CN101474241A - Astragalus dispensing granule as well as preparation method and quality control method - Google Patents
Astragalus dispensing granule as well as preparation method and quality control method Download PDFInfo
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- CN101474241A CN101474241A CN 200810184571 CN200810184571A CN101474241A CN 101474241 A CN101474241 A CN 101474241A CN 200810184571 CN200810184571 CN 200810184571 CN 200810184571 A CN200810184571 A CN 200810184571A CN 101474241 A CN101474241 A CN 101474241A
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Abstract
The invention discloses a radix astragali formula particle and preparation and quality control methods thereof. The formula particle uses radix astragali decoction pieces as raw materials, and the decoction pieces are processed by the technological processes of twice water extraction, vaccum concentration, sponging drying and the like to gain the radix astragali formula particle; and one gram of radix astragali formula particle is equivalent to 3 to 5 grams of crude medicines, and the quality of the radix astragali decoction pieces and the radix astragali formula particle is respectively discriminated by the infrared fingerprint spectra. The radix astragali formula particle of the invention has the advantages of integrated and advanced production process, specific and controllable quality control standard and advanced and realizable process, and a test method related to the quality standard is scientific, advanced, fast and highly operable. Proved by a lot of experiments, the ingredient of a herbal decoction prepared by the radix astragali formula particle of the invention is equivalent to the ingredient of the mixed simmer liquid of the radix astragali contained classical formula, the full ingredient formula particle process is achieved, and the process of the invention is proved to be reasonable; and the invention applies the infrared spectroscopy technology to the quality control of the traditional Chinese medicines, thereby fast solving the principal problem of traditional Chinese medicine truth discrimination in the macroscopic quality control of the traditional Chinese medicines.
Description
Technical field
The present invention relates to a kind of Chinese medicinal granule and preparation method thereof and method of quality control, particularly a kind of astragalus dispensing granule and preparation method thereof and method of quality control.
Background technology
Chinese medicinal granule is under Chinese medical theory instructs, and the prepared slices of Chinese crude drugs are formed through various processes, is used for the granule that clinical tcm prescription allotment is used; Compare with traditional Chinese herbs decoction, its taking convenience, dose is little, and is quality controllable, preserves easily, is easy to carry; Chinese medicinal granule is in the pilot production status at home at present, product technology and quality standard disunity.At present Chinese medicinal granule mostly is traditional water and extracts, and perhaps extracts water extraction behind the volatile oil, and different production unit causes the product quality of different manufacturers inconsistent because production equipment is different with production technology, and there is difference in drug effect.The specificity of its quality standard is limit by certain test conditions and scope, lacks other due quality informations of product, and present standard can't be judged the quality good or not and the overall picture of Chinese medicinal granule product comprehensively.
Infrared spectrometry is one of conventional means of differentiating chemical compound and definite structure of matter.In pharmaceutical analysis, " fingerprint " characteristic that has with infrared spectrum is the common method that adopts of various countries' pharmacopeia as the foundation of drug identification.But since Chinese crude drug, the prepared slices of Chinese crude drugs and Chinese patent medicine itself all be more than the Western medicine complexity many mixture systems, the spectrum analysis difficulty makes conventional infrared spectrometry fail its due effect of performance in Chinese medicine quality control and management in the long term.
Summary of the invention
The objective of the invention is to disclose a kind of astragalus dispensing granule; The present invention also aims to disclose the preparation method of this granule; The present invention also aims to disclose the method for quality control of this granule.
The present invention seeks to be achieved through the following technical solutions:
The suitable crude drug amount of the every gram of astragalus dispensing granule of the present invention 3-5 gram, the Infrared fingerprint spectra of this granule such as Fig. 1.The preparation method of astragalus dispensing granule of the present invention comprises: get Radix Astragali decoction pieces, use twice of water extraction; Wherein Radix Astragali decoction pieces adopts Infrared fingerprint spectra to carry out quality discrimination, Radix Astragali decoction pieces standard Infrared fingerprint spectra such as Fig. 2.
The preparation method of astragalus dispensing granule of the present invention comprises the steps: to get Radix Astragali decoction pieces, adds the water of 5-15 times of weight portion, extracts 0.5-3 hour, promptly one fries in shallow oil; One fries in shallow oil the water that the back medicinal residues add 5-15 times of weight portion of Radix Astragali decoction pieces, extracts 0.5-3 hour, promptly two fries in shallow oil; Merge two liquid of boiling medicine, be evaporated to the concentrated solution of relative density 1.00-1.15; The concentrated solution spray drying gets Radix Astragali spray drying powder; Radix Astragali spray drying powder is directly granulated or add adjuvant dextrin or the lactose dry granulation of himself weight portion 0-25% in Radix Astragali spray drying powder, 20-60 purpose astragalus dispensing granule.
