CN101273957B - Whitening moisture cream with licorice cell extract and method for preparing the same - Google Patents
Whitening moisture cream with licorice cell extract and method for preparing the same Download PDFInfo
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Abstract
The invention relates to a licorice cell extract whitening moisturizing cream and a preparation method thereof, which pertains to the technology of cosmetics which are prepared by natural materials. The licorice cell extract whitening moisturizing cream is composed of licorice cell extract containing flavone and triterpenoid saponins and deionized water, etc. The process of the preparation method comprises the extraction process of the licorice cell extract and the preparation process of the licorice cell extract whitening moisturizing cream by using the licorice cell extract, deionized water and other components. The licorice cell extract whitening moisturizing cream has the advantages that: the licorice cell extract whitening moisturizing cream prepared by the invention contains the licorice cell extract with single component and the effective components with high content, which can better inhibit the formation of melanin and achieve good whitening effect. In addition, the product does not contain any other drug components, and the extraction and preparation process is simple.
Description
Technical field
The present invention relates to a kind of whitening moisture cream with licorice cell extract and preparation method thereof, belong to natural goods preparing cosmetics technology.
Background technology
Radix Glycyrrhizae (Glycyrrhiza realness Frisch.) is the pulse family herbaceos perennial, its root and rhizome has effects such as invigorating the spleen and replenishing QI, eliminating phlegm and stopping cough, heat-clearing and toxic substances removing, coordinating the actions of various ingredients in a prescription, be one of the most frequently used Chinese medicine, saying of " ten sides, nine grass " always just arranged.Along with the Radix Glycyrrhizae The Chemical Constituents, find that flavone in the Radix Glycyrrhizae extract, particularly Radix Glycyrrhizae has the skin of human body to whiten preferably and protective action, and safety, gentleness, can effectively remove oxygen by base.Thereby the application of Radix Glycyrrhizae in cosmetics more and more comes into one's own.
The glycyrrhizin active component Pear Power effect of Radix Glycyrrhizae, its whitening function principle mainly is the activity by tryrosinase and dopachrome interconvertible enzyme (TRP-2) on the glycyrrhizin active component inhibition skin, hinder 5, the polymerization of 6-dihydroxy indole (DHI), stop melanic formation with this, thereby reach skin whitening effects.Radix Glycyrrhizae have antioxygen, antiallergic, antifungal, prevents skin aging and effectively removes effects such as superoxide ion.Liquirtin has antiinflammatory, anti-cutaneous tumor and effectively dispels the effect of skin splash.Glycyrrhizic acid has compatibility widely in cosmetics, normal and other activating agents are shared, can quicken skin to they absorption and potentiation, can be used for sun-proof, brighten, nurse one's health antipruritic.
The cosmetics of white-skinned face function are a lot of in the market, and traditional skin-whitening agents often adopts hydrogen peroxide, ammoniated mercury and various phenol derivatives, and these chemical compounds can make melanin organize rapidly to disintegrate, reach the effect of whitening fast.But because of its corrosivity, cytotoxicity and anaphylaxis, make it have great danger, in the hygienic practice of many countries, forbid skin.Still there is certain hidden danger in safety evaluatio to the whitening function cosmetics at present, a large amount of survey results show, there are serious problems in the whitening product of beauty parlor, and the hydrargyrum disqualification rate is up to 43.8%, and skin care item cause mercury accumulation or chronic mercury poisoning also more and more to use that clean skin is whitened etc.
As seen, there is certain problem in traditional skin-lightening cosmetic, and " green " is the theme of 21 century cosmetics, and the natural activity cosmetics are complied with the trend that goes back to nature and people's consumer psychology.Safely, the whitening product that has no side effect arises at the historic moment, some Chinese herbal medicine with good whitening effect more and more are subjected to the favor of consumer at present, such as Radix Glycyrrhizae.And generally make by multiple medicinal plants in the Chinese herbal medicine cosmetics by Radix Glycyrrhizae extract (flavones ingredient) preparation at present, its preparation process complexity, Radix Glycyrrhizae extract flavones ingredient content is lower in addition, and is undesirable thereby it stops melanic formation, antioxygen, antiallergic, prevents skin aging and effectively removes effect such as superoxide ion.
