Summary of the invention
An object of the present invention is to provide a kind of Chinese medicine composition for the treatment of bovine mastitis, said composition is prepared from by the raw material of Chinese medicine of following weight ratio:
Herba Taraxaci: 20-60 Herba Violae: 20-60 Folium Isatidis: 20-60
Herba Menthae: 5-40 Radix Et Rhizoma Rhei: 5-40 Rhizoma Dioscoreae Bulbiferae: 10-50
Radix Trichosanthis: 10-50 Flos Chrysanthemi Indici: 20-60 Radix Scutellariae: 5-40
Rhizoma Coptidis: 10-50 Radix Sophorae Flavescentis: 10-50 Pericarpium Citri Reticulatae: 10-50
Flos Lonicerae: 10-50.
Preferably, said composition is prepared from by the raw material of Chinese medicine of following weight ratio:
Herba Taraxaci: 25-50 Herba Violae: 25-50 Folium Isatidis: 25-50
Herba Menthae: 15-25 Radix Et Rhizoma Rhei: 15-25 Rhizoma Dioscoreae Bulbiferae: 20-30
Radix Trichosanthis: 20-30 Flos Chrysanthemi Indici: 25-50 Radix Scutellariae: 15-25
Rhizoma Coptidis: 20-30 Radix Sophorae Flavescentis: 20-30 Pericarpium Citri Reticulatae: 20-30
Flos Lonicerae: 20-30.
Most preferably, said composition is prepared from by the raw material of Chinese medicine of following weight ratio:
Herba Taraxaci 35 Herba Violaes 35 Folium Isatidiss 35 Herba Menthaes 20
Radix Et Rhizoma Rhei 20 Rhizoma Dioscoreae Bulbiferaes 25 Radix Trichosanthis 25 Flos Chrysanthemi Indicis 35
Radix Scutellariae 20 Rhizoma Coptidis 25 Radix Sophorae Flavescentiss 25 Pericarpium Citri Reticulataes 25
Flos Lonicerae 25.
Chinese medicine composition of the present invention can be made various types of pharmaceutical preparatioies according to actual needs, for example makes oral powder, and is preferred but be not limited to oral powder.In order to prepare these preparations, the pharmaceutically acceptable auxiliaries that can in compositions of the present invention, add conventional animal taste as required, selection for adjuvant, those skilled in the art can carry out according to the requirement of dosage form, when for example preparing oral powder, in the present composition, can add sweeting agent, flavoring agent and antiseptic.For the concrete selection of adjuvant, the present invention's specific restriction useless.
Another object of the present invention provides a kind of preparation method of the present composition, it is characterized in that: may further comprise the steps:
With described Herba Taraxaci, Herba Violae, Folium Isatidis, Herba Menthae, Radix Et Rhizoma Rhei, Rhizoma Dioscoreae Bulbiferae, Radix Trichosanthis, Flos Chrysanthemi Indici, Radix Scutellariae, Rhizoma Coptidis, Radix Sophorae Flavescentis, Pericarpium Citri Reticulatae, the dried medicine raw material of Flos Lonicerae 13 flavor Chinese medicines cleans, weigh by weight, place heated-air circulation oven oven dry 1 hour---2 hours, be ground into powder with the hammer slice type feed grinder after going out baking oven, add flavoring agent and/or antiseptic as required, cross 80 mesh sieves, sieving powder places mixer to mix 10 minutes---and 30 minutes, then, the check uniformity, 50 grams or 100 grams or 200 grams or 300 grams or unit of 350 grams promptly get oral powder of the present invention with paper bag or mould bag and pack by weight.
Described heated-air circulation oven is the DMH--3 heated-air circulation oven of being made by Nanjing, Jiangsu Province wind group drying equipment factory.
Described hammer slice type feed grinder is the SFY set hammer chip feed grinder that meets clever machine-building company limited to make by Shanghai.
Described mixer is the Wtypeofblender of being made by Shandong Province's absolute sincerity machine-building company limited.
Described sieve is the vortex oscillation sieve of being made by the great pharmaceutical machine company limited of Jiangsu Province's Changzhou gold.
Above-mentioned raw material and equipment are all commercially available to be arrived.
Need to prove that method of the present invention is a kind of preferable preparation technique but is not limited to this.Product by the inventive method preparation has good stability.