The preparation method of astragalus dispensing granule of the present invention is preferably as follows step: get Radix Astragali decoction pieces, add the water of 8 times of weight portions, extracted 2 hours, promptly one fry in shallow oil; One fries in shallow oil the water that the back medicinal residues add 7 times of weight portions of Radix Astragali decoction pieces, extracts 1.5 hours, promptly two fries in shallow oil; Merge two liquid of boiling medicine, be evaporated to the concentrated solution of relative density 1.05-1.10; The concentrated solution spray drying gets Radix Astragali spray drying powder; Radix Astragali spray drying powder is directly granulated or add adjuvant dextrin or the lactose dry granulation of himself weight portion 0-25% in Radix Astragali spray drying powder, 20-60 purpose astragalus dispensing granule.
The preparation method of astragalus dispensing granule of the present invention is preferably as follows step: get Radix Astragali decoction pieces, add the water of 10 times of weight portions, extracted 2 hours, promptly one fry in shallow oil; One fries in shallow oil the water that the back medicinal residues add 6 times of weight portions of Radix Astragali decoction pieces, extracts 1 hour, promptly two fries in shallow oil; Merge two liquid of boiling medicine, be evaporated to the concentrated solution of relative density 1.00-1.05; The concentrated solution spray drying gets Radix Astragali spray drying powder; Radix Astragali spray drying powder is directly granulated or add adjuvant dextrin or the lactose dry granulation of himself weight portion 0-25% in Radix Astragali spray drying powder, 20-60 purpose astragalus dispensing granule.
The preparation method of astragalus dispensing granule of the present invention is preferably as follows step: get Radix Astragali decoction pieces, add the water of 14 times of weight portions, extracted 2.5 hours, promptly one fry in shallow oil; One fries in shallow oil the water that the back medicinal residues add 11 times of weight portions of Radix Astragali decoction pieces, extracts 2.5 hours, promptly two fries in shallow oil; Merge two liquid of boiling medicine, be evaporated to the concentrated solution of relative density 1.10-1.15; The concentrated solution spray drying gets Radix Astragali spray drying powder; Radix Astragali spray drying powder is directly granulated or add adjuvant dextrin or the lactose dry granulation of himself weight portion 0-25% in Radix Astragali spray drying powder, 20-60 purpose astragalus dispensing granule.
The drying process with atomizing parameter is in the above-mentioned preparation method: 40 ℃-50 ℃ of medicinal liquid preheat temperatures; 170 ℃-185 ℃ of inlet temperature; 450-700 rev/min of material revolution speed; 70 ℃-85 ℃ of leaving air temps; Wind send 40 ℃-50 ℃ of temperature.
The granulation parameter is in the above-mentioned preparation method: main pinch roller pressure: 4-6MPa; Side pressure wheel pressure: 0.4-0.6MPa; The speed of mainshaft: 300-500 rev/mins; Feed voltage: 100-150V; Granular size: 20-60 order.
The method of quality control of astragalus dispensing granule of the present invention comprises the steps: that astragalus dispensing granule adopts Infrared fingerprint spectra to carry out quality discrimination, and the Infrared fingerprint spectra discrimination method is: use Fourier transform infrared spectrometer, measurement range is 4000cm
-1-400cm
-1, DTGS detector, resolution 4cm
-1, scanning times 16 times is deducted water and carbon dioxide constantly and is disturbed in the scanning process, and envionmental humidity is lower than 60%, and the potassium bromide direct compression process detects; The astragalus dispensing granule Infrared fingerprint spectra has following feature: as shown in Figure 1 at 1028cm
-1An absworption peak that intensity is big, peak shape is wide is arranged, be stairstepping, it absorbs highest point is 1028cm
-1At 2925cm
-1, 1630cm
-1, 1412cm
-1, 927cm
-1, 607cm
-1There is characteristic absorption at the place.
The method of quality control of the Radix Astragali decoction pieces described in the astragalus dispensing granule preparation method of the present invention comprises the steps: that Radix Astragali decoction pieces is the certified products that meet a regulation of Pharmacopoeia of the People's Republic of China version in 2005; Radix Astragali decoction pieces adopts Infrared fingerprint spectra to carry out quality discrimination, and the Infrared fingerprint spectra discrimination method is: use Fourier transform infrared spectrometer, measurement range is 4000cm
-1-400cm
-1, DTGS detector, resolution 4cm
-1, scanning times 16 times is deducted water and carbon dioxide constantly and is disturbed in the scanning process, and envionmental humidity is lower than 60%, and the potassium bromide direct compression process detects; The Infrared fingerprint spectra of Radix Astragali decoction pieces has following feature: as shown in Figure 2 at 1000cm
-1-1200cm
-1Scope in an absworption peak that intensity is big, peak shape is wide is arranged, be stairstepping, it absorbs highest point is 1031cm
-1At 2928cm
-1, 1640cm
-1, 1424cm
-1, 1241cm
-1, 607cm
-1There is characteristic absorption at the place.