Summary of the invention
The purpose of this invention is to provide a kind of whitening moisture cream with licorice cell extract and preparation method thereof.The licoflavone composition height that contains with the prepared body whitening cr of this method, and preparation process is simple.
The present invention is realized with following technical scheme, a kind of whitening moisture cream with licorice cell extract, it is characterized in that forming: stearic acid 4～5% by following component and quality percentage composition thereof, lanoline 1～1.5%, isopropyl palmitate 5～6%, emulsifier tween 80 be 1～5% and span 80 be 0.3～2%, olive oil 0.5～1%, the licorice cell extract 8～10% that contains flavone and triterpene saponin, triethanolamine 0.2～0.4%, glycerol 6～7%, deionized water 60～70%, lilac compound 0.1～0.6%, isothiazolone 0.06～0.12%, and each component percentage composition sum is absolutely.
Above-mentioned whitening moisture cream with licorice cell extract preparation method is characterized in that comprising following process:
1. the leaching process of licorice cell extract
To count the Glycyrrhiza cell suspension of 15～40g/L with dry cell weight, and with 4000r/min centrifugalize 15～20min, obtain centrifugal sediment, precipitate in 50～60 ℃ of dryings of temperature, is obtained block through pulverizing, sieving obtains powder body.By powder quality gram number and mass concentration is that the ratio of 1% calcium hydroxide aqueous solution volume ml vol is 1: (6～12) mixed is carried out supersound extraction for 30～50 ℃ in temperature, ultrasonic power is 1000W, supersonic frequency is 40KHz, ultrasonic time is 20～30min, extracting solution after filtration, obtain 1 filtrate and filtering residue, by filtering residue quality gram number and mass concentration is that the ratio of 1% calcium hydroxide aqueous solution volume ml vol is 1: (6～12) mixed is carried out supersound extraction, extract 2～5 times by process like this, gained filtrate is merged vacuum filtration get filtrate 2 times.2 filtrate evaporated under reduced pressure are concentrated into 1/5～1/3 of original 2 filtrate volume amounts.After concentrated solution is cooled to room temperature, press concentrated solution and ethanol volume ratio 1: (1.5～2.5) add mass concentration 95% ethanol and mix, leave standstill, filter then, obtain filtrate after the filtration 3 times, 3 times filtrate is carried out centrifugalize under the 4000r/min rotating speed, disgorging, get supernatant, adding mass concentration in supernatant is 3% hydrochloric acid adjust pH to 5～6, centrifugalize under the rotating speed of 4000r/min, get precipitate and supernatant, supernatant being added mass concentration is 3% hydrochloric acid adjust pH 2～3 again, and centrifugalize under the 4000r/min rotating speed gets precipitate, remove supernatant, the precipitate that merges twice obtains extractum after 50～60 ℃ of dryings of temperature, after extractum added deionized water dissolving, the water saturated n-butyl alcohol of reuse extracted, get the n-butanol layer extract, extract is carried out reduction vaporization concentrate, freeze-day with constant temperature promptly gets the licorice cell extract that contains flavone and triterpene saponin again.
2. whitening moisture cream with licorice cell extract preparation
(1) be respectively 8～10%, 0.2～0.4%, 6～7% and 60～70% by the mass percent of the licorice cell extract that contains flavone and triterpene saponin, triethanolamine, glycerol and deionized water and take by weighing each amount of substance and mix, stirring makes the A component.
(2) be respectively 4～5%, 1～1.5%, 5～6%, 1～5%, 0.3～2% and 0.5～1% by the mass percent of stearic acid, lanoline, isopropyl palmitate, emulsifier tween 80, emolsifier span 80 and olive oil and take by weighing each amount of substance and mix, stirring makes the B component.
(3) A component and B component are heated to 80～90 ℃ respectively, low whipping speed is under the condition of 800～1500r/min, the B component is slowly added in the A component go into homogeneous phase.Keep stirring, when temperature is reduced to 80 ℃, under the vacuum, when continuing to be cooled to 50 ℃, according to mass percent is 0.1～0.6% adding lilac compound, is 0.06～0.12% adding isothiazolone according to mass percent, discharging when being cooled to 40～45 ℃ again, through the sterilization of cobalt 60-radiation gamma, promptly get whitening moisture cream with licorice cell extract.
