CN101518577B - Fried bitter almond formula granules as well as preparation method and quality control method thereof - Google Patents
Fried bitter almond formula granules as well as preparation method and quality control method thereof Download PDFInfo
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- CN101518577B CN101518577B CN 200810184559 CN200810184559A CN101518577B CN 101518577 B CN101518577 B CN 101518577B CN 200810184559 CN200810184559 CN 200810184559 CN 200810184559 A CN200810184559 A CN 200810184559A CN 101518577 B CN101518577 B CN 101518577B
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Abstract
The invention discloses fried bitter almond formula granules as well as a preparation method and a quality control method thereof. The fried bitter almond formula granules are prepared from fried bitter almond drinking tablets through process flows such as twice water extraction, concentration under reduced pressure, spray drying and the like; each gram of the fried bitter almond formula granules are equivalent to 5 to 10 grams of crude drug; and the fried bitter almond drinking tablets and the fried bitter almond formula granules all adopt infrared fingerprint for quality discrimination. The fried bitter almond formula granules have a complete and advanced production process and a strong-specificity and controllable quality control standard, the advanced process can be realized, and test methods related to the quality standard are scientific, advanced, quick and strong in operability. Through a great number of experiments, compositions in the soup prepared from the fried bitter almond formula granules are equivalent to those of mixed simmered liquid of classical formula drinking tablets containing fried bitter almond, the process of full composition formula granules is realized, and the reasonability of the process is improved; and the invention applies infrared spectrum technology to quality control of Chinese medicaments so as to quickly solve the first problem of macro quality control of the Chinese medicaments, namely identification of truth of the Chinese medicaments.
Description
Technical field
The present invention relates to a kind of Chinese medicinal granule and preparation method thereof and method of quality control, particularly a kind of Semen Armeniacae Amarum (parched) granule and preparation method thereof and method of quality control.
Background technology
Chinese medicinal granule is under Chinese medical theory instructs, and the prepared slices of Chinese crude drugs are formed through various processes, is used for the granule that clinical tcm prescription allotment is used; Compare with traditional Chinese herbs decoction, its taking convenience, dose is little, and is quality controllable, preserves easily, is easy to carry; Chinese medicinal granule is in the pilot production status at home at present, product technology and quality standard disunity.At present Chinese medicinal granule mostly is traditional water and extracts, and perhaps extracts water extraction behind the volatile oil, and different production unit causes the product quality of different manufacturers inconsistent because production equipment is different with production technology, and there is difference in drug effect.The specificity of its quality standard is limit by certain test conditions and scope, lacks other due quality informations of product, and present standard can't be judged quality good or not and the overall picture of Chinese medicinal granule product comprehensively.
Infrared spectrometry is one of conventional means of differentiating chemical compound and definite structure of matter.In pharmaceutical analysis, " fingerprint " characteristic that has with infrared spectrum is the common method that adopts of various countries' pharmacopeia as the foundation of drug identification.But since Chinese crude drug, the prepared slices of Chinese crude drugs and Chinese patent medicine itself all be more than the Western medicine complexity many mixture systems, the spectrum analysis difficulty makes conventional infrared spectrometry fail its due effect of performance in Chinese medicine quality control and management in the long term.
Summary of the invention
The objective of the invention is to disclose a kind of Semen Armeniacae Amarum (parched) granule; The present invention also aims to disclose the preparation method of this granule; The present invention also aims to disclose the method for quality control of this granule.
The present invention seeks to be achieved through the following technical solutions:
The suitable crude drug amount of the every gram of Semen Armeniacae Amarum (parched) granule of the present invention 5-10 gram, the Infrared fingerprint spectra of this granule such as Fig. 1.The preparation method of Semen Armeniacae Amarum (parched) granule of the present invention comprises: get the Semen Armeniacae Amarum (parched) decoction pieces, use twice of water extraction; Wherein the Semen Armeniacae Amarum (parched) decoction pieces adopts Infrared fingerprint spectra to carry out quality discrimination, Semen Armeniacae Amarum (parched) decoction pieces standard Infrared fingerprint spectra such as Fig. 2.
The preparation method of Semen Armeniacae Amarum (parched) granule of the present invention comprises the steps: to get the Semen Armeniacae Amarum (parched) decoction pieces, adds the water of 5-15 times of weight portion, extracts 0.5-3 hour, namely one fries in shallow oil; One fries in shallow oil the water that the back medicinal residues add 5-15 times of weight portion of Semen Armeniacae Amarum (parched) decoction pieces, extracts 0.5-3 hour, namely two fries in shallow oil; Merge two liquid of boiling medicine, be evaporated to the concentrated solution of relative density 1.00-1.15; The concentrated solution spray drying gets the Semen Armeniacae Amarum (parched) spray drying powder; The Semen Armeniacae Amarum (parched) spray drying powder is directly granulated or add adjuvant dextrin or the lactose dry granulation of himself weight portion 0-25% in the Semen Armeniacae Amarum (parched) spray drying powder, gets 20-60 purpose Semen Armeniacae Amarum (parched) granule.