For many years, adopt Chinese medicine composition of the present invention, particularly the oral medication bovine mastitis obtains better curative effect, does not see any toxic and side effects.
The present invention be directed to the bovine mastitis disease, particularly the intractable mastitis disease.The source of disease of mastitis disease is that the combination of the composition in the prescription is the various pathogenic bacterium of the pin mastitis characteristics prescriptions extremely responsive to this medicine due to the sense beams such as staphylococcus, streptococcus agalactiae, streptococcus dysgalactiae and other funguses, there is very strong killing action this medicine combination back to mastitis pathogenic bacterium, prescription combination is according to the traditional Chinese medical science, monarch, minister, the formulation principle helping, make, each medicine form the back produce very strong collaborative or shape the antibacterial action of making a concerted effort.Can improve tens of times of curative effects.
The functional component of the Chinese medicine composition of treatment bovine mastitis of the present invention is Herba Taraxaci, Herba Violae, Folium Isatidis, Herba Menthae, Radix Et Rhizoma Rhei, Rhizoma Dioscoreae Bulbiferae, Radix Trichosanthis, Flos Chrysanthemi Indici, Radix Scutellariae, Rhizoma Coptidis, Radix Sophorae Flavescentis, Pericarpium Citri Reticulatae, Flos Lonicerae.
In the prescription of treatment bovine mastitis of the present invention: put down in writing according to the Chinese medicine voluminous dictionary:
Herba Taraxaci---[function cures mainly]: heat-clearing and toxic substances removing, diuresis eliminating stagnation; Control acute mastitis, lymphadenitis, scrofula, furuncle carbuncle toxin, acute conjunctivitis, cold, fever, acute tonsillitis, acute bronchitis, gastritis, hepatitis, cholecystitis, urinary tract infection.
Herba Violae---[function cures mainly]: clearing away heat-damp and promoting diuresis, removing toxic substances and promoting subsidence of swelling; Control furuncle, carbuncle, scrofula, jaundice, dysentery, diarrhoea, conjunctival congestion, sore throat, venom.
Herba Menthae---[function cures mainly]: dispelling wind, the heat radiation, ward off dirty, the detoxifcation, control affection due to external wind and heat, the headache, conjunctival congestion, laryngopharynx swelling and pain, the dyspepsia flatulence, aphtha, the toothache, skin ulcer scabies, urticaria.
Folium Isatidis---[function cures mainly]: heat clearing away, detoxifcation, removing heat from blood, hemostasis.Control epidemic febrile disease intenseness of heat excessive thirst, influenza, acute infectious hepatitis, bacillary dysentery, acute gastroenteritis, acute pneumonia, erysipelas is spitted blood epistaxis, jaundice, dysentery, sore throat, aphtha, swollen ulcer drug.
Radix Et Rhizoma Rhei---[function cures mainly]: the poison that purges heat, removing mass stagnates, clots absorbing blood.Control the excess-heat constipation, delirium is gone mad, the food stagnation feeling of fullness, dysentery is from the beginning of, tenesmus, stasis of blood menolipsis is closed, the time row epidemic disease due to heat pathogen, sudden and violent swelling ophthalmalgia is spitted blood epistaxis, YANG jaundice, edema, stranguria with turbid discharge, carbuncle and ulcer toxic swelling, furuncle, burn.
Radix Scutellariae---[function cures mainly]: the removing the relative excess fire, except that damp and hot, hemostasis, antiabortive; Control the high fever excessive thirst, the cough due to lung-heat, warm dysentery, jaundice, pyretic stranguria is told, collapses, is leaked, conjunctival congestion and swelling pain, frequent fetal movement, carbuncle furuncle.
Rhizoma Coptidis---[function cures mainly]: pathogenic fire purging, dampness, detoxifcation, parasite killing.Row pyretic toxicity, typhoid fever when controlling, intenseness of heat is vexed, the feeling of fullness vomiting, bacillary dysentery, diarrhea of heat type stomachache, pulmonary tuberculosis is told, nosebleed, hematochezia, quenches one's thirst infantile malnutrition, ascariasis, pertussis, laryngopharynx swelling and pain, acute catarrhal conjunctivitis, aphtha, skin sore, eczema, the burning hot wound of soup.