Advantage of the present invention: the whitening moisture cream with licorice cell extract of the present invention's preparation, containing composition is single licorice cell extract, not only comprise flavones ingredient but also comprise the triterpene saponin constituents in the extract, the active constituent content height, can suppress melanic formation preferably, reach good whitening effect.This product does not contain the other medicines composition in addition, and it is simple to extract preparation process.
The specific embodiment
Example one:
Get the Glycyrrhiza cell suspension Glycyrrhiza cell suspension 4L that counts 30g/L with dry cell weight, with 4000r/min centrifugalize 15min, obtain centrifugal sediment 415g, precipitate is placed 60 ℃ of dryings of drying baker, obtain block through pulverizing, sieving obtains powder body 120g, and adding mass concentration in powder body is that 1% calcium hydroxide aqueous solution 960mL mixes supersound extraction.Ultrasonic power is 1000W, supersonic frequency is 40KHz, ultrasonic time is 30min, and ultrasonic temperature is 40 ℃, and extracting solution after filtration, obtain filtrate 1 and filtering residue, it is that 1% calcium hydroxide aqueous solution 960mL mixes supersound extraction that filtering residue adds mass concentration again, and ultrasonic power is 1000W, and supersonic frequency is 40KHz, ultrasonic time is 30min, and ultrasonic temperature is 40 ℃.The extracting solution sucking filtration removes slag, and gets filtrate 2.Merging twice filtrate is 1.8L, and the filtrate evaporated under reduced pressure of 1.8L is concentrated into 600mL.After concentrated solution is cooled to room temperature, adding the 1.1L mass fraction in concentrated solution is 95% ethanol, leave standstill, filter to get filtrate 3 then, filtrate 3 is centrifugalize 15min under the rotating speed of 4000r/min, disgorging, obtain supernatant, adding mass concentration in supernatant is 3% hydrochloric acid adjust pH to 5, centrifugalize 15min under the rotating speed of 4000r/min, obtain precipitate and supernatant, supernatant being added mass concentration is 3% hydrochloric acid adjust pH to 2 again, centrifugalize 15min under the rotating speed of 4000r/min, obtain precipitate, merge twice precipitate and obtain extractum 13g, after extractum is used 100mL deionized water heating for dissolving, add the 100mL water-saturated n-butanol and extract 60 ℃ of dryings, get the n-butanol layer extract, extract is carried out reduction vaporization concentrate, dry again, promptly get the licorice cell extract 10g that mainly contains flavone and triterpene saponin.
The weighing following compounds: the licorice cell extract that mainly contains flavone and triterpene saponin: 10g, triethanolamine: 0.4g, glycerol: 7g, deionized water: 65g mixes to stir obtaining the A component at normal temperatures.
Weighing following compounds: stearic acid: 5g, lanoline: 1.5g, isopropyl palmitate: 6g, emulsifier tween 80:3g and span 80: 1g, olive oil: 0.5g mixes to stir obtaining the B component at normal temperatures.
With A component and B component be heated to respectively 90 ℃ and keep this temperature to make two components all become homogeneous phase after, the A component is placed bottle,suction, start the magnetic force heating stirrer, mixing speed is 1000r/min, slowly add the B component, maintain the temperature at 85 ℃, and keep this temperature 15min, make two components fully be mixed into homogeneous phase.Keep stirring, when temperature is reduced to 80 ℃, the unlatching vacuum pump (vacuum-0.085～-0.1MPa), add lilac compound 0.6g, isothiazolone 0.12g, discharging when being cooled to 45 ℃ again when being cooled to 50 ℃, through the sterilization of cobalt 60-radiation gamma, promptly get whitening moisture cream with licorice cell extract 100g
Example two:
Get the Glycyrrhiza cell suspension Glycyrrhiza cell suspension 3L that counts 40g/L with dry cell weight, with 4000r/min centrifugalize 15min, obtain centrifugal sediment 330g, precipitate is placed 60 ℃ of dryings of drying baker, obtain block through pulverizing, sieving obtains powder body 96g, and adding mass concentration in powder body is that 1% calcium hydroxide aqueous solution 960mL mixes supersound extraction.Ultrasonic power is 1000W, supersonic frequency is 40KHz, ultrasonic time is 25min, and ultrasonic temperature is 50 ℃, and extracting solution after filtration, obtain filtrate 1 and filtering residue, it is that 1% calcium hydroxide aqueous solution 960mL mixes supersound extraction that filtering residue adds