The preparation method of Semen Armeniacae Amarum (parched) granule of the present invention is preferably as follows step: get the Semen Armeniacae Amarum (parched) decoction pieces, add the water of 8 times of weight portions, extracted 2 hours, namely one fry in shallow oil; One fries in shallow oil the water that the back medicinal residues add 7 times of weight portions of Semen Armeniacae Amarum (parched) decoction pieces, extracts 1.5 hours, namely two fries in shallow oil; Merge two liquid of boiling medicine, be evaporated to the concentrated solution of relative density 1.05-1.10; The concentrated solution spray drying gets the Semen Armeniacae Amarum (parched) spray drying powder; The Semen Armeniacae Amarum (parched) spray drying powder is directly granulated or add adjuvant dextrin or the lactose dry granulation of himself weight portion 0-25% in the Semen Armeniacae Amarum (parched) spray drying powder, gets 20-60 purpose Semen Armeniacae Amarum (parched) granule.
The preparation method of Semen Armeniacae Amarum (parched) granule of the present invention is preferably as follows step: get the Semen Armeniacae Amarum (parched) decoction pieces, add the water of 10 times of weight portions, extracted 2 hours, namely one fry in shallow oil; One fries in shallow oil the water that the back medicinal residues add 6 times of weight portions of Semen Armeniacae Amarum (parched) decoction pieces, extracts 1 hour, namely two fries in shallow oil; Merge two liquid of boiling medicine, be evaporated to the concentrated solution of relative density 1.00-1.05; The concentrated solution spray drying gets the Semen Armeniacae Amarum (parched) spray drying powder; The Semen Armeniacae Amarum (parched) spray drying powder is directly granulated or add adjuvant dextrin or the lactose dry granulation of himself weight portion 0-25% in the Semen Armeniacae Amarum (parched) spray drying powder, gets 20-60 purpose Semen Armeniacae Amarum (parched) granule.
The preparation method of Semen Armeniacae Amarum (parched) granule of the present invention is preferably as follows step: get the Semen Armeniacae Amarum (parched) decoction pieces, add the water of 14 times of weight portions, extracted 2.5 hours, namely one fry in shallow oil; One fries in shallow oil the water that the back medicinal residues add 11 times of weight portions of Semen Armeniacae Amarum (parched) decoction pieces, extracts 2.5 hours, namely two fries in shallow oil; Merge two liquid of boiling medicine, be evaporated to the concentrated solution of relative density 1.10-1.15; The concentrated solution spray drying gets the Semen Armeniacae Amarum (parched) spray drying powder; The Semen Armeniacae Amarum (parched) spray drying powder is directly granulated or add adjuvant dextrin or the lactose dry granulation of himself weight portion 0-25% in the Semen Armeniacae Amarum (parched) spray drying powder, gets 20-60 purpose Semen Armeniacae Amarum (parched) granule.
The drying process with atomizing parameter is in the above-mentioned preparation method: 40 ℃-50 ℃ of medicinal liquid preheat temperatures; 170 ℃-185 ℃ of inlet temperature; 450-700 rev/min of material revolution speed; 70 ℃-85 ℃ of leaving air temps; Wind send 40 ℃-50 ℃ of temperature.
The granulation parameter is in the above-mentioned preparation method: main pinch roller pressure: 4-6MPa; Side pressure wheel pressure: 0.4-0.6MPa; The speed of mainshaft: 300-500 rev/min; Feed voltage: 100-150V; Granular size: 20-60 order.
The method of quality control of Semen Armeniacae Amarum (parched) granule of the present invention comprises the steps: that the Semen Armeniacae Amarum (parched) granule adopts Infrared fingerprint spectra to carry out quality discrimination, the Infrared fingerprint spectra discrimination method is: use Fourier transform infrared spectrometer, measurement range is 4000cm
-1-400cm
-1, DTGS detector, resolution 4cm
-1, scanning times 16 times is deducted water and carbon dioxide constantly and is disturbed in the scanning process, and envionmental humidity is lower than 60%, and the potassium bromide direct compression process detects; Semen Armeniacae Amarum (parched) granule Infrared fingerprint spectra has following feature: as shown in Figure 1 at 1079cm
-1, 1030cm
-1The absworption peak that has two absorption intensities to be more or less the same; At 2929cm
-1, 1634cm
-1, 1385cm
-1, 861cm
-1There is characteristic absorption at the place.
