CN101541348A - 腙衍生物及其用途 - Google Patents

腙衍生物及其用途 Download PDF

Info

Publication number
CN101541348A
CN101541348A CNA2006800504030A CN200680050403A CN101541348A CN 101541348 A CN101541348 A CN 101541348A CN A2006800504030 A CNA2006800504030 A CN A2006800504030A CN 200680050403 A CN200680050403 A CN 200680050403A CN 101541348 A CN101541348 A CN 101541348A
Authority
CN
China
Prior art keywords
alkyl
group
aryl
unit
substituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CNA2006800504030A
Other languages
English (en)
Chinese (zh)
Inventor
R·W·布莱恩特
R·K·帕尔莫
R·塞尔尼
K·阿特沃尔
S·P·李
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
REDPOINT BIO CORP
Original Assignee
REDPOINT BIO CORP
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by REDPOINT BIO CORP filed Critical REDPOINT BIO CORP
Publication of CN101541348A publication Critical patent/CN101541348A/zh
Pending legal-status Critical Current

Links

Images

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/16Amides, e.g. hydroxamic acids
    • A61K31/165Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/655Azo (—N=N—), diazo (=N2), azoxy (>N—O—N< or N(=O)—N<), azido (—N3) or diazoamino (—N=N—N<) compounds
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23LFOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L27/00Spices; Flavouring agents or condiments; Artificial sweetening agents; Table salts; Dietetic salt substitutes; Preparation or treatment thereof
    • A23L27/84Flavour masking or reducing agents
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23LFOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L27/00Spices; Flavouring agents or condiments; Artificial sweetening agents; Table salts; Dietetic salt substitutes; Preparation or treatment thereof
    • A23L27/86Addition of bitterness inhibitors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/22Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/41Amines
    • A61K8/415Aminophenols
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/42Amides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/46Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/4906Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom
    • A61K8/4913Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom having five membered rings, e.g. pyrrolidone carboxylic acid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/4906Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom
    • A61K8/4913Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom having five membered rings, e.g. pyrrolidone carboxylic acid
    • A61K8/492Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom having five membered rings, e.g. pyrrolidone carboxylic acid having condensed rings, e.g. indol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/4906Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom
    • A61K8/4926Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom having six membered rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/494Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
    • A61K8/4946Imidazoles or their condensed derivatives, e.g. benzimidazoles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/4973Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/4973Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
    • A61K8/498Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom having 6-membered rings or their condensed derivatives, e.g. coumarin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/69Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing fluorine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/69Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing fluorine
    • A61K8/70Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing fluorine containing perfluoro groups, e.g. perfluoroethers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q11/00Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Birds (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Food Science & Technology (AREA)
  • Nutrition Science (AREA)
  • Dermatology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Seasonings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Medicinal Preparation (AREA)
  • Cosmetics (AREA)
CNA2006800504030A 2005-11-03 2006-11-03 腙衍生物及其用途 Pending CN101541348A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US73263405P 2005-11-03 2005-11-03
US60/732,634 2005-11-03

Publications (1)

Publication Number Publication Date
CN101541348A true CN101541348A (zh) 2009-09-23

Family

ID=38023837

Family Applications (1)

Application Number Title Priority Date Filing Date
CNA2006800504030A Pending CN101541348A (zh) 2005-11-03 2006-11-03 腙衍生物及其用途

Country Status (11)

Country Link
US (1) US20070207093A1 (https=)
EP (1) EP1951215A4 (https=)
JP (1) JP2009514878A (https=)
KR (1) KR20080070848A (https=)
CN (1) CN101541348A (https=)
AU (1) AU2006311826C1 (https=)
BR (1) BRPI0618224A2 (https=)
CA (1) CA2626846A1 (https=)
NO (1) NO20082346L (https=)
RU (1) RU2008115539A (https=)
WO (1) WO2007056159A2 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105732476A (zh) * 2016-02-04 2016-07-06 吉首大学 一种咔唑-靛红型化合物及其制法和用途