mass concentration again, and ultrasonic power is 1000W, and supersonic frequency is 40KHz, ultrasonic time is 25min, and ultrasonic temperature is 50 ℃.The extracting solution sucking filtration removes slag, and gets filtrate 2.Merge filtrate twice, twice filtrate evaporated under reduced pressure of 1.8L is concentrated into 600mL.After concentrated solution is cooled to room temperature, adding the 1.1L mass fraction is that 95% ethanol mixes, leave standstill, filter to get filtrate 3 then, filtrate 3 is centrifugalize 15min under the rotating speed of 4000r/min, disgorging obtains supernatant, and adding mass concentration in supernatant is 3% hydrochloric acid adjust pH to 5, centrifugalize 15min under the rotating speed of 4000r/min, obtain precipitate and supernatant, supernatant being added mass concentration is 3% hydrochloric acid adjust pH to 2 again, centrifugalize 15min under the rotating speed of 4000r/min, obtain precipitate, merge twice precipitate and obtain extractum 10g, after extractum is used 80mL deionized water heating for dissolving, add the 80mL water-saturated n-butanol and extract 60 ℃ of dryings, get the n-butanol layer extract, extract is carried out reduction vaporization concentrate, dry again, promptly get the licorice cell extract 8g that mainly contains flavone and triterpene saponin.
The weighing following compounds: the licorice cell extract that mainly contains flavone and triterpene saponin: 8g, triethanolamine: 0.2g, glycerol: 6g, deionized water: 70g mixes to stir obtaining the A component at normal temperatures.
Weighing following compounds: stearic acid: 4g, lanoline: 1g, isopropyl palmitate: 5g, emulsifier tween 80:3g and span 80: 1g, olive oil: 1g mixes to stir obtaining the B component at normal temperatures.
With A component and B component be heated to respectively 90 ℃ and keep this temperature to make two components all become homogeneous phase after, the A component is placed bottle,suction, start the magnetic force heating stirrer, mixing speed is 800r/min, slowly add the B component, maintain the temperature at 85 ℃, and keep this temperature 15min, make two components fully be mixed into homogeneous phase.Keep stirring, when temperature is reduced to 80 ℃, the unlatching vacuum pump (vacuum-0.085～-0.01MPa), add lilac compound 0.1g when being cooled to 50 ℃, isothiazolone 0.06g, discharging when being cooled to 45 ℃ again through the sterilization of cobalt 60-radiation gamma, promptly gets whitening moisture cream with licorice cell extract 100g.
Example three:
Get the Glycyrrhiza cell suspension Glycyrrhiza cell suspension 3.5L that counts 35g/L with dry cell weight, with 4000r/min centrifugalize 15min, obtain centrifugal sediment 370g, precipitate is placed 60 ℃ of dryings of drying baker, obtain block through pulverizing, sieving obtains powder body 108g, and adding mass concentration in powder body is that 1% calcium hydroxide aqueous solution 1.2L mixes supersound extraction.Ultrasonic power is 1000W, supersonic frequency is 40KHz, ultrasonic time is 20min, and ultrasonic temperature is 45 ℃, and extracting solution after filtration, obtain filtrate 1 and filtering residue, it is that 1% calcium hydroxide aqueous solution 1.2L mixes supersound extraction that filtering residue adds mass concentration again, and ultrasonic power is 1000W, and supersonic frequency is 40KHz, ultrasonic time is 20min, and ultrasonic temperature is 45 ℃.The extracting solution sucking filtration removes slag, and gets filtrate 2.Merge filtrate twice, twice filtrate evaporated under reduced pressure of 2.2L is concentrated into 500mL.After concentrated solution is cooled to room temperature, adding the 1L mass fraction is that 95% ethanol mixes, leave standstill, filter to get filtrate 3 then, filtrate 3 is centrifugalize 15min under the rotating speed of 4000r/min, disgorging obtains supernatant, and adding mass concentration in supernatant is 3% hydrochloric acid adjust pH to 5, centrifugalize 15min under the rotating speed of 4000r/min, obtain precipitate and supernatant, supernatant being added mass concentration is 3% hydrochloric acid adjust pH to 2 again, centrifugalize 15min under the rotating speed of 4000r/min, obtain precipitate, merge twice precipitate and obtain extractum 11g, after extractum is used 90mL deionized water heating for dissolving, add the 90mL water-saturated n-butanol and extract 60 ℃ of dryings, get the n-butanol layer extract, extract is carried out reduction vaporization concentrate, dry again, promptly mainly contained the licorice cell extract 9g of flavone and triterpene saponin.