The method of quality control of the Semen Armeniacae Amarum (parched) decoction pieces described in the Semen Armeniacae Amarum (parched) granule preparation method of the present invention comprises the steps: that the Semen Armeniacae Amarum (parched) decoction pieces is the certified products that meet a regulation of Pharmacopoeia of the People's Republic of China version in 2005; The Semen Armeniacae Amarum (parched) decoction pieces adopts Infrared fingerprint spectra to carry out quality discrimination, and the Infrared fingerprint spectra discrimination method is: use Fourier transform infrared spectrometer, measurement range is 4000cm
-1-400cm
-1, DTGS detector, resolution 4cm
-1, scanning times 16 times is deducted water and carbon dioxide constantly and is disturbed in the scanning process, and envionmental humidity is lower than 60%, and the potassium bromide direct compression process detects; The Infrared fingerprint spectra of Semen Armeniacae Amarum (parched) decoction pieces has following feature: as shown in Figure 2 at 1746cm
-1, 1162cm
-1, 722cm
-1The absworption peak peak shape at place is more sharp-pointed; At 2926cm
-1, 2855cm
-1, 1658cm
-1, 1539cm
-1, 1457cm
-1, 1240cm
-1, 1059cm
-1There is characteristic absorption at the place.
Wherein Infrared fingerprint spectra of the present invention can be to reach Infrared fingerprint spectra more than 90% with its dependency.
Description of drawings:
Fig. 1: the Infrared fingerprint spectra of Semen Armeniacae Amarum (parched) granule;
Fig. 2: the Infrared fingerprint spectra of Semen Armeniacae Amarum (parched) decoction pieces Semen Armeniacae Amarum;
Fig. 3: Semen Armeniacae Amarum (parched) granule and Semen Armeniacae Amarum (parched) decoction pieces thin layer chromatography are relatively;
Fig. 4: Semen Armeniacae Amarum (parched) granule and Semen Armeniacae Amarum (parched) decoction pieces thin-layer sample Infrared fingerprint spectra are relatively;
Fig. 5: contain Semen Armeniacae Amarum (parched) classics side decoction pieces decocting liquid and Semen Armeniacae Amarum (parched) soup that granule is joined " whole part " infrared spectrogram relatively.
Semen Armeniacae Amarum (parched) granule of the present invention has complete, advanced production technology and strong, the controlled quality control standard of specificity, and technology advanced person can realize, the detection method science that quality standard relates to, advanced person, quick, workable.By a large amount of experiments, contrast the classical side's decoction pieces that contains the Semen Armeniacae Amarum (parched) decoction pieces and closed decocting liquid and Semen Armeniacae Amarum (parched) soup that granule is joined of the present invention " whole part " infrared spectrogram, Semen Armeniacae Amarum (parched) granule of the present invention and Semen Armeniacae Amarum (parched) decoction pieces thin-layer chromatogram have been contrasted, Semen Armeniacae Amarum (parched) granule and Semen Armeniacae Amarum (parched) decoction pieces thin-layer sample Infrared fingerprint spectra have been contrasted, the result shows that the classical side's decoction pieces that contains the Semen Armeniacae Amarum (parched) decoction pieces closes decocting liquid and Semen Armeniacae Amarum (parched) granule of the present invention is joined soup Infrared fingerprint spectra peak shape, peak position, relative peak intensity basically identical, it is suitable to be that Semen Armeniacae Amarum (parched) soup that granule is joined of the present invention and decoction pieces close the decocting liquid composition, and the Infrared fingerprint spectra peak shape of Semen Armeniacae Amarum (parched) granule of the present invention and decoction pieces thin-layer sample, peak position, relative peak intensity basically identical, therefore Semen Armeniacae Amarum (parched) granule of the present invention has been realized the technology of whole part granule, proves the reasonability of technology of the present invention; And the present invention is applied to infrared spectrum technology the quality control of Chinese medicine, this is the innovation on a kind of thinking, this not only meets Chinese medicine about the theory of " monarch, minister, help, make ", also given prominence to the group effect of Chinese medicine, simultaneously complicated problems is oversimplified, certain Chinese medicine is done as a whole, observed its " fingerprint ", thereby solved a matter of utmost importance--the evaluation of-Chinese medicine true and false in the control of Chinese medicine macroscopic quality rapidly.
Following experimental example and embodiment are used for further specifying but are not limited to the present invention.
Experimental example 1
(1) Semen Armeniacae Amarum (parched) granule and Semen Armeniacae Amarum (parched) decoction pieces thin layer chromatography are relatively
Differentiate a thin layer chromatography test down according to middle Semen Armeniacae Amarum of Pharmacopoeia of the People's Republic of China version in 2005, prepare sample with Semen Armeniacae Amarum (parched) decoction pieces and Semen Armeniacae Amarum (parched) granule of the present invention, measure, the gained result as shown in Figure 3, in the Semen Armeniacae Amarum (parched) granule chromatograph, with the corresponding position of Semen Armeniacae Amarum (parched) decoction pieces chromatograph on, show the speckle of same color.