Infrared fingerprint spectra wherein of the present invention can be to reach Infrared fingerprint spectra more than 90% with its dependency.
Description of drawings:
Fig. 1: the Infrared fingerprint spectra of astragalus dispensing granule;
Fig. 2: the Infrared fingerprint spectra of Radix Astragali decoction pieces Radix Astragali;
Fig. 3: astragalus dispensing granule and Radix Astragali decoction pieces thin layer chromatography are relatively;
Fig. 4: astragalus dispensing granule and Radix Astragali decoction pieces thin-layer sample Infrared fingerprint spectra are relatively;
Fig. 5: contain Radix Astragali classics side decoction pieces decocting liquid and soup that astragalus dispensing granule is joined " whole part " infrared spectrogram relatively.
Complete, advanced production technology that astragalus dispensing granule of the present invention has and specificity strong, Controlled quality control standard, technology advanced person can realize, the detection method that quality standard relates to Science, advanced person, quick, workable. By great many of experiments, contrasted the warp that contains Radix Astragali medicine materical crude slice Allusion quotation side's medicine materical crude slice closes decocting liquid and soup that astragalus dispensing granule of the present invention is joined " full composition " infrared spectrogram, and is right Compare astragalus dispensing granule of the present invention and Radix Astragali medicine materical crude slice thin-layer chromatogram, contrasted astragalus dispensing granule with yellow Stilbene medicine materical crude slice thin-layer sample infrared finger print atlas, the result show the classical side's medicine materical crude slice that contains Radix Astragali medicine materical crude slice close decocting liquid with Astragalus dispensing granule of the present invention is joined soup infrared finger print atlas peak shape, peak position, Relative Peak intensity basic one Cause, namely to close the decocting liquid composition suitable for soup that astragalus dispensing granule of the present invention is joined and medicine materical crude slice, and Huang of the present invention The infrared finger print atlas peak shape of stilbene granule and medicine materical crude slice thin-layer sample, peak position, Relative Peak intensity basic one Cause, so astragalus dispensing granule of the present invention realizes the technology of full component prescription particle, proved worker of the present invention The reasonability of skill; And the present invention is applied to the quality control of Chinese medicine with infrared spectrum technology, and this is a kind of Innovation on the thinking, this not only meets traditional chinese medicine about the theory of " monarch, minister, help, make ", Also given prominence to the group effect of Chinese medicine, simultaneously the problem of complexity oversimplified, certain Chinese medicine as one Integral body is observed its " fingerprint ", thereby has solved rapidly a head in the control of Chinese medicine macroscopic quality Want problem---the evaluation of the Chinese medicine true and false.
Following experimental example and embodiment are used for further specifying but are not limited to the present invention.
Experimental example 1
(1) astragalus dispensing granule and Radix Astragali medicine materical crude slice thin-layer chromatography are relatively
Differentiate a lower thin layer look according to middle Radix Astragali of Pharmacopoeia of the People's Republic of China version in 2005 The spectrometry test prepares sample with Radix Astragali medicine materical crude slice and astragalus dispensing granule of the present invention, measures institute Get the result as shown in Figure 3, in the astragalus dispensing granule chromatogram, corresponding with Radix Astragali medicine materical crude slice chromatogram On the position, the spot of aobvious same color.
(2) astragalus dispensing granule and Radix Astragali medicine materical crude slice thin-layer sample infrared finger print atlas are relatively
Measure the Radix Astragali medicine materical crude slice of preparation in (1) and astragalus dispensing with FTIS The grain thin-layer sample, its result as shown in Figure 4, the thin layer of astragalus dispensing granule and Radix Astragali medicine materical crude slice Sample infrared finger print atlas peak shape, peak position, Relative Peak intensity are basically identical.
The result proves that astragalus dispensing granule of the present invention is consistent with Radix Astragali medicine materical crude slice composition, and technology of the present invention is to close Reason.
Experimental example 2 contains Radix Astragali classics side medicine materical crude slice decocting liquid and soup that astragalus dispensing granule is joined " full composition " infrared spectrogram comparative experiments
Muli San comes from " formulary of peaceful benevolent dispensary ", and prescription forms and comprises oyster, radix ephedrae, the Radix Astragali, light wheat 4 Individual flavour of a drug; The effect strengthening exterior and reducing sweat.