Rhizoma Dioscoreae Bulbiferae---[function cures mainly]: removing heat from blood, pathogenic fire reducing, is controlled haematemesis, epistaxis, sore throat, goiter, carbuncle sore scrofula at the wart that disappears, detoxifcation, pain relieving.
Flos Chrysanthemi Indici---[function cures mainly]: wind and heat dispersing, subduing swelling and detoxicating; Control anemopyretic cold, pneumonia, diphtheria, gastroenteritis, hypertension, furuncle, carbuncle, aphtha, erysipelas, eczema, epidemic blisters.
Radix Trichosanthis---[function cures mainly]: promote the production of body fluid, quench the thirst, pathogenic fire reducing is moisturized, evacuation of pus, detumescence; It is thirsty to control calentura, quenches one's thirst jaundice, dryness of the lung hemoptysis, carbuncle, hemorrhoid flaccidity.
Radix Sophorae Flavescentis---[function cures mainly]: heat clearing away, dampness, parasite killing; Control toxic-heat and blood stasis, discharging fresh blood stool, jaundice, leucorrhea with red and white discharge, infantile pneumonia, infantile malnutrition, acute tonsillitis, anal fistula, proctoptosis, skin pruritus, the mange malignant boil, erosion of vulva pruritus due to damp pathogen, scrofula is scalded.
Flos Lonicerae---[function cures mainly]: heat clearing away, detoxifcation.Control the epidemic febrile disease heating, toxic-heat and blood stasis, carbuncle and ulcer, toxic swelling, scrofula, anal fistula.
In the prescription of treatment bovine mastitis of the present invention: Pericarpium Citri Reticulatae Pericarpium Citri Reticulatae Pericarpium CitriReticulatae (English) Tangerine Peel calls red Fructus Citri tangerinae, Radix Campylotropis Hirtella (Herba Myrsines Africanae), river Fructus Citri tangerinae.The source is the peel of rutaceae orange Citrus reticulata Bianco.[different name] Pericarpium Citri tangerinae Shennong's Herbal, Fructus Citri tangerinae skin " chicken peak Prescriptions for Universal Relief ", Folium Styracis Suberifoliae Materia Medica of Decoction, orange peel " the southern regions of the Yunnan Province book on Chinese herbal medicine ", wide Pericarpium Citri tangerinae " proper book on Chinese herbal medicine ".
Pericarpium Citri Reticulatae---[function cures mainly]: regulating qi-flowing for strengthening spleen, drying dampness to eliminate phlegm.Be used for fullness in the epigastrium and chest, lack of appetite and vomiting, cough ant phlegm.The peel of the variety of [note] Fructus Citri tangerinae also is used as medicine as Pericarpium Citri Reticulatae; The outer peel of its immature fruit also is used as medicine, and medical material is called Pericarpium Citri Reticulatae Viride, and the soothing the liver dispelling the stagnated QI of energy, removing food stagnancyization stagnate.
Above-mentioned various medical materials are combined by weight proportion, are had following characteristics: 1. the pure environmental type veterinary drug of this medicine, reasonable recipe, novelty, nontoxic, have no side effect.2. medication is convenient easy-to-use, and only needing to reconcile into the medicated porridge shape with warm water can gavage.3. consumption evident in efficacy is little, gavages once a day, takes the swelling breast of suffering from animals such as mastitis milch cow in three days continuously and can subside a swelling, bring down a fever, and pain goes down, and it is sagging that breast is column type, and four nipple claim that all the functional rehabilitation of giving milk is normal.Milk yield and fresh milk quality are gone up, and it can also activate old and feeble mammary glandular cell simultaneously, the lactogenic function of activation acinus.Make the dairy farmer increase income.
With the trade name of a kind of Chinese medicine composition preparation for the treatment of bovine mastitis provided by the invention is that swelling of the breast dissipation oral medicine is through the Chinese herbal medicine screening 13 kinds of above raw materials to be ground into Powderedly, and the Chinese powder medicine of making is used for specially controlling milch cow stubbornness mastadenitis.Clinical trial certificate through 4 years: the acute and chronic mastitis that animal mamma as raw material such as milch cow, milk sheep, sow are infected have good therapeutic effect.The hemorrhagic mastitis had antibiotic, hemostatic double effects.The trouble poultry very heavy to hyperpyrexia, mammary swelling, pain reaction due to the acute mastitis, detumescence arranged, bring down a fever, pain relieving, promotion inflammatory products absorb, recover the effect of acinus lactogenic, chronic mastitis is had the good result of controlling and controlling mammary gland atrophy, meat change.It can also activate old and feeble mammary glandular cell simultaneously, and the lactogenic function of activation acinus has been cured more than 300 ten thousand milch cows that suffer from mastadenitis, through service observation after sale, all milch cows of taking this medicine do not have bounce-back, have no side effect, the lactogenic function that activates milk cow mammary glandular cell prolongs gives milk the phase, has improved milk yield.