(2) Semen Armeniacae Amarum (parched) granule and Semen Armeniacae Amarum (parched) decoction pieces thin-layer sample Infrared fingerprint spectra are relatively
Measure the Semen Armeniacae Amarum (parched) decoction pieces of preparation in (1) and the thin-layer sample of Semen Armeniacae Amarum (parched) granule with Fourier transform infrared spectrometer, its result as shown in Figure 4, the thin-layer sample Infrared fingerprint spectra peak shape of Semen Armeniacae Amarum (parched) granule and Semen Armeniacae Amarum (parched) decoction pieces, peak position, relative peak intensity basically identical.
The result proves that Semen Armeniacae Amarum (parched) granule of the present invention is consistent with Semen Armeniacae Amarum (parched) decoction pieces composition, and technology of the present invention is rational.
Experimental example 2 contains Semen Armeniacae Amarum (parched) classics side decoction pieces decocting liquid and Semen Armeniacae Amarum (parched) soup that granule is joined " whole part " infrared spectrogram comparative experiments
Maziren Wan comes from treatise on Febrile Diseases, and prescription is formed and comprised pockmarks core, Radix Et Rhizoma Rhei, Fructus Aurantii Immaturus, Radix Paeoniae, Semen Armeniacae Amarum, 6 flavour of a drug of Cortex Magnoliae Officinalis; The effect relaxing the bowels with lubricant drugs.
1, experiment purpose: study the similarities and differences of Maziren Wan decoction pieces decocting liquid and granular recipe, determine the reasonability of Semen Armeniacae Amarum (parched) granule technology and equivalent.
2, experimental technique: get 6 flavour of a drug prescriptions such as Semen Armeniacae Amarum (parched) by Maziren Wan prescription proportioning, the decocting method of pressing the decoction pieces decoction decocts preparation decoction pieces decocting liquid sample; In addition get other decoction pieces except Semen Armeniacae Amarum (parched) respectively by Maziren Wan prescription proportioning, the decocting method of pressing the decoction pieces decoction decocts, medicinal liquid suitably concentrates, getting the Semen Armeniacae Amarum (parched) granule by Maziren Wan prescription proportioning and equivalent relation adds in the concentrated medicament, be stirred to dissolving fully, preparation granular recipe sample; Drinking sheet decocting liquid sample, granular recipe sample respectively carries out infrared spectrum and detects.
3, testing conditions: instrument is Fourier transform infrared spectrometer, and measurement range is 4000cm
-1-400cm
-1, DTGS detector, resolution 4cm
-1, scanning times 16 times is deducted water and carbon dioxide constantly and is disturbed in the scanning process, and envionmental humidity is lower than 60%, and the potassium bromide direct compression process detects.
4, testing result: decoction pieces decocting liquid sample and granular recipe sample Infrared fingerprint spectra peak shape, peak position, relative peak intensity basically identical as shown in Figure 5, dependency reaches 94.84%.It is consistent to prove that Semen Armeniacae Amarum (parched) soup that granule is joined of the present invention and decoction pieces close the decocting liquid composition, it is consistent with a Semen Armeniacae Amarum (parched) decoction pieces fried composition namely to add Semen Armeniacae Amarum (parched) granule of the present invention, and equivalent and production technology that Semen Armeniacae Amarum (parched) granule 1g of the present invention is equivalent to Semen Armeniacae Amarum (parched) decoction pieces 5-10g are rational.
Following embodiment all can realize the effect of above-mentioned experimental example, and required Semen Armeniacae Amarum (parched) decoction pieces adopts Infrared fingerprint spectra to carry out quality discrimination among the following embodiment, meets the standard Infrared fingerprint spectra of the Semen Armeniacae Amarum (parched) decoction pieces in the technique scheme; The Semen Armeniacae Amarum (parched) granule that following embodiment makes adopts Infrared fingerprint spectra to carry out quality discrimination, meets the Infrared fingerprint spectra of the Semen Armeniacae Amarum (parched) granule in the technique scheme; The every gram of Semen Armeniacae Amarum (parched) granule described in the following embodiment contains suitable crude drug amount 5-10 gram.