1, experiment purpose: the similarities and differences of research Muli San medicine materical crude slice decocting liquid and granular recipe, determine astragalus dispensing The reasonability of particle technology and equivalent.
2, experimental technique: get 4 flavour of a drug prescriptions such as the Radix Astragali by Muli San prescription proportioning, press the medicine materical crude slice decoction Decocting method decoct preparation medicine materical crude slice decocting liquid sample; Get except the Radix Astragali respectively by Muli San prescription proportioning in addition Other medicine materical crude slice, the decocting method of pressing the medicine materical crude slice decoction decocts, and soup suitably concentrates, and presses Muli San prescription proportioning Get astragalus dispensing granule with equivalent relation and add in the concentrated medicament, be stirred to fully dissolving, the preparation particle is joined The quadrat sampling product; Drinking respectively sheet decocting liquid sample, granular recipe sample carries out infrared spectrum and detects.
3, testing conditions: instrument is FTIS, and measurement range is 4000 cm-1-400cm
-1, DTGS detector, resolution ratio 4cm-1, scanning times 16 times, in the scanning process constantly Deduction water and carbon dioxide disturb, and envionmental humidity is lower than 60%, and the KBr direct compression process is examined Survey.
4, testing result: decoction pieces decocting liquid sample and granular recipe sample Infrared fingerprint spectra peak shape, peak position, relative peak intensity basically identical as shown in Figure 5, dependency reaches 94.68%.It is consistent to prove that soup that astragalus dispensing granule of the present invention is joined and decoction pieces close the decocting liquid composition, it is consistent with a Radix Astragali decoction pieces fried composition promptly to add astragalus dispensing granule of the present invention, and equivalent and production technology that astragalus dispensing granule 1g of the present invention is equivalent to Radix Astragali decoction pieces 3-5g are rational.
Following embodiment all can realize the effect of above-mentioned experimental example, and required Radix Astragali decoction pieces adopts Infrared fingerprint spectra to carry out quality discrimination among the following embodiment, meets the standard Infrared fingerprint spectra of the Radix Astragali decoction pieces in the technique scheme; The astragalus dispensing granule that following embodiment makes adopts Infrared fingerprint spectra to carry out quality discrimination, meets the Infrared fingerprint spectra of the astragalus dispensing granule in the technique scheme; The every gram of astragalus dispensing granule described in the following embodiment contains suitable crude drug amount 3-5 gram.
The specific embodiment
Embodiment 1: astragalus dispensing granule
Get Radix Astragali decoction pieces 100kg, add the water of 800kg, extracted 2 hours, promptly one fry in shallow oil; One fries in shallow oil the back medicinal residues adds 800kg water, extracts 1.5 hours, promptly two fries in shallow oil; Merge two liquid of boiling medicine, be evaporated to relative density 1.05-1.10; Concentrated solution is 45 ℃ of preheatings, 180 ℃ of inlet temperature, 550 rev/mins of material revolution speeds, 80 ℃ of leaving air temps, wind send spray drying under the condition of 45 ℃ of temperature, Radix Astragali spray drying powder; The adjuvant dextrin that in Radix Astragali spray drying powder, adds himself weight portion 0-5%; Radix Astragali spray drying powder is 5MPa at main pinch roller pressure, and side pressure wheel pressure is 0.5MPa, and the speed of mainshaft is 400 rev/mins, and feed voltage is a dry granulation under the condition of 120V, 20-60 purpose astragalus dispensing granule, suitable crude drug amount 5 grams of the every gram of astragalus dispensing granule.
Embodiment 2: astragalus dispensing granule
Get Radix Astragali decoction pieces 100kg, add the water of 1000kg, extracted 2 hours, promptly one fry in shallow oil; One fries in shallow oil the back medicinal residues adds 600kg water, extracts 1 hour, promptly two fries in shallow oil; Merge two liquid of boiling medicine, be evaporated to relative density 1.00-1.05; Concentrated solution is 50 ℃ of preheatings, 170 ℃ of inlet temperature, 600 rev/mins of material revolution speeds, 75 ℃ of leaving air temps, wind send spray drying under the condition of 50 ℃ of temperature, Radix Astragali spray drying powder; The adjuvant dextrin that in Radix Astragali spray drying powder, adds himself weight portion 5-15%; At main pinch roller pressure is 6MPa, and side pressure wheel pressure is 0.4MPa, and the speed of mainshaft is 450 rev/mins, and feed voltage is a dry granulation under the condition of 110V, 20-60 purpose astragalus dispensing granule, suitable crude drug amount 4 grams of the every gram of astragalus dispensing granule;
The method of quality control of wherein said Radix Astragali decoction pieces comprises the steps: that Radix Astragali decoction pieces adopts Infrared fingerprint spectra to carry out quality discrimination, and the Infrared fingerprint spectra discrimination method is: use Fourier transform infrared spectrometer, measurement range is 4000cm
-1-400cm
-1, DTGS detector, resolution 4cm
-1, scanning times 16 times is deducted water and carbon dioxide constantly and is disturbed in the scanning process, and envionmental humidity is lower than 60%, and the potassium bromide direct compression process detects; The Infrared fingerprint spectra of Radix Astragali decoction pieces has following feature: as shown in Figure 2 at 1000cm
-1-1200cm
-1Scope in an absworption peak that intensity is big, peak shape is wide is arranged, be stairstepping, it absorbs highest point is 1031cm
-1At 2928cm
-1, 1640cm
-1, 1424cm
-1, 1241cm
-1, 607cm
-1There is characteristic absorption at the place.