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9101160B2 (en) 2005-11-23 2015-08-11 The Coca-Cola Company Condiments with high-potency sweetener
US8871746B2 (en) 2006-03-02 2014-10-28 Kineta Four, LLC Antiviral drugs for treatment of arenavirus infection
EP1988884A4 (en) * 2006-03-02 2009-09-30 Siga Technologies Inc ANTIVIRAL DRUGS FOR THE TREATMENT OF ARENAVIRUS INFECTIONS
EP1988776B1 (en) 2006-03-02 2012-08-08 Siga Technologies, Inc. Antiviral drugs for treatment of arenavirus infection
US8017168B2 (en) 2006-11-02 2011-09-13 The Coca-Cola Company High-potency sweetener composition with rubisco protein, rubiscolin, rubiscolin derivatives, ace inhibitory peptides, and combinations thereof, and compositions sweetened therewith
JP2010518008A (ja) * 2007-02-02 2010-05-27 レッドポイント バイオ コーポレイション インスリンおよびglp−1の放出を調節するtrpm5阻害物質
EP3085367A3 (en) * 2007-03-20 2017-01-25 Brandeis University Compositions for the diagnosis, treatment, and prevention of amyotrophic lateral sclerosis and related
WO2009038722A1 (en) * 2007-09-17 2009-03-26 Redpoint Bio Corporation Modulation of the cooperativity between the ion channels trpm5 and trpa1
US8101649B2 (en) 2007-11-21 2012-01-24 Neurosearch A/S N-acylhydrazone derivatives useful as modulators of nicotinic acetylcholine receptors
US20110033393A1 (en) * 2009-05-12 2011-02-10 Stein Philip Hydrazone Compounds and Their Use
CN103547153A (zh) * 2010-08-20 2014-01-29 陶氏益农公司 包含7-羟基-茚满酮苯甲酰基腙和铜的协同杀真菌和杀藻组合物
CN103748089B (zh) 2011-06-24 2016-08-17 陶氏益农公司 杀虫组合物及其相关方法
JP6122006B2 (ja) 2011-08-15 2017-04-26 ザ ユニバーシティ オブ ユタ リサーチ ファウンデイション ヒストン脱メチル化酵素阻害剤としての、置換された(e)−n’−(1−フェニルエチリデン)ベンゾヒドラジド類似体
US9266838B2 (en) 2011-08-15 2016-02-23 University Of Utah Research Foundation Substituted (E)-N′-(1-phenylethylidene)benzohydrazide analogs as histone demethylase inhibitors
BRPI1106472A2 (pt) * 2011-11-29 2014-04-15 Univ Rio De Janeiro Compostos n-glicinil-n-acilidrazônicos heterocíclicos, processo de síntese, composições farmacêuticas e método de tratamento
WO2014100163A1 (en) * 2012-12-19 2014-06-26 Dow Agrosciences Llc Pesticidal compositions and processes related thereto
RU2638043C2 (ru) 2012-12-19 2017-12-11 ДАУ АГРОСАЙЕНСИЗ ЭлЭлСи Пестицидные композиции и связанные с ними способы
PL2934118T3 (pl) 2012-12-19 2018-07-31 Dow Agrosciences Llc Kompozycje pestycydowe i związane z nimi sposoby
RU2654336C2 (ru) 2012-12-19 2018-05-17 ДАУ АГРОСАЙЕНСИЗ ЭлЭлСи Пестицидные композиции и связанные с ними способы
US9215870B2 (en) 2012-12-19 2015-12-22 Dow Agrosciences Llc Pesticidal compositions and processes related thereto
TWI667224B (zh) 2014-06-09 2019-08-01 美商陶氏農業科學公司 殺蟲組成物及與其相關之方法
KR102777190B1 (ko) 2016-01-25 2025-03-10 코르테바 애그리사이언스 엘엘씨 살충 유용성을 갖는 분자, 및 그와 관련된 중간체, 조성물 및 방법
RU2691454C2 (ru) * 2016-03-30 2019-06-14 Федеральное государственное бюджетное научное учреждение "Научно-исследовательский институт фармакологии имени В.В. Закусова" Использование 3,4,5-триметокси-N'(2,2,6,6-тетраметил-пиперидин-4-илиден)бензогидразида гидрохлорида в качестве анксиолитического средства
RU2699658C2 (ru) * 2016-08-19 2019-09-09 Федеральное государственное бюджетное научное учреждение "Научно-исследовательский институт фармакологии имени В.В. Закусова" Ацилгидразон (2,3,4-триметокси-N'-(8-метил-8-азабицикло[3.2.1.] октан-3-илиден) бензогидразид гидрохлорид), обладающий противомигреневой и анксиолитической активностью
TWI780112B (zh) 2017-03-31 2022-10-11 美商科迪華農業科技有限責任公司 具有殺蟲效用之分子,及其相關之中間物、組成物暨方法
KR102128509B1 (ko) * 2018-12-19 2020-07-01 한국과학기술연구원 말단 아민기에 아릴 또는 헤테로아릴기가 치환된 신규한 히드라존 유도체 및 이의 용도
EP4651866A1 (en) * 2023-01-20 2025-11-26 The Research Foundation for The State University of New York Hydrazonyl sultones and uses thereof