The specific embodiment
Embodiment 1: the Semen Armeniacae Amarum (parched) granule
Get Semen Armeniacae Amarum (parched) decoction pieces 100kg, add the water of 800kg, extracted 2 hours, namely one fry in shallow oil; One fries in shallow oil the back medicinal residues adds 800kg water, extracts 1.5 hours, namely two fries in shallow oil; Merge two liquid of boiling medicine, be evaporated to relative density 1.05-1.10; Concentrated solution is 45 ℃ of preheatings, 180 ℃ of inlet temperature, and 550 rev/mins of material revolution speeds, 80 ℃ of leaving air temps, wind send spray drying under the condition of 45 ℃ of temperature, get the Semen Armeniacae Amarum (parched) spray drying powder; The adjuvant dextrin that in the Semen Armeniacae Amarum (parched) spray drying powder, adds himself weight portion 0-5%; The Semen Armeniacae Amarum (parched) spray drying powder is 5MPa at main pinch roller pressure, side pressure wheel pressure is 0.5MPa, and the speed of mainshaft is 400 rev/mins, and feed voltage is dry granulation under the condition of 120V, get 20-60 purpose Semen Armeniacae Amarum (parched) granule, suitable crude drug amount 10 grams of the every gram of Semen Armeniacae Amarum (parched) granule.
Embodiment 2: the Semen Armeniacae Amarum (parched) granule
Get Semen Armeniacae Amarum (parched) decoction pieces 100kg, add the water of 1000kg, extracted 2 hours, namely one fry in shallow oil; One fries in shallow oil the back medicinal residues adds 600kg water, extracts 1 hour, namely two fries in shallow oil; Merge two liquid of boiling medicine, be evaporated to relative density 1.00-1.05; Concentrated solution is 50 ℃ of preheatings, 170 ℃ of inlet temperature, and 600 rev/mins of material revolution speeds, 75 ℃ of leaving air temps, wind send spray drying under the condition of 50 ℃ of temperature, get the Semen Armeniacae Amarum (parched) spray drying powder; The adjuvant dextrin that in the Semen Armeniacae Amarum (parched) spray drying powder, adds himself weight portion 5-15%; Be 6MPa at main pinch roller pressure, side pressure wheel pressure is 0.4MPa, and the speed of mainshaft is 450 rev/mins, and feed voltage is dry granulation under the condition of 110V, gets 20-60 purpose Semen Armeniacae Amarum (parched) granule, suitable crude drug amount 7 grams of the every gram of Semen Armeniacae Amarum (parched) granule;
The method of quality control of wherein said Semen Armeniacae Amarum (parched) decoction pieces comprises the steps: that the Semen Armeniacae Amarum (parched) decoction pieces adopts Infrared fingerprint spectra to carry out quality discrimination, and the Infrared fingerprint spectra discrimination method is: use Fourier transform infrared spectrometer, measurement range is 4000cm
-1-400cm
-1, DTGS detector, resolution 4cm
-1, scanning times 16 times is deducted water and carbon dioxide constantly and is disturbed in the scanning process, and envionmental humidity is lower than 60%, and the potassium bromide direct compression process detects; The Infrared fingerprint spectra of Semen Armeniacae Amarum (parched) decoction pieces has following feature: as shown in Figure 2 at 1746cm
-1, 1162cm
-1, 722cm
-1The absworption peak peak shape at place is more sharp-pointed; At 2926cm
-1, 2855cm
-1, 1658cm
-1, 1539cm
-1, 1457cm
-1, 1240cm
-1, 1059cm
-1There is characteristic absorption at the place.
Embodiment 3: the Semen Armeniacae Amarum (parched) granule
Get Semen Armeniacae Amarum (parched) decoction pieces 100kg, add the water of 1400kg, extracted 2.5 hours, namely one fry in shallow oil; One fries in shallow oil the back medicinal residues adds 1100kg water, extracts 2.5 hours, namely two fries in shallow oil; Merge two liquid of boiling medicine, be evaporated to relative density 1.10-1.15; Concentrated solution is 45 ℃ of preheatings, 170 ℃ of inlet temperature, and 600 rev/mins of material revolution speeds, 75 ℃ of leaving air temps, wind send spray drying under the condition of 50 ℃ of temperature, get the Semen Armeniacae Amarum (parched) spray drying powder; The lactose that in the Semen Armeniacae Amarum (parched) spray drying powder, adds himself weight portion 15-25%; Be 4MPa at main pinch roller pressure, side pressure wheel pressure is 0.4MPa, and the speed of mainshaft is 500 rev/mins, and feed voltage is dry granulation under the condition of 130V, gets 20-60 purpose Semen Armeniacae Amarum (parched) granule, suitable crude drug amount 5 grams of the every gram of Semen Armeniacae Amarum (parched) granule;
The method of quality control of gained Semen Armeniacae Amarum (parched) granule comprises the steps: to adopt Infrared fingerprint spectra to carry out quality discrimination, and the Infrared fingerprint spectra discrimination method is: use Fourier transform infrared spectrometer, measurement range is 4000cm
-1-400cm
-1, DTGS detector, resolution 4cm
-1, scanning times 16 times is deducted water and carbon dioxide constantly and is disturbed in the scanning process, and envionmental humidity is lower than 60%, and the potassium bromide direct compression process detects; Semen Armeniacae Amarum (parched) granule Infrared fingerprint spectra has following feature: as shown in Figure 1 at 1079cm
-1, 1030cm
-1The absworption peak that has two absorption intensities to be more or less the same; At 2929cm
-1, 1634cm
-1, 1385cm
-1, 861cm
-1There is characteristic absorption at the place.