Embodiment 3: astragalus dispensing granule
Get Radix Astragali decoction pieces 100kg, add the water of 1400kg, extracted 2.5 hours, promptly one fry in shallow oil; One fries in shallow oil the back medicinal residues adds 1100kg water, extracts 2.5 hours, promptly two fries in shallow oil; Merge two liquid of boiling medicine, be evaporated to relative density 1.10-1.15; Concentrated solution is 45 ℃ of preheatings, 170 ℃ of inlet temperature, 600 rev/mins of material revolution speeds, 75 ℃ of leaving air temps, wind send spray drying under the condition of 50 ℃ of temperature, Radix Astragali spray drying powder; The lactose that in Radix Astragali spray drying powder, adds himself weight portion 15-25%; At main pinch roller pressure is 4MPa, and side pressure wheel pressure is 0.4MPa, and the speed of mainshaft is 500 rev/mins, and feed voltage is a dry granulation under the condition of 130V, 20-60 purpose astragalus dispensing granule, suitable crude drug amount 3 grams of the every gram of astragalus dispensing granule;
The method of quality control of gained astragalus dispensing granule comprises the steps: to adopt Infrared fingerprint spectra to carry out quality discrimination, and the Infrared fingerprint spectra discrimination method is: use Fourier transform infrared spectrometer, measurement range is 4000cm
-1-400cm
-1, DTGS detector, resolution 4cm
-1, scanning times 16 times is deducted water and carbon dioxide constantly and is disturbed in the scanning process, and envionmental humidity is lower than 60%, and the potassium bromide direct compression process detects; The astragalus dispensing granule Infrared fingerprint spectra has following feature: as shown in Figure 1 at 1028cm
-1An absworption peak that intensity is big, peak shape is wide is arranged, be stairstepping, it absorbs highest point is 1028cm
-1At 2925cm
-1, 1630cm
-1, 1412cm
-1, 927cm
-1, 607cm
-1There is characteristic absorption at the place.
Claims (9)
1, a kind of astragalus dispensing granule is characterized in that the suitable crude drug amount of the every gram of described astragalus dispensing granule 3-5 gram.
2, a kind of astragalus dispensing granule is characterized in that this astragalus dispensing granule Infrared fingerprint spectra has following feature: adopt Fourier transform infrared spectrometer to measure, at 1028cm
-1An absworption peak that intensity is big, peak shape is wide is arranged, be stairstepping, it absorbs highest point is 1028cm
-1At 2925cm
-1, 1630cm
-1, 1412cm
-1, 927cm
-1, 607cm
-1There is characteristic absorption at the place.
3, astragalus dispensing granule as claimed in claim 1 is characterized in that the Infrared fingerprint spectra of this granule has following feature: at 1028cm
-1An absworption peak that intensity is big, peak shape is wide is arranged, be stairstepping, it absorbs highest point is 1028cm
-1At 2925cm
-1, 1630cm
-1, 1412cm
-1, 927cm
-1, 607cm
-1There is characteristic absorption at the place.