Family Cites Families (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5130324A (en) * 1984-03-19 1992-07-14 The Rockefeller University 2-alkylidene-aminoguanidines and methods of use therefor
US4684534A (en) * 1985-02-19 1987-08-04 Dynagram Corporation Of America Quick-liquifying, chewable tablet
US5011678A (en) * 1989-02-01 1991-04-30 California Biotechnology Inc. Composition and method for administration of pharmaceutically active substances
DE3903990A1 (de) * 1989-02-10 1990-08-30 Basf Ag Phenylhydrazone, ihre herstellung und daraus hergestellte arzneimittel und kosmetika
US6649186B1 (en) * 1996-09-20 2003-11-18 Ethypharm Effervescent granules and methods for their preparation
AU2610299A (en) * 1998-02-05 1999-08-23 Novo Nordisk A/S Hydrazone derivatives
US6368625B1 (en) * 1998-08-12 2002-04-09 Cima Labs Inc. Orally disintegrable tablet forming a viscous slurry
US6060078A (en) * 1998-09-28 2000-05-09 Sae Han Pharm Co., Ltd. Chewable tablet and process for preparation thereof
US6403142B1 (en) * 1998-12-11 2002-06-11 Ralston Purina Company Hypoallergenic pet food
CA2356533C (en) * 1998-12-23 2010-07-13 Mount Sinai School Of Medicine Inhibitors of the bitter taste response
US6773716B2 (en) * 1999-04-06 2004-08-10 Wm. Wrigley Jr. Company Over-coated chewing gum formulations
US6187332B1 (en) * 1999-06-14 2001-02-13 Wisconsin Alumni Research Foundation Acidic buffered nasal spray
WO2001030412A1 (en) * 1999-10-27 2001-05-03 Zapata Technologies Inc. Flavor protectant closure liner compositions
AU2001241042A1 (en) * 2000-03-08 2001-09-17 Takeda Chemical Industries Ltd. Process for the preparation of hydrazine derivatives
US6316029B1 (en) * 2000-05-18 2001-11-13 Flak Pharma International, Ltd. Rapidly disintegrating solid oral dosage form
US6485709B2 (en) * 2001-01-23 2002-11-26 Addent Inc. Dental bleaching gel composition, activator system and method for activating a dental bleaching gel
WO2002096867A2 (en) * 2001-05-30 2002-12-05 Lg Biomedical Institute Inhibitors of protein kinase for the treatment of disease
WO2003011287A1 (en) * 2001-08-03 2003-02-13 Vertex Pharmaceuticals Incorporated Pyrazolon derivatives as inhibitors of gsk-3
CA2469709A1 (en) * 2001-12-10 2003-06-19 Temple University - Of The Commonwealth System Of Higher Education Substituted hydrazones as inhibitors of cyclooxygenase-2
GB0226724D0 (en) * 2002-11-15 2002-12-24 Merck Sharp & Dohme Therapeutic agents
BRPI0407525A (pt) * 2003-02-17 2006-02-14 Ciba Sc Holding Ag corantes de hidrazona substituìdos catiÈnicos
US7723075B2 (en) * 2003-02-21 2010-05-25 The Queens's Medical Center Methods of screening for TRPM5 modulators
AU2004217441A1 (en) * 2003-03-05 2004-09-16 Metabolex Inc. Methods and compositions for treating and diagnosing diabetes and related diseases involving beta-TRP
EP1622686B1 (en) * 2003-03-18 2010-01-13 Basf Se Cationic dimeric dyes
US20050244810A1 (en) * 2003-09-29 2005-11-03 Egan Josephine M Taste signaling in gastrointestinal cells
EP1691891A2 (en) * 2003-11-13 2006-08-23 The Board Of Regents, The University Of Texas System Inhibition of trp channels as a treatment for cardiac hypertrophy and heart failure
WO2007047985A2 (en) * 2005-10-19 2007-04-26 Senomyx, Inc. Trpm5 based assays and the use thereof for the identification of modulators of sweet, bitter or umami (savory) taste
KR20080072644A (ko) * 2005-11-03 2008-08-06 레드포인트 바이오 코포레이션 Trpm5 이온 채널용 고속 처리 스크리닝 검정

