracting solution obtains 3 filtrate and filtering residue after filtration, with 3 filtrates of gained altogether 3.63L under the 4000r/min rotating speed, carry out centrifugalize, disgorging, get supernatant, adding mass concentration in supernatant is 3% hydrochloric acid adjust pH to 1～2.5, centrifugalize under the rotating speed of 4000r/min, get precipitate, remove supernatant, precipitate promptly gets and contains licorice cell extract effective active composition 9g in 50～60 ℃ of dryings of temperature.
The weighing following compounds: mainly contain licorice cell extract effective active composition: 4g, glycerol: 4g, tween 80: 0.6g, Span-80: 0.8g, deionized water: 52g mixes to stir obtaining the A component at normal temperatures.
Weighing following compounds: octadecanol: 2.2g, white oil: 4g, glyceryl monostearate: 0.8g mixes to stir obtaining the B component at normal temperatures.
The A component is heated to 100 ℃, keep 1～2% sterilization, be cooled to 30～40 ℃ standby, the B component is heated to 85 ℃, low whipping speed is under the condition of 250～300r/min, the A component slowly added in the B component go, keep stirring, when temperature is reduced to 80 ℃ into homogeneous phase, the unlatching vacuum pump (vacuum-0.085～-0.1MPa), when temperature is reduced to 40 ℃, add lilac compound 0.3g, add 2-methyl-4-isothiazoline-3-ketone and 5-chloro-2-methyl-4-isothiazoline-3-ketone 0.067g respectively, transfer pH to 6.1 with triethanolamine, discharging when being cooled to 40～30 ℃ again through the sterilization of cobalt 60-radiation gamma, promptly gets liquorice whitening moisturizing lotion 100g.
Claims (2)
1. liquorice whitening moisturizing lotion, the quality that it is characterized in that it is formed: octadecanol 1.3～3%, white oil 4～6%, glyceryl monostearate 1～3%, emulsifier tween 80 be 1～5% and span 80 be 0.5～5%, glycerol 2～5%, licorice cell extract effective active composition 1～4%, triethanolamine 0.2～0.4%, deionized water 60～75%, lilac compound 0.1～0.6%, 2-methyl-4-isothiazoline-3-ketone: 0.02～0.03%, 5-chloro-2-methyl-4-isothiazoline-3-ketone: 0.02～0.03%; Each component sum is 100%;
The extracting method of described licorice cell extract effective active composition is: the Glycyrrhiza cell suspension of dry cell weight being counted 15～40g/L, with 4000r/min centrifugalize 15～20min, obtain centrifugal sediment, with precipitate in 50～60 ℃ of dryings of temperature, obtain block through pulverizing, sieve and obtain powder body, add distilled water and carry out hot dipping, addition is 15 times of dry cell weight, the sodium hydrate aqueous solution that with concentration is 0.2mol/L is 2: 5 mixed by the volume ratio with solvent, carrying out hot dipping 80 ℃ of temperature extracted 1.5 hours, extracting solution after filtration, obtain filtrate and filtering residue for the first time, by the ratio of filtering residue quality gram number and solvent solution volume ml vol is that 1: 10 mixed is carried out hot dipping and extracted, the sodium hydrate aqueous solution that with concentration is 0.2mol/L is 3: 10 mixed by the volume ratio with solvent, carrying out hot dipping in 80 ℃ of temperature extracted 1 hour, extracting solution after filtration, obtain filtrate and filtering residue for the second time, by the ratio of filtering residue quality gram number and solvent solution volume ml vol is that 1: 5 mixed is carried out hot dipping for the third time and extracted, the sodium hydrate aqueous solution that with concentration is 0.2mol/L is 1: 5 mixed by the volume ratio with solvent, in 80 ℃ of temperature, carry out hot dipping and extract half an hour, extracting solution after filtration, obtain filtrate and filtering residue for the third time, three filtrates of gained are carried out centrifugalize under the 4000r/min rotating speed, disgorging, get supernatant, adding mass concentration in supernatant is 3% hydrochloric acid adjust pH to 1～2.5, centrifugalize under the rotating speed of 4000r/min, get precipitate, remove supernatant, precipitate promptly gets licorice cell extract effective active composition in 50～60 ℃ of dryings of temperature.