4, a kind of preparation method of astragalus dispensing granule is characterized in that this method comprises a kind of in the following method:
Get Radix Astragali decoction pieces, add the water of 5-15 times of weight portion, extracted 0.5-3 hour, promptly one fry in shallow oil; One fries in shallow oil the water that the back medicinal residues add 5-15 times of weight portion of Radix Astragali decoction pieces, extracts 0.5-3 hour, promptly two fries in shallow oil; Merge two liquid of boiling medicine, be evaporated to the concentrated solution of relative density 1.00-1.15; The concentrated solution spray drying gets Radix Astragali spray drying powder; Radix Astragali spray drying powder is directly granulated or add adjuvant dextrin or the lactose dry granulation of himself weight portion 0-25% in Radix Astragali spray drying powder, astragalus dispensing granule;
Or get Radix Astragali decoction pieces, and add the water of 8 times of weight portions, extracted 2 hours, promptly one fry in shallow oil; One fries in shallow oil the water that the back medicinal residues add 7 times of weight portions of Radix Astragali decoction pieces, extracts 1.5 hours, promptly two fries in shallow oil; Merge two liquid of boiling medicine, be evaporated to the concentrated solution of relative density 1.05-1.10; The concentrated solution spray drying gets Radix Astragali spray drying powder; Radix Astragali spray drying powder is directly granulated or add adjuvant dextrin or the lactose dry granulation of himself weight portion 0-25% in Radix Astragali spray drying powder, astragalus dispensing granule;
Or get Radix Astragali decoction pieces, and add the water of 10 times of weight portions, extracted 2 hours, promptly one fry in shallow oil; One fries in shallow oil the water that the back medicinal residues add 6 times of weight portions of Radix Astragali decoction pieces, extracts 1 hour, promptly two fries in shallow oil; Merge two liquid of boiling medicine, be evaporated to the concentrated solution of relative density 1.00-1.05; The concentrated solution spray drying gets Radix Astragali spray drying powder; Radix Astragali spray drying powder is directly granulated or add adjuvant dextrin or the lactose dry granulation of himself weight portion 0-25% in Radix Astragali spray drying powder, astragalus dispensing granule;
Or get Radix Astragali decoction pieces, and add the water of 14 times of weight portions, extracted 2.5 hours, promptly one fry in shallow oil; One fries in shallow oil the water that the back medicinal residues add 11 times of weight portions of Radix Astragali decoction pieces, extracts 2.5 hours, promptly two fries in shallow oil; Merge two liquid of boiling medicine, be evaporated to the concentrated solution of relative density 1.10-1.15; The concentrated solution spray drying gets Radix Astragali spray drying powder; Radix Astragali spray drying powder is directly granulated or add adjuvant dextrin or the lactose dry granulation of himself weight portion 0-25% in Radix Astragali spray drying powder, astragalus dispensing granule.
5, the preparation method of astragalus dispensing granule as claimed in claim 4 is characterized in that wherein said drying process with atomizing parameter is: 40 ℃-50 ℃ of medicinal liquid preheat temperatures; 170 ℃-185 ℃ of inlet temperature; 450-700 rev/min of material revolution speed; 70 ℃-85 ℃ of leaving air temps; Wind send 40 ℃-50 ℃ of temperature; Wherein said granulation parameter is: main pinch roller pressure: 4-6MPa; Side pressure wheel pressure: 0.4-0.6MPa; The speed of mainshaft: 300-500 rev/mins; Feed voltage: 100-150V; Granular size: 20-60 order.
6, the preparation method of astragalus dispensing granule as claimed in claim 4 is characterized in that wherein the quality discrimination of Radix Astragali decoction pieces Infrared fingerprint spectra is: use Fourier transform infrared spectrometer, measurement range is 4000cm
-1-400cm
-1, DTGS detector, resolution 4cm
-1, scanning times 16 times is deducted water and carbon dioxide constantly and is disturbed in the scanning process, and envionmental humidity is lower than 60%, and the potassium bromide direct compression process detects; The Infrared fingerprint spectra of Radix Astragali decoction pieces has following feature: at 1000cm
-1-1200cm
-1Scope in an absworption peak that intensity is big, peak shape is wide is arranged, be stairstepping, it absorbs highest point is 1031cm
-1At 2928cm
-1, 1640cm
-1, 1424cm
-1, 1241cm
-1, 607cm
-1There is characteristic absorption at the place.