Claims (4)
1. the detection method of a Semen Armeniacae Amarum (parched) granule is characterized in that this method comprises the steps:
The method of quality control of described Semen Armeniacae Amarum (parched) decoction pieces comprises the steps: that the Semen Armeniacae Amarum (parched) decoction pieces adopts Infrared fingerprint spectra to carry out quality discrimination, and the Infrared fingerprint spectra discrimination method is: use Fourier transform infrared spectrometer, measurement range is 4000 cm
-1-400cm
-1, DTGS detector, resolution 4cm
-1, scanning times 16 times is deducted water and carbon dioxide constantly and is disturbed in the scanning process, and envionmental humidity is lower than 60%, and the potassium bromide direct compression process detects; The Infrared fingerprint spectra of Semen Armeniacae Amarum (parched) decoction pieces has following feature: as shown in Figure 2 at 1746cm
-1, 1162cm
-1, 722cm
-1The absworption peak peak shape at place is more sharp-pointed; At 2926cm
-1, 2855cm
-1, 1658cm
-1, 1539cm
-1, 1457cm
-1, 1240cm
-1, 1059cm
-1There is characteristic absorption at the place;
Described Semen Armeniacae Amarum (parched) granule preparation method comprises the steps: to get the Semen Armeniacae Amarum (parched) decoction pieces, adds the water of 5-15 times of weight portion, extracts 0.5-3 hour, namely one fries in shallow oil; One fries in shallow oil the water that the back medicinal residues add 5-15 times of weight portion of Semen Armeniacae Amarum (parched) decoction pieces, extracts 0.5-3 hour, namely two fries in shallow oil; Merge two liquid of boiling medicine, be evaporated to the concentrated solution of relative density 1.00-1.15; The concentrated solution spray drying gets the Semen Armeniacae Amarum (parched) spray drying powder; In the Semen Armeniacae Amarum (parched) spray drying powder, add adjuvant dextrin or the lactose dry granulation of himself weight portion 0-25%, get 20-60 purpose Semen Armeniacae Amarum (parched) granule;
The method of quality control of described Semen Armeniacae Amarum (parched) granule comprises the steps: that the Semen Armeniacae Amarum (parched) granule adopts Infrared fingerprint spectra to carry out quality discrimination, and the Infrared fingerprint spectra discrimination method is: use Fourier transform infrared spectrometer, measurement range is 4000 cm
-1-400cm
-1, DTGS detector, resolution 4cm
-1, scanning times 16 times is deducted water and carbon dioxide constantly and is disturbed in the scanning process, and envionmental humidity is lower than 60%, and the potassium bromide direct compression process detects; Semen Armeniacae Amarum (parched) granule Infrared fingerprint spectra has following feature: as shown in Figure 1 at 1079cm
-1, 1030cm
-1The absworption peak that has two absorption intensities to be more or less the same; At 2929cm
-1, 1634cm
-1, 1385cm
-1, 861cm
-1There is characteristic absorption at the place.
2. the detection method of Semen Armeniacae Amarum (parched) granule according to claim 1 is characterized in that,
The preparation method of described Semen Armeniacae Amarum (parched) granule comprises the steps: to get the Semen Armeniacae Amarum (parched) decoction pieces, adds the water of 8 times of weight portions, extracts 2 hours, namely one fries in shallow oil; One fries in shallow oil the water that the back medicinal residues add 7 times of weight portions of Semen Armeniacae Amarum (parched) decoction pieces, extracts 1.5 hours, namely two fries in shallow oil; Merge two liquid of boiling medicine, be evaporated to the concentrated solution of relative density 1.05-1.10; The concentrated solution spray drying gets the Semen Armeniacae Amarum (parched) spray drying powder; In the Semen Armeniacae Amarum (parched) spray drying powder, add adjuvant dextrin or the lactose dry granulation of himself weight portion 0-25%, get 20-60 purpose Semen Armeniacae Amarum (parched) granule.