The weighing following compounds: the licorice cell extract that mainly contains flavone and triterpene saponin: 9g, triethanolamine: 0.3g, glycerol: 6.5g, deionized water: 66g mixes to stir obtaining the A component at normal temperatures.
Weighing following compounds: stearic acid: 5g, lanoline: 1.5g, isopropyl palmitate: 6g, emulsifier tween 80:3.8g and span 80: 1.2g, olive oil: 0.5g mixes to stir obtaining the B component at normal temperatures.
With A component and B component be heated to respectively 90 ℃ and keep this temperature to make two components all become homogeneous phase after, the A component is placed bottle,suction, start the magnetic force heating stirrer, mixing speed is 900r/min, slowly add the B component, maintain the temperature at 85 ℃, and keep this temperature 15min, make two components fully be mixed into homogeneous phase.Keep stirring, when temperature is reduced to 80 ℃, the unlatching vacuum pump (vacuum-0.085～-0.01MPa), add lilac compound 0.5g, isothiazolone 0.1g, discharging when being cooled to 45 ℃ again when being cooled to 50 ℃, through the sterilization of cobalt 60-radiation gamma, promptly get whitening moisture cream with licorice cell extract 100g.
Claims (2)
1. whitening moisture cream with licorice cell extract, it is characterized in that forming: stearic acid 4～5% by following component and quality percentage composition thereof, lanoline 1～1.5%, isopropyl palmitate 5～6%, emulsifier tween 80 be 1～5% and span 80 be 0.3～2%, olive oil 0.5～1%, the licorice cell extract 8～10% that contains flavone and triterpene saponin, triethanolamine 0.2～0.4%, glycerol 6～7%, deionized water 60～70%, lilac compound 0.1～0.6%, isothiazolone 0.06～0.12%, and each component percentage composition sum is absolutely;
The extraction of described licorice cell extract: will count the Glycyrrhiza cell suspension of 15～40g/L with dry cell weight, with 4000r/min centrifugalize 15～20min, obtain centrifugal sediment, with precipitate in 50～60 ℃ of dryings of temperature, obtain block through pulverizing, sieve and obtain powder body, by powder quality gram number and mass concentration is that the ratio of 1% calcium hydroxide aqueous solution volume ml vol is that 1: 6～12 mixed are carried out supersound extraction for 30～50 ℃ in temperature, ultrasonic power is 1000W, supersonic frequency is 40KHz, ultrasonic time is 20～30min, extracting solution after filtration, obtain 1 filtrate and filtering residue, by filtering residue quality gram number and mass concentration is that the ratio of 1% calcium hydroxide aqueous solution volume ml vol is that 1: 6～12 mixed are carried out supersound extraction, extract 2～5 times by process like this, gained filtrate is merged vacuum filtration get filtrate 2 times, 2 filtrate evaporated under reduced pressure are concentrated into 1/5～1/3 of original 2 filtrate volume amounts, after concentrated solution is cooled to room temperature, pressing concentrated solution mixes with ethanol volume ratio 1: 1.5～2.5 adding mass concentrations 95% ethanol, leave standstill, filter then, obtain filtrate after the filtration 3 times, 3 times filtrate is carried out centrifugalize under the 4000r/min rotating speed, disgorging, get supernatant, adding mass concentration in supernatant is 3% hydrochloric acid adjust pH to 5～6, centrifugalize under the rotating speed of 4000r/min, get precipitate and supernatant, supernatant being added mass concentration is 3% hydrochloric acid adjust pH 2～3 again, centrifugalize under the 4000r/min rotating speed, get precipitate, remove supernatant, the precipitate that merges twice obtains extractum after 50～60 ℃ of dryings of temperature, after extractum adds deionized water dissolving, the water saturated n-butyl alcohol of reuse extracts, get the n-butanol layer extract, extract is carried out reduction vaporization concentrate, freeze-day with constant temperature promptly gets licorice cell extract again.