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105732476A (zh) * 2016-02-04 2016-07-06 吉首大学 一种咔唑-靛红型化合物及其制法和用途
CN105732476B (zh) * 2016-02-04 2017-12-01 吉首大学 一种咔唑‑靛红型化合物及其制法和用途

Also Published As

Publication number Publication date
BRPI0618224A2 (pt) 2011-08-23
RU2008115539A (ru) 2009-12-10
EP1951215A4 (en) 2009-07-29
WO2007056159A3 (en) 2008-10-16
AU2006311826A1 (en) 2007-05-18
AU2006311826C1 (en) 2011-06-16
KR20080070848A (ko) 2008-07-31
NO20082346L (no) 2008-08-04
US20070207093A1 (en) 2007-09-06
CA2626846A1 (en) 2007-05-18
WO2007056159A2 (en) 2007-05-18
EP1951215A2 (en) 2008-08-06
AU2006311826B2 (en) 2010-11-11
JP2009514878A (ja) 2009-04-09

Similar Documents

Publication Publication Date Title
CN101541348A (zh) 腙衍生物及其用途
US7674831B2 (en) Heterocyclic compounds as sweetener enhancers
US20080153845A1 (en) Trpv1 antagonists and uses thereof
TW201347681A (zh) 含有咪唑胜肽與槲黃素配糖體之組成物
CA2890386C (en) Blood flow promoting agent
JP2005232045A (ja) 抗ストレス及びリラックス用組成物
US20070259875A1 (en) Triaryl substituted imidazole derivatives and taste-inhibiting uses thereof
EP2683352B1 (en) Small molecule modulators of the cold and menthol receptor trpm8
US20200297015A1 (en) Tryptophan derivatives as sweeteners
JP7008452B2 (ja) 高吸収型経口チロシン製剤
WO2025244084A1 (ja) PPARγ活性化により処置し得る状態の処置剤
JP2008127371A (ja) 安定な内服液剤組成物
MX2008005670A (en) Hydrazone derivatives and uses thereof
JP2008024675A (ja) 内服液剤組成物
JP2018016612A (ja) 血流改善用組成物

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C02 Deemed withdrawal of patent application after publication (patent law 2001)
WD01 Invention patent application deemed withdrawn after publication

Open date: 20090923