7, a kind of preparation method of astragalus dispensing granule is characterized in that this method comprises a kind of in the following method:
Get Radix Astragali decoction pieces, add the water of 5-15 times of weight portion, extracted 0.5-3 hour, promptly one fry in shallow oil; One fries in shallow oil the water that the back medicinal residues add 5-15 times of weight portion of Radix Astragali decoction pieces, extracts 0.5-3 hour, promptly two fries in shallow oil; Merge two liquid of boiling medicine, be evaporated to the concentrated solution of relative density 1.00-1.15; The concentrated solution spray drying gets Radix Astragali spray drying powder; Radix Astragali spray drying powder is directly granulated or add adjuvant dextrin or the lactose dry granulation of himself weight portion 0-25% in Radix Astragali spray drying powder, 20-60 purpose astragalus dispensing granule; Wherein Radix Astragali decoction pieces adopts Infrared fingerprint spectra to carry out quality discrimination, and the Infrared fingerprint spectra discrimination method is: use Fourier transform infrared spectrometer, measurement range is 4000cm
-1-400cm
-1, DTGS detector, resolution 4cm
-1, scanning times 16 times is deducted water and carbon dioxide constantly and is disturbed in the scanning process, and envionmental humidity is lower than 60%, and the potassium bromide direct compression process detects; The Infrared fingerprint spectra of Radix Astragali decoction pieces has following feature: at 1000cm
-1-1200cm
-1Scope in an absworption peak that intensity is big, peak shape is wide is arranged, be stairstepping, it absorbs highest point is 1031cm
-1At 2928cm
-1, 1640cm
-1, 1424cm
-1, 1241cm
-1, 607cm
-1There is characteristic absorption at the place;
Or get Radix Astragali decoction pieces, and add the water of 8 times of weight portions, extracted 2 hours, promptly one fry in shallow oil; One fries in shallow oil the water that the back medicinal residues add 7 times of weight portions of Radix Astragali decoction pieces, extracts 1.5 hours, promptly two fries in shallow oil; Merge two liquid of boiling medicine, be evaporated to the concentrated solution of relative density 1.05-1.10; The concentrated solution spray drying gets Radix Astragali spray drying powder; Radix Astragali spray drying powder is directly granulated or add adjuvant dextrin or the lactose dry granulation of himself weight portion 0-25% in Radix Astragali spray drying powder, 20-60 purpose astragalus dispensing granule; Wherein Radix Astragali decoction pieces adopts Infrared fingerprint spectra to carry out quality discrimination, and the Infrared fingerprint spectra discrimination method is: use Fourier transform infrared spectrometer, measurement range is 4000cm
-1-400cm
-1, DTGS detector, resolution 4cm
-1, scanning times 16 times is deducted water and carbon dioxide constantly and is disturbed in the scanning process, and envionmental humidity is lower than 60%, and the potassium bromide direct compression process detects; The Infrared fingerprint spectra of Radix Astragali decoction pieces has following feature: at 1000cm
-1-1200cm
-1Scope in an absworption peak that intensity is big, peak shape is wide is arranged, be stairstepping, it absorbs highest point is 1031cm
-1At 2928cm
-1, 1640cm
-1, 1424cm
-1, 1241cm
-1, 607cm
-1There is characteristic absorption at the place;
Or get Radix Astragali decoction pieces, and add the water of 10 times of weight portions, extracted 2 hours, promptly one fry in shallow oil; One fries in shallow oil the water that the back medicinal residues add 6 times of weight portions of Radix Astragali decoction pieces, extracts 1 hour, promptly two fries in shallow oil; Merge two liquid of boiling medicine, be evaporated to the concentrated solution of relative density 1.00-1.05; The concentrated solution spray drying gets Radix Astragali spray drying powder; Radix Astragali spray drying powder is directly granulated or add adjuvant dextrin or the lactose dry granulation of himself weight portion 0-25% in Radix Astragali spray drying powder, 20-60 purpose astragalus dispensing granule; Wherein Radix Astragali decoction pieces adopts Infrared fingerprint spectra to carry out quality discrimination, and the Infrared fingerprint spectra discrimination method is: use Fourier transform infrared spectrometer, measurement range is 4000cm
-1-400cm
-1, DTGS detector, resolution 4cm
-1, scanning times 16 times is deducted water and carbon dioxide constantly and is disturbed in the scanning process, and envionmental humidity is lower than 60%, and the potassium bromide direct compression process detects; The Infrared fingerprint spectra of Radix Astragali decoction pieces has following feature: at 1000cm
-1-1200cm
-1Scope in an absworption peak that intensity is big, peak shape is wide is arranged, be stairstepping, it absorbs highest point is 1031cm
-1At 2928cm
-1, 1640cm
-1, 1424cm
-1, 1241cm
-1, 607cm
-1There is characteristic absorption at the place;
Or get Radix Astragali decoction pieces, and add the water of 14 times of weight portions, extracted 2.5 hours, promptly one fry in shallow oil; One fries in shallow oil the water that the back medicinal residues add 11 times of weight portions of Radix Astragali decoction pieces, extracts 2.5 hours, promptly two fries in shallow oil; Merge two liquid of boiling medicine, be evaporated to the concentrated solution of relative density 1.10-1.15; The concentrated solution spray drying gets Radix Astragali spray drying powder; Radix Astragali spray drying powder is directly granulated or add adjuvant dextrin or the lactose dry granulation of himself weight portion 0-25% in Radix Astragali spray drying powder, 20-60 purpose astragalus dispensing granule; Wherein Radix Astragali decoction pieces adopts Infrared fingerprint spectra to carry out quality discrimination, and the Infrared fingerprint spectra discrimination method is: use Fourier transform infrared spectrometer, measurement range is 4000cm
-1-400cm
-1, DTGS detector, resolution 4cm
-1, scanning times 16 times is deducted water and carbon dioxide constantly and is disturbed in the scanning process, and envionmental humidity is lower than 60%, and the potassium bromide direct compression process detects; The Infrared fingerprint spectra of Radix Astragali decoction pieces has following feature: at 1000cm
-1-1200cm
-1Scope in an absworption peak that intensity is big, peak shape is wide is arranged, be stairstepping, it absorbs highest point is 1031cm
-1At 2928cm
-1, 1640cm
-1, 1424cm
-1, 1241cm
-1, 607cm
-1There is characteristic absorption at the place.