2. described liquorice whitening moisturizing lotion preparation method of claim 1 is characterized in that the step that comprises:
1) extraction of licorice cell extract effective active composition
Dry cell weight is counted the Glycyrrhiza cell suspension of 15～40g/L, with 4000r/min centrifugalize 15～20min, obtain centrifugal sediment, with precipitate in 50～60 ℃ of dryings of temperature, obtain block through pulverizing, sieve and obtain powder body, add distilled water and carry out hot dipping, addition is 15 times of dry cell weight, the sodium hydrate aqueous solution that with concentration is 0.2mol/L is 2: 5 mixed by the volume ratio with solvent, carrying out hot dipping 80 ℃ of temperature extracted 1.5 hours, extracting solution after filtration, obtain filtrate and filtering residue for the first time, by the ratio of filtering residue quality gram number and solvent solution volume ml vol is that 1: 10 mixed is carried out hot dipping and extracted, the sodium hydrate aqueous solution that with concentration is 0.2mol/L is 3: 10 mixed by the volume ratio with solvent, carrying out hot dipping in 80 ℃ of temperature extracted 1 hour, extracting solution after filtration, obtain filtrate and filtering residue for the second time, by the ratio of filtering residue quality gram number and solvent solution volume ml vol is that 1: 5 mixed is carried out hot dipping for the third time and extracted, the sodium hydrate aqueous solution that with concentration is 0.2mol/L is 1: 5 mixed by the volume ratio with solvent, in 80 ℃ of temperature, carry out hot dipping and extract half an hour, extracting solution after filtration, obtain filtrate and filtering residue for the third time, three filtrates of gained are carried out centrifugalize under the 4000r/min rotating speed, disgorging, get supernatant, adding mass concentration in supernatant is 3% hydrochloric acid adjust pH to 1～2.5, centrifugalize under the rotating speed of 4000r/min, get precipitate, remove supernatant, precipitate promptly gets licorice cell extract effective active composition in 50～60 ℃ of dryings of temperature;
2) liquorice whitening moisturizing lotion preparation
(1) will contain licorice cell extract effective active composition, glycerol, this dish, tween and deionized water by metering and mix, stirring makes the A component;
(2) by metering octadecanol, white oil, glyceryl monostearate are mixed, stirring makes the B component;
(3) the A component is heated to 100 ℃, keep 1～2% sterilization, be cooled to 30～40 ℃ standby, the B component is heated to 85 ℃, and low whipping speed is under the condition of 250～300r/min, the A component is slowly added in the B component go into homogeneous phase, keep stirring, when temperature is reduced to 80 ℃, open vacuum pump, vacuum-0.085～-0.1MPa, when temperature is reduced to 40 ℃, again by measuring with lilac compound 2-methyl-4-isothiazoline-3-ketone, 5-chloro-2-methyl-4-isothiazoline-3-ketone adding, transfer pH to 6.1 with triethanolamine, discharging when being cooled to 40～30 ℃ again through the sterilization of cobalt 60-radiation gamma, promptly gets liquorice whitening moisturizing lotion.
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| CN102772337B (en) * | 2012-08-17 | 2013-06-26 | 珀莱雅化妆品股份有限公司 | Preparation method of composite whitening lipid nanoparticle emulsion |
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| CN108653089A (en) * | 2018-07-02 | 2018-10-16 | 芜湖扬展新材料科技服务有限公司 | A kind of preparation method of anti-aging anti-wrinkle lotion |
| CN108815093A (en) * | 2018-07-02 | 2018-11-16 | 芜湖扬展新材料科技服务有限公司 | A kind of pore shrinks Essence and preparation method thereof |
| CN108542871A (en) * | 2018-07-02 | 2018-09-18 | 芜湖扬展新材料科技服务有限公司 | A kind of nourishing moisturizing maintenance lotion and preparation method thereof |
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| CN108743432A (en) * | 2018-08-04 | 2018-11-06 | 芜湖慧宇商贸有限公司 | A kind of preparation method of the anti-wrinkle Essence containing ooze extract |
| CN108850616A (en) * | 2018-08-11 | 2018-11-23 | 安徽省强家庄生态农业有限公司 | A kind of preparation method of antimicrobial form pannage |
Citations (2)
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| CN1762324A (en) * | 2004-10-22 | 2006-04-26 | 卢藏田 | Composite whitening speckle-removing rehabilitation cosmetic |
| CN101273957A (en) * | 2008-05-21 | 2008-10-01 | 天津大学 | Whitening moisture cream with licorice cell extract and method for preparing the same |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1762324A (en) * | 2004-10-22 | 2006-04-26 | 卢藏田 | Composite whitening speckle-removing rehabilitation cosmetic |
| CN101273957A (en) * | 2008-05-21 | 2008-10-01 | 天津大学 | Whitening moisture cream with licorice cell extract and method for preparing the same |
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