3. the detection method of Semen Armeniacae Amarum (parched) granule according to claim 1 is characterized in that,
The preparation method of described Semen Armeniacae Amarum (parched) granule comprises the steps: to get the Semen Armeniacae Amarum (parched) decoction pieces, adds the water of 10 times of weight portions, extracts 2 hours, namely one fries in shallow oil; One fries in shallow oil the water that the back medicinal residues add 6 times of weight portions of Semen Armeniacae Amarum (parched) decoction pieces, extracts 1 hour, namely two fries in shallow oil; Merge two liquid of boiling medicine, be evaporated to the concentrated solution of relative density 1.00-1.05; The concentrated solution spray drying gets the Semen Armeniacae Amarum (parched) spray drying powder; In the Semen Armeniacae Amarum (parched) spray drying powder, add adjuvant dextrin or the lactose dry granulation of himself weight portion 0-25%, get 20-60 purpose Semen Armeniacae Amarum (parched) granule.
4. the detection method of Semen Armeniacae Amarum (parched) granule according to claim 1 is characterized in that,
The preparation method of described Semen Armeniacae Amarum (parched) granule comprises the steps: to get the Semen Armeniacae Amarum (parched) decoction pieces, adds the water of 14 times of weight portions, extracts 2.5 hours, namely one fries in shallow oil; One fries in shallow oil the water that the back medicinal residues add 11 times of weight portions of Semen Armeniacae Amarum (parched) decoction pieces, extracts 2.5 hours, namely two fries in shallow oil; Merge two liquid of boiling medicine, be evaporated to the concentrated solution of relative density 1.10-1.15; The concentrated solution spray drying gets the Semen Armeniacae Amarum (parched) spray drying powder; In the Semen Armeniacae Amarum (parched) spray drying powder, add adjuvant dextrin or the lactose dry granulation of himself weight portion 0-25%, get 20-60 purpose Semen Armeniacae Amarum (parched) granule.
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| CN 200810184559 CN101518577B (en) | 2007-12-18 | 2008-12-17 | Fried bitter almond formula granules as well as preparation method and quality control method thereof |
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| CN 200810184582 Active CN101474265B (en) | 2007-12-18 | 2008-12-17 | Coptis root dispensing granule as well as preparation method and quality control method thereof |
| CN 200810184570 Active CN101474290B (en) | 2007-12-18 | 2008-12-17 | Detection method of figwort root dispensing granule |
| CN 200810184581 Active CN101474273B (en) | 2007-12-18 | 2008-12-17 | Stir-fried fructus gardenia dispensing granule as well as preparation method and quality control method thereof |
| CN 200810184561 Active CN101474225B (en) | 2007-12-18 | 2008-12-17 | Ledebouriella root granule as well as preparation method and quality control method |
| CN 200810184580 Active CN101474278B (en) | 2007-12-18 | 2008-12-17 | Processed fructus evodiae dispensing granule as well as preparation method and quality control method thereof |
| CN 200810184579 Pending CN101474318A (en) | 2007-12-18 | 2008-12-17 | Rhizoma alismatis dispensing granule as well as preparation method and quality control method thereof |
| CN 200810184563 Active CN101474253B (en) | 2007-12-18 | 2008-12-17 | Detection method of cassia twig dispensing granule |
| CN 200810184575 Active CN101480420B (en) | 2007-12-18 | 2008-12-17 | Detection method of ballonflower dispensing granule |
| CN 200810184568 Active CN101474232B (en) | 2007-12-18 | 2008-12-17 | White atractylodes rhizome dispensing granule as well as preparation method and quality control method |
| CN 200810184559 Active CN101518577B (en) | 2007-12-18 | 2008-12-17 | Fried bitter almond formula granules as well as preparation method and quality control method thereof |
| CN 200810184569 Active CN101474237B (en) | 2007-12-18 | 2008-12-17 | Detection method of trichosanthes dispensing granule |
| CN 200810184578 Active CN101474229B (en) | 2007-12-18 | 2008-12-17 | Oriental wormwood dispensing granule as well as preparation method and quality control method |
| CN 200810184560 Active CN101518589B (en) | 2007-12-18 | 2008-12-17 | Rehmannia Root formula granules as well as preparation method and quality control method thereof |
| CN 200810184576 Active CN101474287B (en) | 2007-12-18 | 2008-12-17 | Detection method of prepared rehmannia root dispensing granule |
| CN 200810184567 Active CN101474224B (en) | 2007-12-18 | 2008-12-17 | Notopterygium root dispensing granule as well as preparation method and quality control method |
| CN 200810184573 Active CN101474293B (en) | 2007-12-18 | 2008-12-17 | Medlar dispensing granule as well as preparation method and quality control method thereof |