2. described whitening moisture cream with licorice cell extract preparation method of claim 1 is characterized in that comprising following process:
1) leaching process of licorice cell extract
To count the Glycyrrhiza cell suspension of 15～40g/L with dry cell weight, with 4000r/min centrifugalize 15～20min, obtain centrifugal sediment, with precipitate in 50～60 ℃ of dryings of temperature, obtain block through pulverizing, sieve and obtain powder body, by powder quality gram number and mass concentration is that the ratio of 1% calcium hydroxide aqueous solution volume ml vol is that 1: 6～12 mixed are carried out supersound extraction for 30～50 ℃ in temperature, ultrasonic power is 1000W, supersonic frequency is 40KHz, ultrasonic time is 20～30min, extracting solution after filtration, obtain 1 filtrate and filtering residue, by filtering residue quality gram number and mass concentration is that the ratio of 1% calcium hydroxide aqueous solution volume ml vol is that 1: 6～12 mixed are carried out supersound extraction, extract 2～5 times by process like this, gained filtrate is merged vacuum filtration get filtrate 2 times, 2 filtrate evaporated under reduced pressure are concentrated into 1/5～1/3 of original 2 filtrate volume amounts, after concentrated solution is cooled to room temperature, pressing concentrated solution mixes with ethanol volume ratio 1: 1.5～2.5 adding mass concentrations 95% ethanol, leave standstill, filter then, obtain filtrate after the filtration 3 times, 3 times filtrate is carried out centrifugalize under the 4000r/min rotating speed, disgorging, get supernatant, adding mass concentration in supernatant is 3% hydrochloric acid adjust pH to 5～6, centrifugalize under the rotating speed of 4000r/min, get precipitate and supernatant, supernatant being added mass concentration is 3% hydrochloric acid adjust pH 2～3 again, centrifugalize under the 4000r/min rotating speed, get precipitate, remove supernatant, the precipitate that merges twice obtains extractum after 50～60 ℃ of dryings of temperature, after extractum adds deionized water dissolving, the water saturated n-butyl alcohol of reuse extracts, get the n-butanol layer extract, extract is carried out reduction vaporization concentrate, freeze-day with constant temperature promptly gets licorice cell extract again;
2) whitening moisture cream with licorice cell extract preparation
(1) be respectively 8～10%, 0.2～0.4%, 6～7% and 60～70% by the mass percent of licorice cell extract, triethanolamine, glycerol and deionized water and take by weighing each amount of substance and mix, stirring makes the A component;
(2) mass percent by stearic acid, lanoline, isopropyl palmitate, emulsifier tween 80, emolsifier span 80 and olive oil is respectively 4～5%, 1～1.5%, 5～6%, 1～5%, 0.3～2% and 0.5～1% takes by weighing each amount of substance mixes, and stirring makes the B component;
(3) A component and B component are heated to 80～90 ℃ respectively, low whipping speed is under the condition of 800～1500r/min, the B component slowly added in the A component go into homogeneous phase, keep stirring, when temperature is reduced to 80 ℃, under the vacuum, when continuing to be cooled to 50 ℃, according to mass percent is 0.1～0.6% adding lilac compound, according to mass percent is 0.06～0.12% adding isothiazolone, discharging when being cooled to 40～45 ℃ again through the sterilization of cobalt 60-radiation gamma, promptly gets whitening moisture cream with licorice cell extract.
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Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN101543468B (en) * | 2009-05-05 | 2010-10-27 | 天津大学 | Liquorice whitening moisturizing lotion and preparation method thereof |
| CN102631301B (en) * | 2012-04-19 | 2014-03-26 | 扬州十二粉黛生物工程有限公司 | Luffa aqueous solution |
| CN103385838A (en) * | 2013-08-05 | 2013-11-13 | 唯美度科技（北京）有限公司 | Anti-freckle whitening emulsion |
| CN106176515B (en) * | 2016-07-27 | 2019-08-20 | 陕西仁康药业有限公司 | A kind of body whitening crème and preparation method thereof |
| CN106691914A (en) * | 2016-11-22 | 2017-05-24 | 厦门上新日用化学制品有限公司 | Preparation method of liquorice extraction liquid with skin whitening effect |
| CN114159545B (en) * | 2021-12-29 | 2022-11-25 | 天中康元药业集团有限公司 | Whitening anti-wrinkle composition containing enzyme and application of composition in medicines |
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