Beneficial effect of the present invention owing to adopt the medical material in the above-mentioned prescription to fit over together by weight complex group, has following effect:
1, pure Chinese medicinal preparation is pure green medicine, and is pollution-free to milk, and noresidue has no side effect.
2, dosage form is many, and what veterinary's technology arranged can medication, and the people of no veterinary's technology also can medication, and is easy to use.
3, curative effect is outstanding, and effect is remarkable, dosage is little, the medication number of times is few, and cost is low, short treating period, and instant effect, cure rate are absolutely.
4, ill curing the disease, anosis medication can prevent the generation of mastadenitis.
5, this Chinese medicine composition can replace the conventional medicament with antibiotics, chemical antimicrobial drug treatment bovine mastitis disease fully, and it is long to have overcome traditional courses of pharmaceuticals, and weak effect pollutes milk, influences the defective of quality of dairy products.This Chinese medicine composition has solved foster milch cow in response to treating mastitis disease with antibiotics, chemical antimicrobial drug, the difficult problem of milk of selling that is caused.
For this reason, another object of the present invention provides the application of a kind of present composition in preparation treatment bovine mastitis medicine.
The specific embodiment
Embodiment 1
(trade name: swelling of the breast dissipates oral powder; Adopted name: general Ji sterilization is loose)
Raw material of Chinese medicine and consumption:
Herba Taraxaci 35g, Herba Violae 35g, Folium Isatidis 35g, Herba Menthae 20g, Radix Et Rhizoma Rhei 20g, Rhizoma Dioscoreae Bulbiferae 25g, Radix Trichosanthis 25g, Flos Chrysanthemi Indici 35g, Radix Scutellariae 20g, Rhizoma Coptidis 25g, Radix Sophorae Flavescentis 25g, Pericarpium Citri Reticulatae 25g, Flos Lonicerae 25g.
Method for making: the dried medicine of above 13 flavor Chinese medicines places heated-air circulation oven oven dry 1 hour, going out baking oven is placed on the hammer slice type feed grinder and is ground into powder, cross 80 mesh sieves, sieving powder places mixer to mix 10 minutes, then, check the uniformity, 100 restrain with 3 bags of plastic bag packagings by weight, 50 grams promptly get oral powder of the present invention with 1 bag of plastic bag packaging by weight.
Character: this product is a brown ceramic powder, gas perfume (or spice), puckery, little hardship.
Usage and consumption: oral: cattle is obeyed 300 grams at every turn, and sheep, pig are obeyed 100 grams at every turn, every day 1 time, or follow the doctor's advice.
[operative norm]: two ones of Chinese veterinary drug allusion quotation versions in 2005.
Embodiment 2
(trade name: swelling of the breast dissipates oral powder; Adopted name: general Ji sterilization is loose)
Raw material of Chinese medicine and consumption:
Herba Taraxaci 20g, Herba Violae 60g, Folium Isatidis 25g, Herba Menthae 20g, Radix Et Rhizoma Rhei 20g, Rhizoma Dioscoreae Bulbiferae 25g, Radix Trichosanthis 25g, Flos Chrysanthemi Indici 35g, Radix Scutellariae 20g, Rhizoma Coptidis 25g, Radix Sophorae Flavescentis 25g, Pericarpium Citri Reticulatae 25g, Flos Lonicerae 25g.
Method for making: the dried medicine of above 13 flavor Chinese medicines places heated-air circulation oven oven dry 1 hour, going out baking oven is placed on the hammer slice type feed grinder and is ground into powder, cross 80 mesh sieves, sieving powder places mixer to mix 10 minutes, then, the check uniformity, by weight 350 the gram one mould the bag packaging together, promptly get oral powder of the present invention.