| CN 200810184562 Active CN101474223B (en) | 2007-12-18 | 2008-12-17 | Chinese angelica root dispensing granule as well as preparation method and quality control method |
| CN 200810184566 Active CN101474219B (en) | 2007-12-18 | 2008-12-17 | Detection method of achyranthes bidentata dispensing granule |
| CN 200810184565 Pending CN101474352A (en) | 2007-12-18 | 2008-12-17 | Ophiopogon root dispensing granule as well as preparation method and quality control method thereof |
| CN 200810184564 Pending CN101474333A (en) | 2007-12-18 | 2008-12-17 | Yam dispensing granule as well as preparation method and quality control method thereof |
| CN 200810184571 Active CN101474241B (en) | 2007-12-18 | 2008-12-17 | Detection method of astragalus dispensing granule |
| CN 200810184572 Active CN101474221B (en) | 2007-12-18 | 2008-12-17 | Detection method of glehnia root dispensing granule |
| CN 200810184583 Pending CN101474244A (en) | 2007-12-18 | 2008-12-17 | Honey-fried licorice root dispensing granule as well as preparation method and quality control method |
| CN 200810184577 Active CN101474228B (en) | 2007-12-18 | 2008-12-17 | Detection method of wild chrysanthemum dispensing granule |
| CN 200810184574 Active CN101474263B (en) | 2007-12-18 | 2008-12-17 | White peony root dispensing granule as well as preparation method and quality control method thereof |
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| CN 200810184570 Active CN101474290B (en) | 2007-12-18 | 2008-12-17 | Detection method of figwort root dispensing granule |
| CN 200810184581 Active CN101474273B (en) | 2007-12-18 | 2008-12-17 | Stir-fried fructus gardenia dispensing granule as well as preparation method and quality control method thereof |
| CN 200810184561 Active CN101474225B (en) | 2007-12-18 | 2008-12-17 | Ledebouriella root granule as well as preparation method and quality control method |
| CN 200810184580 Active CN101474278B (en) | 2007-12-18 | 2008-12-17 | Processed fructus evodiae dispensing granule as well as preparation method and quality control method thereof |
| CN 200810184579 Pending CN101474318A (en) | 2007-12-18 | 2008-12-17 | Rhizoma alismatis dispensing granule as well as preparation method and quality control method thereof |
| CN 200810184563 Active CN101474253B (en) | 2007-12-18 | 2008-12-17 | Detection method of cassia twig dispensing granule |
| CN 200810184575 Active CN101480420B (en) | 2007-12-18 | 2008-12-17 | Detection method of ballonflower dispensing granule |
| CN 200810184568 Active CN101474232B (en) | 2007-12-18 | 2008-12-17 | White atractylodes rhizome dispensing granule as well as preparation method and quality control method |
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| CN 200810184578 Active CN101474229B (en) | 2007-12-18 | 2008-12-17 | Oriental wormwood dispensing granule as well as preparation method and quality control method |
| CN 200810184560 Active CN101518589B (en) | 2007-12-18 | 2008-12-17 | Rehmannia Root formula granules as well as preparation method and quality control method thereof |
| CN 200810184576 Active CN101474287B (en) | 2007-12-18 | 2008-12-17 | Detection method of prepared rehmannia root dispensing granule |
| CN 200810184567 Active CN101474224B (en) | 2007-12-18 | 2008-12-17 | Notopterygium root dispensing granule as well as preparation method and quality control method |
| CN 200810184573 Active CN101474293B (en) | 2007-12-18 | 2008-12-17 | Medlar dispensing granule as well as preparation method and quality control method thereof |
| CN 200810184562 Active CN101474223B (en) | 2007-12-18 | 2008-12-17 | Chinese angelica root dispensing granule as well as preparation method and quality control method |
| CN 200810184566 Active CN101474219B (en) | 2007-12-18 | 2008-12-17 | Detection method of achyranthes bidentata dispensing granule |
| CN 200810184565 Pending CN101474352A (en) | 2007-12-18 | 2008-12-17 | Ophiopogon root dispensing granule as well as preparation method and quality control method thereof |
| CN 200810184564 Pending CN101474333A (en) | 2007-12-18 | 2008-12-17 | Yam dispensing granule as well as preparation method and quality control method thereof |
| CN 200810184571 Active CN101474241B (en) | 2007-12-18 | 2008-12-17 | Detection method of astragalus dispensing granule |
| CN 200810184572 Active CN101474221B (en) | 2007-12-18 | 2008-12-17 | Detection method of glehnia root dispensing granule |
| CN 200810184583 Pending CN101474244A (en) | 2007-12-18 | 2008-12-17 | Honey-fried licorice root dispensing granule as well as preparation method and quality control method |
| CN 200810184577 Active CN101474228B (en) | 2007-12-18 | 2008-12-17 | Detection method of wild chrysanthemum dispensing granule |
| CN 200810184574 Active CN101474263B (en) | 2007-12-18 | 2008-12-17 | White peony root dispensing granule as well as preparation method and quality control method thereof |
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