8, the preparation method of astragalus dispensing granule as claimed in claim 7 is characterized in that wherein said drying process with atomizing parameter is: 40 ℃-50 ℃ of medicinal liquid preheat temperatures; 170 ℃-185 ℃ of inlet temperature; 450-700 rev/min of material revolution speed; 70 ℃-85 ℃ of leaving air temps; Wind send 40 ℃-50 ℃ of temperature; Wherein said granulation parameter is: main pinch roller pressure: 4-6MPa; Side pressure wheel pressure: 0.4-0.6MPa; The speed of mainshaft: 300-500 rev/mins; Feed voltage: 100-150V; Granular size: 20-60 order.
9, as claim 2,3 arbitrary described astragalus dispensing granules, it is characterized in that wherein said Infrared fingerprint spectra testing conditions is: use Fourier transform infrared spectrometer, measurement range is 4000cm
-1-400cm
-1, DTGS detector, resolution 4cm
-1, scanning times 16 times is deducted water and carbon dioxide constantly and is disturbed in the scanning process, and envionmental humidity is lower than 60%, and the potassium bromide direct compression process detects.
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| CN 200810184583 Pending CN101474244A (en) | 2007-12-18 | 2008-12-17 | Honey-fried licorice root dispensing granule as well as preparation method and quality control method |
| CN 200810184568 Active CN101474232B (en) | 2007-12-18 | 2008-12-17 | White atractylodes rhizome dispensing granule as well as preparation method and quality control method |
| CN 200810184576 Active CN101474287B (en) | 2007-12-18 | 2008-12-17 | Detection method of prepared rehmannia root dispensing granule |
| CN 200810184571 Active CN101474241B (en) | 2007-12-18 | 2008-12-17 | Detection method of astragalus dispensing granule |
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| CN 200810184582 Active CN101474265B (en) | 2007-12-18 | 2008-12-17 | Coptis root dispensing granule as well as preparation method and quality control method thereof |
| CN 200810184564 Pending CN101474333A (en) | 2007-12-18 | 2008-12-17 | Yam dispensing granule as well as preparation method and quality control method thereof |
| CN 200810184573 Active CN101474293B (en) | 2007-12-18 | 2008-12-17 | Medlar dispensing granule as well as preparation method and quality control method thereof |
| CN 200810184565 Pending CN101474352A (en) | 2007-12-18 | 2008-12-17 | Ophiopogon root dispensing granule as well as preparation method and quality control method thereof |
| CN 200810184566 Active CN101474219B (en) | 2007-12-18 | 2008-12-17 | Detection method of achyranthes bidentata dispensing granule |
| CN 200810184569 Active CN101474237B (en) | 2007-12-18 | 2008-12-17 | Detection method of trichosanthes dispensing granule |
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| CN 200810184580 Active CN101474278B (en) | 2007-12-18 | 2008-12-17 | Processed fructus evodiae dispensing granule as well as preparation method and quality control method thereof |
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| CN 200810184564 Pending CN101474333A (en) | 2007-12-18 | 2008-12-17 | Yam dispensing granule as well as preparation method and quality control method thereof |
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| CN 200810184565 Pending CN101474352A (en) | 2007-12-18 | 2008-12-17 | Ophiopogon root dispensing granule as well as preparation method and quality control method thereof |
| CN 200810184566 Active CN101474219B (en) | 2007-12-18 | 2008-12-17 | Detection method of achyranthes bidentata dispensing granule |
| CN 200810184569 Active CN101474237B (en) | 2007-12-18 | 2008-12-17 | Detection method of trichosanthes dispensing granule |
| CN 200810184577 Active CN101474228B (en) | 2007-12-18 | 2008-12-17 | Detection method of wild chrysanthemum dispensing granule |
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| CN 200810184575 Active CN101480420B (en) | 2007-12-18 | 2008-12-17 | Detection method of ballonflower dispensing granule |
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