Character: this product is a brown ceramic powder, gas perfume (or spice), puckery, little hardship.
Usage and consumption: oral: cattle is obeyed 300 grams at every turn, and sheep, pig are obeyed 100 grams at every turn, every day 1 time, or follow the doctor's advice.
[operative norm]: two ones of Chinese veterinary drug allusion quotation versions in 2005.
Embodiment 3
(trade name: swelling of the breast dissipates oral powder; Adopted name: general Ji sterilization is loose)
Raw material of Chinese medicine and consumption:
Herba Taraxaci 60g, Herba Violae 20g, Folium Isatidis 25g, Herba Menthae 20g, Radix Et Rhizoma Rhei 20g, Rhizoma Dioscoreae Bulbiferae 25g, Radix Trichosanthis 25g, Flos Chrysanthemi Indici 35g, Radix Scutellariae 20g, Rhizoma Coptidis 25g, Radix Sophorae Flavescentis 25g, Pericarpium Citri Reticulatae 25g, Flos Lonicerae 25g.
Method for making: the dried medicine of above 13 flavor Chinese medicines places heated-air circulation oven oven dry 1 hour, going out baking oven is placed on the hammer slice type feed grinder and is ground into powder, cross 80 mesh sieves, sieve powder and be placed at mixer mixing 10 minutes, then, the check uniformity, 50 one of gram are moulded bag packing by weight, adorn 7 bags altogether, promptly get oral powder of the present invention.
Character: this product is a brown ceramic powder, gas perfume (or spice), puckery, little hardship.
Usage and consumption: oral: cattle is obeyed 300 grams at every turn, and sheep, pig are obeyed 100 grams at every turn, every day 1 time, or follow the doctor's advice.
[operative norm]: two ones of Chinese veterinary drug allusion quotation versions in 2005.
Embodiment 4
Clinical trial
(trade name: swelling of the breast dissipates the oral powder of the application of the invention embodiment 1; Adopted name: the sterilization of general Ji is loose) treatment 120 routine bovine mastitis, 120 routine milk sheep mastitis and 120 example milk pig mastitis prove the curative effect of Chinese medicine composition of the present invention.
The material method:
The usage and the consumption of " oral powders of treatment milch cow, milk sheep and milk pig mastitis "
Experimental result shows the using method dosage form, and consumption has substantial connection, and consumption is better by heavy dose of medication effect, and during consumption is pressed, low dose of medication, effect is a little low, and the course of treatment is longer.From this medicinal medicine optimum efficiency dosage of above description of test: be by the middle dosage medication better effects if the positive usual amounts.
Best usage and dosage is: each consumption 300 grams of the adult milch cow of oral powder, and each consumption 100 grams of milk sheep, each consumption 100 grams of milk pig, medication every day 1 time is until recovery from illness.
The oral liquid medication is convenient, does not have veterinary's disposal technology, all can use, and usage is easy, and everybody can both medication, and oral liquid is popular drug formulation.
Embodiment 5
Concrete case exemplifies
Case 1:2008 JIUYUE, area just outside a city gate, Beian City township Lee * * one 7 years old milch cow is examined the main suit: found both sides breast redness before 10 days, ask the veterinary ineffective with blue or green enzyme extract for treating, loss of appetite.Check: both sides mammary gland redness, lymphonodi supramammarici enlargement.The veterinary is diagnosed as mastitis and enjoins once a day, and the swelling of the breast dissipation 300 with embodiment 1 restrains further consultation after three days at every turn.Red and swollen basic disappearance of breast during further consultation after three days is in order to consolidate curative effect medication three days again, recovery from illness.
Case 2:2008 December, Wudalianchi open * and * one 5 years old milch cow examines the main suit: and the milk amount descends in the last few days, the defective rejection of milking station check milk.The veterinary is diagnosed as mastitis and enjoins once a day, and the swelling of the breast dissipation 300 with embodiment 1 restrains further consultation after three days at every turn.Red and swollen basic disappearance of breast during further consultation after three days is in order to consolidate curative effect medication three days again, recovery from illness.
More than example of the present invention is had been described in detail, but described content only is a preferred embodiments of the present invention, can not be considered to be used to limit practical range of the present invention.All equalizations of doing according to the present patent application scope change and improve etc., all should belong to patent covering scope of the present invention.